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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Disease related genes Enzymes Human disease related genes Metabolic proteins Plasma proteins Potential drug targets RAS pathway related proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
10
Cytoband
q23.33
Chromosome location (bp)
93993931 - 94332823
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. PLCE1 is a bifunctional enzyme which also regulates small GTPases of the Ras superfamily through its Ras guanine-exchange factor (RasGEF) activity. As an effector of heterotrimeric and small G-protein, it may play a role in cell survival, cell growth, actin organization and T-cell activation. In podocytes, is involved in the regulation of lamellipodia formation. Acts downstream of AVIL to allow ARP2/3 complex assembly 1....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Lipid degradation, Lipid metabolism
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Calcium, Metal-binding
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a phospholipase enzyme that catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate to generate two second messengers: inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG). These second messengers subsequently regulate various processes affecting cell growth, differentiation, and gene expression. This enzyme is regulated by small monomeric GTPases of the Ras and Rho families and by heterotrimeric G proteins. In addition to its phospholipase C catalytic activity, this enzyme has an N-terminal domain with guanine nucleotide exchange (GEF) activity. Mutations in this gene cause early-onset nephrotic syndrome; characterized by proteinuria, edema, and diffuse mesangial sclerosis or focal and segmental glomerulosclerosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Sep 2009]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Enzymes ENZYME proteins Hydrolases Metabolic proteins MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins RAS pathway related proteins Disease related genes Potential drug targets Human disease related genes Urinary system diseases Kidney diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000139[Golgi membrane] GO:0001558[regulation of cell growth] GO:0004435[phosphatidylinositol phospholipase C activity] GO:0004629[phospholipase C activity] GO:0005085[guanyl-nucleotide exchange factor activity] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005794[Golgi apparatus] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006629[lipid metabolic process] GO:0006651[diacylglycerol biosynthetic process] GO:0006940[regulation of smooth muscle contraction] GO:0007010[cytoskeleton organization] GO:0007165[signal transduction] GO:0007173[epidermal growth factor receptor signaling pathway] GO:0007200[phospholipase C-activating G protein-coupled receptor signaling pathway] GO:0007204[positive regulation of cytosolic calcium ion concentration] GO:0007264[small GTPase mediated signal transduction] GO:0007265[Ras protein signal transduction] GO:0007507[heart development] GO:0008081[phosphoric diester hydrolase activity] GO:0008277[regulation of G protein-coupled receptor signaling pathway] GO:0010592[positive regulation of lamellipodium assembly] GO:0016020[membrane] GO:0016042[lipid catabolic process] GO:0016787[hydrolase activity] GO:0019722[calcium-mediated signaling] GO:0019899[enzyme binding] GO:0030027[lamellipodium] GO:0031267[small GTPase binding] GO:0032835[glomerulus development] GO:0035556[intracellular signal transduction] GO:0042995[cell projection] GO:0043410[positive regulation of MAPK cascade] GO:0045859[regulation of protein kinase activity] GO:0046578[regulation of Ras protein signal transduction] GO:0046872[metal ion binding] GO:0048015[phosphatidylinositol-mediated signaling] GO:0048016[inositol phosphate-mediated signaling]
Enzymes ENZYME proteins Hydrolases Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins RAS pathway related proteins Disease related genes Potential drug targets Human disease related genes Urinary system diseases Kidney diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000139[Golgi membrane] GO:0001558[regulation of cell growth] GO:0004435[phosphatidylinositol phospholipase C activity] GO:0004629[phospholipase C activity] GO:0005085[guanyl-nucleotide exchange factor activity] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005794[Golgi apparatus] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006629[lipid metabolic process] GO:0006651[diacylglycerol biosynthetic process] GO:0006940[regulation of smooth muscle contraction] GO:0007010[cytoskeleton organization] GO:0007165[signal transduction] GO:0007173[epidermal growth factor receptor signaling pathway] GO:0007200[phospholipase C-activating G protein-coupled receptor signaling pathway] GO:0007204[positive regulation of cytosolic calcium ion concentration] GO:0007264[small GTPase mediated signal transduction] GO:0007265[Ras protein signal transduction] GO:0007507[heart development] GO:0008081[phosphoric diester hydrolase activity] GO:0008277[regulation of G protein-coupled receptor signaling pathway] GO:0010592[positive regulation of lamellipodium assembly] GO:0016020[membrane] GO:0016042[lipid catabolic process] GO:0016787[hydrolase activity] GO:0019722[calcium-mediated signaling] GO:0019899[enzyme binding] GO:0030027[lamellipodium] GO:0031267[small GTPase binding] GO:0032835[glomerulus development] GO:0035556[intracellular signal transduction] GO:0042995[cell projection] GO:0043410[positive regulation of MAPK cascade] GO:0045859[regulation of protein kinase activity] GO:0046578[regulation of Ras protein signal transduction] GO:0046872[metal ion binding] GO:0048015[phosphatidylinositol-mediated signaling] GO:0048016[inositol phosphate-mediated signaling]
A0A7I2PPM5 [Direct mapping] Phosphoinositide phospholipase C
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Metabolic proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Human disease related genes Urinary system diseases Kidney diseases Protein evidence (Ezkurdia et al 2014)
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GO:0004435[phosphatidylinositol phospholipase C activity] GO:0005085[guanyl-nucleotide exchange factor activity] GO:0006629[lipid metabolic process] GO:0007165[signal transduction] GO:0007264[small GTPase mediated signal transduction] GO:0008081[phosphoric diester hydrolase activity] GO:0016042[lipid catabolic process] GO:0016787[hydrolase activity] GO:0035556[intracellular signal transduction]
A0A6Q8PH04 [Direct mapping] Phosphoinositide phospholipase C
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Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Human disease related genes Urinary system diseases Kidney diseases Protein evidence (Ezkurdia et al 2014)
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GO:0004435[phosphatidylinositol phospholipase C activity] GO:0005085[guanyl-nucleotide exchange factor activity] GO:0006629[lipid metabolic process] GO:0007165[signal transduction] GO:0007264[small GTPase mediated signal transduction] GO:0008081[phosphoric diester hydrolase activity] GO:0016042[lipid catabolic process] GO:0016787[hydrolase activity] GO:0035556[intracellular signal transduction]
Enzymes ENZYME proteins Hydrolases Metabolic proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins RAS pathway related proteins Disease related genes Potential drug targets Human disease related genes Urinary system diseases Kidney diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000139[Golgi membrane] GO:0001558[regulation of cell growth] GO:0004435[phosphatidylinositol phospholipase C activity] GO:0004629[phospholipase C activity] GO:0005085[guanyl-nucleotide exchange factor activity] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005794[Golgi apparatus] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006629[lipid metabolic process] GO:0006651[diacylglycerol biosynthetic process] GO:0006940[regulation of smooth muscle contraction] GO:0007010[cytoskeleton organization] GO:0007165[signal transduction] GO:0007173[epidermal growth factor receptor signaling pathway] GO:0007200[phospholipase C-activating G protein-coupled receptor signaling pathway] GO:0007204[positive regulation of cytosolic calcium ion concentration] GO:0007264[small GTPase mediated signal transduction] GO:0007265[Ras protein signal transduction] GO:0007507[heart development] GO:0008081[phosphoric diester hydrolase activity] GO:0008277[regulation of G protein-coupled receptor signaling pathway] GO:0010592[positive regulation of lamellipodium assembly] GO:0016020[membrane] GO:0016042[lipid catabolic process] GO:0016787[hydrolase activity] GO:0019722[calcium-mediated signaling] GO:0019899[enzyme binding] GO:0030027[lamellipodium] GO:0031267[small GTPase binding] GO:0032835[glomerulus development] GO:0035556[intracellular signal transduction] GO:0042995[cell projection] GO:0043410[positive regulation of MAPK cascade] GO:0045859[regulation of protein kinase activity] GO:0046578[regulation of Ras protein signal transduction] GO:0046872[metal ion binding] GO:0048015[phosphatidylinositol-mediated signaling] GO:0048016[inositol phosphate-mediated signaling]
A0A6Q8PHN3 [Direct mapping] Phosphoinositide phospholipase C
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Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Human disease related genes Urinary system diseases Kidney diseases Protein evidence (Ezkurdia et al 2014)
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GO:0004435[phosphatidylinositol phospholipase C activity] GO:0005085[guanyl-nucleotide exchange factor activity] GO:0006629[lipid metabolic process] GO:0007264[small GTPase mediated signal transduction] GO:0008081[phosphoric diester hydrolase activity] GO:0016042[lipid catabolic process] GO:0016787[hydrolase activity] GO:0035556[intracellular signal transduction]
A0A8I5KXT2 [Direct mapping] Phosphoinositide phospholipase C
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Metabolic proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Human disease related genes Urinary system diseases Kidney diseases Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004435[phosphatidylinositol phospholipase C activity] GO:0005085[guanyl-nucleotide exchange factor activity] GO:0006629[lipid metabolic process] GO:0007165[signal transduction] GO:0007264[small GTPase mediated signal transduction] GO:0008081[phosphoric diester hydrolase activity] GO:0016042[lipid catabolic process] GO:0016787[hydrolase activity] GO:0035556[intracellular signal transduction]
A0A8I5KVG7 [Direct mapping] Phosphoinositide phospholipase C
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Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Human disease related genes Urinary system diseases Kidney diseases Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004435[phosphatidylinositol phospholipase C activity] GO:0005085[guanyl-nucleotide exchange factor activity] GO:0006629[lipid metabolic process] GO:0007165[signal transduction] GO:0007264[small GTPase mediated signal transduction] GO:0008081[phosphoric diester hydrolase activity] GO:0016042[lipid catabolic process] GO:0016787[hydrolase activity] GO:0035556[intracellular signal transduction]
B7ZM61 [Direct mapping] Phosphoinositide phospholipase C
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Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Human disease related genes Urinary system diseases Kidney diseases Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004435[phosphatidylinositol phospholipase C activity] GO:0005085[guanyl-nucleotide exchange factor activity] GO:0006629[lipid metabolic process] GO:0007165[signal transduction] GO:0007264[small GTPase mediated signal transduction] GO:0008081[phosphoric diester hydrolase activity] GO:0016042[lipid catabolic process] GO:0016787[hydrolase activity] GO:0035556[intracellular signal transduction]
The Human Protein Atlas project is funded
