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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Calcium/calmodulin dependent protein kinase II delta
Protein classi
Assigned HPA protein class(es) for the encoded protein(s).
Enzymes Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
4
Cytoband
q26
Chromosome location (bp)
113418054 - 113761927
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca(2+) homeostatis and excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins involved in Ca(2+) influx into the myocyte, Ca(2+) release from the sarcoplasmic reticulum (SR), SR Ca(2+) uptake and Na(+) and K(+) channel transport. Targets also transcription factors and signaling molecules to regulate heart function. In its activated form, is involved in the pathogenesis of dilated cardiomyopathy and heart failure. Contributes to cardiac decompensation and heart failure by regulating SR Ca(2+) release via direct phosphorylation of RYR2 Ca(2+) channel on 'Ser-2808'. In the nucleus, phosphorylates the MEF2 repressor HDAC4, promoting its nuclear export and binding to 14-3-3 protein, and expression of MEF2 and genes involved in the hypertrophic program 1. Is essential for left ventricular remodeling responses to myocardial infarction. In pathological myocardial remodeling acts downstream of the beta adrenergic receptor signaling cascade to regulate key proteins involved in ECC. Regulates Ca(2+) influx to myocytes by binding and phosphorylating the L-type Ca(2+) channel subunit beta-2 CACNB2. In addition to Ca(2+) channels, can target and regulate the cardiac sarcolemmal Na(+) channel Nav1.5/SCN5A and the K+ channel Kv4.3/KCND3, which contribute to arrhythmogenesis in heart failure. Phosphorylates phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2, contributing to the enhancement of SR Ca(2+) uptake that may be important in frequency-dependent acceleration of relaxation (FDAR) and maintenance of contractile function during acidosis 2. May participate in the modulation of skeletal muscle function in response to exercise, by regulating SR Ca(2+) transport through phosphorylation of PLN/PLB and triadin, a ryanodine receptor-coupling factor. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (By similarity)....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
ATP-binding, Nucleotide-binding
Gene summary (Entrez)i
Useful information about the gene from Entrez
The product of this gene belongs to the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a delta chain. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Distinct isoforms of this chain have different expression patterns.[provided by RefSeq, Nov 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Q13557 [Direct mapping] Calcium/calmodulin-dependent protein kinase type II subunit delta
Show all
Enzymes ENZYME proteins Transferases Kinases CAMK Ser/Thr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000166[nucleotide binding] GO:0001558[regulation of cell growth] GO:0002026[regulation of the force of heart contraction] GO:0003254[regulation of membrane depolarization] GO:0004672[protein kinase activity] GO:0004674[protein serine/threonine kinase activity] GO:0004683[calmodulin-dependent protein kinase activity] GO:0005515[protein binding] GO:0005516[calmodulin binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0005954[calcium- and calmodulin-dependent protein kinase complex] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006468[protein phosphorylation] GO:0008016[regulation of heart contraction] GO:0010613[positive regulation of cardiac muscle hypertrophy] GO:0010649[regulation of cell communication by electrical coupling] GO:0010666[positive regulation of cardiac muscle cell apoptotic process] GO:0010880[regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum] GO:0010881[regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion] GO:0016020[membrane] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016529[sarcoplasmic reticulum] GO:0016740[transferase activity] GO:0018105[peptidyl-serine phosphorylation] GO:0018107[peptidyl-threonine phosphorylation] GO:0019871[sodium channel inhibitor activity] GO:0030666[endocytic vesicle membrane] GO:0031432[titin binding] GO:0032469[endoplasmic reticulum calcium ion homeostasis] GO:0033017[sarcoplasmic reticulum membrane] GO:0042383[sarcolemma] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0043005[neuron projection] GO:0044325[transmembrane transporter binding] GO:0046777[protein autophosphorylation] GO:0055119[relaxation of cardiac muscle] GO:0060314[regulation of ryanodine-sensitive calcium-release channel activity] GO:0060341[regulation of cellular localization] GO:0071277[cellular response to calcium ion] GO:0086003[cardiac muscle cell contraction] GO:0086091[regulation of heart rate by cardiac conduction] GO:0098901[regulation of cardiac muscle cell action potential] GO:0098909[regulation of cardiac muscle cell action potential involved in regulation of contraction] GO:0106310[protein serine kinase activity] GO:0110165[cellular anatomical entity] GO:1901725[regulation of histone deacetylase activity] GO:1901844[regulation of cell communication by electrical coupling involved in cardiac conduction] GO:1901897[regulation of relaxation of cardiac muscle] GO:1902306[negative regulation of sodium ion transmembrane transport] GO:1902514[regulation of calcium ion transmembrane transport via high voltage-gated calcium channel] GO:2000650[negative regulation of sodium ion transmembrane transporter activity]
Q13557 [Direct mapping] Calcium/calmodulin-dependent protein kinase type II subunit delta
Show all
Enzymes ENZYME proteins Transferases Kinases CAMK Ser/Thr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166[nucleotide binding] GO:0001558[regulation of cell growth] GO:0002026[regulation of the force of heart contraction] GO:0003254[regulation of membrane depolarization] GO:0004672[protein kinase activity] GO:0004674[protein serine/threonine kinase activity] GO:0004683[calmodulin-dependent protein kinase activity] GO:0005515[protein binding] GO:0005516[calmodulin binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0005954[calcium- and calmodulin-dependent protein kinase complex] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006468[protein phosphorylation] GO:0008016[regulation of heart contraction] GO:0010613[positive regulation of cardiac muscle hypertrophy] GO:0010649[regulation of cell communication by electrical coupling] GO:0010666[positive regulation of cardiac muscle cell apoptotic process] GO:0010880[regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum] GO:0010881[regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion] GO:0016020[membrane] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016529[sarcoplasmic reticulum] GO:0016740[transferase activity] GO:0018105[peptidyl-serine phosphorylation] GO:0018107[peptidyl-threonine phosphorylation] GO:0019871[sodium channel inhibitor activity] GO:0030666[endocytic vesicle membrane] GO:0031432[titin binding] GO:0032469[endoplasmic reticulum calcium ion homeostasis] GO:0033017[sarcoplasmic reticulum membrane] GO:0042383[sarcolemma] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0043005[neuron projection] GO:0044325[transmembrane transporter binding] GO:0046777[protein autophosphorylation] GO:0055119[relaxation of cardiac muscle] GO:0060314[regulation of ryanodine-sensitive calcium-release channel activity] GO:0060341[regulation of cellular localization] GO:0071277[cellular response to calcium ion] GO:0086003[cardiac muscle cell contraction] GO:0086091[regulation of heart rate by cardiac conduction] GO:0098901[regulation of cardiac muscle cell action potential] GO:0098909[regulation of cardiac muscle cell action potential involved in regulation of contraction] GO:0106310[protein serine kinase activity] GO:0110165[cellular anatomical entity] GO:1901725[regulation of histone deacetylase activity] GO:1901844[regulation of cell communication by electrical coupling involved in cardiac conduction] GO:1901897[regulation of relaxation of cardiac muscle] GO:1902306[negative regulation of sodium ion transmembrane transport] GO:1902514[regulation of calcium ion transmembrane transport via high voltage-gated calcium channel] GO:2000650[negative regulation of sodium ion transmembrane transporter activity]
Q13557 [Direct mapping] Calcium/calmodulin-dependent protein kinase type II subunit delta
Show all
Enzymes ENZYME proteins Transferases Kinases CAMK Ser/Thr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166[nucleotide binding] GO:0001558[regulation of cell growth] GO:0002026[regulation of the force of heart contraction] GO:0003254[regulation of membrane depolarization] GO:0004672[protein kinase activity] GO:0004674[protein serine/threonine kinase activity] GO:0004683[calmodulin-dependent protein kinase activity] GO:0005515[protein binding] GO:0005516[calmodulin binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0005954[calcium- and calmodulin-dependent protein kinase complex] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006468[protein phosphorylation] GO:0008016[regulation of heart contraction] GO:0010613[positive regulation of cardiac muscle hypertrophy] GO:0010649[regulation of cell communication by electrical coupling] GO:0010666[positive regulation of cardiac muscle cell apoptotic process] GO:0010880[regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum] GO:0010881[regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion] GO:0016020[membrane] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016529[sarcoplasmic reticulum] GO:0016740[transferase activity] GO:0018105[peptidyl-serine phosphorylation] GO:0018107[peptidyl-threonine phosphorylation] GO:0019871[sodium channel inhibitor activity] GO:0030666[endocytic vesicle membrane] GO:0031432[titin binding] GO:0032469[endoplasmic reticulum calcium ion homeostasis] GO:0033017[sarcoplasmic reticulum membrane] GO:0042383[sarcolemma] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0043005[neuron projection] GO:0044325[transmembrane transporter binding] GO:0046777[protein autophosphorylation] GO:0055119[relaxation of cardiac muscle] GO:0060314[regulation of ryanodine-sensitive calcium-release channel activity] GO:0060341[regulation of cellular localization] GO:0071277[cellular response to calcium ion] GO:0086003[cardiac muscle cell contraction] GO:0086091[regulation of heart rate by cardiac conduction] GO:0098901[regulation of cardiac muscle cell action potential] GO:0098909[regulation of cardiac muscle cell action potential involved in regulation of contraction] GO:0106310[protein serine kinase activity] GO:0110165[cellular anatomical entity] GO:1901725[regulation of histone deacetylase activity] GO:1901844[regulation of cell communication by electrical coupling involved in cardiac conduction] GO:1901897[regulation of relaxation of cardiac muscle] GO:1902306[negative regulation of sodium ion transmembrane transport] GO:1902514[regulation of calcium ion transmembrane transport via high voltage-gated calcium channel] GO:2000650[negative regulation of sodium ion transmembrane transporter activity]
Q13557 [Direct mapping] Calcium/calmodulin-dependent protein kinase type II subunit delta
Show all
Enzymes ENZYME proteins Transferases Kinases CAMK Ser/Thr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166[nucleotide binding] GO:0001558[regulation of cell growth] GO:0002026[regulation of the force of heart contraction] GO:0003254[regulation of membrane depolarization] GO:0004672[protein kinase activity] GO:0004674[protein serine/threonine kinase activity] GO:0004683[calmodulin-dependent protein kinase activity] GO:0005515[protein binding] GO:0005516[calmodulin binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0005954[calcium- and calmodulin-dependent protein kinase complex] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006468[protein phosphorylation] GO:0008016[regulation of heart contraction] GO:0010613[positive regulation of cardiac muscle hypertrophy] GO:0010649[regulation of cell communication by electrical coupling] GO:0010666[positive regulation of cardiac muscle cell apoptotic process] GO:0010880[regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum] GO:0010881[regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion] GO:0016020[membrane] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016529[sarcoplasmic reticulum] GO:0016740[transferase activity] GO:0018105[peptidyl-serine phosphorylation] GO:0018107[peptidyl-threonine phosphorylation] GO:0019871[sodium channel inhibitor activity] GO:0030666[endocytic vesicle membrane] GO:0031432[titin binding] GO:0032469[endoplasmic reticulum calcium ion homeostasis] GO:0033017[sarcoplasmic reticulum membrane] GO:0042383[sarcolemma] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0043005[neuron projection] GO:0044325[transmembrane transporter binding] GO:0046777[protein autophosphorylation] GO:0055119[relaxation of cardiac muscle] GO:0060314[regulation of ryanodine-sensitive calcium-release channel activity] GO:0060341[regulation of cellular localization] GO:0071277[cellular response to calcium ion] GO:0086003[cardiac muscle cell contraction] GO:0086091[regulation of heart rate by cardiac conduction] GO:0098901[regulation of cardiac muscle cell action potential] GO:0098909[regulation of cardiac muscle cell action potential involved in regulation of contraction] GO:0106310[protein serine kinase activity] GO:0110165[cellular anatomical entity] GO:1901725[regulation of histone deacetylase activity] GO:1901844[regulation of cell communication by electrical coupling involved in cardiac conduction] GO:1901897[regulation of relaxation of cardiac muscle] GO:1902306[negative regulation of sodium ion transmembrane transport] GO:1902514[regulation of calcium ion transmembrane transport via high voltage-gated calcium channel] GO:2000650[negative regulation of sodium ion transmembrane transporter activity]
Q13557 [Direct mapping] Calcium/calmodulin-dependent protein kinase type II subunit delta
Show all
Enzymes ENZYME proteins Transferases Kinases CAMK Ser/Thr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166[nucleotide binding] GO:0001558[regulation of cell growth] GO:0002026[regulation of the force of heart contraction] GO:0003254[regulation of membrane depolarization] GO:0004672[protein kinase activity] GO:0004674[protein serine/threonine kinase activity] GO:0004683[calmodulin-dependent protein kinase activity] GO:0005515[protein binding] GO:0005516[calmodulin binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0005954[calcium- and calmodulin-dependent protein kinase complex] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006468[protein phosphorylation] GO:0008016[regulation of heart contraction] GO:0010613[positive regulation of cardiac muscle hypertrophy] GO:0010649[regulation of cell communication by electrical coupling] GO:0010666[positive regulation of cardiac muscle cell apoptotic process] GO:0010880[regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum] GO:0010881[regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion] GO:0016020[membrane] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016529[sarcoplasmic reticulum] GO:0016740[transferase activity] GO:0018105[peptidyl-serine phosphorylation] GO:0018107[peptidyl-threonine phosphorylation] GO:0019871[sodium channel inhibitor activity] GO:0030666[endocytic vesicle membrane] GO:0031432[titin binding] GO:0032469[endoplasmic reticulum calcium ion homeostasis] GO:0033017[sarcoplasmic reticulum membrane] GO:0042383[sarcolemma] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0043005[neuron projection] GO:0044325[transmembrane transporter binding] GO:0046777[protein autophosphorylation] GO:0055119[relaxation of cardiac muscle] GO:0060314[regulation of ryanodine-sensitive calcium-release channel activity] GO:0060341[regulation of cellular localization] GO:0071277[cellular response to calcium ion] GO:0086003[cardiac muscle cell contraction] GO:0086091[regulation of heart rate by cardiac conduction] GO:0098901[regulation of cardiac muscle cell action potential] GO:0098909[regulation of cardiac muscle cell action potential involved in regulation of contraction] GO:0106310[protein serine kinase activity] GO:0110165[cellular anatomical entity] GO:1901725[regulation of histone deacetylase activity] GO:1901844[regulation of cell communication by electrical coupling involved in cardiac conduction] GO:1901897[regulation of relaxation of cardiac muscle] GO:1902306[negative regulation of sodium ion transmembrane transport] GO:1902514[regulation of calcium ion transmembrane transport via high voltage-gated calcium channel] GO:2000650[negative regulation of sodium ion transmembrane transporter activity]
Q13557 [Direct mapping] Calcium/calmodulin-dependent protein kinase type II subunit delta
Show all
Enzymes ENZYME proteins Transferases Kinases CAMK Ser/Thr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166[nucleotide binding] GO:0001558[regulation of cell growth] GO:0002026[regulation of the force of heart contraction] GO:0003254[regulation of membrane depolarization] GO:0004672[protein kinase activity] GO:0004674[protein serine/threonine kinase activity] GO:0004683[calmodulin-dependent protein kinase activity] GO:0005515[protein binding] GO:0005516[calmodulin binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0005954[calcium- and calmodulin-dependent protein kinase complex] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006468[protein phosphorylation] GO:0008016[regulation of heart contraction] GO:0010613[positive regulation of cardiac muscle hypertrophy] GO:0010649[regulation of cell communication by electrical coupling] GO:0010666[positive regulation of cardiac muscle cell apoptotic process] GO:0010880[regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum] GO:0010881[regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion] GO:0016020[membrane] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016529[sarcoplasmic reticulum] GO:0016740[transferase activity] GO:0018105[peptidyl-serine phosphorylation] GO:0018107[peptidyl-threonine phosphorylation] GO:0019871[sodium channel inhibitor activity] GO:0030666[endocytic vesicle membrane] GO:0031432[titin binding] GO:0032469[endoplasmic reticulum calcium ion homeostasis] GO:0033017[sarcoplasmic reticulum membrane] GO:0042383[sarcolemma] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0043005[neuron projection] GO:0044325[transmembrane transporter binding] GO:0046777[protein autophosphorylation] GO:0055119[relaxation of cardiac muscle] GO:0060314[regulation of ryanodine-sensitive calcium-release channel activity] GO:0060341[regulation of cellular localization] GO:0071277[cellular response to calcium ion] GO:0086003[cardiac muscle cell contraction] GO:0086091[regulation of heart rate by cardiac conduction] GO:0098901[regulation of cardiac muscle cell action potential] GO:0098909[regulation of cardiac muscle cell action potential involved in regulation of contraction] GO:0106310[protein serine kinase activity] GO:0110165[cellular anatomical entity] GO:1901725[regulation of histone deacetylase activity] GO:1901844[regulation of cell communication by electrical coupling involved in cardiac conduction] GO:1901897[regulation of relaxation of cardiac muscle] GO:1902306[negative regulation of sodium ion transmembrane transport] GO:1902514[regulation of calcium ion transmembrane transport via high voltage-gated calcium channel] GO:2000650[negative regulation of sodium ion transmembrane transporter activity]
H0Y9J2 [Direct mapping] Calcium/calmodulin-dependent protein kinase type II subunit delta
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Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
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GO:0004683[calmodulin-dependent protein kinase activity] GO:0005516[calmodulin binding] GO:0006468[protein phosphorylation]
Q13557 [Direct mapping] Calcium/calmodulin-dependent protein kinase type II subunit delta
Show all
Enzymes ENZYME proteins Transferases Kinases CAMK Ser/Thr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166[nucleotide binding] GO:0001558[regulation of cell growth] GO:0002026[regulation of the force of heart contraction] GO:0003254[regulation of membrane depolarization] GO:0004672[protein kinase activity] GO:0004674[protein serine/threonine kinase activity] GO:0004683[calmodulin-dependent protein kinase activity] GO:0005515[protein binding] GO:0005516[calmodulin binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0005954[calcium- and calmodulin-dependent protein kinase complex] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006468[protein phosphorylation] GO:0008016[regulation of heart contraction] GO:0010613[positive regulation of cardiac muscle hypertrophy] GO:0010649[regulation of cell communication by electrical coupling] GO:0010666[positive regulation of cardiac muscle cell apoptotic process] GO:0010880[regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum] GO:0010881[regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion] GO:0016020[membrane] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016529[sarcoplasmic reticulum] GO:0016740[transferase activity] GO:0018105[peptidyl-serine phosphorylation] GO:0018107[peptidyl-threonine phosphorylation] GO:0019871[sodium channel inhibitor activity] GO:0030666[endocytic vesicle membrane] GO:0031432[titin binding] GO:0032469[endoplasmic reticulum calcium ion homeostasis] GO:0033017[sarcoplasmic reticulum membrane] GO:0042383[sarcolemma] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0043005[neuron projection] GO:0044325[transmembrane transporter binding] GO:0046777[protein autophosphorylation] GO:0055119[relaxation of cardiac muscle] GO:0060314[regulation of ryanodine-sensitive calcium-release channel activity] GO:0060341[regulation of cellular localization] GO:0071277[cellular response to calcium ion] GO:0086003[cardiac muscle cell contraction] GO:0086091[regulation of heart rate by cardiac conduction] GO:0098901[regulation of cardiac muscle cell action potential] GO:0098909[regulation of cardiac muscle cell action potential involved in regulation of contraction] GO:0106310[protein serine kinase activity] GO:0110165[cellular anatomical entity] GO:1901725[regulation of histone deacetylase activity] GO:1901844[regulation of cell communication by electrical coupling involved in cardiac conduction] GO:1901897[regulation of relaxation of cardiac muscle] GO:1902306[negative regulation of sodium ion transmembrane transport] GO:1902514[regulation of calcium ion transmembrane transport via high voltage-gated calcium channel] GO:2000650[negative regulation of sodium ion transmembrane transporter activity]
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