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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
15
Cytoband
q23
Chromosome location (bp)
70047790 - 70098176
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Transcriptional corepressor that binds to a number of transcription factors 1. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling 2. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity)....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Repressor
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
This gene encodes a transcriptional co-repressor protein that belongs to the transducin-like enhancer family of proteins. The members of this family function in the Notch signaling pathway that regulates determination of cell fate during development. Expression of this gene has been associated with a favorable outcome to chemotherapy with taxanes for ovarian carcinoma. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Sep 2013]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Q04726 [Direct mapping] Transducin-like enhancer protein 3
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0003714[transcription corepressor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005667[transcription regulator complex] GO:0006355[regulation of DNA-templated transcription] GO:0007165[signal transduction] GO:0009887[animal organ morphogenesis] GO:0016055[Wnt signaling pathway] GO:0045892[negative regulation of DNA-templated transcription] GO:0090090[negative regulation of canonical Wnt signaling pathway] GO:0120163[negative regulation of cold-induced thermogenesis] GO:1990907[beta-catenin-TCF complex]
Q04726 [Direct mapping] Transducin-like enhancer protein 3
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003714[transcription corepressor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005667[transcription regulator complex] GO:0006355[regulation of DNA-templated transcription] GO:0007165[signal transduction] GO:0009887[animal organ morphogenesis] GO:0016055[Wnt signaling pathway] GO:0045892[negative regulation of DNA-templated transcription] GO:0090090[negative regulation of canonical Wnt signaling pathway] GO:0120163[negative regulation of cold-induced thermogenesis] GO:1990907[beta-catenin-TCF complex]
Q04726 [Direct mapping] Transducin-like enhancer protein 3
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003714[transcription corepressor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005667[transcription regulator complex] GO:0006355[regulation of DNA-templated transcription] GO:0007165[signal transduction] GO:0009887[animal organ morphogenesis] GO:0016055[Wnt signaling pathway] GO:0045892[negative regulation of DNA-templated transcription] GO:0090090[negative regulation of canonical Wnt signaling pathway] GO:0120163[negative regulation of cold-induced thermogenesis] GO:1990907[beta-catenin-TCF complex]
Q04726 [Direct mapping] Transducin-like enhancer protein 3
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003714[transcription corepressor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005667[transcription regulator complex] GO:0006355[regulation of DNA-templated transcription] GO:0007165[signal transduction] GO:0009887[animal organ morphogenesis] GO:0016055[Wnt signaling pathway] GO:0045892[negative regulation of DNA-templated transcription] GO:0090090[negative regulation of canonical Wnt signaling pathway] GO:0120163[negative regulation of cold-induced thermogenesis] GO:1990907[beta-catenin-TCF complex]
Q04726 [Direct mapping] Transducin-like enhancer protein 3
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003714[transcription corepressor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005667[transcription regulator complex] GO:0006355[regulation of DNA-templated transcription] GO:0007165[signal transduction] GO:0009887[animal organ morphogenesis] GO:0016055[Wnt signaling pathway] GO:0045892[negative regulation of DNA-templated transcription] GO:0090090[negative regulation of canonical Wnt signaling pathway] GO:0120163[negative regulation of cold-induced thermogenesis] GO:1990907[beta-catenin-TCF complex]
Q04726 [Direct mapping] Transducin-like enhancer protein 3
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003714[transcription corepressor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005667[transcription regulator complex] GO:0006355[regulation of DNA-templated transcription] GO:0007165[signal transduction] GO:0009887[animal organ morphogenesis] GO:0016055[Wnt signaling pathway] GO:0045892[negative regulation of DNA-templated transcription] GO:0090090[negative regulation of canonical Wnt signaling pathway] GO:0120163[negative regulation of cold-induced thermogenesis] GO:1990907[beta-catenin-TCF complex]
Q04726 [Direct mapping] Transducin-like enhancer protein 3
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003714[transcription corepressor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005667[transcription regulator complex] GO:0006355[regulation of DNA-templated transcription] GO:0007165[signal transduction] GO:0009887[animal organ morphogenesis] GO:0016055[Wnt signaling pathway] GO:0045892[negative regulation of DNA-templated transcription] GO:0090090[negative regulation of canonical Wnt signaling pathway] GO:0120163[negative regulation of cold-induced thermogenesis] GO:1990907[beta-catenin-TCF complex]
Q04726 [Direct mapping] Transducin-like enhancer protein 3
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003714[transcription corepressor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005667[transcription regulator complex] GO:0006355[regulation of DNA-templated transcription] GO:0007165[signal transduction] GO:0009887[animal organ morphogenesis] GO:0016055[Wnt signaling pathway] GO:0045892[negative regulation of DNA-templated transcription] GO:0090090[negative regulation of canonical Wnt signaling pathway] GO:0120163[negative regulation of cold-induced thermogenesis] GO:1990907[beta-catenin-TCF complex]
The Human Protein Atlas project is funded
