GENERAL INFORMATIONi
Gene namei FGF2
Synonyms FGFB
Gene descriptioni Fibroblast growth factor 2
Protein classi Cancer-related genes
Candidate cardiovascular disease genes
FDA approved drug targets
RAS pathway related proteins
Transporters
Predicted locationi Secreted, Intracellular
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi
Chromosome 4
Cytoband q28.1
Chromosome location (bp) 122826682 - 122898236
Number of transcriptsi 3
Ensembl ENSG00000138685 (version 109)
Entrez gene 2247
HGNC HGNC:3676
UniProt P09038 (UniProt - Evidence at protein level)
neXtProt NX_P09038
GeneCards FGF2
Antibodypedia FGF2 antibodies


PROTEIN FUNCTION
Protein function (UniProt)i Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4 1. Also acts as an integrin ligand which is required for FGF2 signaling 2. Binds to integrin ITGAV:ITGB3 3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration 4, 5. Functions as a potent mitogen in vitro 6, 7, 8. Can induce angiogenesis 9, 10. Mediates phosphorylation of ERK1/2 and thereby promotes retinal lens fiber differentiation 11. show less
Molecular function (UniProt)i Developmental protein, Growth factor, Heparin-binding, Mitogen
Biological process (UniProt)i Angiogenesis, Differentiation
Gene summary (Entrez)i The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members bind heparin and possess broad mitogenic and angiogenic activities. This protein has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for this gene contains multiple polyadenylation sites, and is alternatively translated from non-AUG (CUG) and AUG initiation codons, resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF. [provided by RefSeq, Jul 2008] show less
PROTEIN INFORMATIONi
Splice variant SwissProt TrEMBL Protein class Gene ontology Length & mass Signal peptide
(predicted)		 Transmembrane regions
(predicted)
FGF2-201
ENSP00000264498
ENST00000264498
P09038
[Direct mapping] Fibroblast growth factor 2
Show all
A0A0A0MQV6
[Direct mapping] Fibroblast growth factor
Show all
Transporters
   Transporter channels and pores
Predicted secreted proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
FDA approved drug targets
   Small molecule drugs
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001658 [branching involved in ureteric bud morphogenesis]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0001938 [positive regulation of endothelial cell proliferation]
GO:0002042 [cell migration involved in sprouting angiogenesis]
GO:0005104 [fibroblast growth factor receptor binding]
GO:0005125 [cytokine activity]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006661 [phosphatidylinositol biosynthetic process]
GO:0006935 [chemotaxis]
GO:0007165 [signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007399 [nervous system development]
GO:0008083 [growth factor activity]
GO:0008201 [heparin binding]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009887 [animal organ morphogenesis]
GO:0010595 [positive regulation of endothelial cell migration]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0010764 [negative regulation of fibroblast migration]
GO:0010863 [positive regulation of phospholipase C activity]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0014843 [growth factor dependent regulation of skeletal muscle satellite cell proliferation]
GO:0019956 [chemokine binding]
GO:0030154 [cell differentiation]
GO:0030214 [hyaluronan catabolic process]
GO:0030324 [lung development]
GO:0030334 [regulation of cell migration]
GO:0030374 [nuclear receptor coactivator activity]
GO:0032958 [inositol phosphate biosynthetic process]
GO:0038001 [paracrine signaling]
GO:0040037 [negative regulation of fibroblast growth factor receptor signaling pathway]
GO:0042056 [chemoattractant activity]
GO:0042060 [wound healing]
GO:0042660 [positive regulation of cell fate specification]
GO:0042802 [identical protein binding]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0043410 [positive regulation of MAPK cascade]
GO:0043536 [positive regulation of blood vessel endothelial cell migration]
GO:0043537 [negative regulation of blood vessel endothelial cell migration]
GO:0043552 [positive regulation of phosphatidylinositol 3-kinase activity]
GO:0045765 [regulation of angiogenesis]
GO:0045766 [positive regulation of angiogenesis]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0048513 [animal organ development]
GO:0048598 [embryonic morphogenesis]
GO:0048731 [system development]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0050918 [positive chemotaxis]
GO:0051209 [release of sequestered calcium ion into cytosol]
GO:0051781 [positive regulation of cell division]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0060045 [positive regulation of cardiac muscle cell proliferation]
GO:0060548 [negative regulation of cell death]
GO:0060591 [chondroblast differentiation]
GO:0061045 [negative regulation of wound healing]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0072089 [stem cell proliferation]
GO:0090049 [regulation of cell migration involved in sprouting angiogenesis]
GO:0090050 [positive regulation of cell migration involved in sprouting angiogenesis]
GO:0090722 [receptor-receptor interaction]
GO:1902748 [positive regulation of lens fiber cell differentiation]
GO:1902895 [positive regulation of miRNA transcription]
GO:1903587 [regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis]
GO:1903672 [positive regulation of sprouting angiogenesis]
GO:1904707 [positive regulation of vascular associated smooth muscle cell proliferation]
GO:1905278 [positive regulation of epithelial tube formation]
GO:1905564 [positive regulation of vascular endothelial cell proliferation]
GO:2000544 [regulation of endothelial cell chemotaxis to fibroblast growth factor]
GO:2000546 [positive regulation of endothelial cell chemotaxis to fibroblast growth factor]
GO:2000573 [positive regulation of DNA biosynthetic process]
GO:2001028 [positive regulation of endothelial cell chemotaxis]
Show all
 288 aa
30.8 kDa 		No 0
FGF2-202
ENSP00000477134
ENST00000608478
P09038
[Direct mapping] Fibroblast growth factor 2
Show all
D9ZGF5
[Target identity:100%; Query identity:100%] Fibroblast growth factor
Show all
Transporters
   Transporter channels and pores
Predicted secreted proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
FDA approved drug targets
   Small molecule drugs
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001658 [branching involved in ureteric bud morphogenesis]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0001938 [positive regulation of endothelial cell proliferation]
GO:0002042 [cell migration involved in sprouting angiogenesis]
GO:0005104 [fibroblast growth factor receptor binding]
GO:0005125 [cytokine activity]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006661 [phosphatidylinositol biosynthetic process]
GO:0006935 [chemotaxis]
GO:0007165 [signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007399 [nervous system development]
GO:0008083 [growth factor activity]
GO:0008201 [heparin binding]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009887 [animal organ morphogenesis]
GO:0010595 [positive regulation of endothelial cell migration]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0010764 [negative regulation of fibroblast migration]
GO:0010863 [positive regulation of phospholipase C activity]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0014843 [growth factor dependent regulation of skeletal muscle satellite cell proliferation]
GO:0019956 [chemokine binding]
GO:0030154 [cell differentiation]
GO:0030214 [hyaluronan catabolic process]
GO:0030324 [lung development]
GO:0030334 [regulation of cell migration]
GO:0030374 [nuclear receptor coactivator activity]
GO:0032958 [inositol phosphate biosynthetic process]
GO:0038001 [paracrine signaling]
GO:0040037 [negative regulation of fibroblast growth factor receptor signaling pathway]
GO:0042056 [chemoattractant activity]
GO:0042060 [wound healing]
GO:0042660 [positive regulation of cell fate specification]
GO:0042802 [identical protein binding]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0043410 [positive regulation of MAPK cascade]
GO:0043536 [positive regulation of blood vessel endothelial cell migration]
GO:0043537 [negative regulation of blood vessel endothelial cell migration]
GO:0043552 [positive regulation of phosphatidylinositol 3-kinase activity]
GO:0045765 [regulation of angiogenesis]
GO:0045766 [positive regulation of angiogenesis]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0048513 [animal organ development]
GO:0048598 [embryonic morphogenesis]
GO:0048731 [system development]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0050918 [positive chemotaxis]
GO:0051209 [release of sequestered calcium ion into cytosol]
GO:0051781 [positive regulation of cell division]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0060045 [positive regulation of cardiac muscle cell proliferation]
GO:0060548 [negative regulation of cell death]
GO:0060591 [chondroblast differentiation]
GO:0061045 [negative regulation of wound healing]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0072089 [stem cell proliferation]
GO:0090049 [regulation of cell migration involved in sprouting angiogenesis]
GO:0090050 [positive regulation of cell migration involved in sprouting angiogenesis]
GO:0090722 [receptor-receptor interaction]
GO:1902748 [positive regulation of lens fiber cell differentiation]
GO:1902895 [positive regulation of miRNA transcription]
GO:1903587 [regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis]
GO:1903672 [positive regulation of sprouting angiogenesis]
GO:1904707 [positive regulation of vascular associated smooth muscle cell proliferation]
GO:1905278 [positive regulation of epithelial tube formation]
GO:1905564 [positive regulation of vascular endothelial cell proliferation]
GO:2000544 [regulation of endothelial cell chemotaxis to fibroblast growth factor]
GO:2000546 [positive regulation of endothelial cell chemotaxis to fibroblast growth factor]
GO:2000573 [positive regulation of DNA biosynthetic process]
GO:2001028 [positive regulation of endothelial cell chemotaxis]
Show all
 155 aa
17.3 kDa 		No 0
FGF2-203
ENSP00000494222
ENST00000644866
P09038
[Direct mapping] Fibroblast growth factor 2
Show all
D9ZGF5
[Target identity:100%; Query identity:100%] Fibroblast growth factor
Show all
Transporters
   Transporter channels and pores
Predicted secreted proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
FDA approved drug targets
   Small molecule drugs
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001649 [osteoblast differentiation]
GO:0001658 [branching involved in ureteric bud morphogenesis]
GO:0001759 [organ induction]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0001935 [endothelial cell proliferation]
GO:0001938 [positive regulation of endothelial cell proliferation]
GO:0002042 [cell migration involved in sprouting angiogenesis]
GO:0002052 [positive regulation of neuroblast proliferation]
GO:0005104 [fibroblast growth factor receptor binding]
GO:0005125 [cytokine activity]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006366 [transcription by RNA polymerase II]
GO:0006661 [phosphatidylinositol biosynthetic process]
GO:0006935 [chemotaxis]
GO:0007165 [signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007399 [nervous system development]
GO:0007405 [neuroblast proliferation]
GO:0007568 [aging]
GO:0008083 [growth factor activity]
GO:0008201 [heparin binding]
GO:0008283 [cell population proliferation]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008285 [negative regulation of cell population proliferation]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009792 [embryo development ending in birth or egg hatching]
GO:0009887 [animal organ morphogenesis]
GO:0010001 [glial cell differentiation]
GO:0010595 [positive regulation of endothelial cell migration]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0010764 [negative regulation of fibroblast migration]
GO:0010863 [positive regulation of phospholipase C activity]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0014843 [growth factor dependent regulation of skeletal muscle satellite cell proliferation]
GO:0019956 [chemokine binding]
GO:0021762 [substantia nigra development]
GO:0021930 [cerebellar granule cell precursor proliferation]
GO:0021940 [positive regulation of cerebellar granule cell precursor proliferation]
GO:0030154 [cell differentiation]
GO:0030214 [hyaluronan catabolic process]
GO:0030324 [lung development]
GO:0030334 [regulation of cell migration]
GO:0030374 [nuclear receptor coactivator activity]
GO:0032958 [inositol phosphate biosynthetic process]
GO:0038001 [paracrine signaling]
GO:0040037 [negative regulation of fibroblast growth factor receptor signaling pathway]
GO:0042056 [chemoattractant activity]
GO:0042060 [wound healing]
GO:0042491 [inner ear auditory receptor cell differentiation]
GO:0042660 [positive regulation of cell fate specification]
GO:0042802 [identical protein binding]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0043410 [positive regulation of MAPK cascade]
GO:0043491 [protein kinase B signaling]
GO:0043536 [positive regulation of blood vessel endothelial cell migration]
GO:0043537 [negative regulation of blood vessel endothelial cell migration]
GO:0043542 [endothelial cell migration]
GO:0043552 [positive regulation of phosphatidylinositol 3-kinase activity]
GO:0045609 [positive regulation of inner ear auditory receptor cell differentiation]
GO:0045669 [positive regulation of osteoblast differentiation]
GO:0045765 [regulation of angiogenesis]
GO:0045766 [positive regulation of angiogenesis]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046668 [regulation of retinal cell programmed cell death]
GO:0048513 [animal organ development]
GO:0048598 [embryonic morphogenesis]
GO:0048661 [positive regulation of smooth muscle cell proliferation]
GO:0048678 [response to axon injury]
GO:0048731 [system development]
GO:0048863 [stem cell differentiation]
GO:0048864 [stem cell development]
GO:0050673 [epithelial cell proliferation]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0050918 [positive chemotaxis]
GO:0051209 [release of sequestered calcium ion into cytosol]
GO:0051726 [regulation of cell cycle]
GO:0051781 [positive regulation of cell division]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0060045 [positive regulation of cardiac muscle cell proliferation]
GO:0060070 [canonical Wnt signaling pathway]
GO:0060128 [corticotropin hormone secreting cell differentiation]
GO:0060129 [thyroid-stimulating hormone-secreting cell differentiation]
GO:0060548 [negative regulation of cell death]
GO:0060563 [neuroepithelial cell differentiation]
GO:0060591 [chondroblast differentiation]
GO:0060644 [mammary gland epithelial cell differentiation]
GO:0060978 [angiogenesis involved in coronary vascular morphogenesis]
GO:0061045 [negative regulation of wound healing]
GO:0070371 [ERK1 and ERK2 cascade]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0071260 [cellular response to mechanical stimulus]
GO:0072089 [stem cell proliferation]
GO:0090049 [regulation of cell migration involved in sprouting angiogenesis]
GO:0090050 [positive regulation of cell migration involved in sprouting angiogenesis]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
GO:0090722 [receptor-receptor interaction]
GO:1902748 [positive regulation of lens fiber cell differentiation]
GO:1902895 [positive regulation of miRNA transcription]
GO:1902913 [positive regulation of neuroepithelial cell differentiation]
GO:1903587 [regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis]
GO:1903672 [positive regulation of sprouting angiogenesis]
GO:1904707 [positive regulation of vascular associated smooth muscle cell proliferation]
GO:1904977 [lymphatic endothelial cell migration]
GO:1905278 [positive regulation of epithelial tube formation]
GO:1905564 [positive regulation of vascular endothelial cell proliferation]
GO:2000544 [regulation of endothelial cell chemotaxis to fibroblast growth factor]
GO:2000546 [positive regulation of endothelial cell chemotaxis to fibroblast growth factor]
GO:2000573 [positive regulation of DNA biosynthetic process]
GO:2000647 [negative regulation of stem cell proliferation]
GO:2000648 [positive regulation of stem cell proliferation]
GO:2000738 [positive regulation of stem cell differentiation]
GO:2001028 [positive regulation of endothelial cell chemotaxis]
Show all
 155 aa
17.3 kDa 		No 0

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