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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Disease related genes Human disease related genes Transcription factors
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
8
Cytoband
q24.21
Chromosome location (bp)
127735434 - 127742951
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3' 1,2. Activates the transcription of growth-related genes 3,4. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis 5,6. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells (By similarity). Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). Positively regulates transcription of HNRNPA1, HNRNPA2 and PTBP1 which in turn regulate splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform 7....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Activator, DNA-binding
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Transcription, Transcription regulation
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene is a proto-oncogene and encodes a nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. The encoded protein forms a heterodimer with the related transcription factor MAX. This complex binds to the E box DNA consensus sequence and regulates the transcription of specific target genes. Amplification of this gene is frequently observed in numerous human cancers. Translocations involving this gene are associated with Burkitt lymphoma and multiple myeloma in human patients. There is evidence to show that translation initiates both from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site, resulting in the production of two isoforms with distinct N-termini. [provided by RefSeq, Aug 2017]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations COSMIC Translocations Human disease related genes Cancers Head and neck cancers Cancers of the digestive system Cancers of the lung and pleura Skin cancers Cancers of soft tissues and bone Cancers of the breast and female genital organs Cancers of male genital organs Cancers of eye, brain, and central nervous system Cancers of haematopoietic and lymphoid tissues Protein evidence (Ezkurdia et al 2014)
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GO:0003700[DNA-binding transcription factor activity] GO:0005654[nucleoplasm] GO:0006355[regulation of DNA-templated transcription]
P01106 [Direct mapping] Myc proto-oncogene protein
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A0A024R9L7 [Target identity:100%; Query identity:100%] Myc proto-oncogene protein
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Basic domains Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations COSMIC Translocations Disease related genes Human disease related genes Cancers Head and neck cancers Cancers of the digestive system Cancers of the lung and pleura Skin cancers Cancers of soft tissues and bone Cancers of the breast and female genital organs Cancers of male genital organs Cancers of eye, brain, and central nervous system Cancers of haematopoietic and lymphoid tissues Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000082[G1/S transition of mitotic cell cycle] GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000165[MAPK cascade] GO:0000785[chromatin] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001046[core promoter sequence-specific DNA binding] GO:0001221[transcription coregulator binding] GO:0001227[DNA-binding transcription repressor activity, RNA polymerase II-specific] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0001658[branching involved in ureteric bud morphogenesis] GO:0002053[positive regulation of mesenchymal cell proliferation] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005730[nucleolus] GO:0006112[energy reserve metabolic process] GO:0006338[chromatin remodeling] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006879[cellular iron ion homeostasis] GO:0006974[cellular response to DNA damage stimulus] GO:0008284[positive regulation of cell population proliferation] GO:0009410[response to xenobiotic stimulus] GO:0010332[response to gamma radiation] GO:0010468[regulation of gene expression] GO:0010564[regulation of cell cycle process] GO:0010628[positive regulation of gene expression] GO:0015671[oxygen transport] GO:0032204[regulation of telomere maintenance] GO:0032873[negative regulation of stress-activated MAPK cascade] GO:0032986[protein-DNA complex disassembly] GO:0032991[protein-containing complex] GO:0034644[cellular response to UV] GO:0043066[negative regulation of apoptotic process] GO:0043280[positive regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0044346[fibroblast apoptotic process] GO:0044877[protein-containing complex binding] GO:0045656[negative regulation of monocyte differentiation] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046983[protein dimerization activity] GO:0048146[positive regulation of fibroblast proliferation] GO:0048147[negative regulation of fibroblast proliferation] GO:0050679[positive regulation of epithelial cell proliferation] GO:0051276[chromosome organization] GO:0051782[negative regulation of cell division] GO:0051973[positive regulation of telomerase activity] GO:0070371[ERK1 and ERK2 cascade] GO:0070848[response to growth factor] GO:0070888[E-box binding] GO:0071456[cellular response to hypoxia] GO:0071466[cellular response to xenobiotic stimulus] GO:0071943[Myc-Max complex] GO:0090096[positive regulation of metanephric cap mesenchymal cell proliferation] GO:0090571[RNA polymerase II transcription repressor complex] GO:0140297[DNA-binding transcription factor binding] GO:0140537[transcription regulator activator activity] GO:1902255[positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator] GO:1902895[positive regulation of miRNA transcription] GO:1904672[regulation of somatic stem cell population maintenance] GO:1905643[positive regulation of DNA methylation] GO:2000573[positive regulation of DNA biosynthetic process] GO:2001022[positive regulation of response to DNA damage stimulus]
H0YBG3 [Direct mapping] Myc proto-oncogene protein
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations COSMIC Translocations Human disease related genes Cancers Head and neck cancers Cancers of the digestive system Cancers of the lung and pleura Skin cancers Cancers of soft tissues and bone Cancers of the breast and female genital organs Cancers of male genital organs Cancers of eye, brain, and central nervous system Cancers of haematopoietic and lymphoid tissues Protein evidence (Ezkurdia et al 2014)
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GO:0003700[DNA-binding transcription factor activity] GO:0006355[regulation of DNA-templated transcription]
H0YBT0 [Direct mapping] Myc proto-oncogene protein
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations COSMIC Translocations Human disease related genes Cancers Head and neck cancers Cancers of the digestive system Cancers of the lung and pleura Skin cancers Cancers of soft tissues and bone Cancers of the breast and female genital organs Cancers of male genital organs Cancers of eye, brain, and central nervous system Cancers of haematopoietic and lymphoid tissues Protein evidence (Ezkurdia et al 2014)
P01106 [Direct mapping] Myc proto-oncogene protein
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A0A087WUS5 [Direct mapping] Myc proto-oncogene protein
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Basic domains Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations COSMIC Translocations Disease related genes Human disease related genes Cancers Head and neck cancers Cancers of the digestive system Cancers of the lung and pleura Skin cancers Cancers of soft tissues and bone Cancers of the breast and female genital organs Cancers of male genital organs Cancers of eye, brain, and central nervous system Cancers of haematopoietic and lymphoid tissues Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000082[G1/S transition of mitotic cell cycle] GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000165[MAPK cascade] GO:0000785[chromatin] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001046[core promoter sequence-specific DNA binding] GO:0001221[transcription coregulator binding] GO:0001227[DNA-binding transcription repressor activity, RNA polymerase II-specific] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0001658[branching involved in ureteric bud morphogenesis] GO:0002053[positive regulation of mesenchymal cell proliferation] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005730[nucleolus] GO:0006112[energy reserve metabolic process] GO:0006338[chromatin remodeling] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006879[cellular iron ion homeostasis] GO:0006974[cellular response to DNA damage stimulus] GO:0008284[positive regulation of cell population proliferation] GO:0009410[response to xenobiotic stimulus] GO:0010332[response to gamma radiation] GO:0010468[regulation of gene expression] GO:0010564[regulation of cell cycle process] GO:0010628[positive regulation of gene expression] GO:0015671[oxygen transport] GO:0032204[regulation of telomere maintenance] GO:0032873[negative regulation of stress-activated MAPK cascade] GO:0032986[protein-DNA complex disassembly] GO:0032991[protein-containing complex] GO:0034644[cellular response to UV] GO:0043066[negative regulation of apoptotic process] GO:0043280[positive regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0044346[fibroblast apoptotic process] GO:0044877[protein-containing complex binding] GO:0045656[negative regulation of monocyte differentiation] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046983[protein dimerization activity] GO:0048146[positive regulation of fibroblast proliferation] GO:0048147[negative regulation of fibroblast proliferation] GO:0050679[positive regulation of epithelial cell proliferation] GO:0051276[chromosome organization] GO:0051782[negative regulation of cell division] GO:0051973[positive regulation of telomerase activity] GO:0070371[ERK1 and ERK2 cascade] GO:0070848[response to growth factor] GO:0070888[E-box binding] GO:0071456[cellular response to hypoxia] GO:0071466[cellular response to xenobiotic stimulus] GO:0071943[Myc-Max complex] GO:0090096[positive regulation of metanephric cap mesenchymal cell proliferation] GO:0090571[RNA polymerase II transcription repressor complex] GO:0140297[DNA-binding transcription factor binding] GO:0140537[transcription regulator activator activity] GO:1902255[positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator] GO:1902895[positive regulation of miRNA transcription] GO:1904672[regulation of somatic stem cell population maintenance] GO:1905643[positive regulation of DNA methylation] GO:2000573[positive regulation of DNA biosynthetic process] GO:2001022[positive regulation of response to DNA damage stimulus]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations COSMIC Translocations Human disease related genes Cancers Head and neck cancers Cancers of the digestive system Cancers of the lung and pleura Skin cancers Cancers of soft tissues and bone Cancers of the breast and female genital organs Cancers of male genital organs Cancers of eye, brain, and central nervous system Cancers of haematopoietic and lymphoid tissues Protein evidence (Ezkurdia et al 2014)
MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins DeepTMHMM predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations COSMIC Translocations Human disease related genes Cancers Head and neck cancers Cancers of the digestive system Cancers of the lung and pleura Skin cancers Cancers of soft tissues and bone Cancers of the breast and female genital organs Cancers of male genital organs Cancers of eye, brain, and central nervous system Cancers of haematopoietic and lymphoid tissues Protein evidence (Ezkurdia et al 2014)
A0A494C1T8 [Direct mapping] Myc proto-oncogene protein
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations COSMIC Translocations Human disease related genes Cancers Head and neck cancers Cancers of the digestive system Cancers of the lung and pleura Skin cancers Cancers of soft tissues and bone Cancers of the breast and female genital organs Cancers of male genital organs Cancers of eye, brain, and central nervous system Cancers of haematopoietic and lymphoid tissues Protein evidence (Ezkurdia et al 2014)
P01106 [Direct mapping] Myc proto-oncogene protein
Show all
A0A024R9L7 [Target identity:100%; Query identity:100%] Myc proto-oncogene protein
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Basic domains Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations COSMIC Translocations Disease related genes Human disease related genes Cancers Head and neck cancers Cancers of the digestive system Cancers of the lung and pleura Skin cancers Cancers of soft tissues and bone Cancers of the breast and female genital organs Cancers of male genital organs Cancers of eye, brain, and central nervous system Cancers of haematopoietic and lymphoid tissues Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082[G1/S transition of mitotic cell cycle] GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000165[MAPK cascade] GO:0000785[chromatin] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001046[core promoter sequence-specific DNA binding] GO:0001221[transcription coregulator binding] GO:0001227[DNA-binding transcription repressor activity, RNA polymerase II-specific] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0001658[branching involved in ureteric bud morphogenesis] GO:0002053[positive regulation of mesenchymal cell proliferation] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005730[nucleolus] GO:0006112[energy reserve metabolic process] GO:0006338[chromatin remodeling] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006879[cellular iron ion homeostasis] GO:0006974[cellular response to DNA damage stimulus] GO:0008284[positive regulation of cell population proliferation] GO:0009410[response to xenobiotic stimulus] GO:0010332[response to gamma radiation] GO:0010468[regulation of gene expression] GO:0010564[regulation of cell cycle process] GO:0010628[positive regulation of gene expression] GO:0015671[oxygen transport] GO:0032204[regulation of telomere maintenance] GO:0032873[negative regulation of stress-activated MAPK cascade] GO:0032986[protein-DNA complex disassembly] GO:0032991[protein-containing complex] GO:0034644[cellular response to UV] GO:0043066[negative regulation of apoptotic process] GO:0043280[positive regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0044346[fibroblast apoptotic process] GO:0044877[protein-containing complex binding] GO:0045656[negative regulation of monocyte differentiation] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046983[protein dimerization activity] GO:0048146[positive regulation of fibroblast proliferation] GO:0048147[negative regulation of fibroblast proliferation] GO:0050679[positive regulation of epithelial cell proliferation] GO:0051276[chromosome organization] GO:0051782[negative regulation of cell division] GO:0051973[positive regulation of telomerase activity] GO:0070371[ERK1 and ERK2 cascade] GO:0070848[response to growth factor] GO:0070888[E-box binding] GO:0071456[cellular response to hypoxia] GO:0071466[cellular response to xenobiotic stimulus] GO:0071943[Myc-Max complex] GO:0090096[positive regulation of metanephric cap mesenchymal cell proliferation] GO:0090571[RNA polymerase II transcription repressor complex] GO:0140297[DNA-binding transcription factor binding] GO:0140537[transcription regulator activator activity] GO:1902255[positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator] GO:1902895[positive regulation of miRNA transcription] GO:1904672[regulation of somatic stem cell population maintenance] GO:1905643[positive regulation of DNA methylation] GO:2000573[positive regulation of DNA biosynthetic process] GO:2001022[positive regulation of response to DNA damage stimulus]
A0A024R9L7 [Target identity:100%; Query identity:100%] Myc proto-oncogene protein
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations COSMIC Translocations Human disease related genes Cancers Head and neck cancers Cancers of the digestive system Cancers of the lung and pleura Skin cancers Cancers of soft tissues and bone Cancers of the breast and female genital organs Cancers of male genital organs Cancers of eye, brain, and central nervous system Cancers of haematopoietic and lymphoid tissues Protein evidence (Ezkurdia et al 2014)
A0A024R9L7 [Target identity:100%; Query identity:100%] Myc proto-oncogene protein
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations COSMIC Translocations Human disease related genes Cancers Head and neck cancers Cancers of the digestive system Cancers of the lung and pleura Skin cancers Cancers of soft tissues and bone Cancers of the breast and female genital organs Cancers of male genital organs Cancers of eye, brain, and central nervous system Cancers of haematopoietic and lymphoid tissues Protein evidence (Ezkurdia et al 2014)
A0A024R9L7 [Target identity:100%; Query identity:100%] Myc proto-oncogene protein
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations COSMIC Translocations Human disease related genes Cancers Head and neck cancers Cancers of the digestive system Cancers of the lung and pleura Skin cancers Cancers of soft tissues and bone Cancers of the breast and female genital organs Cancers of male genital organs Cancers of eye, brain, and central nervous system Cancers of haematopoietic and lymphoid tissues Protein evidence (Ezkurdia et al 2014)
A0A024R9L7 [Target identity:100%; Query identity:100%] Myc proto-oncogene protein
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations COSMIC Translocations Human disease related genes Cancers Head and neck cancers Cancers of the digestive system Cancers of the lung and pleura Skin cancers Cancers of soft tissues and bone Cancers of the breast and female genital organs Cancers of male genital organs Cancers of eye, brain, and central nervous system Cancers of haematopoietic and lymphoid tissues Protein evidence (Ezkurdia et al 2014)
The Human Protein Atlas project is funded
