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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Disease related genes FDA approved drug targets Human disease related genes Plasma proteins RAS pathway related proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
4
Cytoband
q25
Chromosome location (bp)
109912883 - 110013766
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. Can induce neurite outgrowth in motoneurons of the pond snail Lymnaea stagnalis in vitro 1....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Growth factor
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a member of the epidermal growth factor superfamily. The encoded preproprotein is proteolytically processed to generate the 53-amino acid epidermal growth factor peptide. This protein acts a potent mitogenic factor that plays an important role in the growth, proliferation and differentiation of numerous cell types. This protein acts by binding with high affinity to the cell surface receptor, epidermal growth factor receptor. Defects in this gene are the cause of hypomagnesemia type 4. Dysregulation of this gene has been associated with the growth and progression of certain cancers. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Cancers Cancers of the digestive system Congenital disorders of metabolism Other congenital disorders of metabolism Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) DeepTMHMM predicted membrane proteins
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GO:0001525[angiogenesis] GO:0001938[positive regulation of endothelial cell proliferation] GO:0002092[positive regulation of receptor internalization] GO:0005085[guanyl-nucleotide exchange factor activity] GO:0005154[epidermal growth factor receptor binding] GO:0005509[calcium ion binding] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0005765[lysosomal membrane] GO:0005886[plasma membrane] GO:0007173[epidermal growth factor receptor signaling pathway] GO:0008083[growth factor activity] GO:0008283[cell population proliferation] GO:0008284[positive regulation of cell population proliferation] GO:0010595[positive regulation of endothelial cell migration] GO:0010628[positive regulation of gene expression] GO:0010800[positive regulation of peptidyl-threonine phosphorylation] GO:0014068[positive regulation of phosphatidylinositol 3-kinase signaling] GO:0016004[phospholipase activator activity] GO:0016020[membrane] GO:0018108[peptidyl-tyrosine phosphorylation] GO:0021930[cerebellar granule cell precursor proliferation] GO:0021940[positive regulation of cerebellar granule cell precursor proliferation] GO:0030297[transmembrane receptor protein tyrosine kinase activator activity] GO:0030335[positive regulation of cell migration] GO:0030669[clathrin-coated endocytic vesicle membrane] GO:0031093[platelet alpha granule lumen] GO:0038029[epidermal growth factor receptor signaling pathway via MAPK cascade] GO:0038134[ERBB2-EGFR signaling pathway] GO:0042327[positive regulation of phosphorylation] GO:0043388[positive regulation of DNA binding] GO:0043406[positive regulation of MAP kinase activity] GO:0043410[positive regulation of MAPK cascade] GO:0045740[positive regulation of DNA replication] GO:0045741[positive regulation of epidermal growth factor-activated receptor activity] GO:0045840[positive regulation of mitotic nuclear division] GO:0045893[positive regulation of DNA-templated transcription] GO:0046425[regulation of receptor signaling pathway via JAK-STAT] GO:0048018[receptor ligand activity] GO:0048754[branching morphogenesis of an epithelial tube] GO:0050673[epithelial cell proliferation] GO:0050679[positive regulation of epithelial cell proliferation] GO:0050730[regulation of peptidyl-tyrosine phosphorylation] GO:0050731[positive regulation of peptidyl-tyrosine phosphorylation] GO:0051048[negative regulation of secretion] GO:0051897[positive regulation of protein kinase B signaling] GO:0060749[mammary gland alveolus development] GO:0061098[positive regulation of protein tyrosine kinase activity] GO:0070062[extracellular exosome] GO:0070371[ERK1 and ERK2 cascade] GO:0090263[positive regulation of canonical Wnt signaling pathway] GO:0090279[regulation of calcium ion import] GO:0090370[negative regulation of cholesterol efflux] GO:1900127[positive regulation of hyaluronan biosynthetic process] GO:1902966[positive regulation of protein localization to early endosome] GO:1905278[positive regulation of epithelial tube formation] GO:2000008[regulation of protein localization to cell surface] GO:2000060[positive regulation of ubiquitin-dependent protein catabolic process]
Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Cancers Cancers of the digestive system Congenital disorders of metabolism Other congenital disorders of metabolism Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) DeepTMHMM predicted membrane proteins
Show all
GO:0001525[angiogenesis] GO:0001938[positive regulation of endothelial cell proliferation] GO:0002092[positive regulation of receptor internalization] GO:0005085[guanyl-nucleotide exchange factor activity] GO:0005154[epidermal growth factor receptor binding] GO:0005509[calcium ion binding] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0005765[lysosomal membrane] GO:0005886[plasma membrane] GO:0007173[epidermal growth factor receptor signaling pathway] GO:0008083[growth factor activity] GO:0008284[positive regulation of cell population proliferation] GO:0010595[positive regulation of endothelial cell migration] GO:0010628[positive regulation of gene expression] GO:0010800[positive regulation of peptidyl-threonine phosphorylation] GO:0014068[positive regulation of phosphatidylinositol 3-kinase signaling] GO:0016020[membrane] GO:0030297[transmembrane receptor protein tyrosine kinase activator activity] GO:0030335[positive regulation of cell migration] GO:0030669[clathrin-coated endocytic vesicle membrane] GO:0031093[platelet alpha granule lumen] GO:0038029[epidermal growth factor receptor signaling pathway via MAPK cascade] GO:0038134[ERBB2-EGFR signaling pathway] GO:0042327[positive regulation of phosphorylation] GO:0043388[positive regulation of DNA binding] GO:0043406[positive regulation of MAP kinase activity] GO:0043410[positive regulation of MAPK cascade] GO:0045740[positive regulation of DNA replication] GO:0045741[positive regulation of epidermal growth factor-activated receptor activity] GO:0045840[positive regulation of mitotic nuclear division] GO:0045893[positive regulation of DNA-templated transcription] GO:0046425[regulation of receptor signaling pathway via JAK-STAT] GO:0048018[receptor ligand activity] GO:0051048[negative regulation of secretion] GO:0051897[positive regulation of protein kinase B signaling] GO:0070062[extracellular exosome] GO:0070371[ERK1 and ERK2 cascade] GO:0090263[positive regulation of canonical Wnt signaling pathway] GO:0090279[regulation of calcium ion import] GO:1900127[positive regulation of hyaluronan biosynthetic process] GO:1902966[positive regulation of protein localization to early endosome] GO:1905278[positive regulation of epithelial tube formation] GO:2000008[regulation of protein localization to cell surface]
Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Cancers Cancers of the digestive system Congenital disorders of metabolism Other congenital disorders of metabolism Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) DeepTMHMM predicted membrane proteins
Show all
GO:0001525[angiogenesis] GO:0001938[positive regulation of endothelial cell proliferation] GO:0002092[positive regulation of receptor internalization] GO:0005085[guanyl-nucleotide exchange factor activity] GO:0005154[epidermal growth factor receptor binding] GO:0005509[calcium ion binding] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0005765[lysosomal membrane] GO:0005886[plasma membrane] GO:0007173[epidermal growth factor receptor signaling pathway] GO:0008083[growth factor activity] GO:0008284[positive regulation of cell population proliferation] GO:0010595[positive regulation of endothelial cell migration] GO:0010628[positive regulation of gene expression] GO:0010800[positive regulation of peptidyl-threonine phosphorylation] GO:0014068[positive regulation of phosphatidylinositol 3-kinase signaling] GO:0016020[membrane] GO:0030297[transmembrane receptor protein tyrosine kinase activator activity] GO:0030335[positive regulation of cell migration] GO:0030669[clathrin-coated endocytic vesicle membrane] GO:0031093[platelet alpha granule lumen] GO:0038029[epidermal growth factor receptor signaling pathway via MAPK cascade] GO:0038134[ERBB2-EGFR signaling pathway] GO:0042327[positive regulation of phosphorylation] GO:0043388[positive regulation of DNA binding] GO:0043406[positive regulation of MAP kinase activity] GO:0043410[positive regulation of MAPK cascade] GO:0045740[positive regulation of DNA replication] GO:0045741[positive regulation of epidermal growth factor-activated receptor activity] GO:0045840[positive regulation of mitotic nuclear division] GO:0045893[positive regulation of DNA-templated transcription] GO:0046425[regulation of receptor signaling pathway via JAK-STAT] GO:0048018[receptor ligand activity] GO:0051048[negative regulation of secretion] GO:0051897[positive regulation of protein kinase B signaling] GO:0070062[extracellular exosome] GO:0070371[ERK1 and ERK2 cascade] GO:0090263[positive regulation of canonical Wnt signaling pathway] GO:0090279[regulation of calcium ion import] GO:1900127[positive regulation of hyaluronan biosynthetic process] GO:1902966[positive regulation of protein localization to early endosome] GO:1905278[positive regulation of epithelial tube formation] GO:2000008[regulation of protein localization to cell surface]
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