GENERAL INFORMATIONi
Gene namei PML
Synonyms MYL, RNF71, TRIM19
Gene descriptioni PML nuclear body scaffold
Protein classi Cancer-related genes
Disease related genes
Human disease related genes
Plasma proteins
Predicted locationi Intracellular
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi
Chromosome 15
Cytoband q24.1
Chromosome location (bp) 73994673 - 74047827
Number of transcriptsi 18
Ensembl ENSG00000140464 (version 109)
Entrez gene 5371
HGNC HGNC:9113
UniProt P29590 (UniProt - Evidence at protein level)
neXtProt NX_P29590
GeneCards PML
Antibodypedia PML antibodies


PROTEIN FUNCTION
Protein function (UniProt)i Functions via its association with PML-nuclear bodies (PML-NBs) in a wide range of important cellular processes, including tumor suppression, transcriptional regulation, apoptosis, senescence, DNA damage response, and viral defense mechanisms. Acts as the scaffold of PML-NBs allowing other proteins to shuttle in and out, a process which is regulated by SUMO-mediated modifications and interactions. Inhibits EIF4E-mediated mRNA nuclear export by reducing EIF4E affinity for the 5' 7-methylguanosine (m7G) cap of target mRNAs 1, 2, 3. Isoform PML-4 has a multifaceted role in the regulation of apoptosis and growth suppression: activates RB1 and inhibits AKT1 via interactions with PP1 and PP2A phosphatases respectively, negatively affects the PI3K pathway by inhibiting MTOR and activating PTEN, and positively regulates p53/TP53 by acting at different levels (by promoting its acetylation and phosphorylation and by inhibiting its MDM2-dependent degradation). Isoform PML-4 also: acts as a transcriptional repressor of TBX2 during cellular senescence and the repression is dependent on a functional RBL2/E2F4 repressor complex, regulates double-strand break repair in gamma-irradiation-induced DNA damage responses via its interaction with WRN, acts as a negative regulator of telomerase by interacting with TERT, and regulates PER2 nuclear localization and circadian function. Isoform PML-6 inhibits specifically the activity of the tetrameric form of PKM. The nuclear isoforms (isoform PML-1, isoform PML-2, isoform PML-3, isoform PML-4 and isoform PML-5) in concert with SATB1 are involved in local chromatin-loop remodeling and gene expression regulation at the MHC-I locus. Isoform PML-2 is required for efficient IFN-gamma induced MHC II gene transcription via regulation of CIITA. Cytoplasmic PML is involved in the regulation of the TGF-beta signaling pathway. PML also regulates transcription activity of ELF4 and can act as an important mediator for TNF-alpha- and IFN-alpha-mediated inhibition of endothelial cell network formation and migration. show less
Molecular function (UniProt)i Activator, DNA-binding, Transferase
Biological process (UniProt)i Antiviral defense, Apoptosis, Biological rhythms, Host-virus interaction, Immunity, Innate immunity, Transcription, Transcription regulation
Ligand (UniProt)i Metal-binding, Zinc
Gene summary (Entrez)i The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] show less
PROTEIN INFORMATIONi
Splice variant SwissProt TrEMBL Protein class Gene ontology Length & mass Signal peptide
(predicted)		 Transmembrane regions
(predicted)
PML-201
ENSP00000268058
ENST00000268058
P29590
[Direct mapping] Protein PML
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Human disease related genes
   Cancers
   Cancers of haematopoietic and lymphoid tissues
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000781 [chromosome, telomeric region]
GO:0000785 [chromatin]
GO:0000792 [heterochromatin]
GO:0001666 [response to hypoxia]
GO:0002376 [immune system process]
GO:0003677 [DNA binding]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005829 [cytosol]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006606 [protein import into nucleus]
GO:0006915 [apoptotic process]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007182 [common-partner SMAD protein phosphorylation]
GO:0008270 [zinc ion binding]
GO:0008285 [negative regulation of cell population proliferation]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0008631 [intrinsic apoptotic signaling pathway in response to oxidative stress]
GO:0009411 [response to UV]
GO:0010332 [response to gamma radiation]
GO:0010522 [regulation of calcium ion transport into cytosol]
GO:0010761 [fibroblast migration]
GO:0016020 [membrane]
GO:0016363 [nuclear matrix]
GO:0016525 [negative regulation of angiogenesis]
GO:0016567 [protein ubiquitination]
GO:0016605 [PML body]
GO:0016740 [transferase activity]
GO:0016925 [protein sumoylation]
GO:0019789 [SUMO transferase activity]
GO:0030099 [myeloid cell differentiation]
GO:0030155 [regulation of cell adhesion]
GO:0030308 [negative regulation of cell growth]
GO:0030578 [PML body organization]
GO:0031503 [protein-containing complex localization]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031901 [early endosome membrane]
GO:0032183 [SUMO binding]
GO:0032206 [positive regulation of telomere maintenance]
GO:0032469 [endoplasmic reticulum calcium ion homeostasis]
GO:0032691 [negative regulation of interleukin-1 beta production]
GO:0032692 [negative regulation of interleukin-1 production]
GO:0032922 [circadian regulation of gene expression]
GO:0034097 [response to cytokine]
GO:0042406 [extrinsic component of endoplasmic reticulum membrane]
GO:0042752 [regulation of circadian rhythm]
GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
GO:0042803 [protein homodimerization activity]
GO:0043153 [entrainment of circadian clock by photoperiod]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0044790 [suppression of viral release by host]
GO:0045087 [innate immune response]
GO:0045165 [cell fate commitment]
GO:0045892 [negative regulation of DNA-templated transcription]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0046332 [SMAD binding]
GO:0046872 [metal ion binding]
GO:0048146 [positive regulation of fibroblast proliferation]
GO:0048384 [retinoic acid receptor signaling pathway]
GO:0048511 [rhythmic process]
GO:0051457 [maintenance of protein location in nucleus]
GO:0051607 [defense response to virus]
GO:0060444 [branching involved in mammary gland duct morphogenesis]
GO:0065003 [protein-containing complex assembly]
GO:0070059 [intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress]
GO:0071353 [cellular response to interleukin-4]
GO:0072332 [intrinsic apoptotic signaling pathway by p53 class mediator]
GO:0090398 [cellular senescence]
GO:0090402 [oncogene-induced cell senescence]
GO:0097191 [extrinsic apoptotic signaling pathway]
GO:0140037 []
GO:1901798 [positive regulation of signal transduction by p53 class mediator]
GO:1990830 [cellular response to leukemia inhibitory factor]
GO:2000059 [negative regulation of ubiquitin-dependent protein catabolic process]
GO:2000758 [positive regulation of peptidyl-lysine acetylation]
GO:2000779 [regulation of double-strand break repair]
GO:2001235 [positive regulation of apoptotic signaling pathway]
GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway]
Show all
 882 aa
97.6 kDa 		No 0
PML-202
ENSP00000268059
ENST00000268059
P29590
[Direct mapping] Protein PML
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Human disease related genes
   Cancers
   Cancers of haematopoietic and lymphoid tissues
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000781 [chromosome, telomeric region]
GO:0000785 [chromatin]
GO:0001666 [response to hypoxia]
GO:0002376 [immune system process]
GO:0003677 [DNA binding]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005829 [cytosol]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006915 [apoptotic process]
GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest]
GO:0008270 [zinc ion binding]
GO:0008285 [negative regulation of cell population proliferation]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0010522 [regulation of calcium ion transport into cytosol]
GO:0016020 [membrane]
GO:0016525 [negative regulation of angiogenesis]
GO:0016567 [protein ubiquitination]
GO:0016605 [PML body]
GO:0016740 [transferase activity]
GO:0016925 [protein sumoylation]
GO:0019789 [SUMO transferase activity]
GO:0030308 [negative regulation of cell growth]
GO:0030578 [PML body organization]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031901 [early endosome membrane]
GO:0032183 [SUMO binding]
GO:0032206 [positive regulation of telomere maintenance]
GO:0032469 [endoplasmic reticulum calcium ion homeostasis]
GO:0032922 [circadian regulation of gene expression]
GO:0034097 [response to cytokine]
GO:0042406 [extrinsic component of endoplasmic reticulum membrane]
GO:0042752 [regulation of circadian rhythm]
GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
GO:0042803 [protein homodimerization activity]
GO:0043153 [entrainment of circadian clock by photoperiod]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0044790 [suppression of viral release by host]
GO:0045087 [innate immune response]
GO:0045892 [negative regulation of DNA-templated transcription]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0046872 [metal ion binding]
GO:0048511 [rhythmic process]
GO:0051457 [maintenance of protein location in nucleus]
GO:0051607 [defense response to virus]
GO:0065003 [protein-containing complex assembly]
GO:0090398 [cellular senescence]
GO:0140037 []
GO:2000059 [negative regulation of ubiquitin-dependent protein catabolic process]
GO:2000779 [regulation of double-strand break repair]
GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway]
Show all
 829 aa
90.7 kDa 		No 0
PML-203
ENSP00000315434
ENST00000354026
P29590
[Direct mapping] Protein PML
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Human disease related genes
   Cancers
   Cancers of haematopoietic and lymphoid tissues
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000781 [chromosome, telomeric region]
GO:0000785 [chromatin]
GO:0001666 [response to hypoxia]
GO:0002376 [immune system process]
GO:0003677 [DNA binding]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005829 [cytosol]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006915 [apoptotic process]
GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest]
GO:0008270 [zinc ion binding]
GO:0008285 [negative regulation of cell population proliferation]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0010522 [regulation of calcium ion transport into cytosol]
GO:0016020 [membrane]
GO:0016525 [negative regulation of angiogenesis]
GO:0016567 [protein ubiquitination]
GO:0016605 [PML body]
GO:0016740 [transferase activity]
GO:0016925 [protein sumoylation]
GO:0019789 [SUMO transferase activity]
GO:0030308 [negative regulation of cell growth]
GO:0030578 [PML body organization]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031901 [early endosome membrane]
GO:0032183 [SUMO binding]
GO:0032206 [positive regulation of telomere maintenance]
GO:0032469 [endoplasmic reticulum calcium ion homeostasis]
GO:0032922 [circadian regulation of gene expression]
GO:0034097 [response to cytokine]
GO:0042406 [extrinsic component of endoplasmic reticulum membrane]
GO:0042752 [regulation of circadian rhythm]
GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043153 [entrainment of circadian clock by photoperiod]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0044790 [suppression of viral release by host]
GO:0045087 [innate immune response]
GO:0045892 [negative regulation of DNA-templated transcription]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0046872 [metal ion binding]
GO:0048511 [rhythmic process]
GO:0051457 [maintenance of protein location in nucleus]
GO:0051607 [defense response to virus]
GO:0065003 [protein-containing complex assembly]
GO:0090398 [cellular senescence]
GO:0140037 []
GO:2000059 [negative regulation of ubiquitin-dependent protein catabolic process]
GO:2000779 [regulation of double-strand break repair]
GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway]
Show all
 781 aa
85.7 kDa 		No 0
PML-204
ENSP00000353004
ENST00000359928
P29590
[Direct mapping] Protein PML
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Human disease related genes
   Cancers
   Cancers of haematopoietic and lymphoid tissues
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000781 [chromosome, telomeric region]
GO:0000785 [chromatin]
GO:0001666 [response to hypoxia]
GO:0002376 [immune system process]
GO:0003677 [DNA binding]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005829 [cytosol]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006915 [apoptotic process]
GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest]
GO:0008270 [zinc ion binding]
GO:0008285 [negative regulation of cell population proliferation]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0010522 [regulation of calcium ion transport into cytosol]
GO:0016020 [membrane]
GO:0016525 [negative regulation of angiogenesis]
GO:0016567 [protein ubiquitination]
GO:0016605 [PML body]
GO:0016740 [transferase activity]
GO:0016925 [protein sumoylation]
GO:0019789 [SUMO transferase activity]
GO:0030308 [negative regulation of cell growth]
GO:0030578 [PML body organization]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031901 [early endosome membrane]
GO:0032183 [SUMO binding]
GO:0032206 [positive regulation of telomere maintenance]
GO:0032469 [endoplasmic reticulum calcium ion homeostasis]
GO:0032922 [circadian regulation of gene expression]
GO:0034097 [response to cytokine]
GO:0042406 [extrinsic component of endoplasmic reticulum membrane]
GO:0042752 [regulation of circadian rhythm]
GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
GO:0042803 [protein homodimerization activity]
GO:0043153 [entrainment of circadian clock by photoperiod]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0044790 [suppression of viral release by host]
GO:0045087 [innate immune response]
GO:0045892 [negative regulation of DNA-templated transcription]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0046872 [metal ion binding]
GO:0048511 [rhythmic process]
GO:0051457 [maintenance of protein location in nucleus]
GO:0051607 [defense response to virus]
GO:0065003 [protein-containing complex assembly]
GO:0090398 [cellular senescence]
GO:0140037 []
GO:2000059 [negative regulation of ubiquitin-dependent protein catabolic process]
GO:2000779 [regulation of double-strand break repair]
GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway]
Show all
 423 aa
47.6 kDa 		No 0
PML-205
ENSP00000378564
ENST00000395132
P29590
[Direct mapping] Protein PML
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Human disease related genes
   Cancers
   Cancers of haematopoietic and lymphoid tissues
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000781 [chromosome, telomeric region]
GO:0000785 [chromatin]
GO:0001666 [response to hypoxia]
GO:0002376 [immune system process]
GO:0003677 [DNA binding]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005829 [cytosol]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006915 [apoptotic process]
GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest]
GO:0008270 [zinc ion binding]
GO:0008285 [negative regulation of cell population proliferation]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0010522 [regulation of calcium ion transport into cytosol]
GO:0016020 [membrane]
GO:0016525 [negative regulation of angiogenesis]
GO:0016567 [protein ubiquitination]
GO:0016605 [PML body]
GO:0016740 [transferase activity]
GO:0016925 [protein sumoylation]
GO:0019789 [SUMO transferase activity]
GO:0030308 [negative regulation of cell growth]
GO:0030578 [PML body organization]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031901 [early endosome membrane]
GO:0032183 [SUMO binding]
GO:0032206 [positive regulation of telomere maintenance]
GO:0032469 [endoplasmic reticulum calcium ion homeostasis]
GO:0032922 [circadian regulation of gene expression]
GO:0034097 [response to cytokine]
GO:0042406 [extrinsic component of endoplasmic reticulum membrane]
GO:0042752 [regulation of circadian rhythm]
GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
GO:0042803 [protein homodimerization activity]
GO:0043153 [entrainment of circadian clock by photoperiod]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0044790 [suppression of viral release by host]
GO:0045087 [innate immune response]
GO:0045892 [negative regulation of DNA-templated transcription]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0046872 [metal ion binding]
GO:0048511 [rhythmic process]
GO:0051457 [maintenance of protein location in nucleus]
GO:0051607 [defense response to virus]
GO:0065003 [protein-containing complex assembly]
GO:0090398 [cellular senescence]
GO:0140037 []
GO:2000059 [negative regulation of ubiquitin-dependent protein catabolic process]
GO:2000779 [regulation of double-strand break repair]
GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway]
Show all
 435 aa
48.6 kDa 		No 0
PML-206
ENSP00000378567
ENST00000395135
P29590
[Direct mapping] Protein PML
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Human disease related genes
   Cancers
   Cancers of haematopoietic and lymphoid tissues
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000781 [chromosome, telomeric region]
GO:0000785 [chromatin]
GO:0001666 [response to hypoxia]
GO:0002376 [immune system process]
GO:0003677 [DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005829 [cytosol]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006605 [protein targeting]
GO:0006915 [apoptotic process]
GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest]
GO:0008270 [zinc ion binding]
GO:0008285 [negative regulation of cell population proliferation]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0010522 [regulation of calcium ion transport into cytosol]
GO:0016020 [membrane]
GO:0016363 [nuclear matrix]
GO:0016525 [negative regulation of angiogenesis]
GO:0016567 [protein ubiquitination]
GO:0016605 [PML body]
GO:0016740 [transferase activity]
GO:0016925 [protein sumoylation]
GO:0019789 [SUMO transferase activity]
GO:0030308 [negative regulation of cell growth]
GO:0030578 [PML body organization]
GO:0031065 [positive regulation of histone deacetylation]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031901 [early endosome membrane]
GO:0032183 [SUMO binding]
GO:0032206 [positive regulation of telomere maintenance]
GO:0032211 [negative regulation of telomere maintenance via telomerase]
GO:0032469 [endoplasmic reticulum calcium ion homeostasis]
GO:0032922 [circadian regulation of gene expression]
GO:0032938 [negative regulation of translation in response to oxidative stress]
GO:0034097 [response to cytokine]
GO:0042406 [extrinsic component of endoplasmic reticulum membrane]
GO:0042752 [regulation of circadian rhythm]
GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
GO:0042803 [protein homodimerization activity]
GO:0043153 [entrainment of circadian clock by photoperiod]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0044790 [suppression of viral release by host]
GO:0045087 [innate immune response]
GO:0045892 [negative regulation of DNA-templated transcription]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0046872 [metal ion binding]
GO:0048511 [rhythmic process]
GO:0050821 [protein stabilization]
GO:0051457 [maintenance of protein location in nucleus]
GO:0051607 [defense response to virus]
GO:0051726 [regulation of cell cycle]
GO:0051974 [negative regulation of telomerase activity]
GO:0060058 [positive regulation of apoptotic process involved in mammary gland involution]
GO:0065003 [protein-containing complex assembly]
GO:0090398 [cellular senescence]
GO:0140037 []
GO:1904816 [positive regulation of protein localization to chromosome, telomeric region]
GO:2000059 [negative regulation of ubiquitin-dependent protein catabolic process]
GO:2000779 [regulation of double-strand break repair]
GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway]
Show all
 633 aa
70 kDa 		No 0
PML-207
ENSP00000395576
ENST00000435786
P29590
[Direct mapping] Protein PML
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Human disease related genes
   Cancers
   Cancers of haematopoietic and lymphoid tissues
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000781 [chromosome, telomeric region]
GO:0000785 [chromatin]
GO:0001666 [response to hypoxia]
GO:0002230 [positive regulation of defense response to virus by host]
GO:0002376 [immune system process]
GO:0003677 [DNA binding]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005829 [cytosol]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006915 [apoptotic process]
GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest]
GO:0008270 [zinc ion binding]
GO:0008285 [negative regulation of cell population proliferation]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0010522 [regulation of calcium ion transport into cytosol]
GO:0016020 [membrane]
GO:0016525 [negative regulation of angiogenesis]
GO:0016567 [protein ubiquitination]
GO:0016605 [PML body]
GO:0016740 [transferase activity]
GO:0016925 [protein sumoylation]
GO:0019789 [SUMO transferase activity]
GO:0030308 [negative regulation of cell growth]
GO:0030578 [PML body organization]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031901 [early endosome membrane]
GO:0032183 [SUMO binding]
GO:0032206 [positive regulation of telomere maintenance]
GO:0032469 [endoplasmic reticulum calcium ion homeostasis]
GO:0032922 [circadian regulation of gene expression]
GO:0034097 [response to cytokine]
GO:0042406 [extrinsic component of endoplasmic reticulum membrane]
GO:0042752 [regulation of circadian rhythm]
GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
GO:0042803 [protein homodimerization activity]
GO:0043153 [entrainment of circadian clock by photoperiod]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0044790 [suppression of viral release by host]
GO:0045087 [innate immune response]
GO:0045892 [negative regulation of DNA-templated transcription]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0046872 [metal ion binding]
GO:0048511 [rhythmic process]
GO:0051457 [maintenance of protein location in nucleus]
GO:0051607 [defense response to virus]
GO:0065003 [protein-containing complex assembly]
GO:0090398 [cellular senescence]
GO:0140037 []
GO:2000059 [negative regulation of ubiquitin-dependent protein catabolic process]
GO:2000779 [regulation of double-strand break repair]
GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway]
Show all
 611 aa
67.5 kDa 		No 0
PML-208
ENSP00000394642
ENST00000436891
P29590
[Direct mapping] Protein PML
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Human disease related genes
   Cancers
   Cancers of haematopoietic and lymphoid tissues
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000781 [chromosome, telomeric region]
GO:0000785 [chromatin]
GO:0001666 [response to hypoxia]
GO:0002230 [positive regulation of defense response to virus by host]
GO:0002376 [immune system process]
GO:0003677 [DNA binding]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005829 [cytosol]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006915 [apoptotic process]
GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest]
GO:0008270 [zinc ion binding]
GO:0008285 [negative regulation of cell population proliferation]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0010522 [regulation of calcium ion transport into cytosol]
GO:0016020 [membrane]
GO:0016525 [negative regulation of angiogenesis]
GO:0016567 [protein ubiquitination]
GO:0016605 [PML body]
GO:0016740 [transferase activity]
GO:0016925 [protein sumoylation]
GO:0019789 [SUMO transferase activity]
GO:0030308 [negative regulation of cell growth]
GO:0030578 [PML body organization]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031901 [early endosome membrane]
GO:0032183 [SUMO binding]
GO:0032206 [positive regulation of telomere maintenance]
GO:0032469 [endoplasmic reticulum calcium ion homeostasis]
GO:0032922 [circadian regulation of gene expression]
GO:0034097 [response to cytokine]
GO:0042406 [extrinsic component of endoplasmic reticulum membrane]
GO:0042752 [regulation of circadian rhythm]
GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
GO:0042803 [protein homodimerization activity]
GO:0043153 [entrainment of circadian clock by photoperiod]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0044790 [suppression of viral release by host]
GO:0045087 [innate immune response]
GO:0045892 [negative regulation of DNA-templated transcription]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0046872 [metal ion binding]
GO:0048511 [rhythmic process]
GO:0050897 [cobalt ion binding]
GO:0051457 [maintenance of protein location in nucleus]
GO:0051607 [defense response to virus]
GO:0065003 [protein-containing complex assembly]
GO:0090398 [cellular senescence]
GO:0140037 []
GO:2000059 [negative regulation of ubiquitin-dependent protein catabolic process]
GO:2000779 [regulation of double-strand break repair]
GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway]
Show all
 560 aa
62 kDa 		No 0
PML-209
ENSP00000456329
ENST00000562086
H3BRN3
[Direct mapping] Protein PML
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Human disease related genes
   Cancers
   Cancers of haematopoietic and lymphoid tissues
Protein evidence (Ezkurdia et al 2014)
Show all
 110 aa
11.8 kDa 		No 0
PML-210
ENSP00000457032
ENST00000563500
H3BT57
[Direct mapping] Protein PML
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Human disease related genes
   Cancers
   Cancers of haematopoietic and lymphoid tissues
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008270 [zinc ion binding]
GO:0046872 [metal ion binding]
Show all
 568 aa
62.9 kDa 		No 0
PML-211
ENSP00000457023
ENST00000564428
P29590
[Direct mapping] Protein PML
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Human disease related genes
   Cancers
   Cancers of haematopoietic and lymphoid tissues
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000781 [chromosome, telomeric region]
GO:0000785 [chromatin]
GO:0001666 [response to hypoxia]
GO:0002376 [immune system process]
GO:0003677 [DNA binding]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005829 [cytosol]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006915 [apoptotic process]
GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest]
GO:0008270 [zinc ion binding]
GO:0008285 [negative regulation of cell population proliferation]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0010522 [regulation of calcium ion transport into cytosol]
GO:0016020 [membrane]
GO:0016525 [negative regulation of angiogenesis]
GO:0016567 [protein ubiquitination]
GO:0016605 [PML body]
GO:0016740 [transferase activity]
GO:0016925 [protein sumoylation]
GO:0019789 [SUMO transferase activity]
GO:0030308 [negative regulation of cell growth]
GO:0030578 [PML body organization]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031901 [early endosome membrane]
GO:0032183 [SUMO binding]
GO:0032206 [positive regulation of telomere maintenance]
GO:0032469 [endoplasmic reticulum calcium ion homeostasis]
GO:0032922 [circadian regulation of gene expression]
GO:0034097 [response to cytokine]
GO:0042406 [extrinsic component of endoplasmic reticulum membrane]
GO:0042752 [regulation of circadian rhythm]
GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
GO:0042803 [protein homodimerization activity]
GO:0043153 [entrainment of circadian clock by photoperiod]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0044790 [suppression of viral release by host]
GO:0045087 [innate immune response]
GO:0045892 [negative regulation of DNA-templated transcription]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0046872 [metal ion binding]
GO:0048511 [rhythmic process]
GO:0051457 [maintenance of protein location in nucleus]
GO:0051607 [defense response to virus]
GO:0065003 [protein-containing complex assembly]
GO:0090398 [cellular senescence]
GO:0140037 []
GO:2000059 [negative regulation of ubiquitin-dependent protein catabolic process]
GO:2000779 [regulation of double-strand break repair]
GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway]
Show all
 585 aa
65 kDa 		No 0
PML-213
ENSP00000456989
ENST00000565239
H3BT29
[Direct mapping] Protein PML
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Human disease related genes
   Cancers
   Cancers of haematopoietic and lymphoid tissues
Protein evidence (Ezkurdia et al 2014)
Show all
 240 aa
26.4 kDa 		No 0
PML-215
ENSP00000455838
ENST00000565898
P29590
[Direct mapping] Protein PML
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Human disease related genes
   Cancers
   Cancers of haematopoietic and lymphoid tissues
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000781 [chromosome, telomeric region]
GO:0000785 [chromatin]
GO:0001666 [response to hypoxia]
GO:0002376 [immune system process]
GO:0003677 [DNA binding]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005829 [cytosol]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006915 [apoptotic process]
GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest]
GO:0008270 [zinc ion binding]
GO:0008285 [negative regulation of cell population proliferation]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0010522 [regulation of calcium ion transport into cytosol]
GO:0016020 [membrane]
GO:0016525 [negative regulation of angiogenesis]
GO:0016567 [protein ubiquitination]
GO:0016605 [PML body]
GO:0016740 [transferase activity]
GO:0016925 [protein sumoylation]
GO:0019789 [SUMO transferase activity]
GO:0030308 [negative regulation of cell growth]
GO:0030578 [PML body organization]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031901 [early endosome membrane]
GO:0032183 [SUMO binding]
GO:0032206 [positive regulation of telomere maintenance]
GO:0032469 [endoplasmic reticulum calcium ion homeostasis]
GO:0032922 [circadian regulation of gene expression]
GO:0034097 [response to cytokine]
GO:0042406 [extrinsic component of endoplasmic reticulum membrane]
GO:0042752 [regulation of circadian rhythm]
GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
GO:0042803 [protein homodimerization activity]
GO:0043153 [entrainment of circadian clock by photoperiod]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0044790 [suppression of viral release by host]
GO:0045087 [innate immune response]
GO:0045892 [negative regulation of DNA-templated transcription]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0046872 [metal ion binding]
GO:0048511 [rhythmic process]
GO:0051457 [maintenance of protein location in nucleus]
GO:0051607 [defense response to virus]
GO:0065003 [protein-containing complex assembly]
GO:0090398 [cellular senescence]
GO:0140037 []
GO:2000059 [negative regulation of ubiquitin-dependent protein catabolic process]
GO:2000779 [regulation of double-strand break repair]
GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway]
Show all
 834 aa
92.6 kDa 		No 0
PML-216
ENSP00000458061
ENST00000566068
H3BVD2
[Direct mapping] Protein PML
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Human disease related genes
   Cancers
   Cancers of haematopoietic and lymphoid tissues
Protein evidence (Ezkurdia et al 2014)
Show all
 217 aa
23 kDa 		No 0
PML-217
ENSP00000456277
ENST00000567543
P29590
[Direct mapping] Protein PML
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Human disease related genes
   Cancers
   Cancers of haematopoietic and lymphoid tissues
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000781 [chromosome, telomeric region]
GO:0000785 [chromatin]
GO:0001666 [response to hypoxia]
GO:0002376 [immune system process]
GO:0003677 [DNA binding]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005829 [cytosol]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006915 [apoptotic process]
GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest]
GO:0008270 [zinc ion binding]
GO:0008285 [negative regulation of cell population proliferation]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0010522 [regulation of calcium ion transport into cytosol]
GO:0016020 [membrane]
GO:0016525 [negative regulation of angiogenesis]
GO:0016567 [protein ubiquitination]
GO:0016605 [PML body]
GO:0016740 [transferase activity]
GO:0016925 [protein sumoylation]
GO:0019789 [SUMO transferase activity]
GO:0030308 [negative regulation of cell growth]
GO:0030578 [PML body organization]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031901 [early endosome membrane]
GO:0032183 [SUMO binding]
GO:0032206 [positive regulation of telomere maintenance]
GO:0032469 [endoplasmic reticulum calcium ion homeostasis]
GO:0032922 [circadian regulation of gene expression]
GO:0034097 [response to cytokine]
GO:0042406 [extrinsic component of endoplasmic reticulum membrane]
GO:0042752 [regulation of circadian rhythm]
GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
GO:0042803 [protein homodimerization activity]
GO:0043153 [entrainment of circadian clock by photoperiod]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0044790 [suppression of viral release by host]
GO:0045087 [innate immune response]
GO:0045892 [negative regulation of DNA-templated transcription]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0046872 [metal ion binding]
GO:0048511 [rhythmic process]
GO:0051457 [maintenance of protein location in nucleus]
GO:0051607 [defense response to virus]
GO:0065003 [protein-containing complex assembly]
GO:0090398 [cellular senescence]
GO:0140037 []
GO:2000059 [negative regulation of ubiquitin-dependent protein catabolic process]
GO:2000779 [regulation of double-strand break repair]
GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway]
Show all
 423 aa
47.6 kDa 		No 0
PML-218
ENSP00000457669
ENST00000567606
H3BUJ5
[Direct mapping] Protein PML
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Human disease related genes
   Cancers
   Cancers of haematopoietic and lymphoid tissues
Protein evidence (Ezkurdia et al 2014)
Show all
 261 aa
28.7 kDa 		No 0
PML-220
ENSP00000455612
ENST00000569477
P29590
[Direct mapping] Protein PML
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Human disease related genes
   Cancers
   Cancers of haematopoietic and lymphoid tissues
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000781 [chromosome, telomeric region]
GO:0000785 [chromatin]
GO:0001666 [response to hypoxia]
GO:0002376 [immune system process]
GO:0003677 [DNA binding]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005829 [cytosol]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006915 [apoptotic process]
GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest]
GO:0008270 [zinc ion binding]
GO:0008285 [negative regulation of cell population proliferation]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0010522 [regulation of calcium ion transport into cytosol]
GO:0016020 [membrane]
GO:0016525 [negative regulation of angiogenesis]
GO:0016567 [protein ubiquitination]
GO:0016605 [PML body]
GO:0016740 [transferase activity]
GO:0016925 [protein sumoylation]
GO:0019789 [SUMO transferase activity]
GO:0030308 [negative regulation of cell growth]
GO:0030578 [PML body organization]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031901 [early endosome membrane]
GO:0032183 [SUMO binding]
GO:0032206 [positive regulation of telomere maintenance]
GO:0032469 [endoplasmic reticulum calcium ion homeostasis]
GO:0032922 [circadian regulation of gene expression]
GO:0034097 [response to cytokine]
GO:0042406 [extrinsic component of endoplasmic reticulum membrane]
GO:0042752 [regulation of circadian rhythm]
GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
GO:0042803 [protein homodimerization activity]
GO:0043153 [entrainment of circadian clock by photoperiod]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0044790 [suppression of viral release by host]
GO:0045087 [innate immune response]
GO:0045892 [negative regulation of DNA-templated transcription]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0046872 [metal ion binding]
GO:0048511 [rhythmic process]
GO:0051457 [maintenance of protein location in nucleus]
GO:0051607 [defense response to virus]
GO:0065003 [protein-containing complex assembly]
GO:0090398 [cellular senescence]
GO:0140037 []
GO:2000059 [negative regulation of ubiquitin-dependent protein catabolic process]
GO:2000779 [regulation of double-strand break repair]
GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway]
Show all
 641 aa
70.4 kDa 		No 0
PML-221
ENSP00000456486
ENST00000569965
P29590
[Direct mapping] Protein PML
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Human disease related genes
   Cancers
   Cancers of haematopoietic and lymphoid tissues
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000781 [chromosome, telomeric region]
GO:0000785 [chromatin]
GO:0001666 [response to hypoxia]
GO:0002230 [positive regulation of defense response to virus by host]
GO:0002376 [immune system process]
GO:0003677 [DNA binding]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005829 [cytosol]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006915 [apoptotic process]
GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest]
GO:0008270 [zinc ion binding]
GO:0008285 [negative regulation of cell population proliferation]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0010522 [regulation of calcium ion transport into cytosol]
GO:0016020 [membrane]
GO:0016525 [negative regulation of angiogenesis]
GO:0016567 [protein ubiquitination]
GO:0016605 [PML body]
GO:0016740 [transferase activity]
GO:0016925 [protein sumoylation]
GO:0019789 [SUMO transferase activity]
GO:0030308 [negative regulation of cell growth]
GO:0030578 [PML body organization]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031901 [early endosome membrane]
GO:0032183 [SUMO binding]
GO:0032206 [positive regulation of telomere maintenance]
GO:0032469 [endoplasmic reticulum calcium ion homeostasis]
GO:0032922 [circadian regulation of gene expression]
GO:0034097 [response to cytokine]
GO:0042406 [extrinsic component of endoplasmic reticulum membrane]
GO:0042752 [regulation of circadian rhythm]
GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
GO:0042803 [protein homodimerization activity]
GO:0043153 [entrainment of circadian clock by photoperiod]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0044790 [suppression of viral release by host]
GO:0045087 [innate immune response]
GO:0045892 [negative regulation of DNA-templated transcription]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0046872 [metal ion binding]
GO:0048511 [rhythmic process]
GO:0050897 [cobalt ion binding]
GO:0051457 [maintenance of protein location in nucleus]
GO:0051607 [defense response to virus]
GO:0065003 [protein-containing complex assembly]
GO:0090398 [cellular senescence]
GO:0140037 []
GO:2000059 [negative regulation of ubiquitin-dependent protein catabolic process]
GO:2000779 [regulation of double-strand break repair]
GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway]
Show all
 560 aa
62 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
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contact@proteinatlas.org