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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
16
Cytoband
q13
Chromosome location (bp)
56989485 - 57083531
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Probable regulator of the NF-kappa-B and type I interferon signaling pathways. May also regulate the type II interferon signaling pathway. Plays a role in homeostatic control of innate immunity and in antiviral defense mechanisms....show less
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Immunity, Innate immunity
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
ATP-binding, Nucleotide-binding
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a member of the caspase recruitment domain-containing NLR family. This gene plays a role in cytokine response and antiviral immunity through its inhibition of NF-kappa-B activation and negative regulation of type I interferon signaling pathways. [provided by RefSeq, Oct 2011]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000166[nucleotide binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0002376[immune system process] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005813[centrosome] GO:0005829[cytosol] GO:0032088[negative regulation of NF-kappaB transcription factor activity] GO:0035556[intracellular signal transduction] GO:0043549[regulation of kinase activity] GO:0045087[innate immune response] GO:0045345[positive regulation of MHC class I biosynthetic process] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0051607[defense response to virus] GO:0060335[positive regulation of interferon-gamma-mediated signaling pathway] GO:0060339[negative regulation of type I interferon-mediated signaling pathway] GO:0060340[positive regulation of type I interferon-mediated signaling pathway]
SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166[nucleotide binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0002376[immune system process] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005813[centrosome] GO:0005829[cytosol] GO:0032088[negative regulation of NF-kappaB transcription factor activity] GO:0035556[intracellular signal transduction] GO:0043549[regulation of kinase activity] GO:0045087[innate immune response] GO:0045345[positive regulation of MHC class I biosynthetic process] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0051607[defense response to virus] GO:0060335[positive regulation of interferon-gamma-mediated signaling pathway] GO:0060339[negative regulation of type I interferon-mediated signaling pathway] GO:0060340[positive regulation of type I interferon-mediated signaling pathway]
THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000166[nucleotide binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0002376[immune system process] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005813[centrosome] GO:0005829[cytosol] GO:0009617[response to bacterium] GO:0032088[negative regulation of NF-kappaB transcription factor activity] GO:0035556[intracellular signal transduction] GO:0043549[regulation of kinase activity] GO:0045087[innate immune response] GO:0045345[positive regulation of MHC class I biosynthetic process] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0051607[defense response to virus] GO:0060335[positive regulation of interferon-gamma-mediated signaling pathway] GO:0060339[negative regulation of type I interferon-mediated signaling pathway] GO:0060340[positive regulation of type I interferon-mediated signaling pathway]
The Human Protein Atlas project is funded
