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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Disease related genes Human disease related genes Potential drug targets Transporters
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
1
Cytoband
p36.22
Chromosome location (bp)
10472288 - 10630758
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor 1,2,3. The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm (By similarity). Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix 4,5. Plays a key role for peroxisome movement through a direct interaction with tubulin 6....show less
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Protein transport, Translocation, Transport
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes an essential component of the peroxisomal import machinery. The protein is integrated into peroxisome membranes with its C-terminus exposed to the cytosol, and interacts with the cytosolic receptor for proteins containing a PTS1 peroxisomal targeting signal. The protein also functions as a transcriptional corepressor and interacts with a histone deacetylase. A mutation in this gene results in one form of Zellweger syndrome. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
O75381 [Direct mapping] Peroxisomal membrane protein PEX14
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Transporters Primary Active Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Potential drug targets Human disease related genes Congenital disorders of metabolism Peroxisomal diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001650[fibrillar center] GO:0003714[transcription corepressor activity] GO:0005102[signaling receptor binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005777[peroxisome] GO:0005778[peroxisomal membrane] GO:0005829[cytosol] GO:0007031[peroxisome organization] GO:0008017[microtubule binding] GO:0008320[protein transmembrane transporter activity] GO:0015031[protein transport] GO:0016020[membrane] GO:0016558[protein import into peroxisome matrix] GO:0016560[protein import into peroxisome matrix, docking] GO:0016561[protein import into peroxisome matrix, translocation] GO:0030674[protein-macromolecule adaptor activity] GO:0032091[negative regulation of protein binding] GO:0032991[protein-containing complex] GO:0034453[microtubule anchoring] GO:0036250[peroxisome transport along microtubule] GO:0042802[identical protein binding] GO:0043433[negative regulation of DNA-binding transcription factor activity] GO:0044721[protein import into peroxisome matrix, substrate release] GO:0045892[negative regulation of DNA-templated transcription] GO:0047485[protein N-terminus binding] GO:0048487[beta-tubulin binding] GO:0065003[protein-containing complex assembly] GO:1990429[peroxisomal importomer complex]
The Human Protein Atlas project is funded
