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UGT3A1
HPA
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  • UGT3A1
PROTEIN SUMMARY GENE INFORMATION RNA DATA ANTIBODY DATA
GENERAL INFORMATIONi

General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.

Gene namei

Official gene symbol, which is typically a short form of the gene name, according to HGNC.

UGT3A1
Synonyms FLJ34658
Gene descriptioni

Full gene name according to HGNC.

UDP glycosyltransferase family 3 member A1
Protein classi

Assigned HPA protein class(es) for the encoded protein(s).

Enzymes
Metabolic proteins
Predicted locationi

All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.

  • Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.

  • Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).

The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.

Membrane, Intracellular
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi

Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.

Chromosome 5
Cytoband p13.2
Chromosome location (bp) 35951006 - 36001028
Number of transcriptsi

Number of protein-coding transcripts from the gene as defined by Ensembl.

5
Ensembl ENSG00000145626 (version 109)
Entrez gene 133688
HGNC HGNC:26625
UniProt Q6NUS8 (UniProt - Evidence at transcript level)
neXtProt NX_Q6NUS8
GeneCards UGT3A1
Antibodypedia UGT3A1 antibodies


PROTEIN FUNCTION
Protein function (UniProt)i

Useful information about the protein provided by UniProt.

UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds (By similarity).... show less
Molecular function (UniProt)i

Keywords assigned by UniProt to proteins due to their particular molecular function.

Glycosyltransferase, Transferase
Gene summary (Entrez)i

Useful information about the gene from Entrez

Enables glucuronosyltransferase activity. Part of UDP-N-acetylglucosamine transferase complex. [provided by Alliance of Genome Resources, Apr 2022]... show less
PROTEIN INFORMATIONi

The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.

The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.

The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.

The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Splice variant SwissProt TrEMBL Protein class Gene ontology Length & mass Signal peptide
(predicted)
Transmembrane regions
(predicted)
UGT3A1-201
ENSP00000274278
ENST00000274278
Q6NUS8
[Direct mapping] UDP-glucuronosyltransferase 3A1
Show all
A8K444
[Target identity:100%; Query identity:100%] UDP-glucuronosyltransferase
Show all
Enzymes
   ENZYME proteins
   Transferases
Metabolic proteins
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
   DeepTMHMM predicted membrane proteins
Show all
GO:0008194 [UDP-glycosyltransferase activity]
GO:0015020 [glucuronosyltransferase activity]
GO:0016020 [membrane]
GO:0016740 [transferase activity]
GO:0016757 [glycosyltransferase activity]
GO:0043541 [UDP-N-acetylglucosamine transferase complex]
Show all
523 aa
59.2 kDa
Yes 1
UGT3A1-202
ENSP00000328033
ENST00000333811
Q6NUS8
[Direct mapping] UDP-glucuronosyltransferase 3A1
Show all
A0A024R085
[Target identity:100%; Query identity:100%] UDP glycosyltransferase 3 family, polypeptide A1, isoform CRA_b
Show all
Enzymes
   ENZYME proteins
   Transferases
Metabolic proteins
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Mapped to neXtProt
   neXtProt - Evidence at protein level
Show all
GO:0008194 [UDP-glycosyltransferase activity]
GO:0015020 [glucuronosyltransferase activity]
GO:0016020 [membrane]
GO:0016740 [transferase activity]
GO:0016757 [glycosyltransferase activity]
GO:0043541 [UDP-N-acetylglucosamine transferase complex]
Show all
252 aa
29.2 kDa
No 0
UGT3A1-203
ENSP00000427079
ENST00000503189
B7Z8Q8
[Direct mapping] UDP-glucuronosyltransferase
Show all
Metabolic proteins
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
   DeepTMHMM predicted secreted proteins
   DeepSig predicted secreted proteins
Predicted intracellular proteins
Show all
GO:0008194 [UDP-glycosyltransferase activity]
GO:0015020 [glucuronosyltransferase activity]
GO:0016020 [membrane]
GO:0016740 [transferase activity]
GO:0016757 [glycosyltransferase activity]
Show all
436 aa
49.4 kDa
Yes 0
UGT3A1-204
ENSP00000426100
ENST00000507113
E9PD17
[Direct mapping] UDP-glucuronosyltransferase
Show all
Metabolic proteins
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   DeepTMHMM predicted secreted proteins
   DeepSig predicted secreted proteins
Predicted intracellular proteins
Show all
GO:0008194 [UDP-glycosyltransferase activity]
GO:0015020 [glucuronosyltransferase activity]
GO:0016020 [membrane]
GO:0016740 [transferase activity]
GO:0016757 [glycosyltransferase activity]
Show all
402 aa
45.6 kDa
Yes 0
UGT3A1-207
ENSP00000487376
ENST00000625798
Q6NUS8
[Direct mapping] UDP-glucuronosyltransferase 3A1
Show all
A0A024R085
[Target identity:100%; Query identity:100%] UDP glycosyltransferase 3 family, polypeptide A1, isoform CRA_b
Show all
Enzymes
   ENZYME proteins
   Transferases
Metabolic proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Show all
GO:0008194 [UDP-glycosyltransferase activity]
GO:0015020 [glucuronosyltransferase activity]
GO:0016020 [membrane]
GO:0016740 [transferase activity]
GO:0016757 [glycosyltransferase activity]
GO:0043541 [UDP-N-acetylglucosamine transferase complex]
Show all
252 aa
29.2 kDa
No 0

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