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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Metabolic proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
19
Cytoband
q13.32
Chromosome location (bp)
47113274 - 47210636
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Ligase
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Metabolic proteins MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0004839[ubiquitin activating enzyme activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0008022[protein C-terminus binding] GO:0008047[enzyme activator activity] GO:0008641[ubiquitin-like modifier activating enzyme activity] GO:0016567[protein ubiquitination] GO:0016874[ligase activity] GO:0016925[protein sumoylation] GO:0019948[SUMO activating enzyme activity] GO:0031510[SUMO activating enzyme complex] GO:0032446[protein modification by small protein conjugation] GO:0033235[positive regulation of protein sumoylation] GO:0036211[protein modification process] GO:0043008[ATP-dependent protein binding] GO:0044388[small protein activating enzyme binding] GO:0046982[protein heterodimerization activity] GO:1903955[positive regulation of protein targeting to mitochondrion]
Metabolic proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004839[ubiquitin activating enzyme activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0008022[protein C-terminus binding] GO:0008047[enzyme activator activity] GO:0008641[ubiquitin-like modifier activating enzyme activity] GO:0016567[protein ubiquitination] GO:0016874[ligase activity] GO:0016925[protein sumoylation] GO:0019948[SUMO activating enzyme activity] GO:0031510[SUMO activating enzyme complex] GO:0032446[protein modification by small protein conjugation] GO:0033235[positive regulation of protein sumoylation] GO:0036211[protein modification process] GO:0043008[ATP-dependent protein binding] GO:0044388[small protein activating enzyme binding] GO:0046982[protein heterodimerization activity] GO:1903955[positive regulation of protein targeting to mitochondrion]
Metabolic proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004839[ubiquitin activating enzyme activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0008022[protein C-terminus binding] GO:0008047[enzyme activator activity] GO:0008641[ubiquitin-like modifier activating enzyme activity] GO:0016567[protein ubiquitination] GO:0016874[ligase activity] GO:0016925[protein sumoylation] GO:0019948[SUMO activating enzyme activity] GO:0031510[SUMO activating enzyme complex] GO:0032446[protein modification by small protein conjugation] GO:0033235[positive regulation of protein sumoylation] GO:0036211[protein modification process] GO:0043008[ATP-dependent protein binding] GO:0044388[small protein activating enzyme binding] GO:0046982[protein heterodimerization activity] GO:1903955[positive regulation of protein targeting to mitochondrion]
Metabolic proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
The Human Protein Atlas project is funded
