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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
4
Cytoband
q21.22
Chromosome location (bp)
82352498 - 82374503
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine mRNAs. Also binds to double- and single-stranded DNA sequences in a specific manner and functions a transcription factor. Each of the RNA-binding domains specifically can bind solely to a single-stranded non-monotonous 5'-UUAG-3' sequence and also weaker to the single-stranded 5'-TTAGGG-3' telomeric DNA repeat. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. Binding of RRM1 to DNA inhibits the formation of DNA quadruplex structure which may play a role in telomere elongation. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. May play a role in the regulation of the rhythmic expression of circadian clock core genes. Directly binds to the 3'UTR of CRY1 mRNA and induces CRY1 rhythmic translation. May also be involved in the regulation of PER2 translation....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
DNA-binding, Ribonucleoprotein, RNA-binding
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are nucleic acid binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. It localizes to both the nucleus and the cytoplasm. This protein is implicated in the regulation of mRNA stability. Alternative splicing of this gene results in four transcript variants. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
A1LU37 [Target identity:100%; Query identity:100%] Heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa), isoform CRA_d
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001889[liver development] GO:0003676[nucleic acid binding] GO:0003677[DNA binding] GO:0003680[minor groove of adenine-thymine-rich DNA binding] GO:0003682[chromatin binding] GO:0003723[RNA binding] GO:0003729[mRNA binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006355[regulation of DNA-templated transcription] GO:0006396[RNA processing] GO:0006401[RNA catabolic process] GO:0007420[brain development] GO:0010468[regulation of gene expression] GO:0010604[positive regulation of macromolecule metabolic process] GO:0010628[positive regulation of gene expression] GO:0010629[negative regulation of gene expression] GO:0014069[postsynaptic density] GO:0021549[cerebellum development] GO:0032204[regulation of telomere maintenance] GO:0032355[response to estradiol] GO:0035925[mRNA 3'-UTR AU-rich region binding] GO:0042162[telomeric DNA binding] GO:0042752[regulation of circadian rhythm] GO:0042789[mRNA transcription by RNA polymerase II] GO:0042826[histone deacetylase binding] GO:0043488[regulation of mRNA stability] GO:0045202[synapse] GO:0045727[positive regulation of translation] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0048255[mRNA stabilization] GO:0048511[rhythmic process] GO:0051173[positive regulation of nitrogen compound metabolic process] GO:0051592[response to calcium ion] GO:0051602[response to electrical stimulus] GO:0061158[3'-UTR-mediated mRNA destabilization] GO:0070934[CRD-mediated mRNA stabilization] GO:0071230[cellular response to amino acid stimulus] GO:0071392[cellular response to estradiol stimulus] GO:0071732[cellular response to nitric oxide] GO:0097167[circadian regulation of translation] GO:0098978[glutamatergic synapse] GO:0106002[mCRD-mediated mRNA stability complex] GO:0110165[cellular anatomical entity] GO:1900152[negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay] GO:1901355[response to rapamycin] GO:1904355[positive regulation of telomere capping] GO:1904383[response to sodium phosphate] GO:1904586[cellular response to putrescine] GO:1905663[positive regulation of telomerase RNA reverse transcriptase activity] GO:1990828[hepatocyte dedifferentiation] GO:1990904[ribonucleoprotein complex] GO:2000767[positive regulation of cytoplasmic translation]
A0A024RDB4 [Target identity:100%; Query identity:100%] Heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa), isoform CRA_c
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0003676[nucleic acid binding] GO:0003677[DNA binding] GO:0003723[RNA binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006355[regulation of DNA-templated transcription] GO:0006396[RNA processing] GO:0006401[RNA catabolic process] GO:0010468[regulation of gene expression] GO:0010604[positive regulation of macromolecule metabolic process] GO:0032204[regulation of telomere maintenance] GO:0042162[telomeric DNA binding] GO:0042752[regulation of circadian rhythm] GO:0042789[mRNA transcription by RNA polymerase II] GO:0045727[positive regulation of translation] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0048511[rhythmic process] GO:0051173[positive regulation of nitrogen compound metabolic process] GO:0070934[CRD-mediated mRNA stabilization] GO:0097167[circadian regulation of translation] GO:0106002[mCRD-mediated mRNA stability complex] GO:0110165[cellular anatomical entity] GO:1900152[negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay] GO:1904355[positive regulation of telomere capping] GO:1905663[positive regulation of telomerase RNA reverse transcriptase activity] GO:1990904[ribonucleoprotein complex] GO:2000767[positive regulation of cytoplasmic translation]
A0A024RDF4 [Target identity:100%; Query identity:100%] Heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa), isoform CRA_e
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0003676[nucleic acid binding] GO:0003677[DNA binding] GO:0003723[RNA binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006355[regulation of DNA-templated transcription] GO:0006396[RNA processing] GO:0006401[RNA catabolic process] GO:0010468[regulation of gene expression] GO:0010604[positive regulation of macromolecule metabolic process] GO:0032204[regulation of telomere maintenance] GO:0042162[telomeric DNA binding] GO:0042752[regulation of circadian rhythm] GO:0045727[positive regulation of translation] GO:0045893[positive regulation of DNA-templated transcription] GO:0048511[rhythmic process] GO:0051173[positive regulation of nitrogen compound metabolic process] GO:0070934[CRD-mediated mRNA stabilization] GO:0097167[circadian regulation of translation] GO:0106002[mCRD-mediated mRNA stability complex] GO:0110165[cellular anatomical entity] GO:1900152[negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay] GO:1904355[positive regulation of telomere capping] GO:1905663[positive regulation of telomerase RNA reverse transcriptase activity] GO:1990904[ribonucleoprotein complex] GO:2000767[positive regulation of cytoplasmic translation]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
The Human Protein Atlas project is funded
