GENERAL INFORMATIONi
Gene namei DAB2IP
Synonyms AF9Q34, AIP1, DIP1/2, KIAA1743
Gene descriptioni DAB2 interacting protein
Protein classi Disease related genes
Predicted locationi Intracellular
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi
Chromosome 9
Cytoband q33.2
Chromosome location (bp) 121567057 - 121785530
Number of transcriptsi 7
Ensembl ENSG00000136848 (version 109)
Entrez gene 153090
HGNC HGNC:17294
UniProt Q5VWQ8 (UniProt - Evidence at protein level)
neXtProt NX_Q5VWQ8
GeneCards DAB2IP
Antibodypedia DAB2IP antibodies


PROTEIN FUNCTION
Protein function (UniProt)i Functions as a scaffold protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Involved in several processes such as innate immune response, inflammation and cell growth inhibition, apoptosis, cell survival, angiogenesis, cell migration and maturation. Also plays a role in cell cycle checkpoint control; reduces G1 phase cyclin levels resulting in G0/G1 cell cycle arrest. Mediates signal transduction by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF), interferon (IFN) or lipopolysaccharide (LPS). Modulates the balance between phosphatidylinositol 3-kinase (PI3K)-AKT-mediated cell survival and apoptosis stimulated kinase (MAP3K5)-JNK signaling pathways; sequesters both AKT1 and MAP3K5 and counterbalances the activity of each kinase by modulating their phosphorylation status in response to pro-inflammatory stimuli. Acts as a regulator of the endoplasmic reticulum (ER) unfolded protein response (UPR) pathway; specifically involved in transduction of the ER stress-response to the JNK cascade through ERN1. Mediates TNF-alpha-induced apoptosis activation by facilitating dissociation of inhibitor 14-3-3 from MAP3K5; recruits the PP2A phosphatase complex which dephosphorylates MAP3K5 on 'Ser-966', leading to the dissociation of 13-3-3 proteins and activation of the MAP3K5-JNK signaling pathway in endothelial cells. Mediates also TNF/TRAF2-induced MAP3K5-JNK activation, while it inhibits CHUK-NF-kappa-B signaling. Acts a negative regulator in the IFN-gamma-mediated JAK-STAT signaling cascade by inhibiting smooth muscle cell (VSMCs) proliferation and intimal expansion, and thus, prevents graft arteriosclerosis (GA). Acts as a GTPase-activating protein (GAP) for the ADP ribosylation factor 6 (ARF6) and Ras. Promotes hydrolysis of the ARF6-bound GTP and thus, negatively regulates phosphatidylinositol 4,5-bisphosphate (PIP2)-dependent TLR4-TIRAP-MyD88 and NF-kappa-B signaling pathways in endothelial cells in response to lipopolysaccharides (LPS). Binds specifically to phosphatidylinositol 4-phosphate (PtdIns4P) and phosphatidylinositol 3-phosphate (PtdIns3P). In response to vascular endothelial growth factor (VEGFA), acts as a negative regulator of the VEGFR2-PI3K-mediated angiogenic signaling pathway by inhibiting endothelial cell migration and tube formation. In the developing brain, promotes both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex in a glial-dependent locomotion process. Probable downstream effector of the Reelin signaling pathway; promotes Purkinje cell (PC) dendrites development and formation of cerebellar synapses. Functions also as a tumor suppressor protein in prostate cancer progression; prevents cell proliferation and epithelial-to-mesenchymal transition (EMT) through activation of the glycogen synthase kinase-3 beta (GSK3B)-induced beta-catenin and inhibition of PI3K-AKT and Ras-MAPK survival downstream signaling cascades, respectively. show less
Molecular function (UniProt)i Developmental protein, GTPase activation
Biological process (UniProt)i Angiogenesis, Apoptosis, Cell cycle, Growth regulation, Immunity, Inflammatory response, Innate immunity, Stress response, Unfolded protein response
Gene summary (Entrez)i DAB2IP is a Ras (MIM 190020) GTPase-activating protein (GAP) that acts as a tumor suppressor. The DAB2IP gene is inactivated by methylation in prostate and breast cancers (Yano et al., 2005).[supplied by OMIM, May 2010] show less
PROTEIN INFORMATIONi
Splice variant SwissProt TrEMBL Protein class Gene ontology Length & mass Signal peptide
(predicted)		 Transmembrane regions
(predicted)
DAB2IP-201
ENSP00000259371
ENST00000259371
Q5VWQ8
[Direct mapping] Disabled homolog 2-interacting protein
Show all
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Disease related genes
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0001525 [angiogenesis]
GO:0001933 [negative regulation of protein phosphorylation]
GO:0002376 [immune system process]
GO:0005096 [GTPase activator activity]
GO:0005123 [death receptor binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006915 [apoptotic process]
GO:0006954 [inflammatory response]
GO:0006986 [response to unfolded protein]
GO:0007049 [cell cycle]
GO:0007165 [signal transduction]
GO:0007252 [I-kappaB phosphorylation]
GO:0008285 [negative regulation of cell population proliferation]
GO:0008625 [extrinsic apoptotic signaling pathway via death domain receptors]
GO:0010596 [negative regulation of endothelial cell migration]
GO:0010633 [negative regulation of epithelial cell migration]
GO:0010719 [negative regulation of epithelial to mesenchymal transition]
GO:0010976 [positive regulation of neuron projection development]
GO:0014067 [negative regulation of phosphatidylinositol 3-kinase signaling]
GO:0016020 [membrane]
GO:0016525 [negative regulation of angiogenesis]
GO:0017124 [SH3 domain binding]
GO:0019900 [kinase binding]
GO:0019901 [protein kinase binding]
GO:0021814 [cell motility involved in cerebral cortex radial glia guided migration]
GO:0021819 [layer formation in cerebral cortex]
GO:0030139 [endocytic vesicle]
GO:0030163 [protein catabolic process]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0030948 [negative regulation of vascular endothelial growth factor receptor signaling pathway]
GO:0031334 [positive regulation of protein-containing complex assembly]
GO:0031434 [mitogen-activated protein kinase kinase binding]
GO:0031435 [mitogen-activated protein kinase kinase kinase binding]
GO:0032088 [negative regulation of NF-kappaB transcription factor activity]
GO:0032266 [phosphatidylinositol-3-phosphate binding]
GO:0032809 [neuronal cell body membrane]
GO:0034144 [negative regulation of toll-like receptor 4 signaling pathway]
GO:0034260 [negative regulation of GTPase activity]
GO:0034620 [cellular response to unfolded protein]
GO:0035148 [tube formation]
GO:0035591 [signaling adaptor activity]
GO:0035924 [cellular response to vascular endothelial growth factor stimulus]
GO:0036312 [phosphatidylinositol 3-kinase regulatory subunit binding]
GO:0036324 [vascular endothelial growth factor receptor-2 signaling pathway]
GO:0038026 [reelin-mediated signaling pathway]
GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway]
GO:0042177 [negative regulation of protein catabolic process]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0042995 [cell projection]
GO:0043025 [neuronal cell body]
GO:0043065 [positive regulation of apoptotic process]
GO:0043087 [regulation of GTPase activity]
GO:0043122 [regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043184 [vascular endothelial growth factor receptor 2 binding]
GO:0043254 [regulation of protein-containing complex assembly]
GO:0043407 [negative regulation of MAP kinase activity]
GO:0043410 [positive regulation of MAPK cascade]
GO:0043507 [positive regulation of JUN kinase activity]
GO:0043539 [protein serine/threonine kinase activator activity]
GO:0043548 [phosphatidylinositol 3-kinase binding]
GO:0043553 [negative regulation of phosphatidylinositol 3-kinase activity]
GO:0044300 [cerebellar mossy fiber]
GO:0044301 [climbing fiber]
GO:0044877 [protein-containing complex binding]
GO:0045087 [innate immune response]
GO:0045296 [cadherin binding]
GO:0045732 [positive regulation of protein catabolic process]
GO:0045892 [negative regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046330 [positive regulation of JNK cascade]
GO:0046580 [negative regulation of Ras protein signal transduction]
GO:0048147 [negative regulation of fibroblast proliferation]
GO:0048812 [neuron projection morphogenesis]
GO:0050680 [negative regulation of epithelial cell proliferation]
GO:0051721 [protein phosphatase 2A binding]
GO:0051726 [regulation of cell cycle]
GO:0070059 [intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress]
GO:0070273 [phosphatidylinositol-4-phosphate binding]
GO:0070317 [negative regulation of G0 to G1 transition]
GO:0070373 [negative regulation of ERK1 and ERK2 cascade]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071347 [cellular response to interleukin-1]
GO:0071356 [cellular response to tumor necrosis factor]
GO:0071364 [cellular response to epidermal growth factor stimulus]
GO:0071889 [14-3-3 protein binding]
GO:0071901 [negative regulation of protein serine/threonine kinase activity]
GO:0071902 [positive regulation of protein serine/threonine kinase activity]
GO:0072577 [endothelial cell apoptotic process]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:0090129 [positive regulation of synapse maturation]
GO:1900006 [positive regulation of dendrite development]
GO:1900744 [regulation of p38MAPK cascade]
GO:1900747 [negative regulation of vascular endothelial growth factor signaling pathway]
GO:1901800 [positive regulation of proteasomal protein catabolic process]
GO:1903896 [positive regulation of IRE1-mediated unfolded protein response]
GO:1990032 [parallel fiber]
GO:1990597 [AIP1-IRE1 complex]
GO:2001224 [positive regulation of neuron migration]
GO:2001235 [positive regulation of apoptotic signaling pathway]
Show all
 1132 aa
125 kDa 		No 0
DAB2IP-202
ENSP00000310827
ENST00000309989
Q5VWQ8
[Direct mapping] Disabled homolog 2-interacting protein
Show all
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Disease related genes
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0001525 [angiogenesis]
GO:0001933 [negative regulation of protein phosphorylation]
GO:0002376 [immune system process]
GO:0005096 [GTPase activator activity]
GO:0005123 [death receptor binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006915 [apoptotic process]
GO:0006954 [inflammatory response]
GO:0006986 [response to unfolded protein]
GO:0007049 [cell cycle]
GO:0007165 [signal transduction]
GO:0007252 [I-kappaB phosphorylation]
GO:0008285 [negative regulation of cell population proliferation]
GO:0008625 [extrinsic apoptotic signaling pathway via death domain receptors]
GO:0010596 [negative regulation of endothelial cell migration]
GO:0010633 [negative regulation of epithelial cell migration]
GO:0010719 [negative regulation of epithelial to mesenchymal transition]
GO:0010976 [positive regulation of neuron projection development]
GO:0014067 [negative regulation of phosphatidylinositol 3-kinase signaling]
GO:0016020 [membrane]
GO:0016525 [negative regulation of angiogenesis]
GO:0017124 [SH3 domain binding]
GO:0019900 [kinase binding]
GO:0019901 [protein kinase binding]
GO:0021814 [cell motility involved in cerebral cortex radial glia guided migration]
GO:0021819 [layer formation in cerebral cortex]
GO:0030139 [endocytic vesicle]
GO:0030163 [protein catabolic process]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0030948 [negative regulation of vascular endothelial growth factor receptor signaling pathway]
GO:0031334 [positive regulation of protein-containing complex assembly]
GO:0031434 [mitogen-activated protein kinase kinase binding]
GO:0031435 [mitogen-activated protein kinase kinase kinase binding]
GO:0032088 [negative regulation of NF-kappaB transcription factor activity]
GO:0032266 [phosphatidylinositol-3-phosphate binding]
GO:0032809 [neuronal cell body membrane]
GO:0034144 [negative regulation of toll-like receptor 4 signaling pathway]
GO:0034260 [negative regulation of GTPase activity]
GO:0034620 [cellular response to unfolded protein]
GO:0035148 [tube formation]
GO:0035591 [signaling adaptor activity]
GO:0035924 [cellular response to vascular endothelial growth factor stimulus]
GO:0036312 [phosphatidylinositol 3-kinase regulatory subunit binding]
GO:0036324 [vascular endothelial growth factor receptor-2 signaling pathway]
GO:0038026 [reelin-mediated signaling pathway]
GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway]
GO:0042177 [negative regulation of protein catabolic process]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0042995 [cell projection]
GO:0043025 [neuronal cell body]
GO:0043065 [positive regulation of apoptotic process]
GO:0043087 [regulation of GTPase activity]
GO:0043122 [regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043184 [vascular endothelial growth factor receptor 2 binding]
GO:0043254 [regulation of protein-containing complex assembly]
GO:0043407 [negative regulation of MAP kinase activity]
GO:0043410 [positive regulation of MAPK cascade]
GO:0043507 [positive regulation of JUN kinase activity]
GO:0043539 [protein serine/threonine kinase activator activity]
GO:0043548 [phosphatidylinositol 3-kinase binding]
GO:0043553 [negative regulation of phosphatidylinositol 3-kinase activity]
GO:0044300 [cerebellar mossy fiber]
GO:0044301 [climbing fiber]
GO:0044877 [protein-containing complex binding]
GO:0045087 [innate immune response]
GO:0045296 [cadherin binding]
GO:0045732 [positive regulation of protein catabolic process]
GO:0045892 [negative regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046330 [positive regulation of JNK cascade]
GO:0046580 [negative regulation of Ras protein signal transduction]
GO:0048147 [negative regulation of fibroblast proliferation]
GO:0048812 [neuron projection morphogenesis]
GO:0050680 [negative regulation of epithelial cell proliferation]
GO:0051721 [protein phosphatase 2A binding]
GO:0051726 [regulation of cell cycle]
GO:0070059 [intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress]
GO:0070273 [phosphatidylinositol-4-phosphate binding]
GO:0070317 [negative regulation of G0 to G1 transition]
GO:0070373 [negative regulation of ERK1 and ERK2 cascade]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071347 [cellular response to interleukin-1]
GO:0071356 [cellular response to tumor necrosis factor]
GO:0071364 [cellular response to epidermal growth factor stimulus]
GO:0071889 [14-3-3 protein binding]
GO:0071901 [negative regulation of protein serine/threonine kinase activity]
GO:0071902 [positive regulation of protein serine/threonine kinase activity]
GO:0072577 [endothelial cell apoptotic process]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:0090129 [positive regulation of synapse maturation]
GO:1900006 [positive regulation of dendrite development]
GO:1900744 [regulation of p38MAPK cascade]
GO:1900747 [negative regulation of vascular endothelial growth factor signaling pathway]
GO:1901800 [positive regulation of proteasomal protein catabolic process]
GO:1903896 [positive regulation of IRE1-mediated unfolded protein response]
GO:1990032 [parallel fiber]
GO:1990597 [AIP1-IRE1 complex]
GO:2001224 [positive regulation of neuron migration]
GO:2001235 [positive regulation of apoptotic signaling pathway]
Show all
 1065 aa
117.7 kDa 		No 0
DAB2IP-203
ENSP00000386183
ENST00000408936
Q5VWQ8
[Direct mapping] Disabled homolog 2-interacting protein
Show all
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Disease related genes
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0001525 [angiogenesis]
GO:0001933 [negative regulation of protein phosphorylation]
GO:0002376 [immune system process]
GO:0005096 [GTPase activator activity]
GO:0005123 [death receptor binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006915 [apoptotic process]
GO:0006954 [inflammatory response]
GO:0006986 [response to unfolded protein]
GO:0007049 [cell cycle]
GO:0007165 [signal transduction]
GO:0007252 [I-kappaB phosphorylation]
GO:0008285 [negative regulation of cell population proliferation]
GO:0008625 [extrinsic apoptotic signaling pathway via death domain receptors]
GO:0010596 [negative regulation of endothelial cell migration]
GO:0010633 [negative regulation of epithelial cell migration]
GO:0010719 [negative regulation of epithelial to mesenchymal transition]
GO:0010976 [positive regulation of neuron projection development]
GO:0014067 [negative regulation of phosphatidylinositol 3-kinase signaling]
GO:0016020 [membrane]
GO:0016525 [negative regulation of angiogenesis]
GO:0017124 [SH3 domain binding]
GO:0019900 [kinase binding]
GO:0019901 [protein kinase binding]
GO:0021814 [cell motility involved in cerebral cortex radial glia guided migration]
GO:0021819 [layer formation in cerebral cortex]
GO:0030139 [endocytic vesicle]
GO:0030163 [protein catabolic process]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0030948 [negative regulation of vascular endothelial growth factor receptor signaling pathway]
GO:0031334 [positive regulation of protein-containing complex assembly]
GO:0031434 [mitogen-activated protein kinase kinase binding]
GO:0031435 [mitogen-activated protein kinase kinase kinase binding]
GO:0032088 [negative regulation of NF-kappaB transcription factor activity]
GO:0032266 [phosphatidylinositol-3-phosphate binding]
GO:0032809 [neuronal cell body membrane]
GO:0034144 [negative regulation of toll-like receptor 4 signaling pathway]
GO:0034260 [negative regulation of GTPase activity]
GO:0034620 [cellular response to unfolded protein]
GO:0035148 [tube formation]
GO:0035591 [signaling adaptor activity]
GO:0035924 [cellular response to vascular endothelial growth factor stimulus]
GO:0036312 [phosphatidylinositol 3-kinase regulatory subunit binding]
GO:0036324 [vascular endothelial growth factor receptor-2 signaling pathway]
GO:0038026 [reelin-mediated signaling pathway]
GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway]
GO:0042177 [negative regulation of protein catabolic process]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0042995 [cell projection]
GO:0043025 [neuronal cell body]
GO:0043065 [positive regulation of apoptotic process]
GO:0043087 [regulation of GTPase activity]
GO:0043122 [regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043184 [vascular endothelial growth factor receptor 2 binding]
GO:0043254 [regulation of protein-containing complex assembly]
GO:0043407 [negative regulation of MAP kinase activity]
GO:0043410 [positive regulation of MAPK cascade]
GO:0043507 [positive regulation of JUN kinase activity]
GO:0043539 [protein serine/threonine kinase activator activity]
GO:0043548 [phosphatidylinositol 3-kinase binding]
GO:0043553 [negative regulation of phosphatidylinositol 3-kinase activity]
GO:0044300 [cerebellar mossy fiber]
GO:0044301 [climbing fiber]
GO:0044877 [protein-containing complex binding]
GO:0045087 [innate immune response]
GO:0045296 [cadherin binding]
GO:0045732 [positive regulation of protein catabolic process]
GO:0045892 [negative regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046330 [positive regulation of JNK cascade]
GO:0046580 [negative regulation of Ras protein signal transduction]
GO:0048147 [negative regulation of fibroblast proliferation]
GO:0048812 [neuron projection morphogenesis]
GO:0050680 [negative regulation of epithelial cell proliferation]
GO:0051721 [protein phosphatase 2A binding]
GO:0051726 [regulation of cell cycle]
GO:0070059 [intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress]
GO:0070273 [phosphatidylinositol-4-phosphate binding]
GO:0070317 [negative regulation of G0 to G1 transition]
GO:0070373 [negative regulation of ERK1 and ERK2 cascade]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071347 [cellular response to interleukin-1]
GO:0071356 [cellular response to tumor necrosis factor]
GO:0071364 [cellular response to epidermal growth factor stimulus]
GO:0071889 [14-3-3 protein binding]
GO:0071901 [negative regulation of protein serine/threonine kinase activity]
GO:0071902 [positive regulation of protein serine/threonine kinase activity]
GO:0072577 [endothelial cell apoptotic process]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:0090129 [positive regulation of synapse maturation]
GO:1900006 [positive regulation of dendrite development]
GO:1900744 [regulation of p38MAPK cascade]
GO:1900747 [negative regulation of vascular endothelial growth factor signaling pathway]
GO:1901800 [positive regulation of proteasomal protein catabolic process]
GO:1903896 [positive regulation of IRE1-mediated unfolded protein response]
GO:1990032 [parallel fiber]
GO:1990597 [AIP1-IRE1 complex]
GO:2001224 [positive regulation of neuron migration]
GO:2001235 [positive regulation of apoptotic signaling pathway]
Show all
 1189 aa
131.6 kDa 		No 0
DAB2IP-208
ENSP00000497730
ENST00000489314
A0A3B3ITC7
[Direct mapping] Disabled homolog 2-interacting protein
Show all
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
   DeepTMHMM predicted secreted proteins
   DeepSig predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 69 aa
7.1 kDa 		Yes 0
DAB2IP-209
ENSP00000497706
ENST00000648444
A0A3B3ITG3
[Direct mapping] Disabled homolog 2-interacting protein
Show all
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005096 [GTPase activator activity]
GO:0007165 [signal transduction]
GO:0008285 [negative regulation of cell population proliferation]
GO:0016525 [negative regulation of angiogenesis]
GO:0030948 [negative regulation of vascular endothelial growth factor receptor signaling pathway]
GO:0038026 [reelin-mediated signaling pathway]
GO:0043065 [positive regulation of apoptotic process]
GO:0043087 [regulation of GTPase activity]
Show all
 1128 aa
124.4 kDa 		No 0
DAB2IP-210
ENSP00000498171
ENST00000648693
A0A3B3IUB7
[Direct mapping] Disabled homolog 2-interacting protein
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005096 [GTPase activator activity]
GO:0008285 [negative regulation of cell population proliferation]
GO:0016525 [negative regulation of angiogenesis]
GO:0030948 [negative regulation of vascular endothelial growth factor receptor signaling pathway]
GO:0038026 [reelin-mediated signaling pathway]
GO:0043065 [positive regulation of apoptotic process]
GO:0043087 [regulation of GTPase activity]
Show all
 48 aa
5.4 kDa 		No 0
DAB2IP-211
ENSP00000514398
ENST00000699487
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005096 [GTPase activator activity]
GO:0007165 [signal transduction]
GO:0008285 [negative regulation of cell population proliferation]
GO:0016525 [negative regulation of angiogenesis]
GO:0030948 [negative regulation of vascular endothelial growth factor receptor signaling pathway]
GO:0038026 [reelin-mediated signaling pathway]
GO:0043065 [positive regulation of apoptotic process]
GO:0043087 [regulation of GTPase activity]
Show all
 518 aa
58.2 kDa 		No 0

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