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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Disease related genes Human disease related genes Plasma proteins Ribosomal proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
1
Cytoband
p36.11
Chromosome location (bp)
23691742 - 23696835
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell 1,2. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules 3,4. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain 5,6. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel 7,8. As part of the 5S RNP/5S ribonucleoprotein particle it is an essential component of the LSU, required for its formation and the maturation of rRNAs 9,10,11. It also couples ribosome biogenesis to p53/TP53 activation. As part of the 5S RNP it accumulates in the nucleoplasm and inhibits MDM2, when ribosome biogenesis is perturbed, mediating the stabilization and the activation of TP53 12. Promotes nucleolar location of PML (By similarity)....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L5P family of ribosomal proteins. It is located in the cytoplasm. The protein probably associates with the 5S rRNA. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Dec 2010]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Ribosomal proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Disease related genes Human disease related genes Cardiovascular diseases Hematologic diseases Other congenital disorders Ribosomopathies Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Cardiovascular diseases Hematologic diseases Other congenital disorders Ribosomopathies Protein evidence (Ezkurdia et al 2014)
Q5VVD0 [Target identity:100%; Query identity:100%] 60S ribosomal protein L11
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Ribosomal proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Disease related genes Human disease related genes Cardiovascular diseases Hematologic diseases Other congenital disorders Ribosomopathies Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000027[ribosomal large subunit assembly] GO:0002181[cytoplasmic translation] GO:0003723[RNA binding] GO:0003735[structural constituent of ribosome] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005730[nucleolus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005840[ribosome] GO:0006364[rRNA processing] GO:0006412[translation] GO:0006605[protein targeting] GO:0008097[5S rRNA binding] GO:0010628[positive regulation of gene expression] GO:0016020[membrane] GO:0019843[rRNA binding] GO:0022625[cytosolic large ribosomal subunit] GO:0022626[cytosolic ribosome] GO:0031625[ubiquitin protein ligase binding] GO:0032092[positive regulation of protein binding] GO:0032435[negative regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0032991[protein-containing complex] GO:0034504[protein localization to nucleus] GO:0042273[ribosomal large subunit biogenesis] GO:0042788[polysomal ribosome] GO:0050821[protein stabilization] GO:0070062[extracellular exosome] GO:1901796[regulation of signal transduction by p53 class mediator] GO:1901798[positive regulation of signal transduction by p53 class mediator] GO:1902255[positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator] GO:1904667[negative regulation of ubiquitin protein ligase activity] GO:1990904[ribonucleoprotein complex] GO:1990948[ubiquitin ligase inhibitor activity] GO:2000059[negative regulation of ubiquitin-dependent protein catabolic process] GO:2000435[negative regulation of protein neddylation]
The Human Protein Atlas project is funded
