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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Disease related genes Enzymes Plasma proteins Potential drug targets
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
9
Cytoband
q34.11
Chromosome location (bp)
127785679 - 127790792
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Protein kinase involved in the regulation of transcription 1,2,3,4,5,6,7,8,9,10,11,12. Member of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex, also called positive transcription elongation factor b (P-TEFb), which facilitates the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) POLR2A, SUPT5H and RDBP 13,14,15,16,17,18,19,20,21,22,23,24. This complex is inactive when in the 7SK snRNP complex form 25,26,27,28,29,30,31,32,33,34,35. Phosphorylates EP300, MYOD1, RPB1/POLR2A and AR and the negative elongation factors DSIF and NELFE 36,37,38,39,40,41,42. Regulates cytokine inducible transcription networks by facilitating promoter recognition of target transcription factors (e.g. TNF-inducible RELA/p65 activation and IL-6-inducible STAT3 signaling) 43,44. Promotes RNA synthesis in genetic programs for cell growth, differentiation and viral pathogenesis 45,46. P-TEFb is also involved in cotranscriptional histone modification, mRNA processing and mRNA export 47,48,49. Modulates a complex network of chromatin modifications including histone H2B monoubiquitination (H2Bub1), H3 lysine 4 trimethylation (H3K4me3) and H3K36me3; integrates phosphorylation during transcription with chromatin modifications to control co-transcriptional histone mRNA processing 50,51,52. The CDK9/cyclin-K complex has also a kinase activity towards CTD of RNAP II and can substitute for CDK9/cyclin-T P-TEFb in vitro 53. Replication stress response protein; the CDK9/cyclin-K complex is required for genome integrity maintenance, by promoting cell cycle recovery from replication arrest and limiting single-stranded DNA amount in response to replication stress, thus reducing the breakdown of stalled replication forks and avoiding DNA damage 54. In addition, probable function in DNA repair of isoform 2 via interaction with KU70/XRCC6 55. Promotes cardiac myocyte enlargement 56. RPB1/POLR2A phosphorylation on 'Ser-2' in CTD activates transcription 57. AR phosphorylation modulates AR transcription factor promoter selectivity and cell growth. DSIF and NELF phosphorylation promotes transcription by inhibiting their negative effect 58,59,60. The phosphorylation of MYOD1 enhances its transcriptional activity and thus promotes muscle differentiation 61. Catalyzes phosphorylation of KAT5, promoting KAT5 recruitment to chromatin and histone acetyltransferase activity 62....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
DNA damage, DNA repair, Host-virus interaction, Transcription, Transcription regulation
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
ATP-binding, Nucleotide-binding
Gene summary (Entrez)i
Useful information about the gene from Entrez
The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and known as important cell cycle regulators. This kinase was found to be a component of the multiprotein complex TAK/P-TEFb, which is an elongation factor for RNA polymerase II-directed transcription and functions by phosphorylating the C-terminal domain of the largest subunit of RNA polymerase II. This protein forms a complex with and is regulated by its regulatory subunit cyclin T or cyclin K. HIV-1 Tat protein was found to interact with this protein and cyclin T, which suggested a possible involvement of this protein in AIDS. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Enzymes ENZYME proteins Transferases Kinases CMGC Ser/Thr protein kinases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Disease related genes Potential drug targets Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166[nucleotide binding] GO:0000976[transcription cis-regulatory region binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0001223[transcription coactivator binding] GO:0003677[DNA binding] GO:0003682[chromatin binding] GO:0004672[protein kinase activity] GO:0004674[protein serine/threonine kinase activity] GO:0004693[cyclin-dependent protein serine/threonine kinase activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0006281[DNA repair] GO:0006282[regulation of DNA repair] GO:0006366[transcription by RNA polymerase II] GO:0006367[transcription initiation at RNA polymerase II promoter] GO:0006368[transcription elongation by RNA polymerase II promoter] GO:0006468[protein phosphorylation] GO:0006974[cellular response to DNA damage stimulus] GO:0008023[transcription elongation factor complex] GO:0008024[cyclin/CDK positive transcription elongation factor complex] GO:0008283[cell population proliferation] GO:0008353[RNA polymerase II CTD heptapeptide repeat kinase activity] GO:0009410[response to xenobiotic stimulus] GO:0010613[positive regulation of cardiac muscle hypertrophy] GO:0016020[membrane] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016592[mediator complex] GO:0016605[PML body] GO:0016740[transferase activity] GO:0017069[snRNA binding] GO:0019901[protein kinase binding] GO:0031056[regulation of histone modification] GO:0031297[replication fork processing] GO:0031440[regulation of mRNA 3'-end processing] GO:0032968[positive regulation of transcription elongation by RNA polymerase II] GO:0036464[cytoplasmic ribonucleoprotein granule] GO:0043923[positive regulation by host of viral transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0051147[regulation of muscle cell differentiation] GO:0051726[regulation of cell cycle] GO:0070691[P-TEFb complex] GO:0071345[cellular response to cytokine stimulus] GO:0097322[7SK snRNA binding] GO:0106310[protein serine kinase activity] GO:0120187[positive regulation of protein localization to chromatin] GO:1903654[phosphorylation of RNA polymerase II C-terminal domain serine 5 residues involved in positive regulation of transcription elongation from RNA polymerase II promoter] GO:1903655[phosphorylation of RNA polymerase II C-terminal domain serine 2 residues involved in positive regulation of transcription elongation from RNA polymerase II promoter] GO:1903839[positive regulation of mRNA 3'-UTR binding]
The Human Protein Atlas project is funded
