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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Disease related genes Human disease related genes Plasma proteins Potential drug targets Transcription factors Transporters
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
17
Cytoband
p13.1
Chromosome location (bp)
7661779 - 7687538
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process 16,17,18,19,20,21,22,23,24,25,26,27,28,29. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression 30,31. Its pro-apoptotic activity is activated via its interaction with PPP1R13B/ASPP1 or TP53BP2/ASPP2 32. However, this activity is inhibited when the interaction with PPP1R13B/ASPP1 or TP53BP2/ASPP2 is displaced by PPP1R13L/iASPP 33. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seems to have an effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis. Regulates the circadian clock by repressing CLOCK-BMAL1-mediated transcriptional activation of PER2 34....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Activator, DNA-binding, Repressor
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Metal-binding, Zinc
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). [provided by RefSeq, Dec 2016]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Transporters Transporter channels and pores Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Immunoglobulin fold Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations COSMIC Translocations Disease related genes Potential drug targets Human disease related genes Cancers Head and neck cancers Cancers of the digestive system Cancers of the lung and pleura Skin cancers Cancers of soft tissues and bone Cancers of the breast and female genital organs Cancers of male genital organs Cancers of the urinary system Cancers of eye, brain, and central nervous system Cancers of endocrine organs Cancers of haematopoietic and lymphoid tissues Cardiovascular diseases Hematologic diseases Musculoskeletal diseases Skeletal diseases Nervous system diseases Other nervous and sensory system diseases Other diseases Others Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000423[mitophagy] GO:0000785[chromatin] GO:0000976[transcription cis-regulatory region binding] GO:0000977[RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0000987[cis-regulatory region sequence-specific DNA binding] GO:0001046[core promoter sequence-specific DNA binding] GO:0001094[TFIID-class transcription factor complex binding] GO:0001227[DNA-binding transcription repressor activity, RNA polymerase II-specific] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0001701[in utero embryonic development] GO:0001756[somitogenesis] GO:0001836[release of cytochrome c from mitochondria] GO:0002020[protease binding] GO:0002039[p53 binding] GO:0002244[hematopoietic progenitor cell differentiation] GO:0002309[T cell proliferation involved in immune response] GO:0002326[B cell lineage commitment] GO:0002360[T cell lineage commitment] GO:0002931[response to ischemia] GO:0003677[DNA binding] GO:0003682[chromatin binding] GO:0003700[DNA-binding transcription factor activity] GO:0003730[mRNA 3'-UTR binding] GO:0005507[copper ion binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005657[replication fork] GO:0005667[transcription regulator complex] GO:0005730[nucleolus] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005759[mitochondrial matrix] GO:0005783[endoplasmic reticulum] GO:0005813[centrosome] GO:0005815[microtubule organizing center] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0006289[nucleotide-excision repair] GO:0006302[double-strand break repair] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006606[protein import into nucleus] GO:0006914[autophagy] GO:0006915[apoptotic process] GO:0006974[cellular response to DNA damage stimulus] GO:0006977[DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0006978[DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator] GO:0006979[response to oxidative stress] GO:0006983[ER overload response] GO:0007049[cell cycle] GO:0007179[transforming growth factor beta receptor signaling pathway] GO:0007265[Ras protein signal transduction] GO:0007346[regulation of mitotic cell cycle] GO:0007369[gastrulation] GO:0007405[neuroblast proliferation] GO:0007406[negative regulation of neuroblast proliferation] GO:0007417[central nervous system development] GO:0007507[heart development] GO:0007623[circadian rhythm] GO:0008104[protein localization] GO:0008156[negative regulation of DNA replication] GO:0008270[zinc ion binding] GO:0008283[cell population proliferation] GO:0008285[negative regulation of cell population proliferation] GO:0008340[determination of adult lifespan] GO:0009299[mRNA transcription] GO:0009303[rRNA transcription] GO:0009410[response to xenobiotic stimulus] GO:0009411[response to UV] GO:0009651[response to salt stress] GO:0009792[embryo development ending in birth or egg hatching] GO:0010035[response to inorganic substance] GO:0010165[response to X-ray] GO:0010332[response to gamma radiation] GO:0010628[positive regulation of gene expression] GO:0010629[negative regulation of gene expression] GO:0010659[cardiac muscle cell apoptotic process] GO:0010666[positive regulation of cardiac muscle cell apoptotic process] GO:0012501[programmed cell death] GO:0014009[glial cell proliferation] GO:0016032[viral process] GO:0016363[nuclear matrix] GO:0016604[nuclear body] GO:0016605[PML body] GO:0017053[transcription repressor complex] GO:0019661[glucose catabolic process to lactate via pyruvate] GO:0019899[enzyme binding] GO:0019901[protein kinase binding] GO:0019903[protein phosphatase binding] GO:0021549[cerebellum development] GO:0030308[negative regulation of cell growth] GO:0030330[DNA damage response, signal transduction by p53 class mediator] GO:0030512[negative regulation of transforming growth factor beta receptor signaling pathway] GO:0030971[receptor tyrosine kinase binding] GO:0031065[positive regulation of histone deacetylation] GO:0031571[mitotic G1 DNA damage checkpoint signaling] GO:0031625[ubiquitin protein ligase binding] GO:0032991[protein-containing complex] GO:0033077[T cell differentiation in thymus] GO:0033209[tumor necrosis factor-mediated signaling pathway] GO:0034103[regulation of tissue remodeling] GO:0034644[cellular response to UV] GO:0035033[histone deacetylase regulator activity] GO:0035035[histone acetyltransferase binding] GO:0035264[multicellular organism growth] GO:0035794[positive regulation of mitochondrial membrane permeability] GO:0035861[site of double-strand break] GO:0036003[positive regulation of transcription from RNA polymerase II promoter in response to stress] GO:0036310[ATP-dependent DNA/DNA annealing activity] GO:0042127[regulation of cell population proliferation] GO:0042149[cellular response to glucose starvation] GO:0042771[intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] GO:0042802[identical protein binding] GO:0042826[histone deacetylase binding] GO:0042981[regulation of apoptotic process] GO:0043065[positive regulation of apoptotic process] GO:0043066[negative regulation of apoptotic process] GO:0043073[germ cell nucleus] GO:0043153[entrainment of circadian clock by photoperiod] GO:0043504[mitochondrial DNA repair] GO:0043516[regulation of DNA damage response, signal transduction by p53 class mediator] GO:0043523[regulation of neuron apoptotic process] GO:0043525[positive regulation of neuron apoptotic process] GO:0043621[protein self-association] GO:0045815[transcriptional initiation-coupled chromatin remodeling] GO:0045861[negative regulation of proteolysis] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0045899[positive regulation of RNA polymerase II transcription preinitiation complex assembly] GO:0045930[negative regulation of mitotic cell cycle] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046677[response to antibiotic] GO:0046872[metal ion binding] GO:0046982[protein heterodimerization activity] GO:0047485[protein N-terminus binding] GO:0048144[fibroblast proliferation] GO:0048147[negative regulation of fibroblast proliferation] GO:0048511[rhythmic process] GO:0048512[circadian behavior] GO:0048539[bone marrow development] GO:0048568[embryonic organ development] GO:0050731[positive regulation of peptidyl-tyrosine phosphorylation] GO:0050821[protein stabilization] GO:0051087[chaperone binding] GO:0051097[negative regulation of helicase activity] GO:0051262[protein tetramerization] GO:0051276[chromosome organization] GO:0051402[neuron apoptotic process] GO:0051721[protein phosphatase 2A binding] GO:0051726[regulation of cell cycle] GO:0051974[negative regulation of telomerase activity] GO:0060218[hematopoietic stem cell differentiation] GO:0060253[negative regulation of glial cell proliferation] GO:0060333[type II interferon-mediated signaling pathway] GO:0060411[cardiac septum morphogenesis] GO:0061419[positive regulation of transcription from RNA polymerase II promoter in response to hypoxia] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0062100[positive regulation of programmed necrotic cell death] GO:0065003[protein-containing complex assembly] GO:0070059[intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress] GO:0070242[thymocyte apoptotic process] GO:0070243[regulation of thymocyte apoptotic process] GO:0070245[positive regulation of thymocyte apoptotic process] GO:0070266[necroptotic process] GO:0071456[cellular response to hypoxia] GO:0071466[cellular response to xenobiotic stimulus] GO:0071479[cellular response to ionizing radiation] GO:0071480[cellular response to gamma radiation] GO:0071494[cellular response to UV-C] GO:0071889[14-3-3 protein binding] GO:0072089[stem cell proliferation] GO:0072331[signal transduction by p53 class mediator] GO:0072332[intrinsic apoptotic signaling pathway by p53 class mediator] GO:0072593[reactive oxygen species metabolic process] GO:0072717[cellular response to actinomycin D] GO:0090200[positive regulation of release of cytochrome c from mitochondria] GO:0090398[cellular senescence] GO:0090399[replicative senescence] GO:0090403[oxidative stress-induced premature senescence] GO:0097193[intrinsic apoptotic signaling pathway] GO:0097252[oligodendrocyte apoptotic process] GO:0097371[MDM2/MDM4 family protein binding] GO:0097718[disordered domain specific binding] GO:0140296[general transcription initiation factor binding] GO:0140677[molecular function activator activity] GO:1900119[positive regulation of execution phase of apoptosis] GO:1901525[negative regulation of mitophagy] GO:1902108[regulation of mitochondrial membrane permeability involved in apoptotic process] GO:1902253[regulation of intrinsic apoptotic signaling pathway by p53 class mediator] GO:1902749[regulation of cell cycle G2/M phase transition] GO:1902895[positive regulation of miRNA transcription] GO:1903451[negative regulation of G1 to G0 transition] GO:1903799[negative regulation of miRNA maturation] GO:1904024[negative regulation of glucose catabolic process to lactate via pyruvate] GO:1905856[negative regulation of pentose-phosphate shunt] GO:1990144[intrinsic apoptotic signaling pathway in response to hypoxia] GO:1990248[regulation of transcription from RNA polymerase II promoter in response to DNA damage] GO:1990440[positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress] GO:1990841[promoter-specific chromatin binding] GO:2000269[regulation of fibroblast apoptotic process] GO:2000378[negative regulation of reactive oxygen species metabolic process] GO:2000379[positive regulation of reactive oxygen species metabolic process] GO:2000647[negative regulation of stem cell proliferation] GO:2000772[regulation of cellular senescence] GO:2000774[positive regulation of cellular senescence] GO:2001244[positive regulation of intrinsic apoptotic signaling pathway]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations COSMIC Translocations Human disease related genes Cancers Head and neck cancers Cancers of the digestive system Cancers of the lung and pleura Skin cancers Cancers of soft tissues and bone Cancers of the breast and female genital organs Cancers of male genital organs Cancers of the urinary system Cancers of eye, brain, and central nervous system Cancers of endocrine organs Cancers of haematopoietic and lymphoid tissues Cardiovascular diseases Hematologic diseases Musculoskeletal diseases Skeletal diseases Nervous system diseases Other nervous and sensory system diseases Other diseases Others Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations COSMIC Translocations Human disease related genes Cancers Head and neck cancers Cancers of the digestive system Cancers of the lung and pleura Skin cancers Cancers of soft tissues and bone Cancers of the breast and female genital organs Cancers of male genital organs Cancers of the urinary system Cancers of eye, brain, and central nervous system Cancers of endocrine organs Cancers of haematopoietic and lymphoid tissues Cardiovascular diseases Hematologic diseases Musculoskeletal diseases Skeletal diseases Nervous system diseases Other nervous and sensory system diseases Other diseases Others Protein evidence (Ezkurdia et al 2014)
Transporters Transporter channels and pores Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Immunoglobulin fold Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations COSMIC Translocations Disease related genes Potential drug targets Human disease related genes Cancers Head and neck cancers Cancers of the digestive system Cancers of the lung and pleura Skin cancers Cancers of soft tissues and bone Cancers of the breast and female genital organs Cancers of male genital organs Cancers of the urinary system Cancers of eye, brain, and central nervous system Cancers of endocrine organs Cancers of haematopoietic and lymphoid tissues Cardiovascular diseases Hematologic diseases Musculoskeletal diseases Skeletal diseases Nervous system diseases Other nervous and sensory system diseases Other diseases Others Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000976[transcription cis-regulatory region binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0000987[cis-regulatory region sequence-specific DNA binding] GO:0001046[core promoter sequence-specific DNA binding] GO:0001094[TFIID-class transcription factor complex binding] GO:0001227[DNA-binding transcription repressor activity, RNA polymerase II-specific] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0002020[protease binding] GO:0002039[p53 binding] GO:0002244[hematopoietic progenitor cell differentiation] GO:0003677[DNA binding] GO:0003682[chromatin binding] GO:0003700[DNA-binding transcription factor activity] GO:0003730[mRNA 3'-UTR binding] GO:0005507[copper ion binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005667[transcription regulator complex] GO:0005730[nucleolus] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005759[mitochondrial matrix] GO:0005783[endoplasmic reticulum] GO:0005813[centrosome] GO:0005815[microtubule organizing center] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0006289[nucleotide-excision repair] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006914[autophagy] GO:0006915[apoptotic process] GO:0006974[cellular response to DNA damage stimulus] GO:0006977[DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0006978[DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator] GO:0006983[ER overload response] GO:0007049[cell cycle] GO:0007265[Ras protein signal transduction] GO:0008104[protein localization] GO:0008270[zinc ion binding] GO:0008285[negative regulation of cell population proliferation] GO:0008340[determination of adult lifespan] GO:0009299[mRNA transcription] GO:0010332[response to gamma radiation] GO:0010628[positive regulation of gene expression] GO:0012501[programmed cell death] GO:0016032[viral process] GO:0016363[nuclear matrix] GO:0016604[nuclear body] GO:0016605[PML body] GO:0017053[transcription repressor complex] GO:0019899[enzyme binding] GO:0019901[protein kinase binding] GO:0019903[protein phosphatase binding] GO:0030308[negative regulation of cell growth] GO:0030330[DNA damage response, signal transduction by p53 class mediator] GO:0030971[receptor tyrosine kinase binding] GO:0031571[mitotic G1 DNA damage checkpoint signaling] GO:0031625[ubiquitin protein ligase binding] GO:0032991[protein-containing complex] GO:0033209[tumor necrosis factor-mediated signaling pathway] GO:0034644[cellular response to UV] GO:0035035[histone acetyltransferase binding] GO:0036003[positive regulation of transcription from RNA polymerase II promoter in response to stress] GO:0036310[ATP-dependent DNA/DNA annealing activity] GO:0042149[cellular response to glucose starvation] GO:0042771[intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] GO:0042802[identical protein binding] GO:0042826[histone deacetylase binding] GO:0042981[regulation of apoptotic process] GO:0043065[positive regulation of apoptotic process] GO:0043066[negative regulation of apoptotic process] GO:0043153[entrainment of circadian clock by photoperiod] GO:0043621[protein self-association] GO:0045815[transcriptional initiation-coupled chromatin remodeling] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0045899[positive regulation of RNA polymerase II transcription preinitiation complex assembly] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046677[response to antibiotic] GO:0046872[metal ion binding] GO:0046982[protein heterodimerization activity] GO:0047485[protein N-terminus binding] GO:0048147[negative regulation of fibroblast proliferation] GO:0048511[rhythmic process] GO:0048512[circadian behavior] GO:0048539[bone marrow development] GO:0050731[positive regulation of peptidyl-tyrosine phosphorylation] GO:0051087[chaperone binding] GO:0051097[negative regulation of helicase activity] GO:0051262[protein tetramerization] GO:0051721[protein phosphatase 2A binding] GO:0051726[regulation of cell cycle] GO:0051974[negative regulation of telomerase activity] GO:0060218[hematopoietic stem cell differentiation] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0065003[protein-containing complex assembly] GO:0070245[positive regulation of thymocyte apoptotic process] GO:0071456[cellular response to hypoxia] GO:0071466[cellular response to xenobiotic stimulus] GO:0071479[cellular response to ionizing radiation] GO:0071480[cellular response to gamma radiation] GO:0071889[14-3-3 protein binding] GO:0072331[signal transduction by p53 class mediator] GO:0072332[intrinsic apoptotic signaling pathway by p53 class mediator] GO:0072717[cellular response to actinomycin D] GO:0090200[positive regulation of release of cytochrome c from mitochondria] GO:0090398[cellular senescence] GO:0090399[replicative senescence] GO:0090403[oxidative stress-induced premature senescence] GO:0097193[intrinsic apoptotic signaling pathway] GO:0097252[oligodendrocyte apoptotic process] GO:0097718[disordered domain specific binding] GO:0140296[general transcription initiation factor binding] GO:0140677[molecular function activator activity] GO:1900119[positive regulation of execution phase of apoptosis] GO:1902749[regulation of cell cycle G2/M phase transition] GO:1902895[positive regulation of miRNA transcription] GO:1903451[negative regulation of G1 to G0 transition] GO:1905856[negative regulation of pentose-phosphate shunt] GO:1990248[regulation of transcription from RNA polymerase II promoter in response to DNA damage] GO:1990440[positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress] GO:1990841[promoter-specific chromatin binding] GO:2000379[positive regulation of reactive oxygen species metabolic process] GO:2000774[positive regulation of cellular senescence] GO:2001244[positive regulation of intrinsic apoptotic signaling pathway]
Transporters Transporter channels and pores Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Immunoglobulin fold Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations COSMIC Translocations Disease related genes Potential drug targets Human disease related genes Cancers Head and neck cancers Cancers of the digestive system Cancers of the lung and pleura Skin cancers Cancers of soft tissues and bone Cancers of the breast and female genital organs Cancers of male genital organs Cancers of the urinary system Cancers of eye, brain, and central nervous system Cancers of endocrine organs Cancers of haematopoietic and lymphoid tissues Cardiovascular diseases Hematologic diseases Musculoskeletal diseases Skeletal diseases Nervous system diseases Other nervous and sensory system diseases Other diseases Others Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000976[transcription cis-regulatory region binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0000987[cis-regulatory region sequence-specific DNA binding] GO:0001046[core promoter sequence-specific DNA binding] GO:0001094[TFIID-class transcription factor complex binding] GO:0001227[DNA-binding transcription repressor activity, RNA polymerase II-specific] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0002020[protease binding] GO:0002039[p53 binding] GO:0002244[hematopoietic progenitor cell differentiation] GO:0003677[DNA binding] GO:0003682[chromatin binding] GO:0003700[DNA-binding transcription factor activity] GO:0003730[mRNA 3'-UTR binding] GO:0005507[copper ion binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005667[transcription regulator complex] GO:0005730[nucleolus] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005759[mitochondrial matrix] GO:0005783[endoplasmic reticulum] GO:0005813[centrosome] GO:0005815[microtubule organizing center] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0006289[nucleotide-excision repair] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006914[autophagy] GO:0006915[apoptotic process] GO:0006974[cellular response to DNA damage stimulus] GO:0006977[DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0006978[DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator] GO:0006983[ER overload response] GO:0007049[cell cycle] GO:0007265[Ras protein signal transduction] GO:0008104[protein localization] GO:0008270[zinc ion binding] GO:0008285[negative regulation of cell population proliferation] GO:0008340[determination of adult lifespan] GO:0009299[mRNA transcription] GO:0010332[response to gamma radiation] GO:0010628[positive regulation of gene expression] GO:0012501[programmed cell death] GO:0016032[viral process] GO:0016363[nuclear matrix] GO:0016604[nuclear body] GO:0016605[PML body] GO:0017053[transcription repressor complex] GO:0019899[enzyme binding] GO:0019901[protein kinase binding] GO:0019903[protein phosphatase binding] GO:0030308[negative regulation of cell growth] GO:0030330[DNA damage response, signal transduction by p53 class mediator] GO:0030971[receptor tyrosine kinase binding] GO:0031571[mitotic G1 DNA damage checkpoint signaling] GO:0031625[ubiquitin protein ligase binding] GO:0032991[protein-containing complex] GO:0033209[tumor necrosis factor-mediated signaling pathway] GO:0034644[cellular response to UV] GO:0035035[histone acetyltransferase binding] GO:0036003[positive regulation of transcription from RNA polymerase II promoter in response to stress] GO:0036310[ATP-dependent DNA/DNA annealing activity] GO:0042149[cellular response to glucose starvation] GO:0042771[intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] GO:0042802[identical protein binding] GO:0042826[histone deacetylase binding] GO:0042981[regulation of apoptotic process] GO:0043065[positive regulation of apoptotic process] GO:0043066[negative regulation of apoptotic process] GO:0043153[entrainment of circadian clock by photoperiod] GO:0043621[protein self-association] GO:0045815[transcriptional initiation-coupled chromatin remodeling] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0045899[positive regulation of RNA polymerase II transcription preinitiation complex assembly] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046677[response to antibiotic] GO:0046872[metal ion binding] GO:0046982[protein heterodimerization activity] GO:0047485[protein N-terminus binding] GO:0048147[negative regulation of fibroblast proliferation] GO:0048511[rhythmic process] GO:0048512[circadian behavior] GO:0048539[bone marrow development] GO:0050731[positive regulation of peptidyl-tyrosine phosphorylation] GO:0051087[chaperone binding] GO:0051097[negative regulation of helicase activity] GO:0051262[protein tetramerization] GO:0051721[protein phosphatase 2A binding] GO:0051726[regulation of cell cycle] GO:0051974[negative regulation of telomerase activity] GO:0060218[hematopoietic stem cell differentiation] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0065003[protein-containing complex assembly] GO:0070245[positive regulation of thymocyte apoptotic process] GO:0071456[cellular response to hypoxia] GO:0071466[cellular response to xenobiotic stimulus] GO:0071479[cellular response to ionizing radiation] GO:0071480[cellular response to gamma radiation] GO:0071889[14-3-3 protein binding] GO:0072331[signal transduction by p53 class mediator] GO:0072332[intrinsic apoptotic signaling pathway by p53 class mediator] GO:0072717[cellular response to actinomycin D] GO:0090200[positive regulation of release of cytochrome c from mitochondria] GO:0090398[cellular senescence] GO:0090399[replicative senescence] GO:0090403[oxidative stress-induced premature senescence] GO:0097193[intrinsic apoptotic signaling pathway] GO:0097252[oligodendrocyte apoptotic process] GO:0097718[disordered domain specific binding] GO:0140296[general transcription initiation factor binding] GO:0140677[molecular function activator activity] GO:1900119[positive regulation of execution phase of apoptosis] GO:1902749[regulation of cell cycle G2/M phase transition] GO:1902895[positive regulation of miRNA transcription] GO:1903451[negative regulation of G1 to G0 transition] GO:1905856[negative regulation of pentose-phosphate shunt] GO:1990248[regulation of transcription from RNA polymerase II promoter in response to DNA damage] GO:1990440[positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress] GO:1990841[promoter-specific chromatin binding] GO:2000379[positive regulation of reactive oxygen species metabolic process] GO:2000774[positive regulation of cellular senescence] GO:2001244[positive regulation of intrinsic apoptotic signaling pathway]
Transporters Transporter channels and pores Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Immunoglobulin fold Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations COSMIC Translocations Disease related genes Potential drug targets Human disease related genes Cancers Head and neck cancers Cancers of the digestive system Cancers of the lung and pleura Skin cancers Cancers of soft tissues and bone Cancers of the breast and female genital organs Cancers of male genital organs Cancers of the urinary system Cancers of eye, brain, and central nervous system Cancers of endocrine organs Cancers of haematopoietic and lymphoid tissues Cardiovascular diseases Hematologic diseases Musculoskeletal diseases Skeletal diseases Nervous system diseases Other nervous and sensory system diseases Other diseases Others Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000976[transcription cis-regulatory region binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0000987[cis-regulatory region sequence-specific DNA binding] GO:0001046[core promoter sequence-specific DNA binding] GO:0001094[TFIID-class transcription factor complex binding] GO:0001227[DNA-binding transcription repressor activity, RNA polymerase II-specific] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0002020[protease binding] GO:0002039[p53 binding] GO:0002244[hematopoietic progenitor cell differentiation] GO:0003677[DNA binding] GO:0003682[chromatin binding] GO:0003700[DNA-binding transcription factor activity] GO:0003730[mRNA 3'-UTR binding] GO:0005507[copper ion binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005667[transcription regulator complex] GO:0005730[nucleolus] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005759[mitochondrial matrix] GO:0005783[endoplasmic reticulum] GO:0005813[centrosome] GO:0005815[microtubule organizing center] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0006289[nucleotide-excision repair] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006914[autophagy] GO:0006915[apoptotic process] GO:0006974[cellular response to DNA damage stimulus] GO:0006977[DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0006978[DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator] GO:0006983[ER overload response] GO:0007049[cell cycle] GO:0007265[Ras protein signal transduction] GO:0008104[protein localization] GO:0008270[zinc ion binding] GO:0008285[negative regulation of cell population proliferation] GO:0008340[determination of adult lifespan] GO:0009299[mRNA transcription] GO:0010332[response to gamma radiation] GO:0010628[positive regulation of gene expression] GO:0012501[programmed cell death] GO:0016032[viral process] GO:0016363[nuclear matrix] GO:0016604[nuclear body] GO:0016605[PML body] GO:0017053[transcription repressor complex] GO:0019899[enzyme binding] GO:0019901[protein kinase binding] GO:0019903[protein phosphatase binding] GO:0030308[negative regulation of cell growth] GO:0030330[DNA damage response, signal transduction by p53 class mediator] GO:0030971[receptor tyrosine kinase binding] GO:0031571[mitotic G1 DNA damage checkpoint signaling] GO:0031625[ubiquitin protein ligase binding] GO:0032991[protein-containing complex] GO:0033209[tumor necrosis factor-mediated signaling pathway] GO:0034644[cellular response to UV] GO:0035035[histone acetyltransferase binding] GO:0036003[positive regulation of transcription from RNA polymerase II promoter in response to stress] GO:0036310[ATP-dependent DNA/DNA annealing activity] GO:0042149[cellular response to glucose starvation] GO:0042771[intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] GO:0042802[identical protein binding] GO:0042826[histone deacetylase binding] GO:0042981[regulation of apoptotic process] GO:0043065[positive regulation of apoptotic process] GO:0043066[negative regulation of apoptotic process] GO:0043153[entrainment of circadian clock by photoperiod] GO:0043621[protein self-association] GO:0045815[transcriptional initiation-coupled chromatin remodeling] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0045899[positive regulation of RNA polymerase II transcription preinitiation complex assembly] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046677[response to antibiotic] GO:0046872[metal ion binding] GO:0046982[protein heterodimerization activity] GO:0047485[protein N-terminus binding] GO:0048147[negative regulation of fibroblast proliferation] GO:0048511[rhythmic process] GO:0048512[circadian behavior] GO:0048539[bone marrow development] GO:0050731[positive regulation of peptidyl-tyrosine phosphorylation] GO:0051087[chaperone binding] GO:0051097[negative regulation of helicase activity] GO:0051262[protein tetramerization] GO:0051721[protein phosphatase 2A binding] GO:0051726[regulation of cell cycle] GO:0051974[negative regulation of telomerase activity] GO:0060218[hematopoietic stem cell differentiation] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0065003[protein-containing complex assembly] GO:0070245[positive regulation of thymocyte apoptotic process] GO:0071456[cellular response to hypoxia] GO:0071466[cellular response to xenobiotic stimulus] GO:0071479[cellular response to ionizing radiation] GO:0071480[cellular response to gamma radiation] GO:0071889[14-3-3 protein binding] GO:0072331[signal transduction by p53 class mediator] GO:0072332[intrinsic apoptotic signaling pathway by p53 class mediator] GO:0072717[cellular response to actinomycin D] GO:0090200[positive regulation of release of cytochrome c from mitochondria] GO:0090398[cellular senescence] GO:0090399[replicative senescence] GO:0090403[oxidative stress-induced premature senescence] GO:0097193[intrinsic apoptotic signaling pathway] GO:0097252[oligodendrocyte apoptotic process] GO:0097718[disordered domain specific binding] GO:0140296[general transcription initiation factor binding] GO:0140677[molecular function activator activity] GO:1900119[positive regulation of execution phase of apoptosis] GO:1902749[regulation of cell cycle G2/M phase transition] GO:1902895[positive regulation of miRNA transcription] GO:1903451[negative regulation of G1 to G0 transition] GO:1905856[negative regulation of pentose-phosphate shunt] GO:1990248[regulation of transcription from RNA polymerase II promoter in response to DNA damage] GO:1990440[positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress] GO:1990841[promoter-specific chromatin binding] GO:2000379[positive regulation of reactive oxygen species metabolic process] GO:2000774[positive regulation of cellular senescence] GO:2001244[positive regulation of intrinsic apoptotic signaling pathway]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations COSMIC Translocations Human disease related genes Cancers Head and neck cancers Cancers of the digestive system Cancers of the lung and pleura Skin cancers Cancers of soft tissues and bone Cancers of the breast and female genital organs Cancers of male genital organs Cancers of the urinary system Cancers of eye, brain, and central nervous system Cancers of endocrine organs Cancers of haematopoietic and lymphoid tissues Cardiovascular diseases Hematologic diseases Musculoskeletal diseases Skeletal diseases Nervous system diseases Other nervous and sensory system diseases Other diseases Others Protein evidence (Ezkurdia et al 2014)
Transporters Transporter channels and pores Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Immunoglobulin fold Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations COSMIC Translocations Disease related genes Potential drug targets Human disease related genes Cancers Head and neck cancers Cancers of the digestive system Cancers of the lung and pleura Skin cancers Cancers of soft tissues and bone Cancers of the breast and female genital organs Cancers of male genital organs Cancers of the urinary system Cancers of eye, brain, and central nervous system Cancers of endocrine organs Cancers of haematopoietic and lymphoid tissues Cardiovascular diseases Hematologic diseases Musculoskeletal diseases Skeletal diseases Nervous system diseases Other nervous and sensory system diseases Other diseases Others Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000976[transcription cis-regulatory region binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0000987[cis-regulatory region sequence-specific DNA binding] GO:0001046[core promoter sequence-specific DNA binding] GO:0001094[TFIID-class transcription factor complex binding] GO:0001227[DNA-binding transcription repressor activity, RNA polymerase II-specific] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0002020[protease binding] GO:0002039[p53 binding] GO:0002244[hematopoietic progenitor cell differentiation] GO:0003677[DNA binding] GO:0003682[chromatin binding] GO:0003700[DNA-binding transcription factor activity] GO:0003730[mRNA 3'-UTR binding] GO:0005507[copper ion binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005667[transcription regulator complex] GO:0005730[nucleolus] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005759[mitochondrial matrix] GO:0005783[endoplasmic reticulum] GO:0005813[centrosome] GO:0005815[microtubule organizing center] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0006289[nucleotide-excision repair] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006914[autophagy] GO:0006915[apoptotic process] GO:0006974[cellular response to DNA damage stimulus] GO:0006977[DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0006978[DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator] GO:0006983[ER overload response] GO:0007049[cell cycle] GO:0007265[Ras protein signal transduction] GO:0008104[protein localization] GO:0008270[zinc ion binding] GO:0008285[negative regulation of cell population proliferation] GO:0008340[determination of adult lifespan] GO:0009299[mRNA transcription] GO:0010332[response to gamma radiation] GO:0010628[positive regulation of gene expression] GO:0012501[programmed cell death] GO:0016032[viral process] GO:0016363[nuclear matrix] GO:0016604[nuclear body] GO:0016605[PML body] GO:0017053[transcription repressor complex] GO:0019899[enzyme binding] GO:0019901[protein kinase binding] GO:0019903[protein phosphatase binding] GO:0030308[negative regulation of cell growth] GO:0030330[DNA damage response, signal transduction by p53 class mediator] GO:0030971[receptor tyrosine kinase binding] GO:0031571[mitotic G1 DNA damage checkpoint signaling] GO:0031625[ubiquitin protein ligase binding] GO:0032991[protein-containing complex] GO:0033209[tumor necrosis factor-mediated signaling pathway] GO:0034644[cellular response to UV] GO:0035035[histone acetyltransferase binding] GO:0036003[positive regulation of transcription from RNA polymerase II promoter in response to stress] GO:0036310[ATP-dependent DNA/DNA annealing activity] GO:0042149[cellular response to glucose starvation] GO:0042771[intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] GO:0042802[identical protein binding] GO:0042826[histone deacetylase binding] GO:0042981[regulation of apoptotic process] GO:0043065[positive regulation of apoptotic process] GO:0043066[negative regulation of apoptotic process] GO:0043153[entrainment of circadian clock by photoperiod] GO:0043621[protein self-association] GO:0045815[transcriptional initiation-coupled chromatin remodeling] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0045899[positive regulation of RNA polymerase II transcription preinitiation complex assembly] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046677[response to antibiotic] GO:0046872[metal ion binding] GO:0046982[protein heterodimerization activity] GO:0047485[protein N-terminus binding] GO:0048147[negative regulation of fibroblast proliferation] GO:0048511[rhythmic process] GO:0048512[circadian behavior] GO:0048539[bone marrow development] GO:0050731[positive regulation of peptidyl-tyrosine phosphorylation] GO:0051087[chaperone binding] GO:0051097[negative regulation of helicase activity] GO:0051262[protein tetramerization] GO:0051721[protein phosphatase 2A binding] GO:0051726[regulation of cell cycle] GO:0051974[negative regulation of telomerase activity] GO:0060218[hematopoietic stem cell differentiation] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0065003[protein-containing complex assembly] GO:0070245[positive regulation of thymocyte apoptotic process] GO:0071456[cellular response to hypoxia] GO:0071466[cellular response to xenobiotic stimulus] GO:0071479[cellular response to ionizing radiation] GO:0071480[cellular response to gamma radiation] GO:0071889[14-3-3 protein binding] GO:0072331[signal transduction by p53 class mediator] GO:0072332[intrinsic apoptotic signaling pathway by p53 class mediator] GO:0072717[cellular response to actinomycin D] GO:0090200[positive regulation of release of cytochrome c from mitochondria] GO:0090398[cellular senescence] GO:0090399[replicative senescence] GO:0090403[oxidative stress-induced premature senescence] GO:0097193[intrinsic apoptotic signaling pathway] GO:0097252[oligodendrocyte apoptotic process] GO:0097718[disordered domain specific binding] GO:0140296[general transcription initiation factor binding] GO:0140677[molecular function activator activity] GO:1900119[positive regulation of execution phase of apoptosis] GO:1902749[regulation of cell cycle G2/M phase transition] GO:1902895[positive regulation of miRNA transcription] GO:1903451[negative regulation of G1 to G0 transition] GO:1905856[negative regulation of pentose-phosphate shunt] GO:1990248[regulation of transcription from RNA polymerase II promoter in response to DNA damage] GO:1990440[positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress] GO:1990841[promoter-specific chromatin binding] GO:2000379[positive regulation of reactive oxygen species metabolic process] GO:2000774[positive regulation of cellular senescence] GO:2001244[positive regulation of intrinsic apoptotic signaling pathway]
Transporters Transporter channels and pores Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Immunoglobulin fold Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations COSMIC Translocations Disease related genes Potential drug targets Human disease related genes Cancers Head and neck cancers Cancers of the digestive system Cancers of the lung and pleura Skin cancers Cancers of soft tissues and bone Cancers of the breast and female genital organs Cancers of male genital organs Cancers of the urinary system Cancers of eye, brain, and central nervous system Cancers of endocrine organs Cancers of haematopoietic and lymphoid tissues Cardiovascular diseases Hematologic diseases Musculoskeletal diseases Skeletal diseases Nervous system diseases Other nervous and sensory system diseases Other diseases Others Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000976[transcription cis-regulatory region binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0000987[cis-regulatory region sequence-specific DNA binding] GO:0001046[core promoter sequence-specific DNA binding] GO:0001094[TFIID-class transcription factor complex binding] GO:0001227[DNA-binding transcription repressor activity, RNA polymerase II-specific] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0002020[protease binding] GO:0002039[p53 binding] GO:0002244[hematopoietic progenitor cell differentiation] GO:0003677[DNA binding] GO:0003682[chromatin binding] GO:0003700[DNA-binding transcription factor activity] GO:0003730[mRNA 3'-UTR binding] GO:0005507[copper ion binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005667[transcription regulator complex] GO:0005730[nucleolus] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005759[mitochondrial matrix] GO:0005783[endoplasmic reticulum] GO:0005813[centrosome] GO:0005815[microtubule organizing center] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0006289[nucleotide-excision repair] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006914[autophagy] GO:0006915[apoptotic process] GO:0006974[cellular response to DNA damage stimulus] GO:0006977[DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0006978[DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator] GO:0006983[ER overload response] GO:0007049[cell cycle] GO:0007265[Ras protein signal transduction] GO:0008104[protein localization] GO:0008270[zinc ion binding] GO:0008285[negative regulation of cell population proliferation] GO:0008340[determination of adult lifespan] GO:0009299[mRNA transcription] GO:0010332[response to gamma radiation] GO:0010628[positive regulation of gene expression] GO:0012501[programmed cell death] GO:0016032[viral process] GO:0016363[nuclear matrix] GO:0016604[nuclear body] GO:0016605[PML body] GO:0017053[transcription repressor complex] GO:0019899[enzyme binding] GO:0019901[protein kinase binding] GO:0019903[protein phosphatase binding] GO:0030308[negative regulation of cell growth] GO:0030330[DNA damage response, signal transduction by p53 class mediator] GO:0030971[receptor tyrosine kinase binding] GO:0031571[mitotic G1 DNA damage checkpoint signaling] GO:0031625[ubiquitin protein ligase binding] GO:0032991[protein-containing complex] GO:0033209[tumor necrosis factor-mediated signaling pathway] GO:0034644[cellular response to UV] GO:0035035[histone acetyltransferase binding] GO:0036003[positive regulation of transcription from RNA polymerase II promoter in response to stress] GO:0036310[ATP-dependent DNA/DNA annealing activity] GO:0042149[cellular response to glucose starvation] GO:0042771[intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] GO:0042802[identical protein binding] GO:0042826[histone deacetylase binding] GO:0042981[regulation of apoptotic process] GO:0043065[positive regulation of apoptotic process] GO:0043066[negative regulation of apoptotic process] GO:0043153[entrainment of circadian clock by photoperiod] GO:0043621[protein self-association] GO:0045815[transcriptional initiation-coupled chromatin remodeling] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0045899[positive regulation of RNA polymerase II transcription preinitiation complex assembly] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046677[response to antibiotic] GO:0046872[metal ion binding] GO:0046982[protein heterodimerization activity] GO:0047485[protein N-terminus binding] GO:0048147[negative regulation of fibroblast proliferation] GO:0048511[rhythmic process] GO:0048512[circadian behavior] GO:0048539[bone marrow development] GO:0050731[positive regulation of peptidyl-tyrosine phosphorylation] GO:0051087[chaperone binding] GO:0051097[negative regulation of helicase activity] GO:0051262[protein tetramerization] GO:0051721[protein phosphatase 2A binding] GO:0051726[regulation of cell cycle] GO:0051974[negative regulation of telomerase activity] GO:0060218[hematopoietic stem cell differentiation] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0065003[protein-containing complex assembly] GO:0070245[positive regulation of thymocyte apoptotic process] GO:0071456[cellular response to hypoxia] GO:0071466[cellular response to xenobiotic stimulus] GO:0071479[cellular response to ionizing radiation] GO:0071480[cellular response to gamma radiation] GO:0071889[14-3-3 protein binding] GO:0072331[signal transduction by p53 class mediator] GO:0072332[intrinsic apoptotic signaling pathway by p53 class mediator] GO:0072717[cellular response to actinomycin D] GO:0090200[positive regulation of release of cytochrome c from mitochondria] GO:0090398[cellular senescence] GO:0090399[replicative senescence] GO:0090403[oxidative stress-induced premature senescence] GO:0097193[intrinsic apoptotic signaling pathway] GO:0097252[oligodendrocyte apoptotic process] GO:0097718[disordered domain specific binding] GO:0140296[general transcription initiation factor binding] GO:0140677[molecular function activator activity] GO:1900119[positive regulation of execution phase of apoptosis] GO:1902749[regulation of cell cycle G2/M phase transition] GO:1902895[positive regulation of miRNA transcription] GO:1903451[negative regulation of G1 to G0 transition] GO:1905856[negative regulation of pentose-phosphate shunt] GO:1990248[regulation of transcription from RNA polymerase II promoter in response to DNA damage] GO:1990440[positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress] GO:1990841[promoter-specific chromatin binding] GO:2000379[positive regulation of reactive oxygen species metabolic process] GO:2000774[positive regulation of cellular senescence] GO:2001244[positive regulation of intrinsic apoptotic signaling pathway]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations COSMIC Translocations Human disease related genes Cancers Head and neck cancers Cancers of the digestive system Cancers of the lung and pleura Skin cancers Cancers of soft tissues and bone Cancers of the breast and female genital organs Cancers of male genital organs Cancers of the urinary system Cancers of eye, brain, and central nervous system Cancers of endocrine organs Cancers of haematopoietic and lymphoid tissues Cardiovascular diseases Hematologic diseases Musculoskeletal diseases Skeletal diseases Nervous system diseases Other nervous and sensory system diseases Other diseases Others Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations COSMIC Translocations Human disease related genes Cancers Head and neck cancers Cancers of the digestive system Cancers of the lung and pleura Skin cancers Cancers of soft tissues and bone Cancers of the breast and female genital organs Cancers of male genital organs Cancers of the urinary system Cancers of eye, brain, and central nervous system Cancers of endocrine organs Cancers of haematopoietic and lymphoid tissues Cardiovascular diseases Hematologic diseases Musculoskeletal diseases Skeletal diseases Nervous system diseases Other nervous and sensory system diseases Other diseases Others Protein evidence (Ezkurdia et al 2014)
Transporters Transporter channels and pores Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Immunoglobulin fold Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations COSMIC Translocations Disease related genes Potential drug targets Human disease related genes Cancers Head and neck cancers Cancers of the digestive system Cancers of the lung and pleura Skin cancers Cancers of soft tissues and bone Cancers of the breast and female genital organs Cancers of male genital organs Cancers of the urinary system Cancers of eye, brain, and central nervous system Cancers of endocrine organs Cancers of haematopoietic and lymphoid tissues Cardiovascular diseases Hematologic diseases Musculoskeletal diseases Skeletal diseases Nervous system diseases Other nervous and sensory system diseases Other diseases Others Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000976[transcription cis-regulatory region binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0000987[cis-regulatory region sequence-specific DNA binding] GO:0001046[core promoter sequence-specific DNA binding] GO:0001094[TFIID-class transcription factor complex binding] GO:0001227[DNA-binding transcription repressor activity, RNA polymerase II-specific] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0002020[protease binding] GO:0002039[p53 binding] GO:0002244[hematopoietic progenitor cell differentiation] GO:0003677[DNA binding] GO:0003682[chromatin binding] GO:0003700[DNA-binding transcription factor activity] GO:0003730[mRNA 3'-UTR binding] GO:0005507[copper ion binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005667[transcription regulator complex] GO:0005730[nucleolus] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005759[mitochondrial matrix] GO:0005783[endoplasmic reticulum] GO:0005813[centrosome] GO:0005815[microtubule organizing center] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0006289[nucleotide-excision repair] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006914[autophagy] GO:0006915[apoptotic process] GO:0006974[cellular response to DNA damage stimulus] GO:0006977[DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0006978[DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator] GO:0006983[ER overload response] GO:0007049[cell cycle] GO:0007265[Ras protein signal transduction] GO:0008104[protein localization] GO:0008270[zinc ion binding] GO:0008285[negative regulation of cell population proliferation] GO:0008340[determination of adult lifespan] GO:0009299[mRNA transcription] GO:0010332[response to gamma radiation] GO:0010628[positive regulation of gene expression] GO:0012501[programmed cell death] GO:0016032[viral process] GO:0016363[nuclear matrix] GO:0016604[nuclear body] GO:0016605[PML body] GO:0017053[transcription repressor complex] GO:0019899[enzyme binding] GO:0019901[protein kinase binding] GO:0019903[protein phosphatase binding] GO:0030308[negative regulation of cell growth] GO:0030330[DNA damage response, signal transduction by p53 class mediator] GO:0030971[receptor tyrosine kinase binding] GO:0031571[mitotic G1 DNA damage checkpoint signaling] GO:0031625[ubiquitin protein ligase binding] GO:0032991[protein-containing complex] GO:0033209[tumor necrosis factor-mediated signaling pathway] GO:0034644[cellular response to UV] GO:0035035[histone acetyltransferase binding] GO:0036003[positive regulation of transcription from RNA polymerase II promoter in response to stress] GO:0036310[ATP-dependent DNA/DNA annealing activity] GO:0042149[cellular response to glucose starvation] GO:0042771[intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] GO:0042802[identical protein binding] GO:0042826[histone deacetylase binding] GO:0042981[regulation of apoptotic process] GO:0043065[positive regulation of apoptotic process] GO:0043066[negative regulation of apoptotic process] GO:0043153[entrainment of circadian clock by photoperiod] GO:0043621[protein self-association] GO:0045815[transcriptional initiation-coupled chromatin remodeling] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0045899[positive regulation of RNA polymerase II transcription preinitiation complex assembly] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046677[response to antibiotic] GO:0046872[metal ion binding] GO:0046982[protein heterodimerization activity] GO:0047485[protein N-terminus binding] GO:0048147[negative regulation of fibroblast proliferation] GO:0048511[rhythmic process] GO:0048512[circadian behavior] GO:0048539[bone marrow development] GO:0050731[positive regulation of peptidyl-tyrosine phosphorylation] GO:0051087[chaperone binding] GO:0051097[negative regulation of helicase activity] GO:0051262[protein tetramerization] GO:0051721[protein phosphatase 2A binding] GO:0051726[regulation of cell cycle] GO:0051974[negative regulation of telomerase activity] GO:0060218[hematopoietic stem cell differentiation] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0065003[protein-containing complex assembly] GO:0070245[positive regulation of thymocyte apoptotic process] GO:0071456[cellular response to hypoxia] GO:0071466[cellular response to xenobiotic stimulus] GO:0071479[cellular response to ionizing radiation] GO:0071480[cellular response to gamma radiation] GO:0071889[14-3-3 protein binding] GO:0072331[signal transduction by p53 class mediator] GO:0072332[intrinsic apoptotic signaling pathway by p53 class mediator] GO:0072717[cellular response to actinomycin D] GO:0090200[positive regulation of release of cytochrome c from mitochondria] GO:0090398[cellular senescence] GO:0090399[replicative senescence] GO:0090403[oxidative stress-induced premature senescence] GO:0097193[intrinsic apoptotic signaling pathway] GO:0097252[oligodendrocyte apoptotic process] GO:0097718[disordered domain specific binding] GO:0140296[general transcription initiation factor binding] GO:0140677[molecular function activator activity] GO:1900119[positive regulation of execution phase of apoptosis] GO:1902749[regulation of cell cycle G2/M phase transition] GO:1902895[positive regulation of miRNA transcription] GO:1903451[negative regulation of G1 to G0 transition] GO:1905856[negative regulation of pentose-phosphate shunt] GO:1990248[regulation of transcription from RNA polymerase II promoter in response to DNA damage] GO:1990440[positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress] GO:1990841[promoter-specific chromatin binding] GO:2000379[positive regulation of reactive oxygen species metabolic process] GO:2000774[positive regulation of cellular senescence] GO:2001244[positive regulation of intrinsic apoptotic signaling pathway]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations COSMIC Translocations Human disease related genes Cancers Head and neck cancers Cancers of the digestive system Cancers of the lung and pleura Skin cancers Cancers of soft tissues and bone Cancers of the breast and female genital organs Cancers of male genital organs Cancers of the urinary system Cancers of eye, brain, and central nervous system Cancers of endocrine organs Cancers of haematopoietic and lymphoid tissues Cardiovascular diseases Hematologic diseases Musculoskeletal diseases Skeletal diseases Nervous system diseases Other nervous and sensory system diseases Other diseases Others Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations COSMIC Translocations Human disease related genes Cancers Head and neck cancers Cancers of the digestive system Cancers of the lung and pleura Skin cancers Cancers of soft tissues and bone Cancers of the breast and female genital organs Cancers of male genital organs Cancers of the urinary system Cancers of eye, brain, and central nervous system Cancers of endocrine organs Cancers of haematopoietic and lymphoid tissues Cardiovascular diseases Hematologic diseases Musculoskeletal diseases Skeletal diseases Nervous system diseases Other nervous and sensory system diseases Other diseases Others Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations COSMIC Translocations Human disease related genes Cancers Head and neck cancers Cancers of the digestive system Cancers of the lung and pleura Skin cancers Cancers of soft tissues and bone Cancers of the breast and female genital organs Cancers of male genital organs Cancers of the urinary system Cancers of eye, brain, and central nervous system Cancers of endocrine organs Cancers of haematopoietic and lymphoid tissues Cardiovascular diseases Hematologic diseases Musculoskeletal diseases Skeletal diseases Nervous system diseases Other nervous and sensory system diseases Other diseases Others Protein evidence (Ezkurdia et al 2014)
Transporters Transporter channels and pores Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Immunoglobulin fold Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations COSMIC Translocations Disease related genes Potential drug targets Human disease related genes Cancers Head and neck cancers Cancers of the digestive system Cancers of the lung and pleura Skin cancers Cancers of soft tissues and bone Cancers of the breast and female genital organs Cancers of male genital organs Cancers of the urinary system Cancers of eye, brain, and central nervous system Cancers of endocrine organs Cancers of haematopoietic and lymphoid tissues Cardiovascular diseases Hematologic diseases Musculoskeletal diseases Skeletal diseases Nervous system diseases Other nervous and sensory system diseases Other diseases Others Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000976[transcription cis-regulatory region binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0000987[cis-regulatory region sequence-specific DNA binding] GO:0001046[core promoter sequence-specific DNA binding] GO:0001094[TFIID-class transcription factor complex binding] GO:0001227[DNA-binding transcription repressor activity, RNA polymerase II-specific] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0002020[protease binding] GO:0002039[p53 binding] GO:0002244[hematopoietic progenitor cell differentiation] GO:0003677[DNA binding] GO:0003682[chromatin binding] GO:0003700[DNA-binding transcription factor activity] GO:0003730[mRNA 3'-UTR binding] GO:0005507[copper ion binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005667[transcription regulator complex] GO:0005730[nucleolus] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005759[mitochondrial matrix] GO:0005783[endoplasmic reticulum] GO:0005813[centrosome] GO:0005815[microtubule organizing center] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0006289[nucleotide-excision repair] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006914[autophagy] GO:0006915[apoptotic process] GO:0006974[cellular response to DNA damage stimulus] GO:0006977[DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0006978[DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator] GO:0006983[ER overload response] GO:0007049[cell cycle] GO:0007265[Ras protein signal transduction] GO:0008104[protein localization] GO:0008270[zinc ion binding] GO:0008285[negative regulation of cell population proliferation] GO:0008340[determination of adult lifespan] GO:0009299[mRNA transcription] GO:0010332[response to gamma radiation] GO:0010628[positive regulation of gene expression] GO:0012501[programmed cell death] GO:0016032[viral process] GO:0016363[nuclear matrix] GO:0016604[nuclear body] GO:0016605[PML body] GO:0017053[transcription repressor complex] GO:0019899[enzyme binding] GO:0019901[protein kinase binding] GO:0019903[protein phosphatase binding] GO:0030308[negative regulation of cell growth] GO:0030330[DNA damage response, signal transduction by p53 class mediator] GO:0030971[receptor tyrosine kinase binding] GO:0031571[mitotic G1 DNA damage checkpoint signaling] GO:0031625[ubiquitin protein ligase binding] GO:0032991[protein-containing complex] GO:0033209[tumor necrosis factor-mediated signaling pathway] GO:0034644[cellular response to UV] GO:0035035[histone acetyltransferase binding] GO:0036003[positive regulation of transcription from RNA polymerase II promoter in response to stress] GO:0036310[ATP-dependent DNA/DNA annealing activity] GO:0042149[cellular response to glucose starvation] GO:0042771[intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] GO:0042802[identical protein binding] GO:0042826[histone deacetylase binding] GO:0042981[regulation of apoptotic process] GO:0043065[positive regulation of apoptotic process] GO:0043066[negative regulation of apoptotic process] GO:0043153[entrainment of circadian clock by photoperiod] GO:0043621[protein self-association] GO:0045815[transcriptional initiation-coupled chromatin remodeling] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0045899[positive regulation of RNA polymerase II transcription preinitiation complex assembly] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046677[response to antibiotic] GO:0046872[metal ion binding] GO:0046982[protein heterodimerization activity] GO:0047485[protein N-terminus binding] GO:0048147[negative regulation of fibroblast proliferation] GO:0048511[rhythmic process] GO:0048512[circadian behavior] GO:0048539[bone marrow development] GO:0050731[positive regulation of peptidyl-tyrosine phosphorylation] GO:0051087[chaperone binding] GO:0051097[negative regulation of helicase activity] GO:0051262[protein tetramerization] GO:0051721[protein phosphatase 2A binding] GO:0051726[regulation of cell cycle] GO:0051974[negative regulation of telomerase activity] GO:0060218[hematopoietic stem cell differentiation] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0065003[protein-containing complex assembly] GO:0070245[positive regulation of thymocyte apoptotic process] GO:0071456[cellular response to hypoxia] GO:0071466[cellular response to xenobiotic stimulus] GO:0071479[cellular response to ionizing radiation] GO:0071480[cellular response to gamma radiation] GO:0071889[14-3-3 protein binding] GO:0072331[signal transduction by p53 class mediator] GO:0072332[intrinsic apoptotic signaling pathway by p53 class mediator] GO:0072717[cellular response to actinomycin D] GO:0090200[positive regulation of release of cytochrome c from mitochondria] GO:0090398[cellular senescence] GO:0090399[replicative senescence] GO:0090403[oxidative stress-induced premature senescence] GO:0097193[intrinsic apoptotic signaling pathway] GO:0097252[oligodendrocyte apoptotic process] GO:0097718[disordered domain specific binding] GO:0140296[general transcription initiation factor binding] GO:0140677[molecular function activator activity] GO:1900119[positive regulation of execution phase of apoptosis] GO:1902749[regulation of cell cycle G2/M phase transition] GO:1902895[positive regulation of miRNA transcription] GO:1903451[negative regulation of G1 to G0 transition] GO:1905856[negative regulation of pentose-phosphate shunt] GO:1990248[regulation of transcription from RNA polymerase II promoter in response to DNA damage] GO:1990440[positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress] GO:1990841[promoter-specific chromatin binding] GO:2000379[positive regulation of reactive oxygen species metabolic process] GO:2000774[positive regulation of cellular senescence] GO:2001244[positive regulation of intrinsic apoptotic signaling pathway]
Transporters Transporter channels and pores Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Immunoglobulin fold Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations COSMIC Translocations Disease related genes Potential drug targets Human disease related genes Cancers Head and neck cancers Cancers of the digestive system Cancers of the lung and pleura Skin cancers Cancers of soft tissues and bone Cancers of the breast and female genital organs Cancers of male genital organs Cancers of the urinary system Cancers of eye, brain, and central nervous system Cancers of endocrine organs Cancers of haematopoietic and lymphoid tissues Cardiovascular diseases Hematologic diseases Musculoskeletal diseases Skeletal diseases Nervous system diseases Other nervous and sensory system diseases Other diseases Others Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000976[transcription cis-regulatory region binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0000987[cis-regulatory region sequence-specific DNA binding] GO:0001046[core promoter sequence-specific DNA binding] GO:0001094[TFIID-class transcription factor complex binding] GO:0001227[DNA-binding transcription repressor activity, RNA polymerase II-specific] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0002020[protease binding] GO:0002039[p53 binding] GO:0002244[hematopoietic progenitor cell differentiation] GO:0003677[DNA binding] GO:0003682[chromatin binding] GO:0003700[DNA-binding transcription factor activity] GO:0003730[mRNA 3'-UTR binding] GO:0005507[copper ion binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005667[transcription regulator complex] GO:0005730[nucleolus] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005759[mitochondrial matrix] GO:0005783[endoplasmic reticulum] GO:0005813[centrosome] GO:0005815[microtubule organizing center] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0006289[nucleotide-excision repair] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006914[autophagy] GO:0006915[apoptotic process] GO:0006974[cellular response to DNA damage stimulus] GO:0006977[DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0006978[DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator] GO:0006983[ER overload response] GO:0007049[cell cycle] GO:0007265[Ras protein signal transduction] GO:0008104[protein localization] GO:0008270[zinc ion binding] GO:0008285[negative regulation of cell population proliferation] GO:0008340[determination of adult lifespan] GO:0009299[mRNA transcription] GO:0010332[response to gamma radiation] GO:0010628[positive regulation of gene expression] GO:0012501[programmed cell death] GO:0016032[viral process] GO:0016363[nuclear matrix] GO:0016604[nuclear body] GO:0016605[PML body] GO:0017053[transcription repressor complex] GO:0019899[enzyme binding] GO:0019901[protein kinase binding] GO:0019903[protein phosphatase binding] GO:0030308[negative regulation of cell growth] GO:0030330[DNA damage response, signal transduction by p53 class mediator] GO:0030971[receptor tyrosine kinase binding] GO:0031571[mitotic G1 DNA damage checkpoint signaling] GO:0031625[ubiquitin protein ligase binding] GO:0032991[protein-containing complex] GO:0033209[tumor necrosis factor-mediated signaling pathway] GO:0034644[cellular response to UV] GO:0035035[histone acetyltransferase binding] GO:0036003[positive regulation of transcription from RNA polymerase II promoter in response to stress] GO:0036310[ATP-dependent DNA/DNA annealing activity] GO:0042149[cellular response to glucose starvation] GO:0042771[intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] GO:0042802[identical protein binding] GO:0042826[histone deacetylase binding] GO:0042981[regulation of apoptotic process] GO:0043065[positive regulation of apoptotic process] GO:0043066[negative regulation of apoptotic process] GO:0043153[entrainment of circadian clock by photoperiod] GO:0043621[protein self-association] GO:0045815[transcriptional initiation-coupled chromatin remodeling] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0045899[positive regulation of RNA polymerase II transcription preinitiation complex assembly] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046677[response to antibiotic] GO:0046872[metal ion binding] GO:0046982[protein heterodimerization activity] GO:0047485[protein N-terminus binding] GO:0048147[negative regulation of fibroblast proliferation] GO:0048511[rhythmic process] GO:0048512[circadian behavior] GO:0048539[bone marrow development] GO:0050731[positive regulation of peptidyl-tyrosine phosphorylation] GO:0051087[chaperone binding] GO:0051097[negative regulation of helicase activity] GO:0051262[protein tetramerization] GO:0051721[protein phosphatase 2A binding] GO:0051726[regulation of cell cycle] GO:0051974[negative regulation of telomerase activity] GO:0060218[hematopoietic stem cell differentiation] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0065003[protein-containing complex assembly] GO:0070245[positive regulation of thymocyte apoptotic process] GO:0071456[cellular response to hypoxia] GO:0071466[cellular response to xenobiotic stimulus] GO:0071479[cellular response to ionizing radiation] GO:0071480[cellular response to gamma radiation] GO:0071889[14-3-3 protein binding] GO:0072331[signal transduction by p53 class mediator] GO:0072332[intrinsic apoptotic signaling pathway by p53 class mediator] GO:0072717[cellular response to actinomycin D] GO:0090200[positive regulation of release of cytochrome c from mitochondria] GO:0090398[cellular senescence] GO:0090399[replicative senescence] GO:0090403[oxidative stress-induced premature senescence] GO:0097193[intrinsic apoptotic signaling pathway] GO:0097252[oligodendrocyte apoptotic process] GO:0097718[disordered domain specific binding] GO:0140296[general transcription initiation factor binding] GO:0140677[molecular function activator activity] GO:1900119[positive regulation of execution phase of apoptosis] GO:1902749[regulation of cell cycle G2/M phase transition] GO:1902895[positive regulation of miRNA transcription] GO:1903451[negative regulation of G1 to G0 transition] GO:1905856[negative regulation of pentose-phosphate shunt] GO:1990248[regulation of transcription from RNA polymerase II promoter in response to DNA damage] GO:1990440[positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress] GO:1990841[promoter-specific chromatin binding] GO:2000379[positive regulation of reactive oxygen species metabolic process] GO:2000774[positive regulation of cellular senescence] GO:2001244[positive regulation of intrinsic apoptotic signaling pathway]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations COSMIC Translocations Human disease related genes Cancers Head and neck cancers Cancers of the digestive system Cancers of the lung and pleura Skin cancers Cancers of soft tissues and bone Cancers of the breast and female genital organs Cancers of male genital organs Cancers of the urinary system Cancers of eye, brain, and central nervous system Cancers of endocrine organs Cancers of haematopoietic and lymphoid tissues Cardiovascular diseases Hematologic diseases Musculoskeletal diseases Skeletal diseases Nervous system diseases Other nervous and sensory system diseases Other diseases Others Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations COSMIC Translocations Human disease related genes Cancers Head and neck cancers Cancers of the digestive system Cancers of the lung and pleura Skin cancers Cancers of soft tissues and bone Cancers of the breast and female genital organs Cancers of male genital organs Cancers of the urinary system Cancers of eye, brain, and central nervous system Cancers of endocrine organs Cancers of haematopoietic and lymphoid tissues Cardiovascular diseases Hematologic diseases Musculoskeletal diseases Skeletal diseases Nervous system diseases Other nervous and sensory system diseases Other diseases Others Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations COSMIC Translocations Human disease related genes Cancers Head and neck cancers Cancers of the digestive system Cancers of the lung and pleura Skin cancers Cancers of soft tissues and bone Cancers of the breast and female genital organs Cancers of male genital organs Cancers of the urinary system Cancers of eye, brain, and central nervous system Cancers of endocrine organs Cancers of haematopoietic and lymphoid tissues Cardiovascular diseases Hematologic diseases Musculoskeletal diseases Skeletal diseases Nervous system diseases Other nervous and sensory system diseases Other diseases Others Protein evidence (Ezkurdia et al 2014)
Transporters Transporter channels and pores Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Immunoglobulin fold Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations COSMIC Translocations Disease related genes Potential drug targets Human disease related genes Cancers Head and neck cancers Cancers of the digestive system Cancers of the lung and pleura Skin cancers Cancers of soft tissues and bone Cancers of the breast and female genital organs Cancers of male genital organs Cancers of the urinary system Cancers of eye, brain, and central nervous system Cancers of endocrine organs Cancers of haematopoietic and lymphoid tissues Cardiovascular diseases Hematologic diseases Musculoskeletal diseases Skeletal diseases Nervous system diseases Other nervous and sensory system diseases Other diseases Others Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000976[transcription cis-regulatory region binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0000987[cis-regulatory region sequence-specific DNA binding] GO:0001046[core promoter sequence-specific DNA binding] GO:0001094[TFIID-class transcription factor complex binding] GO:0001227[DNA-binding transcription repressor activity, RNA polymerase II-specific] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0002020[protease binding] GO:0002039[p53 binding] GO:0002244[hematopoietic progenitor cell differentiation] GO:0003677[DNA binding] GO:0003682[chromatin binding] GO:0003700[DNA-binding transcription factor activity] GO:0003730[mRNA 3'-UTR binding] GO:0005507[copper ion binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005667[transcription regulator complex] GO:0005730[nucleolus] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005759[mitochondrial matrix] GO:0005783[endoplasmic reticulum] GO:0005813[centrosome] GO:0005815[microtubule organizing center] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0006289[nucleotide-excision repair] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006914[autophagy] GO:0006915[apoptotic process] GO:0006974[cellular response to DNA damage stimulus] GO:0006977[DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0006978[DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator] GO:0006983[ER overload response] GO:0007049[cell cycle] GO:0007265[Ras protein signal transduction] GO:0008104[protein localization] GO:0008270[zinc ion binding] GO:0008285[negative regulation of cell population proliferation] GO:0008340[determination of adult lifespan] GO:0009299[mRNA transcription] GO:0010332[response to gamma radiation] GO:0010628[positive regulation of gene expression] GO:0012501[programmed cell death] GO:0016032[viral process] GO:0016363[nuclear matrix] GO:0016604[nuclear body] GO:0016605[PML body] GO:0017053[transcription repressor complex] GO:0019899[enzyme binding] GO:0019901[protein kinase binding] GO:0019903[protein phosphatase binding] GO:0030308[negative regulation of cell growth] GO:0030330[DNA damage response, signal transduction by p53 class mediator] GO:0030971[receptor tyrosine kinase binding] GO:0031571[mitotic G1 DNA damage checkpoint signaling] GO:0031625[ubiquitin protein ligase binding] GO:0032991[protein-containing complex] GO:0033209[tumor necrosis factor-mediated signaling pathway] GO:0034644[cellular response to UV] GO:0035035[histone acetyltransferase binding] GO:0036003[positive regulation of transcription from RNA polymerase II promoter in response to stress] GO:0036310[ATP-dependent DNA/DNA annealing activity] GO:0042149[cellular response to glucose starvation] GO:0042771[intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] GO:0042802[identical protein binding] GO:0042826[histone deacetylase binding] GO:0042981[regulation of apoptotic process] GO:0043065[positive regulation of apoptotic process] GO:0043066[negative regulation of apoptotic process] GO:0043153[entrainment of circadian clock by photoperiod] GO:0043621[protein self-association] GO:0045815[transcriptional initiation-coupled chromatin remodeling] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0045899[positive regulation of RNA polymerase II transcription preinitiation complex assembly] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046677[response to antibiotic] GO:0046872[metal ion binding] GO:0046982[protein heterodimerization activity] GO:0047485[protein N-terminus binding] GO:0048147[negative regulation of fibroblast proliferation] GO:0048511[rhythmic process] GO:0048512[circadian behavior] GO:0048539[bone marrow development] GO:0050731[positive regulation of peptidyl-tyrosine phosphorylation] GO:0051087[chaperone binding] GO:0051097[negative regulation of helicase activity] GO:0051262[protein tetramerization] GO:0051721[protein phosphatase 2A binding] GO:0051726[regulation of cell cycle] GO:0051974[negative regulation of telomerase activity] GO:0060218[hematopoietic stem cell differentiation] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0065003[protein-containing complex assembly] GO:0070245[positive regulation of thymocyte apoptotic process] GO:0071456[cellular response to hypoxia] GO:0071466[cellular response to xenobiotic stimulus] GO:0071479[cellular response to ionizing radiation] GO:0071480[cellular response to gamma radiation] GO:0071889[14-3-3 protein binding] GO:0072331[signal transduction by p53 class mediator] GO:0072332[intrinsic apoptotic signaling pathway by p53 class mediator] GO:0072717[cellular response to actinomycin D] GO:0090200[positive regulation of release of cytochrome c from mitochondria] GO:0090398[cellular senescence] GO:0090399[replicative senescence] GO:0090403[oxidative stress-induced premature senescence] GO:0097193[intrinsic apoptotic signaling pathway] GO:0097252[oligodendrocyte apoptotic process] GO:0097718[disordered domain specific binding] GO:0140296[general transcription initiation factor binding] GO:0140677[molecular function activator activity] GO:1900119[positive regulation of execution phase of apoptosis] GO:1902749[regulation of cell cycle G2/M phase transition] GO:1902895[positive regulation of miRNA transcription] GO:1903451[negative regulation of G1 to G0 transition] GO:1905856[negative regulation of pentose-phosphate shunt] GO:1990248[regulation of transcription from RNA polymerase II promoter in response to DNA damage] GO:1990440[positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress] GO:1990841[promoter-specific chromatin binding] GO:2000379[positive regulation of reactive oxygen species metabolic process] GO:2000774[positive regulation of cellular senescence] GO:2001244[positive regulation of intrinsic apoptotic signaling pathway]
Transporters Transporter channels and pores Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Immunoglobulin fold Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations COSMIC Translocations Disease related genes Potential drug targets Human disease related genes Cancers Head and neck cancers Cancers of the digestive system Cancers of the lung and pleura Skin cancers Cancers of soft tissues and bone Cancers of the breast and female genital organs Cancers of male genital organs Cancers of the urinary system Cancers of eye, brain, and central nervous system Cancers of endocrine organs Cancers of haematopoietic and lymphoid tissues Cardiovascular diseases Hematologic diseases Musculoskeletal diseases Skeletal diseases Nervous system diseases Other nervous and sensory system diseases Other diseases Others Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000976[transcription cis-regulatory region binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0000987[cis-regulatory region sequence-specific DNA binding] GO:0001046[core promoter sequence-specific DNA binding] GO:0001094[TFIID-class transcription factor complex binding] GO:0001227[DNA-binding transcription repressor activity, RNA polymerase II-specific] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0002020[protease binding] GO:0002039[p53 binding] GO:0002244[hematopoietic progenitor cell differentiation] GO:0003677[DNA binding] GO:0003682[chromatin binding] GO:0003700[DNA-binding transcription factor activity] GO:0003730[mRNA 3'-UTR binding] GO:0005507[copper ion binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005667[transcription regulator complex] GO:0005730[nucleolus] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005759[mitochondrial matrix] GO:0005783[endoplasmic reticulum] GO:0005813[centrosome] GO:0005815[microtubule organizing center] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0006289[nucleotide-excision repair] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006914[autophagy] GO:0006915[apoptotic process] GO:0006974[cellular response to DNA damage stimulus] GO:0006977[DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0006978[DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator] GO:0006983[ER overload response] GO:0007049[cell cycle] GO:0007265[Ras protein signal transduction] GO:0008104[protein localization] GO:0008270[zinc ion binding] GO:0008285[negative regulation of cell population proliferation] GO:0008340[determination of adult lifespan] GO:0009299[mRNA transcription] GO:0010332[response to gamma radiation] GO:0010628[positive regulation of gene expression] GO:0012501[programmed cell death] GO:0016032[viral process] GO:0016363[nuclear matrix] GO:0016604[nuclear body] GO:0016605[PML body] GO:0017053[transcription repressor complex] GO:0019899[enzyme binding] GO:0019901[protein kinase binding] GO:0019903[protein phosphatase binding] GO:0030308[negative regulation of cell growth] GO:0030330[DNA damage response, signal transduction by p53 class mediator] GO:0030971[receptor tyrosine kinase binding] GO:0031571[mitotic G1 DNA damage checkpoint signaling] GO:0031625[ubiquitin protein ligase binding] GO:0032991[protein-containing complex] GO:0033209[tumor necrosis factor-mediated signaling pathway] GO:0034644[cellular response to UV] GO:0035035[histone acetyltransferase binding] GO:0036003[positive regulation of transcription from RNA polymerase II promoter in response to stress] GO:0036310[ATP-dependent DNA/DNA annealing activity] GO:0042149[cellular response to glucose starvation] GO:0042771[intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] GO:0042802[identical protein binding] GO:0042826[histone deacetylase binding] GO:0042981[regulation of apoptotic process] GO:0043065[positive regulation of apoptotic process] GO:0043066[negative regulation of apoptotic process] GO:0043153[entrainment of circadian clock by photoperiod] GO:0043621[protein self-association] GO:0045815[transcriptional initiation-coupled chromatin remodeling] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0045899[positive regulation of RNA polymerase II transcription preinitiation complex assembly] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046677[response to antibiotic] GO:0046872[metal ion binding] GO:0046982[protein heterodimerization activity] GO:0047485[protein N-terminus binding] GO:0048147[negative regulation of fibroblast proliferation] GO:0048511[rhythmic process] GO:0048512[circadian behavior] GO:0048539[bone marrow development] GO:0050731[positive regulation of peptidyl-tyrosine phosphorylation] GO:0051087[chaperone binding] GO:0051097[negative regulation of helicase activity] GO:0051262[protein tetramerization] GO:0051721[protein phosphatase 2A binding] GO:0051726[regulation of cell cycle] GO:0051974[negative regulation of telomerase activity] GO:0060218[hematopoietic stem cell differentiation] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0065003[protein-containing complex assembly] GO:0070245[positive regulation of thymocyte apoptotic process] GO:0071456[cellular response to hypoxia] GO:0071466[cellular response to xenobiotic stimulus] GO:0071479[cellular response to ionizing radiation] GO:0071480[cellular response to gamma radiation] GO:0071889[14-3-3 protein binding] GO:0072331[signal transduction by p53 class mediator] GO:0072332[intrinsic apoptotic signaling pathway by p53 class mediator] GO:0072717[cellular response to actinomycin D] GO:0090200[positive regulation of release of cytochrome c from mitochondria] GO:0090398[cellular senescence] GO:0090399[replicative senescence] GO:0090403[oxidative stress-induced premature senescence] GO:0097193[intrinsic apoptotic signaling pathway] GO:0097252[oligodendrocyte apoptotic process] GO:0097718[disordered domain specific binding] GO:0140296[general transcription initiation factor binding] GO:0140677[molecular function activator activity] GO:1900119[positive regulation of execution phase of apoptosis] GO:1902749[regulation of cell cycle G2/M phase transition] GO:1902895[positive regulation of miRNA transcription] GO:1903451[negative regulation of G1 to G0 transition] GO:1905856[negative regulation of pentose-phosphate shunt] GO:1990248[regulation of transcription from RNA polymerase II promoter in response to DNA damage] GO:1990440[positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress] GO:1990841[promoter-specific chromatin binding] GO:2000379[positive regulation of reactive oxygen species metabolic process] GO:2000774[positive regulation of cellular senescence] GO:2001244[positive regulation of intrinsic apoptotic signaling pathway]
Transporters Transporter channels and pores Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Immunoglobulin fold Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations COSMIC Translocations Disease related genes Potential drug targets Human disease related genes Cancers Head and neck cancers Cancers of the digestive system Cancers of the lung and pleura Skin cancers Cancers of soft tissues and bone Cancers of the breast and female genital organs Cancers of male genital organs Cancers of the urinary system Cancers of eye, brain, and central nervous system Cancers of endocrine organs Cancers of haematopoietic and lymphoid tissues Cardiovascular diseases Hematologic diseases Musculoskeletal diseases Skeletal diseases Nervous system diseases Other nervous and sensory system diseases Other diseases Others Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000976[transcription cis-regulatory region binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0000987[cis-regulatory region sequence-specific DNA binding] GO:0001046[core promoter sequence-specific DNA binding] GO:0001094[TFIID-class transcription factor complex binding] GO:0001227[DNA-binding transcription repressor activity, RNA polymerase II-specific] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0002020[protease binding] GO:0002039[p53 binding] GO:0002244[hematopoietic progenitor cell differentiation] GO:0003677[DNA binding] GO:0003682[chromatin binding] GO:0003700[DNA-binding transcription factor activity] GO:0003730[mRNA 3'-UTR binding] GO:0005507[copper ion binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005667[transcription regulator complex] GO:0005730[nucleolus] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005759[mitochondrial matrix] GO:0005783[endoplasmic reticulum] GO:0005813[centrosome] GO:0005815[microtubule organizing center] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0006289[nucleotide-excision repair] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006914[autophagy] GO:0006915[apoptotic process] GO:0006974[cellular response to DNA damage stimulus] GO:0006977[DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0006978[DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator] GO:0006983[ER overload response] GO:0007049[cell cycle] GO:0007265[Ras protein signal transduction] GO:0008104[protein localization] GO:0008270[zinc ion binding] GO:0008285[negative regulation of cell population proliferation] GO:0008340[determination of adult lifespan] GO:0009299[mRNA transcription] GO:0010332[response to gamma radiation] GO:0010628[positive regulation of gene expression] GO:0012501[programmed cell death] GO:0016032[viral process] GO:0016363[nuclear matrix] GO:0016604[nuclear body] GO:0016605[PML body] GO:0017053[transcription repressor complex] GO:0019899[enzyme binding] GO:0019901[protein kinase binding] GO:0019903[protein phosphatase binding] GO:0030308[negative regulation of cell growth] GO:0030330[DNA damage response, signal transduction by p53 class mediator] GO:0030971[receptor tyrosine kinase binding] GO:0031571[mitotic G1 DNA damage checkpoint signaling] GO:0031625[ubiquitin protein ligase binding] GO:0032991[protein-containing complex] GO:0033209[tumor necrosis factor-mediated signaling pathway] GO:0034644[cellular response to UV] GO:0035035[histone acetyltransferase binding] GO:0036003[positive regulation of transcription from RNA polymerase II promoter in response to stress] GO:0036310[ATP-dependent DNA/DNA annealing activity] GO:0042149[cellular response to glucose starvation] GO:0042771[intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] GO:0042802[identical protein binding] GO:0042826[histone deacetylase binding] GO:0042981[regulation of apoptotic process] GO:0043065[positive regulation of apoptotic process] GO:0043066[negative regulation of apoptotic process] GO:0043153[entrainment of circadian clock by photoperiod] GO:0043621[protein self-association] GO:0045815[transcriptional initiation-coupled chromatin remodeling] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0045899[positive regulation of RNA polymerase II transcription preinitiation complex assembly] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046677[response to antibiotic] GO:0046872[metal ion binding] GO:0046982[protein heterodimerization activity] GO:0047485[protein N-terminus binding] GO:0048147[negative regulation of fibroblast proliferation] GO:0048511[rhythmic process] GO:0048512[circadian behavior] GO:0048539[bone marrow development] GO:0050731[positive regulation of peptidyl-tyrosine phosphorylation] GO:0051087[chaperone binding] GO:0051097[negative regulation of helicase activity] GO:0051262[protein tetramerization] GO:0051721[protein phosphatase 2A binding] GO:0051726[regulation of cell cycle] GO:0051974[negative regulation of telomerase activity] GO:0060218[hematopoietic stem cell differentiation] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0065003[protein-containing complex assembly] GO:0070245[positive regulation of thymocyte apoptotic process] GO:0071456[cellular response to hypoxia] GO:0071466[cellular response to xenobiotic stimulus] GO:0071479[cellular response to ionizing radiation] GO:0071480[cellular response to gamma radiation] GO:0071889[14-3-3 protein binding] GO:0072331[signal transduction by p53 class mediator] GO:0072332[intrinsic apoptotic signaling pathway by p53 class mediator] GO:0072717[cellular response to actinomycin D] GO:0090200[positive regulation of release of cytochrome c from mitochondria] GO:0090398[cellular senescence] GO:0090399[replicative senescence] GO:0090403[oxidative stress-induced premature senescence] GO:0097193[intrinsic apoptotic signaling pathway] GO:0097252[oligodendrocyte apoptotic process] GO:0097718[disordered domain specific binding] GO:0140296[general transcription initiation factor binding] GO:0140677[molecular function activator activity] GO:1900119[positive regulation of execution phase of apoptosis] GO:1902749[regulation of cell cycle G2/M phase transition] GO:1902895[positive regulation of miRNA transcription] GO:1903451[negative regulation of G1 to G0 transition] GO:1905856[negative regulation of pentose-phosphate shunt] GO:1990248[regulation of transcription from RNA polymerase II promoter in response to DNA damage] GO:1990440[positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress] GO:1990841[promoter-specific chromatin binding] GO:2000379[positive regulation of reactive oxygen species metabolic process] GO:2000774[positive regulation of cellular senescence] GO:2001244[positive regulation of intrinsic apoptotic signaling pathway]
The Human Protein Atlas project is funded
