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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Enzymes Metabolic proteins Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
3
Cytoband
q21.3
Chromosome location (bp)
126103562 - 126197994
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Cytosolic 10-formyltetrahydrofolate dehydrogenase that catalyzes the NADP(+)-dependent conversion of 10-formyltetrahydrofolate to tetrahydrofolate and carbon dioxide 1,2. May also have an NADP(+)-dependent aldehyde dehydrogenase activity towards formaldehyde, acetaldehyde, propionaldehyde, and benzaldehyde (By similarity)....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Oxidoreductase
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
One-carbon metabolism
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
NADP
Gene summary (Entrez)i
Useful information about the gene from Entrez
The protein encoded by this gene catalyzes the conversion of 10-formyltetrahydrofolate, nicotinamide adenine dinucleotide phosphate (NADP+), and water to tetrahydrofolate, NADPH, and carbon dioxide. The encoded protein belongs to the aldehyde dehydrogenase family. Loss of function or expression of this gene is associated with decreased apoptosis, increased cell motility, and cancer progression. There is an antisense transcript that overlaps on the opposite strand with this gene locus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Enzymes ENZYME proteins Oxidoreductases Metabolic proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0003824[catalytic activity] GO:0004029[aldehyde dehydrogenase (NAD+) activity] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006730[one-carbon metabolic process] GO:0006740[NADPH regeneration] GO:0009058[biosynthetic process] GO:0009258[10-formyltetrahydrofolate catabolic process] GO:0016155[formyltetrahydrofolate dehydrogenase activity] GO:0016491[oxidoreductase activity] GO:0016620[oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor] GO:0016742[hydroxymethyl-, formyl- and related transferase activity] GO:0070062[extracellular exosome]
Enzymes ENZYME proteins Oxidoreductases Metabolic proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0003824[catalytic activity] GO:0004029[aldehyde dehydrogenase (NAD+) activity] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006730[one-carbon metabolic process] GO:0006740[NADPH regeneration] GO:0009058[biosynthetic process] GO:0009258[10-formyltetrahydrofolate catabolic process] GO:0016155[formyltetrahydrofolate dehydrogenase activity] GO:0016491[oxidoreductase activity] GO:0016620[oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor] GO:0016742[hydroxymethyl-, formyl- and related transferase activity] GO:0070062[extracellular exosome]
Enzymes ENZYME proteins Oxidoreductases Metabolic proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0003824[catalytic activity] GO:0004029[aldehyde dehydrogenase (NAD+) activity] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006730[one-carbon metabolic process] GO:0006740[NADPH regeneration] GO:0009058[biosynthetic process] GO:0009258[10-formyltetrahydrofolate catabolic process] GO:0016155[formyltetrahydrofolate dehydrogenase activity] GO:0016491[oxidoreductase activity] GO:0016620[oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor] GO:0016742[hydroxymethyl-, formyl- and related transferase activity] GO:0070062[extracellular exosome]
Enzymes ENZYME proteins Oxidoreductases Metabolic proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0003824[catalytic activity] GO:0004029[aldehyde dehydrogenase (NAD+) activity] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006730[one-carbon metabolic process] GO:0006740[NADPH regeneration] GO:0009058[biosynthetic process] GO:0009258[10-formyltetrahydrofolate catabolic process] GO:0016155[formyltetrahydrofolate dehydrogenase activity] GO:0016491[oxidoreductase activity] GO:0016620[oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor] GO:0016742[hydroxymethyl-, formyl- and related transferase activity] GO:0070062[extracellular exosome]
Enzymes ENZYME proteins Oxidoreductases Metabolic proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824[catalytic activity] GO:0004029[aldehyde dehydrogenase (NAD+) activity] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006730[one-carbon metabolic process] GO:0006740[NADPH regeneration] GO:0009058[biosynthetic process] GO:0009258[10-formyltetrahydrofolate catabolic process] GO:0016155[formyltetrahydrofolate dehydrogenase activity] GO:0016491[oxidoreductase activity] GO:0016620[oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor] GO:0016742[hydroxymethyl-, formyl- and related transferase activity] GO:0070062[extracellular exosome]
Enzymes ENZYME proteins Oxidoreductases Metabolic proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824[catalytic activity] GO:0004029[aldehyde dehydrogenase (NAD+) activity] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006730[one-carbon metabolic process] GO:0006740[NADPH regeneration] GO:0009058[biosynthetic process] GO:0009258[10-formyltetrahydrofolate catabolic process] GO:0016155[formyltetrahydrofolate dehydrogenase activity] GO:0016491[oxidoreductase activity] GO:0016620[oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor] GO:0016742[hydroxymethyl-, formyl- and related transferase activity] GO:0070062[extracellular exosome]
The Human Protein Atlas project is funded
