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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
1
Cytoband
p22.1
Chromosome location (bp)
93561741 - 93847150
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Acts as an adapter protein downstream of several growth factor receptors to promote cell proliferation, migration, and redistribution of actin fibers 1. Specifically involved in INS/insulin signaling pathway by mediating MAPK1/ERK2-MAPK3/ERK1 activation and DNA synthesis 2. Promotes insulin-mediated membrane ruffling (By similarity). In response to vasoconstrictor peptide EDN1, involved in the activation of RAP1 downstream of PTK2B via interaction with phosphorylated BCAR1 3. Inhibits cell migration and invasion via regulation of TGFB-mediated matrix digestion, actin filament rearrangement, and inhibition of invadopodia activity (By similarity). May inhibit TGFB-SMAD signaling, via facilitating BCAR1 and SMAD2 and/or SMAD3 interaction (By similarity). Regulates EGF-induced DNA synthesis 4. Required for the maintenance of ocular lens morphology and structural integrity, potentially via regulation of focal adhesion complex signaling (By similarity). Acts upstream of PTPRA to regulate the localization of BCAR1 and PTPRA to focal adhesions, via regulation of SRC-mediated phosphorylation of PTPRA (By similarity). Positively regulates integrin-induced tyrosine phosphorylation of BCAR1 (By similarity). Acts as a guanine nucleotide exchange factor (GEF) for small GTPases RALA, RAP1A and RRAS (By similarity). However, in a contrasting study, lacks GEF activity towards RAP1 5....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Guanine-nucleotide releasing factor
Gene summary (Entrez)i
Useful information about the gene from Entrez
Breast tumors are initially dependent on estrogens for growth and progression and can be inhibited by anti-estrogens such as tamoxifen. However, breast cancers progress to become anti-estrogen resistant. Breast cancer anti-estrogen resistance gene 3 was identified in the search for genes involved in the development of estrogen resistance. The gene encodes a component of intracellular signal transduction that causes estrogen-independent proliferation in human breast cancer cells. The protein contains a putative src homology 2 (SH2) domain, a hall mark of cellular tyrosine kinase signaling molecules, and is partly homologous to the cell division cycle protein CDC48. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
O75815 [Direct mapping] Breast cancer anti-estrogen resistance protein 3
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A0A384MTS3 [Target identity:100%; Query identity:100%] Epididymis secretory sperm binding protein
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001784[phosphotyrosine residue binding] GO:0002089[lens morphogenesis in camera-type eye] GO:0005085[guanyl-nucleotide exchange factor activity] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005925[focal adhesion] GO:0007165[signal transduction] GO:0007264[small GTPase mediated signal transduction] GO:0008286[insulin receptor signaling pathway] GO:0009410[response to xenobiotic stimulus] GO:0016020[membrane] GO:0019900[kinase binding] GO:0033138[positive regulation of peptidyl-serine phosphorylation] GO:0043410[positive regulation of MAPK cascade] GO:0043547[positive regulation of GTPase activity] GO:0045740[positive regulation of DNA replication] GO:0045742[positive regulation of epidermal growth factor receptor signaling pathway] GO:0070161[anchoring junction] GO:0086100[endothelin receptor signaling pathway]
O75815 [Direct mapping] Breast cancer anti-estrogen resistance protein 3
Show all
A0A384MTS3 [Target identity:100%; Query identity:100%] Epididymis secretory sperm binding protein
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001784[phosphotyrosine residue binding] GO:0005085[guanyl-nucleotide exchange factor activity] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005925[focal adhesion] GO:0007165[signal transduction] GO:0007264[small GTPase mediated signal transduction] GO:0008286[insulin receptor signaling pathway] GO:0009410[response to xenobiotic stimulus] GO:0016020[membrane] GO:0019900[kinase binding] GO:0033138[positive regulation of peptidyl-serine phosphorylation] GO:0043410[positive regulation of MAPK cascade] GO:0043547[positive regulation of GTPase activity] GO:0045740[positive regulation of DNA replication] GO:0045742[positive regulation of epidermal growth factor receptor signaling pathway] GO:0070161[anchoring junction] GO:0086100[endothelin receptor signaling pathway]
O75815 [Direct mapping] Breast cancer anti-estrogen resistance protein 3
Show all
A0A384MTS3 [Target identity:100%; Query identity:100%] Epididymis secretory sperm binding protein
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001784[phosphotyrosine residue binding] GO:0005085[guanyl-nucleotide exchange factor activity] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005925[focal adhesion] GO:0007165[signal transduction] GO:0007264[small GTPase mediated signal transduction] GO:0008286[insulin receptor signaling pathway] GO:0009410[response to xenobiotic stimulus] GO:0016020[membrane] GO:0019900[kinase binding] GO:0033138[positive regulation of peptidyl-serine phosphorylation] GO:0043410[positive regulation of MAPK cascade] GO:0043547[positive regulation of GTPase activity] GO:0045740[positive regulation of DNA replication] GO:0045742[positive regulation of epidermal growth factor receptor signaling pathway] GO:0070161[anchoring junction] GO:0086100[endothelin receptor signaling pathway]
O75815 [Direct mapping] Breast cancer anti-estrogen resistance protein 3
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001784[phosphotyrosine residue binding] GO:0005085[guanyl-nucleotide exchange factor activity] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005925[focal adhesion] GO:0007165[signal transduction] GO:0007264[small GTPase mediated signal transduction] GO:0008286[insulin receptor signaling pathway] GO:0009410[response to xenobiotic stimulus] GO:0016020[membrane] GO:0019900[kinase binding] GO:0033138[positive regulation of peptidyl-serine phosphorylation] GO:0043410[positive regulation of MAPK cascade] GO:0043547[positive regulation of GTPase activity] GO:0045740[positive regulation of DNA replication] GO:0045742[positive regulation of epidermal growth factor receptor signaling pathway] GO:0070161[anchoring junction] GO:0086100[endothelin receptor signaling pathway]
O75815 [Direct mapping] Breast cancer anti-estrogen resistance protein 3
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001784[phosphotyrosine residue binding] GO:0005085[guanyl-nucleotide exchange factor activity] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005925[focal adhesion] GO:0007165[signal transduction] GO:0007264[small GTPase mediated signal transduction] GO:0008286[insulin receptor signaling pathway] GO:0009410[response to xenobiotic stimulus] GO:0016020[membrane] GO:0019900[kinase binding] GO:0033138[positive regulation of peptidyl-serine phosphorylation] GO:0043410[positive regulation of MAPK cascade] GO:0043547[positive regulation of GTPase activity] GO:0045740[positive regulation of DNA replication] GO:0045742[positive regulation of epidermal growth factor receptor signaling pathway] GO:0070161[anchoring junction] GO:0086100[endothelin receptor signaling pathway]
The Human Protein Atlas project is funded
