GENERAL INFORMATIONi
Gene namei HSPD1
Synonyms GroEL, HSP60, SPG13
Gene descriptioni Heat shock protein family D (Hsp60) member 1
Protein classi Cancer-related genes
Disease related genes
Enzymes
Human disease related genes
Plasma proteins
Potential drug targets
Predicted locationi Intracellular
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi
Chromosome 2
Cytoband q33.1
Chromosome location (bp) 197486584 - 197516737
Number of transcriptsi 13
Ensembl ENSG00000144381 (version 109)
Entrez gene 3329
HGNC HGNC:5261
UniProt P10809 (UniProt - Evidence at protein level)
neXtProt NX_P10809
GeneCards HSPD1
Antibodypedia HSPD1 antibodies


PROTEIN FUNCTION
Protein function (UniProt)i Chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp10, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix 1, 2. The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein (Probable). show less
Molecular function (UniProt)i Chaperone, Isomerase
Biological process (UniProt)i Host-virus interaction
Ligand (UniProt)i ATP-binding, Nucleotide-binding
Gene summary (Entrez)i This gene encodes a member of the chaperonin family. The encoded mitochondrial protein may function as a signaling molecule in the innate immune system. This protein is essential for the folding and assembly of newly imported proteins in the mitochondria. This gene is adjacent to a related family member and the region between the 2 genes functions as a bidirectional promoter. Several pseudogenes have been associated with this gene. Two transcript variants encoding the same protein have been identified for this gene. Mutations associated with this gene cause autosomal recessive spastic paraplegia 13. [provided by RefSeq, Jun 2010] show less
PROTEIN INFORMATIONi
Splice variant SwissProt TrEMBL Protein class Gene ontology Length & mass Signal peptide
(predicted)		 Transmembrane regions
(predicted)
HSPD1-201
ENSP00000340019
ENST00000345042
P10809
[Direct mapping] 60 kDa heat shock protein, mitochondrial
Show all
A0A024R3X4
[Target identity:100%; Query identity:100%] 60 kDa heat shock protein, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Isomerase
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Human disease related genes
   Congenital disorders of metabolism
   Congenital disorders of lipid/glycolipid metabolism
   Nervous system diseases
   Other nervous and sensory system diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0001530 [lipopolysaccharide binding]
GO:0002039 [p53 binding]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002842 [positive regulation of T cell mediated immune response to tumor cell]
GO:0003688 [DNA replication origin binding]
GO:0003697 [single-stranded DNA binding]
GO:0003723 [RNA binding]
GO:0003725 [double-stranded RNA binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005759 [mitochondrial matrix]
GO:0005769 [early endosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005905 [clathrin-coated pit]
GO:0006457 [protein folding]
GO:0006458 ['de novo' protein folding]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0006986 [response to unfolded protein]
GO:0008035 [high-density lipoprotein particle binding]
GO:0008637 [apoptotic mitochondrial changes]
GO:0009409 [response to cold]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0016853 [isomerase activity]
GO:0016887 [ATP hydrolysis activity]
GO:0019899 [enzyme binding]
GO:0030135 [coated vesicle]
GO:0030141 [secretory granule]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032727 [positive regulation of interferon-alpha production]
GO:0032729 [positive regulation of interferon-gamma production]
GO:0032733 [positive regulation of interleukin-10 production]
GO:0032735 [positive regulation of interleukin-12 production]
GO:0032755 [positive regulation of interleukin-6 production]
GO:0032991 [protein-containing complex]
GO:0034185 [apolipoprotein binding]
GO:0034186 [apolipoprotein A-I binding]
GO:0034514 [mitochondrial unfolded protein response]
GO:0042026 [protein refolding]
GO:0042100 [B cell proliferation]
GO:0042110 [T cell activation]
GO:0042113 [B cell activation]
GO:0043032 [positive regulation of macrophage activation]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0045041 [protein import into mitochondrial intermembrane space]
GO:0046696 [lipopolysaccharide receptor complex]
GO:0048291 [isotype switching to IgG isotypes]
GO:0050821 [protein stabilization]
GO:0050870 [positive regulation of T cell activation]
GO:0051082 [unfolded protein binding]
GO:0051087 [chaperone binding]
GO:0051131 [chaperone-mediated protein complex assembly]
GO:0051604 [protein maturation]
GO:0051702 [biological process involved in interaction with symbiont]
GO:0070062 [extracellular exosome]
GO:0097225 [sperm midpiece]
GO:0140662 [ATP-dependent protein folding chaperone]
Show all
 573 aa
61.1 kDa 		No 0
HSPD1-202
ENSP00000373620
ENST00000388968
P10809
[Direct mapping] 60 kDa heat shock protein, mitochondrial
Show all
A0A024R3X4
[Target identity:100%; Query identity:100%] 60 kDa heat shock protein, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Isomerase
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Human disease related genes
   Congenital disorders of metabolism
   Congenital disorders of lipid/glycolipid metabolism
   Nervous system diseases
   Other nervous and sensory system diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0001530 [lipopolysaccharide binding]
GO:0002039 [p53 binding]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002842 [positive regulation of T cell mediated immune response to tumor cell]
GO:0003688 [DNA replication origin binding]
GO:0003697 [single-stranded DNA binding]
GO:0003723 [RNA binding]
GO:0003725 [double-stranded RNA binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005759 [mitochondrial matrix]
GO:0005769 [early endosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005905 [clathrin-coated pit]
GO:0006457 [protein folding]
GO:0006458 ['de novo' protein folding]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0006986 [response to unfolded protein]
GO:0008035 [high-density lipoprotein particle binding]
GO:0008637 [apoptotic mitochondrial changes]
GO:0009409 [response to cold]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0016853 [isomerase activity]
GO:0016887 [ATP hydrolysis activity]
GO:0019899 [enzyme binding]
GO:0030135 [coated vesicle]
GO:0030141 [secretory granule]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032727 [positive regulation of interferon-alpha production]
GO:0032729 [positive regulation of interferon-gamma production]
GO:0032733 [positive regulation of interleukin-10 production]
GO:0032735 [positive regulation of interleukin-12 production]
GO:0032755 [positive regulation of interleukin-6 production]
GO:0032991 [protein-containing complex]
GO:0034185 [apolipoprotein binding]
GO:0034186 [apolipoprotein A-I binding]
GO:0034514 [mitochondrial unfolded protein response]
GO:0042026 [protein refolding]
GO:0042100 [B cell proliferation]
GO:0042110 [T cell activation]
GO:0042113 [B cell activation]
GO:0043032 [positive regulation of macrophage activation]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045041 [protein import into mitochondrial intermembrane space]
GO:0046696 [lipopolysaccharide receptor complex]
GO:0048291 [isotype switching to IgG isotypes]
GO:0050821 [protein stabilization]
GO:0050870 [positive regulation of T cell activation]
GO:0051082 [unfolded protein binding]
GO:0051087 [chaperone binding]
GO:0051131 [chaperone-mediated protein complex assembly]
GO:0051604 [protein maturation]
GO:0051702 [biological process involved in interaction with symbiont]
GO:0070062 [extracellular exosome]
GO:0097225 [sperm midpiece]
GO:0097524 [sperm plasma membrane]
GO:0098761 [cellular response to interleukin-7]
GO:0140494 [migrasome]
GO:0140662 [ATP-dependent protein folding chaperone]
Show all
 573 aa
61.1 kDa 		No 0
HSPD1-203
ENSP00000412227
ENST00000418022
P10809
[Direct mapping] 60 kDa heat shock protein, mitochondrial
Show all
C9J0S9
[Direct mapping] 60 kDa heat shock protein, mitochondrial
A0A024R3X4
[Target identity:100%; Query identity:100%] 60 kDa heat shock protein, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Isomerase
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Human disease related genes
   Congenital disorders of metabolism
   Congenital disorders of lipid/glycolipid metabolism
   Nervous system diseases
   Other nervous and sensory system diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0001530 [lipopolysaccharide binding]
GO:0002039 [p53 binding]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002842 [positive regulation of T cell mediated immune response to tumor cell]
GO:0003688 [DNA replication origin binding]
GO:0003697 [single-stranded DNA binding]
GO:0003723 [RNA binding]
GO:0003725 [double-stranded RNA binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005759 [mitochondrial matrix]
GO:0005769 [early endosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005905 [clathrin-coated pit]
GO:0006457 [protein folding]
GO:0006458 ['de novo' protein folding]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0006986 [response to unfolded protein]
GO:0008035 [high-density lipoprotein particle binding]
GO:0008637 [apoptotic mitochondrial changes]
GO:0009409 [response to cold]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0016853 [isomerase activity]
GO:0016887 [ATP hydrolysis activity]
GO:0019899 [enzyme binding]
GO:0030135 [coated vesicle]
GO:0030141 [secretory granule]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032727 [positive regulation of interferon-alpha production]
GO:0032729 [positive regulation of interferon-gamma production]
GO:0032733 [positive regulation of interleukin-10 production]
GO:0032735 [positive regulation of interleukin-12 production]
GO:0032755 [positive regulation of interleukin-6 production]
GO:0032991 [protein-containing complex]
GO:0034185 [apolipoprotein binding]
GO:0034186 [apolipoprotein A-I binding]
GO:0034514 [mitochondrial unfolded protein response]
GO:0042026 [protein refolding]
GO:0042100 [B cell proliferation]
GO:0042110 [T cell activation]
GO:0042113 [B cell activation]
GO:0043032 [positive regulation of macrophage activation]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0045041 [protein import into mitochondrial intermembrane space]
GO:0046696 [lipopolysaccharide receptor complex]
GO:0048291 [isotype switching to IgG isotypes]
GO:0050821 [protein stabilization]
GO:0050870 [positive regulation of T cell activation]
GO:0051082 [unfolded protein binding]
GO:0051087 [chaperone binding]
GO:0051131 [chaperone-mediated protein complex assembly]
GO:0051604 [protein maturation]
GO:0051702 [biological process involved in interaction with symbiont]
GO:0070062 [extracellular exosome]
GO:0097225 [sperm midpiece]
GO:0140662 [ATP-dependent protein folding chaperone]
Show all
 573 aa
61.1 kDa 		No 0
HSPD1-204
ENSP00000414446
ENST00000426480
P10809
[Direct mapping] 60 kDa heat shock protein, mitochondrial
Show all
C9JL25
[Direct mapping] 60 kDa heat shock protein, mitochondrial
A0A024R3X4
[Target identity:100%; Query identity:100%] 60 kDa heat shock protein, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Isomerase
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Human disease related genes
   Congenital disorders of metabolism
   Congenital disorders of lipid/glycolipid metabolism
   Nervous system diseases
   Other nervous and sensory system diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0001530 [lipopolysaccharide binding]
GO:0002039 [p53 binding]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002842 [positive regulation of T cell mediated immune response to tumor cell]
GO:0003688 [DNA replication origin binding]
GO:0003697 [single-stranded DNA binding]
GO:0003723 [RNA binding]
GO:0003725 [double-stranded RNA binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005759 [mitochondrial matrix]
GO:0005769 [early endosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005905 [clathrin-coated pit]
GO:0006457 [protein folding]
GO:0006458 ['de novo' protein folding]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0006986 [response to unfolded protein]
GO:0008035 [high-density lipoprotein particle binding]
GO:0008637 [apoptotic mitochondrial changes]
GO:0009409 [response to cold]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0016853 [isomerase activity]
GO:0016887 [ATP hydrolysis activity]
GO:0019899 [enzyme binding]
GO:0030135 [coated vesicle]
GO:0030141 [secretory granule]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032727 [positive regulation of interferon-alpha production]
GO:0032729 [positive regulation of interferon-gamma production]
GO:0032733 [positive regulation of interleukin-10 production]
GO:0032735 [positive regulation of interleukin-12 production]
GO:0032755 [positive regulation of interleukin-6 production]
GO:0032991 [protein-containing complex]
GO:0034185 [apolipoprotein binding]
GO:0034186 [apolipoprotein A-I binding]
GO:0034514 [mitochondrial unfolded protein response]
GO:0042026 [protein refolding]
GO:0042100 [B cell proliferation]
GO:0042110 [T cell activation]
GO:0042113 [B cell activation]
GO:0043032 [positive regulation of macrophage activation]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0045041 [protein import into mitochondrial intermembrane space]
GO:0046696 [lipopolysaccharide receptor complex]
GO:0048291 [isotype switching to IgG isotypes]
GO:0050821 [protein stabilization]
GO:0050870 [positive regulation of T cell activation]
GO:0051082 [unfolded protein binding]
GO:0051087 [chaperone binding]
GO:0051131 [chaperone-mediated protein complex assembly]
GO:0051604 [protein maturation]
GO:0051702 [biological process involved in interaction with symbiont]
GO:0070062 [extracellular exosome]
GO:0097225 [sperm midpiece]
GO:0140662 [ATP-dependent protein folding chaperone]
Show all
 573 aa
61.1 kDa 		No 0
HSPD1-205
ENSP00000396460
ENST00000428204
P10809
[Direct mapping] 60 kDa heat shock protein, mitochondrial
Show all
C9JCQ4
[Direct mapping] 60 kDa heat shock protein, mitochondrial
A0A024R3X4
[Target identity:100%; Query identity:100%] 60 kDa heat shock protein, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Isomerase
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Human disease related genes
   Congenital disorders of metabolism
   Congenital disorders of lipid/glycolipid metabolism
   Nervous system diseases
   Other nervous and sensory system diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0001530 [lipopolysaccharide binding]
GO:0002039 [p53 binding]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002842 [positive regulation of T cell mediated immune response to tumor cell]
GO:0003688 [DNA replication origin binding]
GO:0003697 [single-stranded DNA binding]
GO:0003723 [RNA binding]
GO:0003725 [double-stranded RNA binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005759 [mitochondrial matrix]
GO:0005769 [early endosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005905 [clathrin-coated pit]
GO:0006457 [protein folding]
GO:0006458 ['de novo' protein folding]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0006986 [response to unfolded protein]
GO:0008035 [high-density lipoprotein particle binding]
GO:0008637 [apoptotic mitochondrial changes]
GO:0009409 [response to cold]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0016853 [isomerase activity]
GO:0016887 [ATP hydrolysis activity]
GO:0019899 [enzyme binding]
GO:0030135 [coated vesicle]
GO:0030141 [secretory granule]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032727 [positive regulation of interferon-alpha production]
GO:0032729 [positive regulation of interferon-gamma production]
GO:0032733 [positive regulation of interleukin-10 production]
GO:0032735 [positive regulation of interleukin-12 production]
GO:0032755 [positive regulation of interleukin-6 production]
GO:0032991 [protein-containing complex]
GO:0034185 [apolipoprotein binding]
GO:0034186 [apolipoprotein A-I binding]
GO:0034514 [mitochondrial unfolded protein response]
GO:0042026 [protein refolding]
GO:0042100 [B cell proliferation]
GO:0042110 [T cell activation]
GO:0042113 [B cell activation]
GO:0043032 [positive regulation of macrophage activation]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0045041 [protein import into mitochondrial intermembrane space]
GO:0046696 [lipopolysaccharide receptor complex]
GO:0048291 [isotype switching to IgG isotypes]
GO:0050821 [protein stabilization]
GO:0050870 [positive regulation of T cell activation]
GO:0051082 [unfolded protein binding]
GO:0051087 [chaperone binding]
GO:0051131 [chaperone-mediated protein complex assembly]
GO:0051604 [protein maturation]
GO:0051702 [biological process involved in interaction with symbiont]
GO:0070062 [extracellular exosome]
GO:0097225 [sperm midpiece]
GO:0140662 [ATP-dependent protein folding chaperone]
Show all
 573 aa
61.1 kDa 		No 0
HSPD1-206
ENSP00000393670
ENST00000430176
E7ESH4
[Direct mapping] 60 kDa heat shock protein, mitochondrial
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Congenital disorders of metabolism
   Congenital disorders of lipid/glycolipid metabolism
   Nervous system diseases
   Other nervous and sensory system diseases
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0005524 [ATP binding]
GO:0005739 [mitochondrion]
GO:0042026 [protein refolding]
GO:0140662 [ATP-dependent protein folding chaperone]
Show all
 231 aa
24.9 kDa 		No 0
HSPD1-207
ENSP00000402478
ENST00000439605
P10809
[Direct mapping] 60 kDa heat shock protein, mitochondrial
Show all
C9JL19
[Direct mapping] 60 kDa heat shock protein, mitochondrial
A0A024R3X4
[Target identity:100%; Query identity:100%] 60 kDa heat shock protein, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Isomerase
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Human disease related genes
   Congenital disorders of metabolism
   Congenital disorders of lipid/glycolipid metabolism
   Nervous system diseases
   Other nervous and sensory system diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0001530 [lipopolysaccharide binding]
GO:0002039 [p53 binding]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002842 [positive regulation of T cell mediated immune response to tumor cell]
GO:0003688 [DNA replication origin binding]
GO:0003697 [single-stranded DNA binding]
GO:0003723 [RNA binding]
GO:0003725 [double-stranded RNA binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005759 [mitochondrial matrix]
GO:0005769 [early endosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005905 [clathrin-coated pit]
GO:0006457 [protein folding]
GO:0006458 ['de novo' protein folding]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0006986 [response to unfolded protein]
GO:0008035 [high-density lipoprotein particle binding]
GO:0008637 [apoptotic mitochondrial changes]
GO:0009409 [response to cold]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0016853 [isomerase activity]
GO:0016887 [ATP hydrolysis activity]
GO:0019899 [enzyme binding]
GO:0030135 [coated vesicle]
GO:0030141 [secretory granule]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032727 [positive regulation of interferon-alpha production]
GO:0032729 [positive regulation of interferon-gamma production]
GO:0032733 [positive regulation of interleukin-10 production]
GO:0032735 [positive regulation of interleukin-12 production]
GO:0032755 [positive regulation of interleukin-6 production]
GO:0032991 [protein-containing complex]
GO:0034185 [apolipoprotein binding]
GO:0034186 [apolipoprotein A-I binding]
GO:0034514 [mitochondrial unfolded protein response]
GO:0042026 [protein refolding]
GO:0042100 [B cell proliferation]
GO:0042110 [T cell activation]
GO:0042113 [B cell activation]
GO:0043032 [positive regulation of macrophage activation]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0045041 [protein import into mitochondrial intermembrane space]
GO:0046696 [lipopolysaccharide receptor complex]
GO:0048291 [isotype switching to IgG isotypes]
GO:0050821 [protein stabilization]
GO:0050870 [positive regulation of T cell activation]
GO:0051082 [unfolded protein binding]
GO:0051087 [chaperone binding]
GO:0051131 [chaperone-mediated protein complex assembly]
GO:0051604 [protein maturation]
GO:0051702 [biological process involved in interaction with symbiont]
GO:0070062 [extracellular exosome]
GO:0097225 [sperm midpiece]
GO:0140662 [ATP-dependent protein folding chaperone]
Show all
 573 aa
61.1 kDa 		No 0
HSPD1-209
ENSP00000412717
ENST00000452200
P10809
[Direct mapping] 60 kDa heat shock protein, mitochondrial
Show all
E7EXB4
[Direct mapping] 60 kDa heat shock protein, mitochondrial
A0A024R3X4
[Target identity:100%; Query identity:100%] 60 kDa heat shock protein, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Isomerase
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Human disease related genes
   Congenital disorders of metabolism
   Congenital disorders of lipid/glycolipid metabolism
   Nervous system diseases
   Other nervous and sensory system diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0001530 [lipopolysaccharide binding]
GO:0002039 [p53 binding]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002842 [positive regulation of T cell mediated immune response to tumor cell]
GO:0003688 [DNA replication origin binding]
GO:0003697 [single-stranded DNA binding]
GO:0003723 [RNA binding]
GO:0003725 [double-stranded RNA binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005759 [mitochondrial matrix]
GO:0005769 [early endosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005905 [clathrin-coated pit]
GO:0006457 [protein folding]
GO:0006458 ['de novo' protein folding]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0006986 [response to unfolded protein]
GO:0008035 [high-density lipoprotein particle binding]
GO:0008637 [apoptotic mitochondrial changes]
GO:0009409 [response to cold]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0016853 [isomerase activity]
GO:0016887 [ATP hydrolysis activity]
GO:0019899 [enzyme binding]
GO:0030135 [coated vesicle]
GO:0030141 [secretory granule]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032727 [positive regulation of interferon-alpha production]
GO:0032729 [positive regulation of interferon-gamma production]
GO:0032733 [positive regulation of interleukin-10 production]
GO:0032735 [positive regulation of interleukin-12 production]
GO:0032755 [positive regulation of interleukin-6 production]
GO:0032991 [protein-containing complex]
GO:0034185 [apolipoprotein binding]
GO:0034186 [apolipoprotein A-I binding]
GO:0034514 [mitochondrial unfolded protein response]
GO:0042026 [protein refolding]
GO:0042100 [B cell proliferation]
GO:0042110 [T cell activation]
GO:0042113 [B cell activation]
GO:0043032 [positive regulation of macrophage activation]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0045041 [protein import into mitochondrial intermembrane space]
GO:0046696 [lipopolysaccharide receptor complex]
GO:0048291 [isotype switching to IgG isotypes]
GO:0050821 [protein stabilization]
GO:0050870 [positive regulation of T cell activation]
GO:0051082 [unfolded protein binding]
GO:0051087 [chaperone binding]
GO:0051131 [chaperone-mediated protein complex assembly]
GO:0051604 [protein maturation]
GO:0051702 [biological process involved in interaction with symbiont]
GO:0070062 [extracellular exosome]
GO:0097225 [sperm midpiece]
GO:0140662 [ATP-dependent protein folding chaperone]
Show all
 573 aa
61.1 kDa 		No 0
HSPD1-214
ENSP00000503144
ENST00000676933
A0A7I2V2X6
[Direct mapping] 60 kDa heat shock protein, mitochondrial
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Congenital disorders of metabolism
   Congenital disorders of lipid/glycolipid metabolism
   Nervous system diseases
   Other nervous and sensory system diseases
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005524 [ATP binding]
GO:0006457 [protein folding]
GO:0042026 [protein refolding]
GO:0140662 [ATP-dependent protein folding chaperone]
Show all
 541 aa
57.8 kDa 		No 0
HSPD1-218
ENSP00000503139
ENST00000677913
P10809
[Direct mapping] 60 kDa heat shock protein, mitochondrial
Show all
A0A024R3X4
[Target identity:100%; Query identity:100%] 60 kDa heat shock protein, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Isomerase
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Human disease related genes
   Congenital disorders of metabolism
   Congenital disorders of lipid/glycolipid metabolism
   Nervous system diseases
   Other nervous and sensory system diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0001530 [lipopolysaccharide binding]
GO:0002039 [p53 binding]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002842 [positive regulation of T cell mediated immune response to tumor cell]
GO:0003688 [DNA replication origin binding]
GO:0003697 [single-stranded DNA binding]
GO:0003723 [RNA binding]
GO:0003725 [double-stranded RNA binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005759 [mitochondrial matrix]
GO:0005769 [early endosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005905 [clathrin-coated pit]
GO:0006457 [protein folding]
GO:0006458 ['de novo' protein folding]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0006986 [response to unfolded protein]
GO:0008035 [high-density lipoprotein particle binding]
GO:0008637 [apoptotic mitochondrial changes]
GO:0009409 [response to cold]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0016853 [isomerase activity]
GO:0016887 [ATP hydrolysis activity]
GO:0019899 [enzyme binding]
GO:0030135 [coated vesicle]
GO:0030141 [secretory granule]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032727 [positive regulation of interferon-alpha production]
GO:0032729 [positive regulation of interferon-gamma production]
GO:0032733 [positive regulation of interleukin-10 production]
GO:0032735 [positive regulation of interleukin-12 production]
GO:0032755 [positive regulation of interleukin-6 production]
GO:0032991 [protein-containing complex]
GO:0034185 [apolipoprotein binding]
GO:0034186 [apolipoprotein A-I binding]
GO:0034514 [mitochondrial unfolded protein response]
GO:0042026 [protein refolding]
GO:0042100 [B cell proliferation]
GO:0042110 [T cell activation]
GO:0042113 [B cell activation]
GO:0043032 [positive regulation of macrophage activation]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0045041 [protein import into mitochondrial intermembrane space]
GO:0046696 [lipopolysaccharide receptor complex]
GO:0048291 [isotype switching to IgG isotypes]
GO:0050821 [protein stabilization]
GO:0050870 [positive regulation of T cell activation]
GO:0051082 [unfolded protein binding]
GO:0051087 [chaperone binding]
GO:0051131 [chaperone-mediated protein complex assembly]
GO:0051604 [protein maturation]
GO:0051702 [biological process involved in interaction with symbiont]
GO:0070062 [extracellular exosome]
GO:0097225 [sperm midpiece]
GO:0140662 [ATP-dependent protein folding chaperone]
Show all
 573 aa
61.1 kDa 		No 0
HSPD1-219
ENSP00000503910
ENST00000678170
A0A7I2YQK6
[Direct mapping] 60 kDa heat shock protein, mitochondrial
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Congenital disorders of metabolism
   Congenital disorders of lipid/glycolipid metabolism
   Nervous system diseases
   Other nervous and sensory system diseases
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005524 [ATP binding]
GO:0006457 [protein folding]
GO:0042026 [protein refolding]
GO:0140662 [ATP-dependent protein folding chaperone]
Show all
 482 aa
51.2 kDa 		No 0
HSPD1-221
ENSP00000504328
ENST00000678621
A0A7I2V599
[Direct mapping] 60 kDa heat shock protein, mitochondrial
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Congenital disorders of metabolism
   Congenital disorders of lipid/glycolipid metabolism
   Nervous system diseases
   Other nervous and sensory system diseases
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0005524 [ATP binding]
GO:0006457 [protein folding]
GO:0042026 [protein refolding]
GO:0140662 [ATP-dependent protein folding chaperone]
Show all
 537 aa
57.8 kDa 		No 0
HSPD1-222
ENSP00000503894
ENST00000678761
P10809
[Direct mapping] 60 kDa heat shock protein, mitochondrial
Show all
A0A024R3X4
[Target identity:100%; Query identity:100%] 60 kDa heat shock protein, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Isomerase
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Human disease related genes
   Congenital disorders of metabolism
   Congenital disorders of lipid/glycolipid metabolism
   Nervous system diseases
   Other nervous and sensory system diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0001530 [lipopolysaccharide binding]
GO:0002039 [p53 binding]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002842 [positive regulation of T cell mediated immune response to tumor cell]
GO:0003688 [DNA replication origin binding]
GO:0003697 [single-stranded DNA binding]
GO:0003723 [RNA binding]
GO:0003725 [double-stranded RNA binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005759 [mitochondrial matrix]
GO:0005769 [early endosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005905 [clathrin-coated pit]
GO:0006457 [protein folding]
GO:0006458 ['de novo' protein folding]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0006986 [response to unfolded protein]
GO:0008035 [high-density lipoprotein particle binding]
GO:0008637 [apoptotic mitochondrial changes]
GO:0009409 [response to cold]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0016853 [isomerase activity]
GO:0016887 [ATP hydrolysis activity]
GO:0019899 [enzyme binding]
GO:0030135 [coated vesicle]
GO:0030141 [secretory granule]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032727 [positive regulation of interferon-alpha production]
GO:0032729 [positive regulation of interferon-gamma production]
GO:0032733 [positive regulation of interleukin-10 production]
GO:0032735 [positive regulation of interleukin-12 production]
GO:0032755 [positive regulation of interleukin-6 production]
GO:0032991 [protein-containing complex]
GO:0034185 [apolipoprotein binding]
GO:0034186 [apolipoprotein A-I binding]
GO:0034514 [mitochondrial unfolded protein response]
GO:0042026 [protein refolding]
GO:0042100 [B cell proliferation]
GO:0042110 [T cell activation]
GO:0042113 [B cell activation]
GO:0043032 [positive regulation of macrophage activation]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0045041 [protein import into mitochondrial intermembrane space]
GO:0046696 [lipopolysaccharide receptor complex]
GO:0048291 [isotype switching to IgG isotypes]
GO:0050821 [protein stabilization]
GO:0050870 [positive regulation of T cell activation]
GO:0051082 [unfolded protein binding]
GO:0051087 [chaperone binding]
GO:0051131 [chaperone-mediated protein complex assembly]
GO:0051604 [protein maturation]
GO:0051702 [biological process involved in interaction with symbiont]
GO:0070062 [extracellular exosome]
GO:0097225 [sperm midpiece]
GO:0140662 [ATP-dependent protein folding chaperone]
Show all
 573 aa
61.1 kDa 		No 0

Contact

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The Human Protein Atlas

The Human Protein Atlas project is funded
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contact@proteinatlas.org