GENERAL INFORMATIONi
Gene namei LEF1
Synonyms TCF10, TCF1ALPHA, TCF7L3
Gene descriptioni Lymphoid enhancer binding factor 1
Protein classi Cancer-related genes
Plasma proteins
Transcription factors
Predicted locationi Intracellular
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi
Chromosome 4
Cytoband q25
Chromosome location (bp) 108047545 - 108168956
Number of transcriptsi 6
Ensembl ENSG00000138795 (version 109)
Entrez gene 51176
HGNC HGNC:6551
UniProt Q9UJU2 (UniProt - Evidence at protein level)
neXtProt NX_Q9UJU2
GeneCards LEF1
Antibodypedia LEF1 antibodies


PROTEIN FUNCTION
Protein function (UniProt)i Transcription factor that binds DNA in a sequence-specific manner 1. Participates in the Wnt signaling pathway (By similarity). Activates transcription of target genes in the presence of CTNNB1 and EP300 (By similarity). PIAG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1 (By similarity). TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1 2. Regulates T-cell receptor alpha enhancer function 3. Required for IL17A expressing gamma-delta T-cell maturation and development, via binding to regulator loci of BLK to modulate expression (By similarity). Acts as a positive regulator of odontoblast differentiation during mesenchymal tooth germ formation, expression is repressed during the bell stage by MSX1-mediated inhibition of CTNNB1 signaling (By similarity). May play a role in hair cell differentiation and follicle morphogenesis (By similarity). show less
Molecular function (UniProt)i Activator, DNA-binding
Biological process (UniProt)i Transcription, Transcription regulation, Wnt signaling pathway
Gene summary (Entrez)i This gene encodes a transcription factor belonging to a family of proteins that share homology with the high mobility group protein-1. The protein encoded by this gene can bind to a functionally important site in the T-cell receptor-alpha enhancer, thereby conferring maximal enhancer activity. This transcription factor is involved in the Wnt signaling pathway, and it may function in hair cell differentiation and follicle morphogenesis. Mutations in this gene have been found in somatic sebaceous tumors. This gene has also been linked to other cancers, including androgen-independent prostate cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009] show less
PROTEIN INFORMATIONi
Splice variant SwissProt TrEMBL Protein class Gene ontology Length & mass Signal peptide
(predicted)		 Transmembrane regions
(predicted)
LEF1-201
ENSP00000265165
ENST00000265165
Q9UJU2
[Direct mapping] Lymphoid enhancer-binding factor 1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Transcription factors
   Other all-alpha-helical DNA-binding domains
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000976 [transcription cis-regulatory region binding]
GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0000987 [cis-regulatory region sequence-specific DNA binding]
GO:0001222 [transcription corepressor binding]
GO:0001227 [DNA-binding transcription repressor activity, RNA polymerase II-specific]
GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific]
GO:0001569 [branching involved in blood vessel morphogenesis]
GO:0001649 [osteoblast differentiation]
GO:0001756 [somitogenesis]
GO:0001837 [epithelial to mesenchymal transition]
GO:0001944 [vasculature development]
GO:0002040 [sprouting angiogenesis]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription regulator complex]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0006366 [transcription by RNA polymerase II]
GO:0008013 [beta-catenin binding]
GO:0008301 [DNA binding, bending]
GO:0010628 [positive regulation of gene expression]
GO:0010718 [positive regulation of epithelial to mesenchymal transition]
GO:0016055 [Wnt signaling pathway]
GO:0021542 [dentate gyrus development]
GO:0021766 [hippocampus development]
GO:0021861 [forebrain radial glial cell differentiation]
GO:0021873 [forebrain neuroblast division]
GO:0021943 [formation of radial glial scaffolds]
GO:0022407 [regulation of cell-cell adhesion]
GO:0030111 [regulation of Wnt signaling pathway]
GO:0030177 [positive regulation of Wnt signaling pathway]
GO:0030223 [neutrophil differentiation]
GO:0030326 [embryonic limb morphogenesis]
GO:0030331 [nuclear estrogen receptor binding]
GO:0030335 [positive regulation of cell migration]
GO:0030509 [BMP signaling pathway]
GO:0030854 [positive regulation of granulocyte differentiation]
GO:0030879 [mammary gland development]
GO:0032696 [negative regulation of interleukin-13 production]
GO:0032713 [negative regulation of interleukin-4 production]
GO:0032714 [negative regulation of interleukin-5 production]
GO:0032993 [protein-DNA complex]
GO:0033153 [T cell receptor V(D)J recombination]
GO:0042100 [B cell proliferation]
GO:0042393 [histone binding]
GO:0042475 [odontogenesis of dentin-containing tooth]
GO:0042826 [histone deacetylase binding]
GO:0043066 [negative regulation of apoptotic process]
GO:0043392 [negative regulation of DNA binding]
GO:0043565 [sequence-specific DNA binding]
GO:0043586 [tongue development]
GO:0043923 [positive regulation by host of viral transcription]
GO:0045063 [T-helper 1 cell differentiation]
GO:0045295 [gamma-catenin binding]
GO:0045588 [positive regulation of gamma-delta T cell differentiation]
GO:0045597 [positive regulation of cell differentiation]
GO:0045843 [negative regulation of striated muscle tissue development]
GO:0045892 [negative regulation of DNA-templated transcription]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046632 [alpha-beta T cell differentiation]
GO:0048341 [paraxial mesoderm formation]
GO:0048468 [cell development]
GO:0050767 [regulation of neurogenesis]
GO:0050909 [sensory perception of taste]
GO:0060033 [anatomical structure regression]
GO:0060070 [canonical Wnt signaling pathway]
GO:0060325 [face morphogenesis]
GO:0060326 [cell chemotaxis]
GO:0060561 [apoptotic process involved in morphogenesis]
GO:0060710 [chorio-allantoic fusion]
GO:0061153 [trachea gland development]
GO:0062009 [secondary palate development]
GO:0070016 [armadillo repeat domain binding]
GO:0070742 [C2H2 zinc finger domain binding]
GO:0071168 [protein localization to chromatin]
GO:0071345 [cellular response to cytokine stimulus]
GO:0071353 [cellular response to interleukin-4]
GO:0071864 [positive regulation of cell proliferation in bone marrow]
GO:0071866 [negative regulation of apoptotic process in bone marrow cell]
GO:0090575 [RNA polymerase II transcription regulator complex]
GO:0097043 [histone H3-K56 acetylation]
GO:0140416 [transcription regulator inhibitor activity]
GO:1902262 [apoptotic process involved in blood vessel morphogenesis]
GO:1902732 [positive regulation of chondrocyte proliferation]
GO:1904019 [epithelial cell apoptotic process]
GO:1990837 [sequence-specific double-stranded DNA binding]
GO:1990907 [beta-catenin-TCF complex]
Show all
 399 aa
44.2 kDa 		No 0
LEF1-202
ENSP00000369284
ENST00000379951
Q9UJU2
[Direct mapping] Lymphoid enhancer-binding factor 1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Transcription factors
   Other all-alpha-helical DNA-binding domains
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0001222 [transcription corepressor binding]
GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific]
GO:0001649 [osteoblast differentiation]
GO:0001837 [epithelial to mesenchymal transition]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription regulator complex]
GO:0005737 [cytoplasm]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0008013 [beta-catenin binding]
GO:0008301 [DNA binding, bending]
GO:0010628 [positive regulation of gene expression]
GO:0010718 [positive regulation of epithelial to mesenchymal transition]
GO:0016055 [Wnt signaling pathway]
GO:0030223 [neutrophil differentiation]
GO:0030331 [nuclear estrogen receptor binding]
GO:0030335 [positive regulation of cell migration]
GO:0030854 [positive regulation of granulocyte differentiation]
GO:0032696 [negative regulation of interleukin-13 production]
GO:0032713 [negative regulation of interleukin-4 production]
GO:0032714 [negative regulation of interleukin-5 production]
GO:0032993 [protein-DNA complex]
GO:0042393 [histone binding]
GO:0042826 [histone deacetylase binding]
GO:0043066 [negative regulation of apoptotic process]
GO:0043392 [negative regulation of DNA binding]
GO:0043565 [sequence-specific DNA binding]
GO:0043923 [positive regulation by host of viral transcription]
GO:0045063 [T-helper 1 cell differentiation]
GO:0045295 [gamma-catenin binding]
GO:0045588 [positive regulation of gamma-delta T cell differentiation]
GO:0045597 [positive regulation of cell differentiation]
GO:0045892 [negative regulation of DNA-templated transcription]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0050767 [regulation of neurogenesis]
GO:0060070 [canonical Wnt signaling pathway]
GO:0060326 [cell chemotaxis]
GO:0062009 [secondary palate development]
GO:0070016 [armadillo repeat domain binding]
GO:0070742 [C2H2 zinc finger domain binding]
GO:0071168 [protein localization to chromatin]
GO:0071345 [cellular response to cytokine stimulus]
GO:0071353 [cellular response to interleukin-4]
GO:0071864 [positive regulation of cell proliferation in bone marrow]
GO:0071866 [negative regulation of apoptotic process in bone marrow cell]
GO:0140416 [transcription regulator inhibitor activity]
GO:1990837 [sequence-specific double-stranded DNA binding]
GO:1990907 [beta-catenin-TCF complex]
Show all
 386 aa
42.7 kDa 		No 0
LEF1-203
ENSP00000406176
ENST00000438313
Q9UJU2
[Direct mapping] Lymphoid enhancer-binding factor 1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Transcription factors
   Other all-alpha-helical DNA-binding domains
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0001222 [transcription corepressor binding]
GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific]
GO:0001649 [osteoblast differentiation]
GO:0001837 [epithelial to mesenchymal transition]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription regulator complex]
GO:0005737 [cytoplasm]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0008013 [beta-catenin binding]
GO:0008301 [DNA binding, bending]
GO:0010628 [positive regulation of gene expression]
GO:0010718 [positive regulation of epithelial to mesenchymal transition]
GO:0016055 [Wnt signaling pathway]
GO:0030223 [neutrophil differentiation]
GO:0030331 [nuclear estrogen receptor binding]
GO:0030335 [positive regulation of cell migration]
GO:0030854 [positive regulation of granulocyte differentiation]
GO:0032696 [negative regulation of interleukin-13 production]
GO:0032713 [negative regulation of interleukin-4 production]
GO:0032714 [negative regulation of interleukin-5 production]
GO:0032993 [protein-DNA complex]
GO:0042393 [histone binding]
GO:0042826 [histone deacetylase binding]
GO:0043066 [negative regulation of apoptotic process]
GO:0043392 [negative regulation of DNA binding]
GO:0043565 [sequence-specific DNA binding]
GO:0043923 [positive regulation by host of viral transcription]
GO:0045063 [T-helper 1 cell differentiation]
GO:0045295 [gamma-catenin binding]
GO:0045588 [positive regulation of gamma-delta T cell differentiation]
GO:0045597 [positive regulation of cell differentiation]
GO:0045892 [negative regulation of DNA-templated transcription]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0050767 [regulation of neurogenesis]
GO:0060070 [canonical Wnt signaling pathway]
GO:0060326 [cell chemotaxis]
GO:0062009 [secondary palate development]
GO:0070016 [armadillo repeat domain binding]
GO:0070742 [C2H2 zinc finger domain binding]
GO:0071168 [protein localization to chromatin]
GO:0071345 [cellular response to cytokine stimulus]
GO:0071353 [cellular response to interleukin-4]
GO:0071864 [positive regulation of cell proliferation in bone marrow]
GO:0071866 [negative regulation of apoptotic process in bone marrow cell]
GO:0090068 [positive regulation of cell cycle process]
GO:0140416 [transcription regulator inhibitor activity]
GO:1990837 [sequence-specific double-stranded DNA binding]
GO:1990907 [beta-catenin-TCF complex]
Show all
 371 aa
41.2 kDa 		No 0
LEF1-216
ENSP00000422840
ENST00000510624
Q9UJU2
[Direct mapping] Lymphoid enhancer-binding factor 1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Transcription factors
   Other all-alpha-helical DNA-binding domains
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0001222 [transcription corepressor binding]
GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific]
GO:0001649 [osteoblast differentiation]
GO:0001837 [epithelial to mesenchymal transition]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription regulator complex]
GO:0005737 [cytoplasm]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0008013 [beta-catenin binding]
GO:0008301 [DNA binding, bending]
GO:0010628 [positive regulation of gene expression]
GO:0010718 [positive regulation of epithelial to mesenchymal transition]
GO:0016055 [Wnt signaling pathway]
GO:0030223 [neutrophil differentiation]
GO:0030331 [nuclear estrogen receptor binding]
GO:0030335 [positive regulation of cell migration]
GO:0030854 [positive regulation of granulocyte differentiation]
GO:0032696 [negative regulation of interleukin-13 production]
GO:0032713 [negative regulation of interleukin-4 production]
GO:0032714 [negative regulation of interleukin-5 production]
GO:0032993 [protein-DNA complex]
GO:0042393 [histone binding]
GO:0042826 [histone deacetylase binding]
GO:0043066 [negative regulation of apoptotic process]
GO:0043392 [negative regulation of DNA binding]
GO:0043565 [sequence-specific DNA binding]
GO:0043923 [positive regulation by host of viral transcription]
GO:0045063 [T-helper 1 cell differentiation]
GO:0045295 [gamma-catenin binding]
GO:0045588 [positive regulation of gamma-delta T cell differentiation]
GO:0045597 [positive regulation of cell differentiation]
GO:0045892 [negative regulation of DNA-templated transcription]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0050767 [regulation of neurogenesis]
GO:0060070 [canonical Wnt signaling pathway]
GO:0060326 [cell chemotaxis]
GO:0062009 [secondary palate development]
GO:0070016 [armadillo repeat domain binding]
GO:0070742 [C2H2 zinc finger domain binding]
GO:0071168 [protein localization to chromatin]
GO:0071345 [cellular response to cytokine stimulus]
GO:0071353 [cellular response to interleukin-4]
GO:0071864 [positive regulation of cell proliferation in bone marrow]
GO:0071866 [negative regulation of apoptotic process in bone marrow cell]
GO:0140416 [transcription regulator inhibitor activity]
GO:1990837 [sequence-specific double-stranded DNA binding]
GO:1990907 [beta-catenin-TCF complex]
Show all
 303 aa
34.1 kDa 		No 0
LEF1-218
ENSP00000427365
ENST00000512172
D6RIV1
[Direct mapping] Lymphoid enhancer-binding factor 1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0008013 [beta-catenin binding]
GO:0016055 [Wnt signaling pathway]
Show all
 145 aa
15.8 kDa 		No 0
LEF1-221
ENSP00000422801
ENST00000515500
D6RAB1
[Direct mapping] Lymphoid enhancer-binding factor 1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0008013 [beta-catenin binding]
GO:0016055 [Wnt signaling pathway]
Show all
 173 aa
18.8 kDa 		No 0

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