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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Transporters
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
4
Cytoband
p15.31
Chromosome location (bp)
20251905 - 20620561
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions. SLIT1 and SLIT2 seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb. In spinal cord development may play a role in guiding commissural axons once they reached the floor plate by modulating the response to netrin. In vitro, silences the attractive effect of NTN1 but not its growth-stimulatory effect and silencing requires the formation of a ROBO1-DCC complex. May be implicated in spinal cord midline post-crossing axon repulsion. In vitro, only commissural axons that crossed the midline responded to SLIT2. In the developing visual system appears to function as repellent for retinal ganglion axons by providing a repulsion that directs these axons along their appropriate paths prior to, and after passage through, the optic chiasm. In vitro, collapses and repels retinal ganglion cell growth cones. Seems to play a role in branching and arborization of CNS sensory axons, and in neuronal cell migration. In vitro, Slit homolog 2 protein N-product, but not Slit homolog 2 protein C-product, repels olfactory bulb (OB) but not dorsal root ganglia (DRG) axons, induces OB growth cones collapse and induces branching of DRG axons. Seems to be involved in regulating leukocyte migration....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Developmental protein, Heparin-binding
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Chemotaxis, Differentiation, Neurogenesis
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a member of the slit family of secreted glycoproteins, which are ligands for the Robo family of immunoglobulin receptors. Slit proteins play highly conserved roles in axon guidance and neuronal migration and may also have functions during other cell migration processes including leukocyte migration. Members of the slit family are characterized by an N-terminal signal peptide, four leucine-rich repeats, nine epidermal growth factor repeats, and a C-terminal cysteine knot. Proteolytic processing of this protein gives rise to an N-terminal fragment that contains the four leucine-rich repeats and five epidermal growth factor repeats and a C-terminal fragment that contains four epidermal growth factor repeats and the cysteine knot. Both full length and cleaved proteins are secreted extracellularly and can function in axon repulsion as well as other specific processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
O94813 [Direct mapping] Slit homolog 2 protein Slit homolog 2 protein N-product Slit homolog 2 protein C-product
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Transporters Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins DeepTMHMM predicted secreted proteins DeepSig predicted secreted proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001657[ureteric bud development] GO:0001933[negative regulation of protein phosphorylation] GO:0002042[cell migration involved in sprouting angiogenesis] GO:0002689[negative regulation of leukocyte chemotaxis] GO:0003180[aortic valve morphogenesis] GO:0003184[pulmonary valve morphogenesis] GO:0005095[GTPase inhibitor activity] GO:0005509[calcium ion binding] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0005737[cytoplasm] GO:0006935[chemotaxis] GO:0007399[nervous system development] GO:0007411[axon guidance] GO:0008045[motor neuron axon guidance] GO:0008201[heparin binding] GO:0010593[negative regulation of lamellipodium assembly] GO:0010596[negative regulation of endothelial cell migration] GO:0014912[negative regulation of smooth muscle cell migration] GO:0016020[membrane] GO:0016043[cellular component organization] GO:0021836[chemorepulsion involved in postnatal olfactory bulb interneuron migration] GO:0021972[corticospinal neuron axon guidance through spinal cord] GO:0030154[cell differentiation] GO:0030308[negative regulation of cell growth] GO:0030336[negative regulation of cell migration] GO:0030837[negative regulation of actin filament polymerization] GO:0031290[retinal ganglion cell axon guidance] GO:0032870[cellular response to hormone stimulus] GO:0035385[Roundabout signaling pathway] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0043065[positive regulation of apoptotic process] GO:0043116[negative regulation of vascular permeability] GO:0043237[laminin-1 binding] GO:0043394[proteoglycan binding] GO:0048495[Roundabout binding] GO:0048754[branching morphogenesis of an epithelial tube] GO:0048846[axon extension involved in axon guidance] GO:0050772[positive regulation of axonogenesis] GO:0050919[negative chemotaxis] GO:0050929[induction of negative chemotaxis] GO:0051058[negative regulation of small GTPase mediated signal transduction] GO:0051414[response to cortisol] GO:0060412[ventricular septum morphogenesis] GO:0061364[apoptotic process involved in luteolysis] GO:0070062[extracellular exosome] GO:0070100[negative regulation of chemokine-mediated signaling pathway] GO:0071504[cellular response to heparin] GO:0071672[negative regulation of smooth muscle cell chemotaxis] GO:0071676[negative regulation of mononuclear cell migration] GO:0090024[negative regulation of neutrophil chemotaxis] GO:0090027[negative regulation of monocyte chemotaxis] GO:0090260[negative regulation of retinal ganglion cell axon guidance] GO:0090288[negative regulation of cellular response to growth factor stimulus]
DeepTMHMM predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
Phobius predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
The Human Protein Atlas project is funded
