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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Disease related genes Human disease related genes Metabolic proteins Plasma proteins RAS pathway related proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
5
Cytoband
q13.1
Chromosome location (bp)
68215740 - 68301821
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling 1,2,3. Modulates the cellular response to ER stress by promoting nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement 4....show less
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Host-virus interaction, Protein transport, Stress response, Transport
Gene summary (Entrez)i
Useful information about the gene from Entrez
Phosphatidylinositol 3-kinase phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position. The enzyme comprises a 110 kD catalytic subunit and a regulatory subunit of either 85, 55, or 50 kD. This gene encodes the 85 kD regulatory subunit. Phosphatidylinositol 3-kinase plays an important role in the metabolic actions of insulin, and a mutation in this gene has been associated with insulin resistance. Alternative splicing of this gene results in four transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Disease related genes Human disease related genes Congenital malformations Other congenital malformations Immune system diseases Primary immunodeficiency Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001678[cellular glucose homeostasis] GO:0001784[phosphotyrosine residue binding] GO:0005068[transmembrane receptor protein tyrosine kinase adaptor activity] GO:0005158[insulin receptor binding] GO:0005159[insulin-like growth factor receptor binding] GO:0005168[neurotrophin TRKA receptor binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0005942[phosphatidylinositol 3-kinase complex] GO:0005943[phosphatidylinositol 3-kinase complex, class IA] GO:0006955[immune response] GO:0007165[signal transduction] GO:0008286[insulin receptor signaling pathway] GO:0010592[positive regulation of lamellipodium assembly] GO:0014065[phosphatidylinositol 3-kinase signaling] GO:0015031[protein transport] GO:0016020[membrane] GO:0019903[protein phosphatase binding] GO:0030183[B cell differentiation] GO:0030217[T cell differentiation] GO:0032869[cellular response to insulin stimulus] GO:0033120[positive regulation of RNA splicing] GO:0034446[substrate adhesion-dependent cell spreading] GO:0034976[response to endoplasmic reticulum stress] GO:0035014[phosphatidylinositol 3-kinase regulator activity] GO:0042307[positive regulation of protein import into nucleus] GO:0043066[negative regulation of apoptotic process] GO:0043125[ErbB-3 class receptor binding] GO:0043548[phosphatidylinositol 3-kinase binding] GO:0043551[regulation of phosphatidylinositol 3-kinase activity] GO:0043559[insulin binding] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046326[positive regulation of glucose import] GO:0046854[phosphatidylinositol phosphate biosynthetic process] GO:0046935[1-phosphatidylinositol-3-kinase regulator activity] GO:0048009[insulin-like growth factor receptor signaling pathway] GO:0048471[perinuclear region of cytoplasm] GO:0050821[protein stabilization] GO:0051491[positive regulation of filopodium assembly] GO:0051497[negative regulation of stress fiber assembly] GO:0060396[growth hormone receptor signaling pathway] GO:0120183[positive regulation of focal adhesion disassembly] GO:1900103[positive regulation of endoplasmic reticulum unfolded protein response] GO:1903078[positive regulation of protein localization to plasma membrane]
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Disease related genes Human disease related genes Congenital malformations Other congenital malformations Immune system diseases Primary immunodeficiency Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001678[cellular glucose homeostasis] GO:0001784[phosphotyrosine residue binding] GO:0005068[transmembrane receptor protein tyrosine kinase adaptor activity] GO:0005158[insulin receptor binding] GO:0005159[insulin-like growth factor receptor binding] GO:0005168[neurotrophin TRKA receptor binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0005942[phosphatidylinositol 3-kinase complex] GO:0005943[phosphatidylinositol 3-kinase complex, class IA] GO:0006955[immune response] GO:0007165[signal transduction] GO:0008286[insulin receptor signaling pathway] GO:0010592[positive regulation of lamellipodium assembly] GO:0014065[phosphatidylinositol 3-kinase signaling] GO:0015031[protein transport] GO:0016020[membrane] GO:0019903[protein phosphatase binding] GO:0030183[B cell differentiation] GO:0030217[T cell differentiation] GO:0032869[cellular response to insulin stimulus] GO:0033120[positive regulation of RNA splicing] GO:0034446[substrate adhesion-dependent cell spreading] GO:0034976[response to endoplasmic reticulum stress] GO:0035014[phosphatidylinositol 3-kinase regulator activity] GO:0042307[positive regulation of protein import into nucleus] GO:0043066[negative regulation of apoptotic process] GO:0043125[ErbB-3 class receptor binding] GO:0043548[phosphatidylinositol 3-kinase binding] GO:0043551[regulation of phosphatidylinositol 3-kinase activity] GO:0043559[insulin binding] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046326[positive regulation of glucose import] GO:0046854[phosphatidylinositol phosphate biosynthetic process] GO:0046935[1-phosphatidylinositol-3-kinase regulator activity] GO:0048009[insulin-like growth factor receptor signaling pathway] GO:0048471[perinuclear region of cytoplasm] GO:0050821[protein stabilization] GO:0051491[positive regulation of filopodium assembly] GO:0051497[negative regulation of stress fiber assembly] GO:0060396[growth hormone receptor signaling pathway] GO:0120183[positive regulation of focal adhesion disassembly] GO:1900103[positive regulation of endoplasmic reticulum unfolded protein response] GO:1903078[positive regulation of protein localization to plasma membrane]
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Human disease related genes Congenital malformations Other congenital malformations Immune system diseases Primary immunodeficiency Protein evidence (Ezkurdia et al 2014)
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Human disease related genes Congenital malformations Other congenital malformations Immune system diseases Primary immunodeficiency Protein evidence (Ezkurdia et al 2014)
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Human disease related genes Congenital malformations Other congenital malformations Immune system diseases Primary immunodeficiency Protein evidence (Ezkurdia et al 2014)
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Disease related genes Human disease related genes Congenital malformations Other congenital malformations Immune system diseases Primary immunodeficiency Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001678[cellular glucose homeostasis] GO:0001784[phosphotyrosine residue binding] GO:0001953[negative regulation of cell-matrix adhesion] GO:0002687[positive regulation of leukocyte migration] GO:0005068[transmembrane receptor protein tyrosine kinase adaptor activity] GO:0005158[insulin receptor binding] GO:0005159[insulin-like growth factor receptor binding] GO:0005168[neurotrophin TRKA receptor binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005801[cis-Golgi network] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0005911[cell-cell junction] GO:0005942[phosphatidylinositol 3-kinase complex] GO:0005943[phosphatidylinositol 3-kinase complex, class IA] GO:0006366[transcription by RNA polymerase II] GO:0006468[protein phosphorylation] GO:0006606[protein import into nucleus] GO:0006955[immune response] GO:0007162[negative regulation of cell adhesion] GO:0007165[signal transduction] GO:0008286[insulin receptor signaling pathway] GO:0008625[extrinsic apoptotic signaling pathway via death domain receptors] GO:0008630[intrinsic apoptotic signaling pathway in response to DNA damage] GO:0010592[positive regulation of lamellipodium assembly] GO:0014065[phosphatidylinositol 3-kinase signaling] GO:0015031[protein transport] GO:0016020[membrane] GO:0019903[protein phosphatase binding] GO:0030183[B cell differentiation] GO:0030217[T cell differentiation] GO:0030316[osteoclast differentiation] GO:0032760[positive regulation of tumor necrosis factor production] GO:0032869[cellular response to insulin stimulus] GO:0032991[protein-containing complex] GO:0033120[positive regulation of RNA splicing] GO:0034446[substrate adhesion-dependent cell spreading] GO:0034644[cellular response to UV] GO:0034976[response to endoplasmic reticulum stress] GO:0035014[phosphatidylinositol 3-kinase regulator activity] GO:0036312[phosphatidylinositol 3-kinase regulatory subunit binding] GO:0042307[positive regulation of protein import into nucleus] GO:0043066[negative regulation of apoptotic process] GO:0043125[ErbB-3 class receptor binding] GO:0043539[protein serine/threonine kinase activator activity] GO:0043548[phosphatidylinositol 3-kinase binding] GO:0043551[regulation of phosphatidylinositol 3-kinase activity] GO:0043559[insulin binding] GO:0043560[insulin receptor substrate binding] GO:0045671[negative regulation of osteoclast differentiation] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046326[positive regulation of glucose import] GO:0046626[regulation of insulin receptor signaling pathway] GO:0046854[phosphatidylinositol phosphate biosynthetic process] GO:0046935[1-phosphatidylinositol-3-kinase regulator activity] GO:0046982[protein heterodimerization activity] GO:0048009[insulin-like growth factor receptor signaling pathway] GO:0048471[perinuclear region of cytoplasm] GO:0050821[protein stabilization] GO:0051491[positive regulation of filopodium assembly] GO:0051492[regulation of stress fiber assembly] GO:0051497[negative regulation of stress fiber assembly] GO:0060396[growth hormone receptor signaling pathway] GO:0097529[myeloid leukocyte migration] GO:0120183[positive regulation of focal adhesion disassembly] GO:1900103[positive regulation of endoplasmic reticulum unfolded protein response] GO:1903076[regulation of protein localization to plasma membrane] GO:1903078[positive regulation of protein localization to plasma membrane] GO:1990578[perinuclear endoplasmic reticulum membrane]
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Human disease related genes Congenital malformations Other congenital malformations Immune system diseases Primary immunodeficiency Protein evidence (Ezkurdia et al 2014)
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Disease related genes Human disease related genes Congenital malformations Other congenital malformations Immune system diseases Primary immunodeficiency Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001678[cellular glucose homeostasis] GO:0001784[phosphotyrosine residue binding] GO:0005068[transmembrane receptor protein tyrosine kinase adaptor activity] GO:0005158[insulin receptor binding] GO:0005159[insulin-like growth factor receptor binding] GO:0005168[neurotrophin TRKA receptor binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0005942[phosphatidylinositol 3-kinase complex] GO:0005943[phosphatidylinositol 3-kinase complex, class IA] GO:0006955[immune response] GO:0007165[signal transduction] GO:0008286[insulin receptor signaling pathway] GO:0010592[positive regulation of lamellipodium assembly] GO:0014065[phosphatidylinositol 3-kinase signaling] GO:0015031[protein transport] GO:0016020[membrane] GO:0019903[protein phosphatase binding] GO:0030183[B cell differentiation] GO:0030217[T cell differentiation] GO:0032869[cellular response to insulin stimulus] GO:0033120[positive regulation of RNA splicing] GO:0034446[substrate adhesion-dependent cell spreading] GO:0034976[response to endoplasmic reticulum stress] GO:0035014[phosphatidylinositol 3-kinase regulator activity] GO:0042307[positive regulation of protein import into nucleus] GO:0043066[negative regulation of apoptotic process] GO:0043125[ErbB-3 class receptor binding] GO:0043548[phosphatidylinositol 3-kinase binding] GO:0043551[regulation of phosphatidylinositol 3-kinase activity] GO:0043559[insulin binding] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046326[positive regulation of glucose import] GO:0046854[phosphatidylinositol phosphate biosynthetic process] GO:0046935[1-phosphatidylinositol-3-kinase regulator activity] GO:0048009[insulin-like growth factor receptor signaling pathway] GO:0048471[perinuclear region of cytoplasm] GO:0050821[protein stabilization] GO:0051491[positive regulation of filopodium assembly] GO:0051497[negative regulation of stress fiber assembly] GO:0060396[growth hormone receptor signaling pathway] GO:0120183[positive regulation of focal adhesion disassembly] GO:1900103[positive regulation of endoplasmic reticulum unfolded protein response] GO:1903078[positive regulation of protein localization to plasma membrane]
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Human disease related genes Congenital malformations Other congenital malformations Immune system diseases Primary immunodeficiency Protein evidence (Ezkurdia et al 2014)
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Human disease related genes Congenital malformations Other congenital malformations Immune system diseases Primary immunodeficiency Protein evidence (Ezkurdia et al 2014)
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Disease related genes Human disease related genes Congenital malformations Other congenital malformations Immune system diseases Primary immunodeficiency Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001678[cellular glucose homeostasis] GO:0001784[phosphotyrosine residue binding] GO:0005068[transmembrane receptor protein tyrosine kinase adaptor activity] GO:0005158[insulin receptor binding] GO:0005159[insulin-like growth factor receptor binding] GO:0005168[neurotrophin TRKA receptor binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0005942[phosphatidylinositol 3-kinase complex] GO:0005943[phosphatidylinositol 3-kinase complex, class IA] GO:0006955[immune response] GO:0007165[signal transduction] GO:0008286[insulin receptor signaling pathway] GO:0010592[positive regulation of lamellipodium assembly] GO:0014065[phosphatidylinositol 3-kinase signaling] GO:0015031[protein transport] GO:0016020[membrane] GO:0019903[protein phosphatase binding] GO:0030183[B cell differentiation] GO:0030217[T cell differentiation] GO:0032869[cellular response to insulin stimulus] GO:0033120[positive regulation of RNA splicing] GO:0034446[substrate adhesion-dependent cell spreading] GO:0034976[response to endoplasmic reticulum stress] GO:0035014[phosphatidylinositol 3-kinase regulator activity] GO:0042307[positive regulation of protein import into nucleus] GO:0043066[negative regulation of apoptotic process] GO:0043125[ErbB-3 class receptor binding] GO:0043548[phosphatidylinositol 3-kinase binding] GO:0043551[regulation of phosphatidylinositol 3-kinase activity] GO:0043559[insulin binding] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046326[positive regulation of glucose import] GO:0046854[phosphatidylinositol phosphate biosynthetic process] GO:0046935[1-phosphatidylinositol-3-kinase regulator activity] GO:0048009[insulin-like growth factor receptor signaling pathway] GO:0048471[perinuclear region of cytoplasm] GO:0050821[protein stabilization] GO:0051491[positive regulation of filopodium assembly] GO:0051497[negative regulation of stress fiber assembly] GO:0060396[growth hormone receptor signaling pathway] GO:0120183[positive regulation of focal adhesion disassembly] GO:1900103[positive regulation of endoplasmic reticulum unfolded protein response] GO:1903078[positive regulation of protein localization to plasma membrane]
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Human disease related genes Congenital malformations Other congenital malformations Immune system diseases Primary immunodeficiency Protein evidence (Ezkurdia et al 2014)
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Human disease related genes Congenital malformations Other congenital malformations Immune system diseases Primary immunodeficiency Protein evidence (Ezkurdia et al 2014)
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Human disease related genes Congenital malformations Other congenital malformations Immune system diseases Primary immunodeficiency Protein evidence (Ezkurdia et al 2014)
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Human disease related genes Congenital malformations Other congenital malformations Immune system diseases Primary immunodeficiency Protein evidence (Ezkurdia et al 2014)
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Human disease related genes Congenital malformations Other congenital malformations Immune system diseases Primary immunodeficiency Protein evidence (Ezkurdia et al 2014)
B3KWZ7 [Target identity:100%; Query identity:100%] cDNA FLJ44373 fis, clone TRACH3009455, highly similar to Phosphatidylinositol 3-kinase regulatory subunit alpha
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Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Human disease related genes Congenital malformations Other congenital malformations Immune system diseases Primary immunodeficiency Protein evidence (Ezkurdia et al 2014)
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Human disease related genes Congenital malformations Other congenital malformations Immune system diseases Primary immunodeficiency Protein evidence (Ezkurdia et al 2014)
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Human disease related genes Congenital malformations Other congenital malformations Immune system diseases Primary immunodeficiency Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Human disease related genes Congenital malformations Other congenital malformations Immune system diseases Primary immunodeficiency Protein evidence (Ezkurdia et al 2014)
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Human disease related genes Congenital malformations Other congenital malformations Immune system diseases Primary immunodeficiency Protein evidence (Ezkurdia et al 2014)
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Human disease related genes Congenital malformations Other congenital malformations Immune system diseases Primary immunodeficiency Protein evidence (Ezkurdia et al 2014)
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Human disease related genes Congenital malformations Other congenital malformations Immune system diseases Primary immunodeficiency Protein evidence (Ezkurdia et al 2014)
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Human disease related genes Congenital malformations Other congenital malformations Immune system diseases Primary immunodeficiency Protein evidence (Ezkurdia et al 2014)
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