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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
4
Cytoband
q21.1
Chromosome location (bp)
77157207 - 77433388
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
May play a role in growth regulation and in negative regulation of cell cycle progression....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Cyclin
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Cell cycle, Cell division, Mitosis
Gene summary (Entrez)i
Useful information about the gene from Entrez
The eukaryotic cell cycle is governed by cyclin-dependent protein kinases (CDKs) whose activities are regulated by cyclins and CDK inhibitors. The 8 species of cyclins reported in mammals, cyclins A through H, share a conserved amino acid sequence of about 90 residues called the cyclin box. The amino acid sequence of cyclin G is well conserved among mammals. The nucleotide sequence of cyclin G1 and cyclin G2 are 53% identical. Unlike cyclin G1, cyclin G2 contains a C-terminal PEST protein destabilization motif, suggesting that cyclin G2 expression is tightly regulated through the cell cycle. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level
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GO:0000079[regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0000307[cyclin-dependent protein kinase holoenzyme complex] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0007049[cell cycle] GO:0016538[cyclin-dependent protein serine/threonine kinase regulator activity] GO:0044772[mitotic cell cycle phase transition] GO:0051301[cell division] GO:0051726[regulation of cell cycle]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0000079[regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0000307[cyclin-dependent protein kinase holoenzyme complex] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0007049[cell cycle] GO:0016538[cyclin-dependent protein serine/threonine kinase regulator activity] GO:0044772[mitotic cell cycle phase transition] GO:0051301[cell division] GO:0051726[regulation of cell cycle]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0000079[regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0000307[cyclin-dependent protein kinase holoenzyme complex] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0007049[cell cycle] GO:0016538[cyclin-dependent protein serine/threonine kinase regulator activity] GO:0044772[mitotic cell cycle phase transition] GO:0051301[cell division] GO:0051726[regulation of cell cycle]
SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level
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GO:0000079[regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0000307[cyclin-dependent protein kinase holoenzyme complex] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0007049[cell cycle] GO:0016538[cyclin-dependent protein serine/threonine kinase regulator activity] GO:0044772[mitotic cell cycle phase transition] GO:0051301[cell division] GO:0051726[regulation of cell cycle]
The Human Protein Atlas project is funded
