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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Enzymes
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
15
Cytoband
q23
Chromosome location (bp)
67542703 - 67807117
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis. As part of the MAPK/ERK signaling pathway, acts as a negative regulator of apoptosis in cardiomyocytes via promotion of STUB1/CHIP-mediated ubiquitination and degradation of ICER-type isoforms of CREM (By similarity)....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been described. [provided by RefSeq, May 2011]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Enzymes ENZYME proteins Transferases Kinases STE Ser/Thr protein kinases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000165[MAPK cascade] GO:0000166[nucleotide binding] GO:0004672[protein kinase activity] GO:0004674[protein serine/threonine kinase activity] GO:0004708[MAP kinase kinase activity] GO:0004713[protein tyrosine kinase activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005819[spindle] GO:0005829[cytosol] GO:0006468[protein phosphorylation] GO:0007165[signal transduction] GO:0007507[heart development] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016740[transferase activity] GO:0018108[peptidyl-tyrosine phosphorylation] GO:0030307[positive regulation of cell growth] GO:0032088[negative regulation of NF-kappaB transcription factor activity] GO:0032717[negative regulation of interleukin-8 production] GO:0034115[negative regulation of heterotypic cell-cell adhesion] GO:0043154[negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043406[positive regulation of MAP kinase activity] GO:0043539[protein serine/threonine kinase activator activity] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding] GO:0048009[insulin-like growth factor receptor signaling pathway] GO:0050679[positive regulation of epithelial cell proliferation] GO:0051247[positive regulation of protein metabolic process] GO:0060761[negative regulation of response to cytokine stimulus] GO:0070375[ERK5 cascade] GO:0071363[cellular response to growth factor stimulus] GO:0071499[cellular response to laminar fluid shear stress] GO:0090051[negative regulation of cell migration involved in sprouting angiogenesis] GO:0106310[protein serine kinase activity] GO:2000342[negative regulation of chemokine (C-X-C motif) ligand 2 production] GO:2001240[negative regulation of extrinsic apoptotic signaling pathway in absence of ligand]
Q13163 [Direct mapping] Dual specificity mitogen-activated protein kinase kinase 5
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Enzymes ENZYME proteins Transferases Kinases STE Ser/Thr protein kinases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000165[MAPK cascade] GO:0000166[nucleotide binding] GO:0004672[protein kinase activity] GO:0004674[protein serine/threonine kinase activity] GO:0004708[MAP kinase kinase activity] GO:0004713[protein tyrosine kinase activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0006468[protein phosphorylation] GO:0007165[signal transduction] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016740[transferase activity] GO:0018108[peptidyl-tyrosine phosphorylation] GO:0032088[negative regulation of NF-kappaB transcription factor activity] GO:0032717[negative regulation of interleukin-8 production] GO:0034115[negative regulation of heterotypic cell-cell adhesion] GO:0043154[negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043406[positive regulation of MAP kinase activity] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding] GO:0051247[positive regulation of protein metabolic process] GO:0060761[negative regulation of response to cytokine stimulus] GO:0071363[cellular response to growth factor stimulus] GO:0071499[cellular response to laminar fluid shear stress] GO:0090051[negative regulation of cell migration involved in sprouting angiogenesis] GO:0106310[protein serine kinase activity] GO:2000342[negative regulation of chemokine (C-X-C motif) ligand 2 production] GO:2001240[negative regulation of extrinsic apoptotic signaling pathway in absence of ligand]
Enzymes ENZYME proteins Transferases Kinases STE Ser/Thr protein kinases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000165[MAPK cascade] GO:0000166[nucleotide binding] GO:0004672[protein kinase activity] GO:0004674[protein serine/threonine kinase activity] GO:0004708[MAP kinase kinase activity] GO:0004713[protein tyrosine kinase activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0006468[protein phosphorylation] GO:0007165[signal transduction] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016740[transferase activity] GO:0018108[peptidyl-tyrosine phosphorylation] GO:0032088[negative regulation of NF-kappaB transcription factor activity] GO:0032717[negative regulation of interleukin-8 production] GO:0034115[negative regulation of heterotypic cell-cell adhesion] GO:0043154[negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043406[positive regulation of MAP kinase activity] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding] GO:0051247[positive regulation of protein metabolic process] GO:0060761[negative regulation of response to cytokine stimulus] GO:0071363[cellular response to growth factor stimulus] GO:0071499[cellular response to laminar fluid shear stress] GO:0090051[negative regulation of cell migration involved in sprouting angiogenesis] GO:0106310[protein serine kinase activity] GO:2000342[negative regulation of chemokine (C-X-C motif) ligand 2 production] GO:2001240[negative regulation of extrinsic apoptotic signaling pathway in absence of ligand]
The Human Protein Atlas project is funded
