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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Disease related genes
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
19
Cytoband
p13.12
Chromosome location (bp)
15235519 - 15332545
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Chromatin reader protein that recognizes and binds acetylated histones and plays a key role in transmission of epigenetic memory across cell divisions and transcription regulation 1,2,3,4,5. Remains associated with acetylated chromatin throughout the entire cell cycle and provides epigenetic memory for postmitotic G1 gene transcription by preserving acetylated chromatin status and maintaining high-order chromatin structure 6,7,8. During interphase, plays a key role in regulating the transcription of signal-inducible genes by associating with the P-TEFb complex and recruiting it to promoters 9,10,11,12,13. Also recruits P-TEFb complex to distal enhancers, so called anti-pause enhancers in collaboration with JMJD6 14,15,16,17,18. BRD4 and JMJD6 are required to form the transcriptionally active P-TEFb complex by displacing negative regulators such as HEXIM1 and 7SKsnRNA complex from P-TEFb, thereby transforming it into an active form that can then phosphorylate the C-terminal domain (CTD) of RNA polymerase II 19,20,21,22,23. Regulates differentiation of naive CD4(+) T-cells into T-helper Th17 by promoting recruitment of P-TEFb to promoters (By similarity). Promotes phosphorylation of 'Ser-2' of the C-terminal domain (CTD) of RNA polymerase II 24. According to a report, directly acts as an atypical protein kinase and mediates phosphorylation of 'Ser-2' of the C-terminal domain (CTD) of RNA polymerase II; these data however need additional evidences in vivo 25. In addition to acetylated histones, also recognizes and binds acetylated RELA, leading to further recruitment of the P-TEFb complex and subsequent activation of NF-kappa-B 26. Also acts as a regulator of p53/TP53-mediated transcription: following phosphorylation by CK2, recruited to p53/TP53 specific target promoters 27....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Chromatin regulator
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
DNA damage, Host-virus interaction, Transcription, Transcription regulation
Gene summary (Entrez)i
Useful information about the gene from Entrez
The protein encoded by this gene is homologous to the murine protein MCAP, which associates with chromosomes during mitosis, and to the human RING3 protein, a serine/threonine kinase. Each of these proteins contains two bromodomains, a conserved sequence motif which may be involved in chromatin targeting. This gene has been implicated as the chromosome 19 target of translocation t(15;19)(q13;p13.1), which defines an upper respiratory tract carcinoma in young people. Two alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
O60885 [Direct mapping] Bromodomain-containing protein 4
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000083[regulation of transcription involved in G1/S transition of mitotic cell cycle] GO:0000785[chromatin] GO:0000794[condensed nuclear chromosome] GO:0000976[transcription cis-regulatory region binding] GO:0002039[p53 binding] GO:0003682[chromatin binding] GO:0003712[transcription coregulator activity] GO:0003713[transcription coactivator activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005694[chromosome] GO:0006325[chromatin organization] GO:0006338[chromatin remodeling] GO:0006351[DNA-templated transcription] GO:0006355[regulation of DNA-templated transcription] GO:0006974[cellular response to DNA damage stimulus] GO:0008353[RNA polymerase II CTD heptapeptide repeat kinase activity] GO:0010971[positive regulation of G2/M transition of mitotic cell cycle] GO:0019899[enzyme binding] GO:0032968[positive regulation of transcription elongation by RNA polymerase II] GO:0043123[positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043922[negative regulation by host of viral transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0050727[regulation of inflammatory response] GO:0070577[lysine-acetylated histone binding] GO:0099122[RNA polymerase II C-terminal domain binding] GO:0106140[P-TEFb complex binding] GO:0140566[histone reader activity]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000083[regulation of transcription involved in G1/S transition of mitotic cell cycle] GO:0000785[chromatin] GO:0000794[condensed nuclear chromosome] GO:0000976[transcription cis-regulatory region binding] GO:0002039[p53 binding] GO:0003682[chromatin binding] GO:0003712[transcription coregulator activity] GO:0003713[transcription coactivator activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005694[chromosome] GO:0006325[chromatin organization] GO:0006338[chromatin remodeling] GO:0006351[DNA-templated transcription] GO:0006355[regulation of DNA-templated transcription] GO:0006974[cellular response to DNA damage stimulus] GO:0008353[RNA polymerase II CTD heptapeptide repeat kinase activity] GO:0010971[positive regulation of G2/M transition of mitotic cell cycle] GO:0019899[enzyme binding] GO:0032968[positive regulation of transcription elongation by RNA polymerase II] GO:0043123[positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0050727[regulation of inflammatory response] GO:0070577[lysine-acetylated histone binding] GO:0099122[RNA polymerase II C-terminal domain binding] GO:0106140[P-TEFb complex binding] GO:0140566[histone reader activity] GO:2000002[negative regulation of DNA damage checkpoint]
O60885 [Direct mapping] Bromodomain-containing protein 4
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000083[regulation of transcription involved in G1/S transition of mitotic cell cycle] GO:0000785[chromatin] GO:0000794[condensed nuclear chromosome] GO:0000976[transcription cis-regulatory region binding] GO:0002039[p53 binding] GO:0003682[chromatin binding] GO:0003712[transcription coregulator activity] GO:0003713[transcription coactivator activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005694[chromosome] GO:0006325[chromatin organization] GO:0006338[chromatin remodeling] GO:0006351[DNA-templated transcription] GO:0006355[regulation of DNA-templated transcription] GO:0006974[cellular response to DNA damage stimulus] GO:0008353[RNA polymerase II CTD heptapeptide repeat kinase activity] GO:0010971[positive regulation of G2/M transition of mitotic cell cycle] GO:0019899[enzyme binding] GO:0032968[positive regulation of transcription elongation by RNA polymerase II] GO:0043123[positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0050727[regulation of inflammatory response] GO:0070577[lysine-acetylated histone binding] GO:0099122[RNA polymerase II C-terminal domain binding] GO:0106140[P-TEFb complex binding] GO:0140566[histone reader activity]
M0QZD9 [Direct mapping] Bromodomain-containing protein 4
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
M0R0H4 [Direct mapping] Bromodomain-containing protein 4
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
O60885 [Direct mapping] Bromodomain-containing protein 4
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000083[regulation of transcription involved in G1/S transition of mitotic cell cycle] GO:0000785[chromatin] GO:0000794[condensed nuclear chromosome] GO:0000976[transcription cis-regulatory region binding] GO:0002039[p53 binding] GO:0003682[chromatin binding] GO:0003712[transcription coregulator activity] GO:0003713[transcription coactivator activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005694[chromosome] GO:0006325[chromatin organization] GO:0006338[chromatin remodeling] GO:0006351[DNA-templated transcription] GO:0006355[regulation of DNA-templated transcription] GO:0006974[cellular response to DNA damage stimulus] GO:0008353[RNA polymerase II CTD heptapeptide repeat kinase activity] GO:0010971[positive regulation of G2/M transition of mitotic cell cycle] GO:0019899[enzyme binding] GO:0032968[positive regulation of transcription elongation by RNA polymerase II] GO:0043123[positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043922[negative regulation by host of viral transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0050727[regulation of inflammatory response] GO:0070577[lysine-acetylated histone binding] GO:0099122[RNA polymerase II C-terminal domain binding] GO:0106140[P-TEFb complex binding] GO:0140566[histone reader activity]
The Human Protein Atlas project is funded
