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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes CD markers Disease related genes Enzymes FDA approved drug targets Human disease related genes Plasma proteins Transporters
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
17
Cytoband
q12
Chromosome location (bp)
39687914 - 39730426
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Transcription, Transcription regulation
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
ATP-binding, Nucleotide-binding
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases CD markers Transporters Accessory Factors Involved in Transport Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations Disease related genes FDA approved drug targets Biotech drugs Small molecule drugs Human disease related genes Cancers Head and neck cancers Cancers of the digestive system Cancers of the breast and female genital organs Cancers of the urinary system Cancers of eye, brain, and central nervous system Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) DeepTMHMM predicted membrane proteins
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GO:0000166[nucleotide binding] GO:0001042[RNA polymerase I core binding] GO:0001934[positive regulation of protein phosphorylation] GO:0004672[protein kinase activity] GO:0004713[protein tyrosine kinase activity] GO:0004714[transmembrane receptor protein tyrosine kinase activity] GO:0004888[transmembrane signaling receptor activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005768[endosome] GO:0005769[early endosome] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006468[protein phosphorylation] GO:0007165[signal transduction] GO:0007166[cell surface receptor signaling pathway] GO:0007167[enzyme-linked receptor protein signaling pathway] GO:0007169[transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007399[nervous system development] GO:0007422[peripheral nervous system development] GO:0007507[heart development] GO:0007528[neuromuscular junction development] GO:0008022[protein C-terminus binding] GO:0008045[motor neuron axon guidance] GO:0008284[positive regulation of cell population proliferation] GO:0009925[basal plasma membrane] GO:0010008[endosome membrane] GO:0010628[positive regulation of gene expression] GO:0014065[phosphatidylinositol 3-kinase signaling] GO:0016020[membrane] GO:0016021[integral component of membrane] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016323[basolateral plasma membrane] GO:0016324[apical plasma membrane] GO:0016740[transferase activity] GO:0018108[peptidyl-tyrosine phosphorylation] GO:0019838[growth factor binding] GO:0019903[protein phosphatase binding] GO:0022008[neurogenesis] GO:0030182[neuron differentiation] GO:0030307[positive regulation of cell growth] GO:0031410[cytoplasmic vesicle] GO:0031594[neuromuscular junction] GO:0032587[ruffle membrane] GO:0032886[regulation of microtubule-based process] GO:0033080[immature T cell proliferation in thymus] GO:0033088[negative regulation of immature T cell proliferation in thymus] GO:0033674[positive regulation of kinase activity] GO:0035556[intracellular signal transduction] GO:0038127[ERBB signaling pathway] GO:0038133[ERBB2-ERBB3 signaling pathway] GO:0038134[ERBB2-EGFR signaling pathway] GO:0038135[ERBB2-ERBB4 signaling pathway] GO:0038143[ERBB3:ERBB2 complex] GO:0042060[wound healing] GO:0042127[regulation of cell population proliferation] GO:0042552[myelination] GO:0042734[presynaptic membrane] GO:0042802[identical protein binding] GO:0042995[cell projection] GO:0043066[negative regulation of apoptotic process] GO:0043125[ErbB-3 class receptor binding] GO:0043209[myelin sheath] GO:0043235[receptor complex] GO:0043406[positive regulation of MAP kinase activity] GO:0043410[positive regulation of MAPK cascade] GO:0043547[positive regulation of GTPase activity] GO:0045727[positive regulation of translation] GO:0045765[regulation of angiogenesis] GO:0045785[positive regulation of cell adhesion] GO:0045943[positive regulation of transcription by RNA polymerase I] GO:0046777[protein autophosphorylation] GO:0046982[protein heterodimerization activity] GO:0048471[perinuclear region of cytoplasm] GO:0048709[oligodendrocyte differentiation] GO:0050679[positive regulation of epithelial cell proliferation] GO:0070372[regulation of ERK1 and ERK2 cascade] GO:0071363[cellular response to growth factor stimulus] GO:0071364[cellular response to epidermal growth factor stimulus] GO:0090314[positive regulation of protein targeting to membrane] GO:0098590[plasma membrane region] GO:0099645[neurotransmitter receptor localization to postsynaptic specialization membrane]
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases CD markers Transporters Accessory Factors Involved in Transport Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations Disease related genes FDA approved drug targets Biotech drugs Small molecule drugs Human disease related genes Cancers Head and neck cancers Cancers of the digestive system Cancers of the breast and female genital organs Cancers of the urinary system Cancers of eye, brain, and central nervous system Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014) DeepTMHMM predicted membrane proteins
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GO:0000166[nucleotide binding] GO:0001042[RNA polymerase I core binding] GO:0001934[positive regulation of protein phosphorylation] GO:0004672[protein kinase activity] GO:0004713[protein tyrosine kinase activity] GO:0004714[transmembrane receptor protein tyrosine kinase activity] GO:0004888[transmembrane signaling receptor activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005768[endosome] GO:0005769[early endosome] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006468[protein phosphorylation] GO:0007165[signal transduction] GO:0007166[cell surface receptor signaling pathway] GO:0007167[enzyme-linked receptor protein signaling pathway] GO:0007169[transmembrane receptor protein tyrosine kinase signaling pathway] GO:0008022[protein C-terminus binding] GO:0008284[positive regulation of cell population proliferation] GO:0009925[basal plasma membrane] GO:0010008[endosome membrane] GO:0014065[phosphatidylinositol 3-kinase signaling] GO:0016020[membrane] GO:0016021[integral component of membrane] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016323[basolateral plasma membrane] GO:0016740[transferase activity] GO:0018108[peptidyl-tyrosine phosphorylation] GO:0019838[growth factor binding] GO:0019903[protein phosphatase binding] GO:0022008[neurogenesis] GO:0030182[neuron differentiation] GO:0030307[positive regulation of cell growth] GO:0032587[ruffle membrane] GO:0032886[regulation of microtubule-based process] GO:0033674[positive regulation of kinase activity] GO:0035556[intracellular signal transduction] GO:0038127[ERBB signaling pathway] GO:0038134[ERBB2-EGFR signaling pathway] GO:0038143[ERBB3:ERBB2 complex] GO:0042060[wound healing] GO:0042127[regulation of cell population proliferation] GO:0042802[identical protein binding] GO:0042995[cell projection] GO:0043066[negative regulation of apoptotic process] GO:0043125[ErbB-3 class receptor binding] GO:0043235[receptor complex] GO:0043406[positive regulation of MAP kinase activity] GO:0043410[positive regulation of MAPK cascade] GO:0043547[positive regulation of GTPase activity] GO:0045727[positive regulation of translation] GO:0045765[regulation of angiogenesis] GO:0045785[positive regulation of cell adhesion] GO:0045943[positive regulation of transcription by RNA polymerase I] GO:0046777[protein autophosphorylation] GO:0046982[protein heterodimerization activity] GO:0048471[perinuclear region of cytoplasm] GO:0050679[positive regulation of epithelial cell proliferation] GO:0070372[regulation of ERK1 and ERK2 cascade] GO:0071363[cellular response to growth factor stimulus] GO:0071364[cellular response to epidermal growth factor stimulus] GO:0090314[positive regulation of protein targeting to membrane] GO:0098590[plasma membrane region]
B4DTR1 [Direct mapping] Receptor tyrosine-protein kinase erbB-2; cDNA FLJ59426, highly similar to Receptor tyrosine-protein kinase erbB-2
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Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations Human disease related genes Cancers Head and neck cancers Cancers of the digestive system Cancers of the breast and female genital organs Cancers of the urinary system Cancers of eye, brain, and central nervous system Protein evidence (Ezkurdia et al 2014) DeepTMHMM predicted membrane proteins
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases CD markers Transporters Accessory Factors Involved in Transport Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations Disease related genes FDA approved drug targets Biotech drugs Small molecule drugs Human disease related genes Cancers Head and neck cancers Cancers of the digestive system Cancers of the breast and female genital organs Cancers of the urinary system Cancers of eye, brain, and central nervous system Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014) DeepTMHMM predicted membrane proteins
Show all
GO:0000166[nucleotide binding] GO:0001042[RNA polymerase I core binding] GO:0001934[positive regulation of protein phosphorylation] GO:0004672[protein kinase activity] GO:0004713[protein tyrosine kinase activity] GO:0004714[transmembrane receptor protein tyrosine kinase activity] GO:0004888[transmembrane signaling receptor activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005768[endosome] GO:0005769[early endosome] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006468[protein phosphorylation] GO:0007165[signal transduction] GO:0007166[cell surface receptor signaling pathway] GO:0007167[enzyme-linked receptor protein signaling pathway] GO:0007169[transmembrane receptor protein tyrosine kinase signaling pathway] GO:0008022[protein C-terminus binding] GO:0008284[positive regulation of cell population proliferation] GO:0009925[basal plasma membrane] GO:0010008[endosome membrane] GO:0014065[phosphatidylinositol 3-kinase signaling] GO:0016020[membrane] GO:0016021[integral component of membrane] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016323[basolateral plasma membrane] GO:0016740[transferase activity] GO:0018108[peptidyl-tyrosine phosphorylation] GO:0019838[growth factor binding] GO:0019903[protein phosphatase binding] GO:0022008[neurogenesis] GO:0030182[neuron differentiation] GO:0030307[positive regulation of cell growth] GO:0032587[ruffle membrane] GO:0032886[regulation of microtubule-based process] GO:0033674[positive regulation of kinase activity] GO:0035556[intracellular signal transduction] GO:0038127[ERBB signaling pathway] GO:0038134[ERBB2-EGFR signaling pathway] GO:0038143[ERBB3:ERBB2 complex] GO:0042060[wound healing] GO:0042127[regulation of cell population proliferation] GO:0042802[identical protein binding] GO:0042995[cell projection] GO:0043066[negative regulation of apoptotic process] GO:0043125[ErbB-3 class receptor binding] GO:0043235[receptor complex] GO:0043406[positive regulation of MAP kinase activity] GO:0043410[positive regulation of MAPK cascade] GO:0043547[positive regulation of GTPase activity] GO:0045727[positive regulation of translation] GO:0045765[regulation of angiogenesis] GO:0045785[positive regulation of cell adhesion] GO:0045943[positive regulation of transcription by RNA polymerase I] GO:0046777[protein autophosphorylation] GO:0046982[protein heterodimerization activity] GO:0048471[perinuclear region of cytoplasm] GO:0050679[positive regulation of epithelial cell proliferation] GO:0070372[regulation of ERK1 and ERK2 cascade] GO:0071363[cellular response to growth factor stimulus] GO:0071364[cellular response to epidermal growth factor stimulus] GO:0090314[positive regulation of protein targeting to membrane] GO:0098590[plasma membrane region]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations Human disease related genes Cancers Head and neck cancers Cancers of the digestive system Cancers of the breast and female genital organs Cancers of the urinary system Cancers of eye, brain, and central nervous system Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations Human disease related genes Cancers Head and neck cancers Cancers of the digestive system Cancers of the breast and female genital organs Cancers of the urinary system Cancers of eye, brain, and central nervous system Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations Human disease related genes Cancers Head and neck cancers Cancers of the digestive system Cancers of the breast and female genital organs Cancers of the urinary system Cancers of eye, brain, and central nervous system Protein evidence (Ezkurdia et al 2014)
Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations Human disease related genes Cancers Head and neck cancers Cancers of the digestive system Cancers of the breast and female genital organs Cancers of the urinary system Cancers of eye, brain, and central nervous system Protein evidence (Ezkurdia et al 2014) DeepTMHMM predicted membrane proteins
Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations Human disease related genes Cancers Head and neck cancers Cancers of the digestive system Cancers of the breast and female genital organs Cancers of the urinary system Cancers of eye, brain, and central nervous system Protein evidence (Ezkurdia et al 2014) DeepTMHMM predicted membrane proteins
Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations Human disease related genes Cancers Head and neck cancers Cancers of the digestive system Cancers of the breast and female genital organs Cancers of the urinary system Cancers of eye, brain, and central nervous system Protein evidence (Ezkurdia et al 2014) DeepTMHMM predicted membrane proteins
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases CD markers Transporters Accessory Factors Involved in Transport Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations Disease related genes FDA approved drug targets Biotech drugs Small molecule drugs Human disease related genes Cancers Head and neck cancers Cancers of the digestive system Cancers of the breast and female genital organs Cancers of the urinary system Cancers of eye, brain, and central nervous system Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) DeepTMHMM predicted membrane proteins
Show all
GO:0000166[nucleotide binding] GO:0001042[RNA polymerase I core binding] GO:0001934[positive regulation of protein phosphorylation] GO:0004672[protein kinase activity] GO:0004713[protein tyrosine kinase activity] GO:0004714[transmembrane receptor protein tyrosine kinase activity] GO:0004888[transmembrane signaling receptor activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005768[endosome] GO:0005769[early endosome] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006468[protein phosphorylation] GO:0007165[signal transduction] GO:0007166[cell surface receptor signaling pathway] GO:0007167[enzyme-linked receptor protein signaling pathway] GO:0007169[transmembrane receptor protein tyrosine kinase signaling pathway] GO:0008022[protein C-terminus binding] GO:0008284[positive regulation of cell population proliferation] GO:0009925[basal plasma membrane] GO:0010008[endosome membrane] GO:0014065[phosphatidylinositol 3-kinase signaling] GO:0016020[membrane] GO:0016021[integral component of membrane] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016323[basolateral plasma membrane] GO:0016740[transferase activity] GO:0018108[peptidyl-tyrosine phosphorylation] GO:0019838[growth factor binding] GO:0019903[protein phosphatase binding] GO:0022008[neurogenesis] GO:0030182[neuron differentiation] GO:0030307[positive regulation of cell growth] GO:0032587[ruffle membrane] GO:0032886[regulation of microtubule-based process] GO:0033674[positive regulation of kinase activity] GO:0035556[intracellular signal transduction] GO:0038127[ERBB signaling pathway] GO:0038134[ERBB2-EGFR signaling pathway] GO:0038143[ERBB3:ERBB2 complex] GO:0042060[wound healing] GO:0042127[regulation of cell population proliferation] GO:0042802[identical protein binding] GO:0042995[cell projection] GO:0043066[negative regulation of apoptotic process] GO:0043125[ErbB-3 class receptor binding] GO:0043235[receptor complex] GO:0043406[positive regulation of MAP kinase activity] GO:0043410[positive regulation of MAPK cascade] GO:0043547[positive regulation of GTPase activity] GO:0045727[positive regulation of translation] GO:0045765[regulation of angiogenesis] GO:0045785[positive regulation of cell adhesion] GO:0045943[positive regulation of transcription by RNA polymerase I] GO:0046777[protein autophosphorylation] GO:0046982[protein heterodimerization activity] GO:0048471[perinuclear region of cytoplasm] GO:0050679[positive regulation of epithelial cell proliferation] GO:0070372[regulation of ERK1 and ERK2 cascade] GO:0071363[cellular response to growth factor stimulus] GO:0071364[cellular response to epidermal growth factor stimulus] GO:0090314[positive regulation of protein targeting to membrane] GO:0098590[plasma membrane region]
The Human Protein Atlas project is funded
