Expression of RPL35 in urothelial cancer

BLADDER UROTHELIAL CARCINOMA (TCGA) - Interactive survival scatter plotⁱ

The Survival Scatter plot shows the clinical status (i.e. dead or alive) for all individuals in the patient cohort, based on the same data that underlies the corresponding Kaplan-Meier plots. Patients that are alive at last time for follow-up are shown in blue and patients who have died during the study are shown in red.

The x-axis shows the expression levels (FPKM) of the investigated gene in the tumor tissue at the time of diagnosis. The y-axis shows the follow-up time after diagnosis (years). Both axes are complimented with kernel density curves demonstrating the data density over the axes. The top density plot shows the expression levels (FPKM) distribution among dead (red) and alive patients (blue). The right density plot shows the data density of the survived years of dead patients with high and low expression levels respectively, stratified using the cutoff indicated by the vertical dashed line through the Survival Scatter plot. This cutoff is automatically defined based on the FPKM cutoff that minimizes the p-score. The cutoff can be changed by dragging the vertical line or by entering a cutoff value in the square labeled "Current cut-off".

Under the Survival Scatter plot the p-score landscape (black curve; left axis) is shown together with dead median separation (red curve; right axis). Dead median separation is the difference in median mRNA expression between patients who have died with high and low expression, respectively. It is calculated as follows: median FPKM expression of dead patients with high expression - median FPKM expression of dead patients with low expression. This is intended to aid the user in visually exploring custom cutoffs and the associated p-scores and dead median separation.

Individual patient data is displayed and can be filtered by clicking on one or more of the category buttons on the top of the page. Categories describing expression level and patient information include: high, low, alive, dead, female, male and tumor stages. The scale of the x-axis can be toggled between linear and log-scale by clicking on the "x log" button. Mouse-over function shows TCGA ID, patient information and mRNA expression (FPKM) for each patient.

& Survival analysisⁱ

RPL35 is potential prognostic, high expression is unfavorable in Bladder Urothelial Carcinoma (TCGA)

Stage:

Survival analysis

Current cut offⁱ :

Best expression cut offⁱ : 1084.55

Median expressionⁱ : N/A

Median follow up timeⁱ : N/A

P scoreⁱ N/A

5-year survival highⁱ N/A

5-year survival lowⁱ N/A

TCGA RNA samplesⁱ

Average pTPM

2168.7

Number of samples

169

Samples

Sample	Description	pTPM
TCGA-FD-A3B4-01A	55 years, female, black or african american, stage:Stage III, dead, 510 days	6520.8
TCGA-CF-A47T-01A	58 years, female, asian, stage:Stage II, dead, 385 days	6128.6
TCGA-FD-A5BV-01A	47 years, female, white, stage:Stage III, dead, 163 days	5156.2
TCGA-ZF-AA5N-01A	62 years, female, white, stage:Stage IV, dead, 168 days	4860.8
TCGA-FJ-A871-01A	49 years, male, white, stage:Stage III, dead, 272 days	4733.5
TCGA-FD-A6TH-01A	63 years, male, white, stage:Stage IV, dead, 131 days	4551.4
TCGA-E7-A4XJ-01A	66 years, male, asian, stage:Stage II, dead, 68 days	4493.3
TCGA-ZF-AA4N-01A	74 years, male, white, stage:Stage II, dead, 88 days	4341.6
TCGA-GU-A762-01A	87 years, male, white, stage:Stage IV, dead, 232 days	4329.2
TCGA-FD-A5BX-01A	82 years, male, white, stage:Stage IV, dead, 173 days	4070.9
TCGA-UY-A78N-01A	80 years, male, white, stage:Stage IV, dead, 2641 days	3938.5
TCGA-E5-A4TZ-01A	64 years, male, white, stage:Stage IV, dead, 467 days	3927.2
TCGA-K4-A4AC-01A	83 years, male, white, stage:Stage II, dead, 278 days	3853.8
TCGA-FJ-A3Z9-01A	72 years, male, white, stage:'--, dead, 385 days	3836.3
TCGA-DK-AA6Q-01A	61 years, female, white, stage:Stage IV, dead, 413 days	3830.3
TCGA-FD-A43Y-01A	65 years, male, white, stage:Stage III, dead, 474 days	3715.4
TCGA-FJ-A3ZE-01A	65 years, male, white, stage:Stage IV, dead, 324 days	3651.7
TCGA-XF-AAN2-01A	73 years, male, white, stage:Stage II, dead, 1869 days	3623.0
TCGA-HQ-A5ND-01A	78 years, male, stage:Stage IV, dead, 274 days	3603.4
TCGA-XF-AAMH-01A	80 years, male, white, stage:Stage IV, dead, 344 days	3569.0
TCGA-UY-A78M-01A	81 years, female, asian, stage:Stage IV, dead, 690 days	3567.2
TCGA-BT-A20J-01A	75 years, male, white, stage:Stage II, dead, 579 days	3515.0
TCGA-K4-A5RI-01A	67 years, female, white, stage:Stage III, dead, 356 days	3479.9
TCGA-GU-A42Q-01A	67 years, male, white, stage:Stage III, dead, 344 days	3464.0
TCGA-ZF-A9RD-01A	75 years, female, white, stage:Stage IV, dead, 408 days	3460.6
TCGA-XF-AAN8-01A	74 years, female, white, stage:Stage III, dead, 118 days	3403.3
TCGA-BT-A3PK-01A	80 years, male, white, stage:Stage II, dead, 303 days	3363.2
TCGA-4Z-AA82-01A	59 years, male, black or african american, stage:Stage IV, dead, 1556 days	3305.9
TCGA-FD-A62P-01A	76 years, male, white, stage:Stage II, dead, 191 days	3278.3
TCGA-BT-A20V-01A	59 years, female, black or african american, stage:Stage IV, dead, 154 days	3269.8
TCGA-XF-A8HF-01A	80 years, male, white, stage:Stage III, dead, 2954 days	3263.3
TCGA-BT-A20N-01A	72 years, male, stage:Stage III, dead, 795 days	3162.8
TCGA-GU-AATQ-01A	68 years, male, white, stage:Stage III, dead, 213 days	3160.9
TCGA-BT-A0S7-01A	75 years, male, white, stage:Stage III, dead, 200 days	3140.3
TCGA-XF-A8HC-01A	79 years, male, asian, stage:Stage IV, dead, 200 days	3109.4
TCGA-XF-AAN7-01A	60 years, male, white, stage:Stage IV, dead, 565 days	3084.4
TCGA-HQ-A5NE-01A	57 years, male, stage:Stage III, dead, 370 days	3077.4
TCGA-FD-A6TF-01A	80 years, female, white, stage:Stage IV, dead, 69 days	3019.2
TCGA-FD-A3B3-01A	74 years, female, white, stage:Stage III, dead, 974 days	3014.5
TCGA-FD-A6TD-01A	77 years, male, white, stage:Stage III, dead, 386 days	2989.4
TCGA-4Z-AA7Q-01A	79 years, male, white, stage:Stage III, dead, 510 days	2946.2
TCGA-FD-A62O-01A	74 years, male, white, stage:Stage IV, dead, 216 days	2900.0
TCGA-FD-A3SS-01A	66 years, male, white, stage:Stage IV, dead, 391 days	2891.8
TCGA-BT-A20W-01A	71 years, male, white, stage:Stage II, dead, 254 days	2887.4
TCGA-XF-AAMT-01A	75 years, female, white, stage:Stage IV, dead, 90 days	2850.0
TCGA-ZF-A9RN-01A	67 years, female, white, stage:Stage III, dead, 615 days	2803.4
TCGA-C4-A0EZ-01A	69 years, female, stage:Stage IV, dead, 273 days	2768.7
TCGA-XF-AAML-01A	75 years, male, white, stage:Stage II, dead, 232 days	2767.1
TCGA-5N-A9KI-01A	76 years, female, white, stage:Stage III, dead, 76 days	2743.6
TCGA-XF-A9SH-01A	65 years, female, asian, stage:Stage II, dead, 1971 days	2740.1
TCGA-BT-A20X-01A	56 years, male, white, stage:Stage IV, dead, 251 days	2739.9
TCGA-XF-A9SZ-01A	79 years, male, white, stage:Stage IV, dead, 859 days	2703.5
TCGA-G2-A2ES-01A	85 years, male, white, stage:Stage II, dead, 1004 days	2696.7
TCGA-DK-AA75-01A	82 years, male, white, stage:Stage III, dead, 340 days	2673.8
TCGA-G2-A2EO-01A	69 years, male, white, stage:Stage III, dead, 1804 days	2669.6
TCGA-BT-A3PH-01A	76 years, male, white, stage:Stage IV, dead, 142 days	2664.2
TCGA-XF-A9SP-01A	59 years, male, white, stage:Stage III, dead, 454 days	2631.7
TCGA-XF-A8HH-01A	61 years, female, white, stage:Stage IV, dead, 57 days	2624.5
TCGA-FD-A3SJ-01A	59 years, male, white, stage:Stage IV, dead, 739 days	2615.6
TCGA-DK-A1AB-01A	74 years, female, white, stage:Stage IV, dead, 508 days	2612.0
TCGA-DK-A2I2-01A	63 years, female, white, stage:Stage IV, dead, 237 days	2606.5
TCGA-G2-A3IB-01A	66 years, male, black or african american, stage:Stage II, dead, 220 days	2605.4
TCGA-DK-A3IU-01A	58 years, male, white, stage:Stage II, dead, 706 days	2594.0
TCGA-CU-A0YN-01A	60 years, male, white, stage:Stage III, dead, 393 days	2577.6
TCGA-2F-A9KP-01A	66 years, male, white, stage:Stage IV, dead, 364 days	2548.3
TCGA-BT-A2LD-01A	78 years, female, white, stage:Stage IV, dead, 623 days	2543.7
TCGA-E7-A97P-01A	73 years, male, asian, stage:Stage II, dead, 437 days	2535.6
TCGA-4Z-AA86-01A	66 years, male, black or african american, stage:Stage IV, dead, 311 days	2514.7
TCGA-UY-A78K-01A	60 years, male, white, stage:Stage IV, dead, 536 days	2486.1
TCGA-CU-A5W6-01A	70 years, male, white, stage:Stage III, dead, 56 days	2428.2
TCGA-FD-A5BT-01A	84 years, male, white, stage:Stage III, dead, 328 days	2405.8
TCGA-ZF-AA56-01A	79 years, female, white, stage:Stage III, dead, 259 days	2398.2
TCGA-CU-A0YR-01A	83 years, male, white, stage:Stage IV, dead, 460 days	2355.1
TCGA-FD-A3N5-01A	69 years, male, black or african american, stage:Stage II, dead, 685 days	2343.4
TCGA-XF-AAN0-01A	68 years, male, white, stage:Stage IV, dead, 1718 days	2340.2
TCGA-DK-AA6W-01A	78 years, male, white, stage:Stage II, dead, 415 days	2338.2
TCGA-2F-A9KW-01A	67 years, female, white, stage:Stage III, dead, 254 days	2288.5
TCGA-FD-A5C0-01A	61 years, male, white, stage:Stage IV, dead, 550 days	2277.6
TCGA-ZF-AA54-01A	71 years, male, white, stage:Stage III, dead, 590 days	2268.5
TCGA-FD-A3B6-01A	75 years, male, white, stage:Stage II, dead, 1005 days	2267.8
TCGA-BL-A13J-01A	65 years, male, white, stage:Stage IV, dead, 81 days	2229.1
TCGA-XF-AAMW-01A	79 years, female, white, stage:Stage IV, dead, 253 days	2228.2
TCGA-DK-A1A3-01A	60 years, male, white, stage:Stage IV, dead, 665 days	2210.3
TCGA-GV-A3JV-01A	66 years, male, white, stage:Stage IV, dead, 434 days	2142.5
TCGA-XF-AAN1-01A	75 years, female, stage:Stage III, dead, 941 days	2131.2
TCGA-FD-A3B5-01A	86 years, male, black or african american, stage:Stage IV, dead, 272 days	2103.6
TCGA-GV-A3QF-01A	79 years, male, white, stage:Stage IV, dead, 617 days	2081.4
TCGA-FD-A3B7-01A	66 years, male, black or african american, stage:Stage III, dead, 122 days	2056.0
TCGA-CU-A0YO-01A	84 years, male, white, stage:Stage IV, dead, 149 days	2029.1
TCGA-GC-A3BM-01A	70 years, male, white, stage:Stage II, dead, 651 days	2002.4
TCGA-BT-A0YX-01A	70 years, female, white, stage:Stage III, dead, 400 days	1974.7
TCGA-ZF-A9R0-01A	82 years, male, white, stage:Stage III, dead, 680 days	1926.8
TCGA-DK-A3IK-01A	87 years, male, white, stage:Stage IV, dead, 146 days	1924.9
TCGA-C4-A0F7-01A	77 years, male, stage:Stage IV, dead, 62 days	1922.3
TCGA-GV-A3QH-01A	67 years, male, white, stage:Stage II, dead, 258 days	1913.3
TCGA-XF-A9SK-01A	65 years, male, white, stage:Stage IV, dead, 486 days	1865.5
TCGA-2F-A9KO-01A	63 years, male, white, stage:Stage IV, dead, 734 days	1861.3
TCGA-4Z-AA7N-01A	65 years, male, white, stage:Stage III, dead, 1367 days	1840.4
TCGA-CF-A9FL-01A	85 years, male, asian, stage:Stage III, dead, 565 days	1782.7
TCGA-DK-A3IM-01A	76 years, male, white, stage:Stage III, dead, 248 days	1760.0
TCGA-CU-A72E-01A	76 years, male, white, stage:Stage IV, dead, 413 days	1721.0
TCGA-ZF-AA4U-01A	70 years, male, white, stage:Stage III, dead, 262 days	1686.5
TCGA-DK-A3IQ-01A	74 years, male, white, stage:Stage III, dead, 539 days	1666.3
TCGA-XF-A9ST-01A	68 years, male, white, stage:Stage III, dead, 128 days	1647.5
TCGA-BL-A3JM-01A	62 years, male, white, stage:Stage III, dead, 205 days	1625.6
TCGA-G2-A2EC-01A	58 years, female, black or african american, stage:Stage II, dead, 696 days	1603.7
TCGA-G2-AA3C-01A	66 years, male, white, stage:Stage IV, dead, 211 days	1596.8
TCGA-FD-A6TG-01A	73 years, male, white, stage:Stage IV, dead, 93 days	1517.0
TCGA-GU-A42R-01A	68 years, male, white, stage:Stage IV, dead, 577 days	1496.5
TCGA-GU-AATO-01A	75 years, male, white, stage:Stage IV, dead, 324 days	1485.2
TCGA-5N-A9KM-01A	73 years, female, white, stage:Stage III, dead, 530 days	1426.8
TCGA-FD-A6TI-01A	73 years, male, white, stage:Stage IV, dead, 294 days	1423.0
TCGA-G2-A3IE-01A	51 years, male, white, stage:Stage II, dead, 612 days	1421.4
TCGA-YC-A9TC-01A	71 years, male, white, stage:Stage IV, dead, 20 days	1409.0
TCGA-BT-A2LB-01A	73 years, female, white, stage:Stage III, dead, 492 days	1407.0
TCGA-S5-A6DX-01A	83 years, male, white, stage:Stage IV, dead, 56 days	1385.2
TCGA-FD-A3SQ-01A	62 years, male, white, stage:Stage IV, dead, 1423 days	1358.3
TCGA-E7-A3X6-01A	70 years, male, white, stage:Stage II, dead, 904 days	1331.2
TCGA-BL-A13I-01A	57 years, female, white, stage:Stage III, dead, 223 days	1325.6
TCGA-GV-A40E-01A	75 years, male, white, stage:Stage II, dead, 261 days	1310.6
TCGA-GC-A3I6-01A	45 years, male, white, stage:Stage III, dead, 630 days	1297.2
TCGA-GU-A767-01A	81 years, male, white, stage:Stage IV, dead, 144 days	1291.6
TCGA-XF-A9SJ-01A	83 years, male, white, stage:Stage IV, dead, 98 days	1254.1
TCGA-DK-A3X2-01A	85 years, male, white, stage:Stage IV, dead, 547 days	1243.7
TCGA-DK-A3IL-01A	79 years, female, white, stage:Stage IV, dead, 413 days	1241.2
TCGA-XF-A8HG-01A	69 years, male, white, stage:Stage III, dead, 467 days	1231.3
TCGA-DK-A1A5-01A	79 years, male, white, stage:Stage II, dead, 65 days	1220.1
TCGA-XF-A9T2-01A	54 years, male, white, stage:Stage III, dead, 575 days	1215.5
TCGA-XF-A8HI-01A	57 years, female, white, stage:Stage IV, dead, 544 days	1165.8
TCGA-G2-A2EL-01A	77 years, male, white, stage:Stage II, dead, 819 days	1159.1
TCGA-4Z-AA7R-01A	73 years, male, black or african american, stage:Stage IV, dead, 522 days	1152.8
TCGA-FD-A3SO-01A	68 years, male, white, stage:Stage IV, dead, 168 days	1125.5
TCGA-BT-A20Q-01A	73 years, male, white, stage:Stage IV, dead, 593 days	1111.0
TCGA-FD-A62S-01A	60 years, female, black or african american, stage:Stage III, dead, 406 days	1110.4
TCGA-BT-A20P-01A	81 years, female, white, stage:Stage III, dead, 544 days	1086.4
TCGA-BT-A20U-01A	70 years, female, white, stage:Stage III, dead, 455 days	1082.7
TCGA-4Z-AA81-01A	80 years, male, white, stage:Stage II, dead, 1270 days	1044.1
TCGA-DK-A3IN-01A	72 years, male, white, stage:Stage III, dead, 250 days	979.1
TCGA-XF-AAMX-01A	87 years, female, black or african american, stage:Stage III, dead, 206 days	977.9
TCGA-FD-A3SM-01A	70 years, male, white, stage:Stage IV, dead, 547 days	919.8
TCGA-ZF-A9R3-01A	53 years, female, white, stage:Stage II, dead, 949 days	916.8
TCGA-XF-A9SL-01A	69 years, male, white, stage:Stage IV, dead, 2020 days	859.2
TCGA-XF-A9T8-01A	64 years, male, white, stage:Stage III, dead, 418 days	856.1
TCGA-FD-A3SL-01A	60 years, male, white, stage:Stage IV, dead, 712 days	824.6
TCGA-XF-AAN4-01A	77 years, female, white, stage:Stage III, dead, 823 days	824.4
TCGA-E7-A541-01A	66 years, male, white, stage:Stage II, dead, 778 days	808.1
TCGA-XF-A9SV-01A	82 years, male, white, stage:Stage IV, dead, 388 days	793.4
TCGA-XF-A9SW-01A	85 years, male, white, stage:Stage IV, dead, 362 days	792.0
TCGA-ZF-AA4T-01A	65 years, male, white, stage:Stage IV, dead, 599 days	753.9
TCGA-GU-A42P-01A	72 years, male, white, stage:Stage IV, dead, 332 days	740.5
TCGA-DK-AA6L-01A	48 years, male, white, stage:Stage IV, dead, 1163 days	697.0
TCGA-XF-AAME-01A	64 years, female, white, stage:Stage II, dead, 2828 days	678.9
TCGA-FD-A3SR-01A	68 years, male, white, stage:Stage IV, dead, 602 days	677.0
TCGA-XF-A9SU-01A	74 years, female, white, stage:Stage IV, dead, 182 days	663.4
TCGA-XF-AAMZ-01A	81 years, female, white, stage:Stage IV, dead, 1348 days	661.5
TCGA-DK-A2HX-01A	80 years, female, white, stage:Stage IV, dead, 1420 days	608.0
TCGA-XF-A9SX-01A	63 years, female, white, stage:Stage IV, dead, 719 days	594.8
TCGA-2F-A9KR-01A	59 years, female, stage:Stage III, dead, 3183 days	572.6
TCGA-ZF-AA4R-01A	67 years, male, white, stage:Stage IV, dead, 1036 days	568.3
TCGA-ZF-AA52-01A	70 years, male, white, stage:Stage III, dead, 1077 days	563.2
TCGA-BT-A20O-01A	75 years, male, white, stage:Stage III, dead, 370 days	552.3
TCGA-ZF-A9R9-01A	58 years, male, white, stage:Stage IV, dead, 864 days	543.0
TCGA-XF-AAMJ-01A	70 years, male, asian, stage:Stage III, dead, 1670 days	496.0
TCGA-SY-A9G0-01A	82 years, male, white, stage:Stage IV, dead, 1008 days	495.3
TCGA-4Z-AA80-01A	73 years, male, white, stage:Stage II, dead, 19 days	464.4
TCGA-FD-A5BZ-01A	77 years, female, white, stage:Stage IV, dead, 835 days	412.9
TCGA-ZF-A9RE-01A	78 years, female, white, stage:Stage II, dead, 106 days	345.0
TCGA-BT-A20T-01A	63 years, male, white, stage:Stage IV, dead, 453 days	327.4
TCGA-4Z-AA7S-01A	66 years, male, black or african american, stage:Stage III, dead, 1064 days	173.4
Show allShow less

UROTHELIAL CANCER - Protein expressionⁱ A mouse-over function shows sample information and annotation data. Click on an image to view it in a full screen mode. Samples can be filtered based on level of antibody staining by selecting one or several of the following categories: high, medium, low and not detected. The assay and annotation is described here. Note that samples used for immunohistochemistry by the Human Protein Atlas do not correspond to samples in the TCGA dataset.

Antibody stainingⁱ Antibody staining in the annotated cell types in the current human tissue is reported as not detected, low, medium, or high, based on conventional immunohistochemistry profiling in selected tissues. This score is based on the combination of the staining intensity and fraction of stained cells. Each image is clickable and will lead to virtual microscopy that enables deeper exploration of all samples and also displays staining intensity scores, fraction scores and subcellular localization as well as patient and tissue information for each sample.	Antibody HPA006047
Staining
High
Medium
Low
Not detected
Intensity
Strong
Moderate
Weak
Negative
Quantity
>75%
75%-25%
<25%
None
Location
Nuclear
Cytoplasmic/membranous
Cytoplasmic/membranous,nuclear
None
Urothelial carcinoma, High grade
Urothelial carcinoma, Low grade