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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
17
Cytoband
q21.32
Chromosome location (bp)
48133442 - 48430275
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Positively regulates T-cell receptor signaling by enhancing the MAP kinase pathway. Required for optimal conjugation between T-cells and antigen-presenting cells by promoting the clustering of integrin ITGAL on the surface of T-cells. May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells....show less
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Adaptive immunity, Immunity
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a T cell adaptor protein, a class of intracellular molecules with modular domains capable of recruiting additional proteins but that exhibit no intrinsic enzymatic activity. The encoded protein contains a unique N-terminal region followed by a PH domain and C-terminal SH3 domain. Along with the adhesion and degranulation-promoting adaptor protein, the encoded protein plays a critical role in inside-out signaling by coupling T-cell antigen receptor stimulation to the activation of integrins. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001772[immunological synapse] GO:0001954[positive regulation of cell-matrix adhesion] GO:0002250[adaptive immune response] GO:0002376[immune system process] GO:0002821[positive regulation of adaptive immune response] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0005911[cell-cell junction] GO:0016020[membrane] GO:0017124[SH3 domain binding] GO:0019901[protein kinase binding] GO:0019903[protein phosphatase binding] GO:0033625[positive regulation of integrin activation] GO:0033634[positive regulation of cell-cell adhesion mediated by integrin] GO:0034116[positive regulation of heterotypic cell-cell adhesion] GO:0042101[T cell receptor complex] GO:0042169[SH2 domain binding] GO:0044853[plasma membrane raft] GO:0045785[positive regulation of cell adhesion] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0050852[T cell receptor signaling pathway] GO:0072659[protein localization to plasma membrane] GO:1903039[positive regulation of leukocyte cell-cell adhesion]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001772[immunological synapse] GO:0001954[positive regulation of cell-matrix adhesion] GO:0002250[adaptive immune response] GO:0002376[immune system process] GO:0002821[positive regulation of adaptive immune response] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0016020[membrane] GO:0017124[SH3 domain binding] GO:0019901[protein kinase binding] GO:0019903[protein phosphatase binding] GO:0033625[positive regulation of integrin activation] GO:0033634[positive regulation of cell-cell adhesion mediated by integrin] GO:0034116[positive regulation of heterotypic cell-cell adhesion] GO:0042169[SH2 domain binding] GO:0044853[plasma membrane raft] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0050852[T cell receptor signaling pathway] GO:1903039[positive regulation of leukocyte cell-cell adhesion]
The Human Protein Atlas project is funded
