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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Disease related genes Enzymes FDA approved drug targets Human disease related genes Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
15
Cytoband
q25.3
Chromosome location (bp)
87859751 - 88256791
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Differentiation, Neurogenesis
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
ATP-binding, Nucleotide-binding
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Q96CY4 [Target identity:100%; Query identity:100%] Neurotrophic tyrosine kinase, receptor, type 3; Neurotrophic tyrosine kinase, receptor, type 3, isoform CRA_e
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Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Cancers Head and neck cancers Cancers of eye, brain, and central nervous system Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) DeepTMHMM predicted membrane proteins
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GO:0000166[nucleotide binding] GO:0001933[negative regulation of protein phosphorylation] GO:0001934[positive regulation of protein phosphorylation] GO:0002039[p53 binding] GO:0004672[protein kinase activity] GO:0004713[protein tyrosine kinase activity] GO:0004714[transmembrane receptor protein tyrosine kinase activity] GO:0005030[neurotrophin receptor activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005886[plasma membrane] GO:0005887[integral component of plasma membrane] GO:0006468[protein phosphorylation] GO:0007169[transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007399[nervous system development] GO:0007507[heart development] GO:0008284[positive regulation of cell population proliferation] GO:0010628[positive regulation of gene expression] GO:0010976[positive regulation of neuron projection development] GO:0014068[positive regulation of phosphatidylinositol 3-kinase signaling] GO:0016020[membrane] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016740[transferase activity] GO:0018108[peptidyl-tyrosine phosphorylation] GO:0030154[cell differentiation] GO:0030335[positive regulation of cell migration] GO:0030424[axon] GO:0032148[activation of protein kinase B activity] GO:0033138[positive regulation of peptidyl-serine phosphorylation] GO:0033674[positive regulation of kinase activity] GO:0038179[neurotrophin signaling pathway] GO:0043121[neurotrophin binding] GO:0043235[receptor complex] GO:0043406[positive regulation of MAP kinase activity] GO:0048013[ephrin receptor signaling pathway] GO:0050927[positive regulation of positive chemotaxis] GO:0051716[cellular response to stimulus] GO:0051896[regulation of protein kinase B signaling] GO:0090630[activation of GTPase activity] GO:1990090[cellular response to nerve growth factor stimulus] GO:2000251[positive regulation of actin cytoskeleton reorganization]
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Cancers Head and neck cancers Cancers of eye, brain, and central nervous system Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014) DeepTMHMM predicted membrane proteins
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GO:0000166[nucleotide binding] GO:0001933[negative regulation of protein phosphorylation] GO:0001934[positive regulation of protein phosphorylation] GO:0002039[p53 binding] GO:0004672[protein kinase activity] GO:0004713[protein tyrosine kinase activity] GO:0004714[transmembrane receptor protein tyrosine kinase activity] GO:0005030[neurotrophin receptor activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005886[plasma membrane] GO:0005887[integral component of plasma membrane] GO:0006468[protein phosphorylation] GO:0007169[transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007399[nervous system development] GO:0007507[heart development] GO:0008284[positive regulation of cell population proliferation] GO:0010628[positive regulation of gene expression] GO:0010976[positive regulation of neuron projection development] GO:0014068[positive regulation of phosphatidylinositol 3-kinase signaling] GO:0016020[membrane] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016740[transferase activity] GO:0018108[peptidyl-tyrosine phosphorylation] GO:0030154[cell differentiation] GO:0030335[positive regulation of cell migration] GO:0030424[axon] GO:0032148[activation of protein kinase B activity] GO:0033138[positive regulation of peptidyl-serine phosphorylation] GO:0033674[positive regulation of kinase activity] GO:0038179[neurotrophin signaling pathway] GO:0043121[neurotrophin binding] GO:0043235[receptor complex] GO:0043406[positive regulation of MAP kinase activity] GO:0048013[ephrin receptor signaling pathway] GO:0050927[positive regulation of positive chemotaxis] GO:0051716[cellular response to stimulus] GO:0051896[regulation of protein kinase B signaling] GO:0090630[activation of GTPase activity] GO:1990090[cellular response to nerve growth factor stimulus] GO:2000251[positive regulation of actin cytoskeleton reorganization]
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Cancers Head and neck cancers Cancers of eye, brain, and central nervous system Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) DeepTMHMM predicted membrane proteins
Show all
GO:0000166[nucleotide binding] GO:0001933[negative regulation of protein phosphorylation] GO:0001934[positive regulation of protein phosphorylation] GO:0002039[p53 binding] GO:0004672[protein kinase activity] GO:0004713[protein tyrosine kinase activity] GO:0004714[transmembrane receptor protein tyrosine kinase activity] GO:0005030[neurotrophin receptor activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005886[plasma membrane] GO:0005887[integral component of plasma membrane] GO:0006468[protein phosphorylation] GO:0007169[transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007399[nervous system development] GO:0007507[heart development] GO:0008284[positive regulation of cell population proliferation] GO:0010628[positive regulation of gene expression] GO:0010976[positive regulation of neuron projection development] GO:0014068[positive regulation of phosphatidylinositol 3-kinase signaling] GO:0016020[membrane] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016740[transferase activity] GO:0018108[peptidyl-tyrosine phosphorylation] GO:0030154[cell differentiation] GO:0030335[positive regulation of cell migration] GO:0030424[axon] GO:0032148[activation of protein kinase B activity] GO:0033138[positive regulation of peptidyl-serine phosphorylation] GO:0033674[positive regulation of kinase activity] GO:0038179[neurotrophin signaling pathway] GO:0043121[neurotrophin binding] GO:0043235[receptor complex] GO:0043406[positive regulation of MAP kinase activity] GO:0048013[ephrin receptor signaling pathway] GO:0050927[positive regulation of positive chemotaxis] GO:0051716[cellular response to stimulus] GO:0051896[regulation of protein kinase B signaling] GO:0090630[activation of GTPase activity] GO:1990090[cellular response to nerve growth factor stimulus] GO:2000251[positive regulation of actin cytoskeleton reorganization]
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Cancers Head and neck cancers Cancers of eye, brain, and central nervous system Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) DeepTMHMM predicted membrane proteins
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GO:0000166[nucleotide binding] GO:0001933[negative regulation of protein phosphorylation] GO:0001934[positive regulation of protein phosphorylation] GO:0002039[p53 binding] GO:0004672[protein kinase activity] GO:0004713[protein tyrosine kinase activity] GO:0004714[transmembrane receptor protein tyrosine kinase activity] GO:0005030[neurotrophin receptor activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005886[plasma membrane] GO:0005887[integral component of plasma membrane] GO:0006468[protein phosphorylation] GO:0007169[transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007399[nervous system development] GO:0007507[heart development] GO:0008284[positive regulation of cell population proliferation] GO:0010628[positive regulation of gene expression] GO:0010976[positive regulation of neuron projection development] GO:0014068[positive regulation of phosphatidylinositol 3-kinase signaling] GO:0016020[membrane] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016740[transferase activity] GO:0018108[peptidyl-tyrosine phosphorylation] GO:0030154[cell differentiation] GO:0030335[positive regulation of cell migration] GO:0030424[axon] GO:0032148[activation of protein kinase B activity] GO:0033138[positive regulation of peptidyl-serine phosphorylation] GO:0033674[positive regulation of kinase activity] GO:0038179[neurotrophin signaling pathway] GO:0043121[neurotrophin binding] GO:0043235[receptor complex] GO:0043406[positive regulation of MAP kinase activity] GO:0048013[ephrin receptor signaling pathway] GO:0050927[positive regulation of positive chemotaxis] GO:0051716[cellular response to stimulus] GO:0051896[regulation of protein kinase B signaling] GO:0090630[activation of GTPase activity] GO:1990090[cellular response to nerve growth factor stimulus] GO:2000251[positive regulation of actin cytoskeleton reorganization]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Human disease related genes Cancers Head and neck cancers Cancers of eye, brain, and central nervous system Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Human disease related genes Cancers Head and neck cancers Cancers of eye, brain, and central nervous system Protein evidence (Ezkurdia et al 2014)
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Cancers Head and neck cancers Cancers of eye, brain, and central nervous system Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) DeepTMHMM predicted membrane proteins
Show all
GO:0000166[nucleotide binding] GO:0001764[neuron migration] GO:0001933[negative regulation of protein phosphorylation] GO:0001934[positive regulation of protein phosphorylation] GO:0002039[p53 binding] GO:0004672[protein kinase activity] GO:0004713[protein tyrosine kinase activity] GO:0004714[transmembrane receptor protein tyrosine kinase activity] GO:0005004[GPI-linked ephrin receptor activity] GO:0005030[neurotrophin receptor activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005737[cytoplasm] GO:0005886[plasma membrane] GO:0005887[integral component of plasma membrane] GO:0006468[protein phosphorylation] GO:0007169[transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007399[nervous system development] GO:0007507[heart development] GO:0008284[positive regulation of cell population proliferation] GO:0010628[positive regulation of gene expression] GO:0010976[positive regulation of neuron projection development] GO:0014068[positive regulation of phosphatidylinositol 3-kinase signaling] GO:0016020[membrane] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016740[transferase activity] GO:0018108[peptidyl-tyrosine phosphorylation] GO:0030154[cell differentiation] GO:0030335[positive regulation of cell migration] GO:0030424[axon] GO:0032148[activation of protein kinase B activity] GO:0033138[positive regulation of peptidyl-serine phosphorylation] GO:0033674[positive regulation of kinase activity] GO:0038179[neurotrophin signaling pathway] GO:0043121[neurotrophin binding] GO:0043235[receptor complex] GO:0043406[positive regulation of MAP kinase activity] GO:0045211[postsynaptic membrane] GO:0045471[response to ethanol] GO:0048013[ephrin receptor signaling pathway] GO:0048665[neuron fate specification] GO:0048678[response to axon injury] GO:0048712[negative regulation of astrocyte differentiation] GO:0050927[positive regulation of positive chemotaxis] GO:0051412[response to corticosterone] GO:0051716[cellular response to stimulus] GO:0051896[regulation of protein kinase B signaling] GO:0060548[negative regulation of cell death] GO:0071300[cellular response to retinoic acid] GO:0090102[cochlea development] GO:0090630[activation of GTPase activity] GO:0097107[postsynaptic density assembly] GO:0098978[glutamatergic synapse] GO:1905606[regulation of presynapse assembly] GO:1990090[cellular response to nerve growth factor stimulus] GO:2000251[positive regulation of actin cytoskeleton reorganization]
The Human Protein Atlas project is funded
