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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
16
Cytoband
p11.2
Chromosome location (bp)
31471585 - 31477960
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. May also regulate SLC6A3 and SLC6A4 targeting to the plasma membrane hence regulating their activity. In the nucleus, functions as a nuclear receptor coactivator regulating glucocorticoid, androgen, mineralocorticoid and progesterone receptor transcriptional activity. May play a role in the processes of cell growth, proliferation, migration, differentiation and senescence. May have a zinc-dependent DNA-binding activity....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Activator
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Differentiation, Wnt signaling pathway
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Metal-binding, Zinc
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a coactivator of the androgen receptor, a transcription factor which is activated by androgen and has a key role in male sexual differentiation. The encoded protein is thought to regulate androgen receptor activity and may have a role to play in the treatment of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0003712[transcription coregulator activity] GO:0003713[transcription coactivator activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0005886[plasma membrane] GO:0005925[focal adhesion] GO:0006351[DNA-templated transcription] GO:0007155[cell adhesion] GO:0008285[negative regulation of cell population proliferation] GO:0010718[positive regulation of epithelial to mesenchymal transition] GO:0016055[Wnt signaling pathway] GO:0016363[nuclear matrix] GO:0030154[cell differentiation] GO:0030511[positive regulation of transforming growth factor beta receptor signaling pathway] GO:0030512[negative regulation of transforming growth factor beta receptor signaling pathway] GO:0030579[ubiquitin-dependent SMAD protein catabolic process] GO:0045893[positive regulation of DNA-templated transcription] GO:0046872[metal ion binding] GO:0048495[Roundabout binding] GO:0050681[nuclear androgen receptor binding] GO:0062023[collagen-containing extracellular matrix] GO:0070161[anchoring junction] GO:0070411[I-SMAD binding]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0003712[transcription coregulator activity] GO:0003713[transcription coactivator activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0005886[plasma membrane] GO:0005925[focal adhesion] GO:0006351[DNA-templated transcription] GO:0007155[cell adhesion] GO:0008285[negative regulation of cell population proliferation] GO:0010718[positive regulation of epithelial to mesenchymal transition] GO:0016055[Wnt signaling pathway] GO:0016363[nuclear matrix] GO:0030154[cell differentiation] GO:0030511[positive regulation of transforming growth factor beta receptor signaling pathway] GO:0030512[negative regulation of transforming growth factor beta receptor signaling pathway] GO:0030579[ubiquitin-dependent SMAD protein catabolic process] GO:0045893[positive regulation of DNA-templated transcription] GO:0046872[metal ion binding] GO:0048495[Roundabout binding] GO:0050681[nuclear androgen receptor binding] GO:0062023[collagen-containing extracellular matrix] GO:0070161[anchoring junction] GO:0070411[I-SMAD binding]
O43294 [Direct mapping] Transforming growth factor beta-1-induced transcript 1 protein
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0003712[transcription coregulator activity] GO:0003713[transcription coactivator activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0005886[plasma membrane] GO:0005925[focal adhesion] GO:0006351[DNA-templated transcription] GO:0007155[cell adhesion] GO:0008285[negative regulation of cell population proliferation] GO:0010718[positive regulation of epithelial to mesenchymal transition] GO:0016055[Wnt signaling pathway] GO:0016331[morphogenesis of embryonic epithelium] GO:0016363[nuclear matrix] GO:0030154[cell differentiation] GO:0030511[positive regulation of transforming growth factor beta receptor signaling pathway] GO:0030512[negative regulation of transforming growth factor beta receptor signaling pathway] GO:0030579[ubiquitin-dependent SMAD protein catabolic process] GO:0030855[epithelial cell differentiation] GO:0045165[cell fate commitment] GO:0045444[fat cell differentiation] GO:0045599[negative regulation of fat cell differentiation] GO:0045893[positive regulation of DNA-templated transcription] GO:0046872[metal ion binding] GO:0048495[Roundabout binding] GO:0050681[nuclear androgen receptor binding] GO:0062023[collagen-containing extracellular matrix] GO:0070161[anchoring junction] GO:0070411[I-SMAD binding]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0003712[transcription coregulator activity] GO:0003713[transcription coactivator activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0005886[plasma membrane] GO:0005925[focal adhesion] GO:0006351[DNA-templated transcription] GO:0007155[cell adhesion] GO:0008285[negative regulation of cell population proliferation] GO:0010718[positive regulation of epithelial to mesenchymal transition] GO:0016055[Wnt signaling pathway] GO:0016363[nuclear matrix] GO:0030154[cell differentiation] GO:0030511[positive regulation of transforming growth factor beta receptor signaling pathway] GO:0030512[negative regulation of transforming growth factor beta receptor signaling pathway] GO:0030579[ubiquitin-dependent SMAD protein catabolic process] GO:0045893[positive regulation of DNA-templated transcription] GO:0046872[metal ion binding] GO:0048495[Roundabout binding] GO:0050681[nuclear androgen receptor binding] GO:0062023[collagen-containing extracellular matrix] GO:0070161[anchoring junction] GO:0070411[I-SMAD binding]
The Human Protein Atlas project is funded
