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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Enzymes
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
2
Cytoband
p21
Chromosome location (bp)
44167969 - 44244384
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Enzyme with a broad specificity. Dephosphorylates CDK2 and CDK6 in vitro. Dephosphorylates PRKAA1 and PRKAA2. Inhibits TBK1-mediated antiviral signaling by dephosphorylating it at 'Ser-172'. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Hydrolase, Protein phosphatase
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Magnesium, Manganese, Metal-binding
Gene summary (Entrez)i
Useful information about the gene from Entrez
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase has been shown to dephosphorylate cyclin-dependent kinases (CDKs), and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to cause cell-growth arrest or cell death. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional transcript variants have been described, but currently do not represent full-length sequences. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000287[magnesium ion binding] GO:0004721[phosphoprotein phosphatase activity] GO:0004722[protein serine/threonine phosphatase activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005730[nucleolus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006470[protein dephosphorylation] GO:0006499[N-terminal protein myristoylation] GO:0016020[membrane] GO:0016787[hydrolase activity] GO:0017018[myosin phosphatase activity] GO:0030145[manganese ion binding] GO:0032688[negative regulation of interferon-beta production] GO:0035970[peptidyl-threonine dephosphorylation] GO:0043124[negative regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043169[cation binding] GO:0046872[metal ion binding] GO:0050687[negative regulation of defense response to virus] GO:0090263[positive regulation of canonical Wnt signaling pathway] GO:0110165[cellular anatomical entity] GO:1901223[negative regulation of NIK/NF-kappaB signaling]
Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287[magnesium ion binding] GO:0004721[phosphoprotein phosphatase activity] GO:0004722[protein serine/threonine phosphatase activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005730[nucleolus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006470[protein dephosphorylation] GO:0006499[N-terminal protein myristoylation] GO:0016020[membrane] GO:0016787[hydrolase activity] GO:0017018[myosin phosphatase activity] GO:0030145[manganese ion binding] GO:0032688[negative regulation of interferon-beta production] GO:0035970[peptidyl-threonine dephosphorylation] GO:0043124[negative regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043169[cation binding] GO:0046872[metal ion binding] GO:0050687[negative regulation of defense response to virus] GO:0090263[positive regulation of canonical Wnt signaling pathway] GO:0110165[cellular anatomical entity] GO:1901223[negative regulation of NIK/NF-kappaB signaling]
Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287[magnesium ion binding] GO:0004721[phosphoprotein phosphatase activity] GO:0004722[protein serine/threonine phosphatase activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005730[nucleolus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006470[protein dephosphorylation] GO:0006499[N-terminal protein myristoylation] GO:0016020[membrane] GO:0016787[hydrolase activity] GO:0017018[myosin phosphatase activity] GO:0030145[manganese ion binding] GO:0032688[negative regulation of interferon-beta production] GO:0035970[peptidyl-threonine dephosphorylation] GO:0043124[negative regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043169[cation binding] GO:0046872[metal ion binding] GO:0050687[negative regulation of defense response to virus] GO:0090263[positive regulation of canonical Wnt signaling pathway] GO:0110165[cellular anatomical entity] GO:1901223[negative regulation of NIK/NF-kappaB signaling]
Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287[magnesium ion binding] GO:0004721[phosphoprotein phosphatase activity] GO:0004722[protein serine/threonine phosphatase activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005730[nucleolus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006470[protein dephosphorylation] GO:0006499[N-terminal protein myristoylation] GO:0016020[membrane] GO:0016787[hydrolase activity] GO:0017018[myosin phosphatase activity] GO:0030145[manganese ion binding] GO:0032688[negative regulation of interferon-beta production] GO:0035970[peptidyl-threonine dephosphorylation] GO:0043124[negative regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043169[cation binding] GO:0046872[metal ion binding] GO:0050687[negative regulation of defense response to virus] GO:0090263[positive regulation of canonical Wnt signaling pathway] GO:0110165[cellular anatomical entity] GO:1901223[negative regulation of NIK/NF-kappaB signaling]
The Human Protein Atlas project is funded
