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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Plasma proteins Transporters
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
6
Cytoband
p21.33
Chromosome location (bp)
30727709 - 30742732
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles....show less
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes an protein that localizes to the caveolae, which are small domains on the inner cell membranes. This protein plays a role in vesicle trafficking and cell morphology. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Transporters Accessory Factors Involved in Transport Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001819[positive regulation of cytokine production] GO:0001931[uropod] GO:0001934[positive regulation of protein phosphorylation] GO:0002020[protease binding] GO:0002090[regulation of receptor internalization] GO:0005515[protein binding] GO:0005765[lysosomal membrane] GO:0005768[endosome] GO:0005769[early endosome] GO:0005815[microtubule organizing center] GO:0005886[plasma membrane] GO:0005901[caveola] GO:0005911[cell-cell junction] GO:0005912[adherens junction] GO:0005925[focal adhesion] GO:0007409[axonogenesis] GO:0008180[COP9 signalosome] GO:0009897[external side of plasma membrane] GO:0016020[membrane] GO:0016323[basolateral plasma membrane] GO:0016600[flotillin complex] GO:0022617[extracellular matrix disassembly] GO:0030027[lamellipodium] GO:0030864[cortical actin cytoskeleton] GO:0031410[cytoplasmic vesicle] GO:0032092[positive regulation of protein binding] GO:0032226[positive regulation of synaptic transmission, dopaminergic] GO:0032728[positive regulation of interferon-beta production] GO:0033227[dsRNA transport] GO:0034116[positive regulation of heterotypic cell-cell adhesion] GO:0034141[positive regulation of toll-like receptor 3 signaling pathway] GO:0034451[centriolar satellite] GO:0034976[response to endoplasmic reticulum stress] GO:0035023[regulation of Rho protein signal transduction] GO:0035255[ionotropic glutamate receptor binding] GO:0042383[sarcolemma] GO:0042470[melanosome] GO:0044291[cell-cell contact zone] GO:0044853[plasma membrane raft] GO:0044854[plasma membrane raft assembly] GO:0044857[plasma membrane raft organization] GO:0045121[membrane raft] GO:0045202[synapse] GO:0045807[positive regulation of endocytosis] GO:0048643[positive regulation of skeletal muscle tissue development] GO:0048786[presynaptic active zone] GO:0050821[protein stabilization] GO:0051092[positive regulation of NF-kappaB transcription factor activity] GO:0051580[regulation of neurotransmitter uptake] GO:0070062[extracellular exosome] GO:0070528[protein kinase C signaling] GO:0071360[cellular response to exogenous dsRNA] GO:0072659[protein localization to plasma membrane] GO:0098691[dopaminergic synapse] GO:0098793[presynapse] GO:0098978[glutamatergic synapse] GO:0098982[GABA-ergic synapse] GO:1901741[positive regulation of myoblast fusion] GO:1901890[positive regulation of cell junction assembly] GO:2000049[positive regulation of cell-cell adhesion mediated by cadherin]
Phobius predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
The Human Protein Atlas project is funded
