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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
FDA approved drug targets Nuclear receptors Plasma proteins Transcription factors Transporters
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
3
Cytoband
q13.33
Chromosome location (bp)
119780484 - 119818487
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds. Activated by the antibiotic rifampicin and various plant metabolites, such as hyperforin, guggulipid, colupulone, and isoflavones. Response to specific ligands is species-specific. Activated by naturally occurring steroids, such as pregnenolone and progesterone. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Activator, DNA-binding, Receptor
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Transcription, Transcription regulation
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Metal-binding, Zinc
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG (CUG) translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
O75469 [Direct mapping] Nuclear receptor subfamily 1 group I member 2
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F1D8P9 [Target identity:100%; Query identity:100%] Nuclear receptor subfamily 1, group I, member 2, isoform CRA_b; Pregnane X nuclear receptor variant 2
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Nuclear receptors Transporters Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Zinc-coordinating DNA-binding domains FDA approved drug targets Small molecule drugs Mapped to neXtProt neXtProt - Evidence at protein level
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000977[RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0004879[nuclear receptor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005667[transcription regulator complex] GO:0006351[DNA-templated transcription] GO:0006355[regulation of DNA-templated transcription] GO:0006805[xenobiotic metabolic process] GO:0007165[signal transduction] GO:0008202[steroid metabolic process] GO:0008270[zinc ion binding] GO:0016604[nuclear body] GO:0016922[nuclear receptor binding] GO:0030154[cell differentiation] GO:0030522[intracellular receptor signaling pathway] GO:0042178[xenobiotic catabolic process] GO:0042908[xenobiotic transport] GO:0043565[sequence-specific DNA binding] GO:0045111[intermediate filament cytoskeleton] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding] GO:1990837[sequence-specific double-stranded DNA binding]
O75469 [Direct mapping] Nuclear receptor subfamily 1 group I member 2
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J3KPQ3 [Direct mapping] Nuclear receptor subfamily 1 group I member 2; Nuclear receptor subfamily 1, group I, member 2, isoform CRA_a
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Nuclear receptors Transporters Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Zinc-coordinating DNA-binding domains FDA approved drug targets Small molecule drugs Mapped to neXtProt neXtProt - Evidence at protein level
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000977[RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0004879[nuclear receptor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005667[transcription regulator complex] GO:0006351[DNA-templated transcription] GO:0006355[regulation of DNA-templated transcription] GO:0006805[xenobiotic metabolic process] GO:0007165[signal transduction] GO:0008202[steroid metabolic process] GO:0008270[zinc ion binding] GO:0010628[positive regulation of gene expression] GO:0016604[nuclear body] GO:0016922[nuclear receptor binding] GO:0030154[cell differentiation] GO:0030522[intracellular receptor signaling pathway] GO:0042178[xenobiotic catabolic process] GO:0042908[xenobiotic transport] GO:0043565[sequence-specific DNA binding] GO:0045111[intermediate filament cytoskeleton] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding] GO:1990837[sequence-specific double-stranded DNA binding]
O75469 [Direct mapping] Nuclear receptor subfamily 1 group I member 2
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H0Y8E2 [Direct mapping] Nuclear receptor subfamily 1 group I member 2; Nuclear receptor subfamily 1, group I, member 2, isoform CRA_c
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Nuclear receptors Transporters Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Zinc-coordinating DNA-binding domains FDA approved drug targets Small molecule drugs Mapped to neXtProt neXtProt - Evidence at protein level
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000977[RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0004879[nuclear receptor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005667[transcription regulator complex] GO:0006351[DNA-templated transcription] GO:0006355[regulation of DNA-templated transcription] GO:0006805[xenobiotic metabolic process] GO:0007165[signal transduction] GO:0008202[steroid metabolic process] GO:0008270[zinc ion binding] GO:0016604[nuclear body] GO:0016922[nuclear receptor binding] GO:0030154[cell differentiation] GO:0030522[intracellular receptor signaling pathway] GO:0042178[xenobiotic catabolic process] GO:0042908[xenobiotic transport] GO:0043565[sequence-specific DNA binding] GO:0045111[intermediate filament cytoskeleton] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding] GO:1990837[sequence-specific double-stranded DNA binding]
The Human Protein Atlas project is funded
