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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Disease related genes Human disease related genes Plasma proteins RAS pathway related proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
5
Cytoband
q14.3
Chromosome location (bp)
87267883 - 87391931
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Inhibitory regulator of the Ras-cyclic AMP pathway. Stimulates the GTPase of normal but not oncogenic Ras p21; this stimulation may be further increased in the presence of NCK1....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
GTPase activation
Gene summary (Entrez)i
Useful information about the gene from Entrez
The protein encoded by this gene is located in the cytoplasm and is part of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. Mutations leading to changes in the binding sites of either protein are associated with basal cell carcinomas. Mutations also have been associated with hereditary capillary malformations (CM) with or without arteriovenous malformations (AVM) and Parkes Weber syndrome. Alternative splicing results in two isoforms where the shorter isoform, lacking the N-terminal hydrophobic region but retaining the same activity, appears to be abundantly expressed in placental but not adult tissues. [provided by RefSeq, May 2012]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
P20936 [Direct mapping] Ras GTPase-activating protein 1
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MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes Disease related genes Human disease related genes Cancers Skin cancers Congenital malformations Congenital malformations of the circulatory system Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
P20936 [Direct mapping] Ras GTPase-activating protein 1
Show all
MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes Disease related genes Human disease related genes Cancers Skin cancers Congenital malformations Congenital malformations of the circulatory system Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000281[mitotic cytokinesis] GO:0001570[vasculogenesis] GO:0001784[phosphotyrosine residue binding] GO:0001953[negative regulation of cell-matrix adhesion] GO:0003924[GTPase activity] GO:0005096[GTPase activator activity] GO:0005102[signaling receptor binding] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0007162[negative regulation of cell adhesion] GO:0007165[signal transduction] GO:0008360[regulation of cell shape] GO:0019870[potassium channel inhibitor activity] GO:0030833[regulation of actin filament polymerization] GO:0035556[intracellular signal transduction] GO:0043066[negative regulation of apoptotic process] GO:0043087[regulation of GTPase activity] GO:0043524[negative regulation of neuron apoptotic process] GO:0043547[positive regulation of GTPase activity] GO:0046580[negative regulation of Ras protein signal transduction] GO:0048013[ephrin receptor signaling pathway] GO:0048514[blood vessel morphogenesis] GO:0050896[response to stimulus] GO:0051020[GTPase binding] GO:0051252[regulation of RNA metabolic process]
E9PGC0 [Direct mapping] Ras GTPase-activating protein 1
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MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes Human disease related genes Cancers Skin cancers Congenital malformations Congenital malformations of the circulatory system Protein evidence (Ezkurdia et al 2014)
P20936 [Direct mapping] Ras GTPase-activating protein 1
Show all
MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes Disease related genes Human disease related genes Cancers Skin cancers Congenital malformations Congenital malformations of the circulatory system Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000281[mitotic cytokinesis] GO:0001570[vasculogenesis] GO:0001784[phosphotyrosine residue binding] GO:0001953[negative regulation of cell-matrix adhesion] GO:0003924[GTPase activity] GO:0005096[GTPase activator activity] GO:0005102[signaling receptor binding] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0007162[negative regulation of cell adhesion] GO:0007165[signal transduction] GO:0008360[regulation of cell shape] GO:0019870[potassium channel inhibitor activity] GO:0030833[regulation of actin filament polymerization] GO:0035556[intracellular signal transduction] GO:0043066[negative regulation of apoptotic process] GO:0043087[regulation of GTPase activity] GO:0043524[negative regulation of neuron apoptotic process] GO:0043547[positive regulation of GTPase activity] GO:0046580[negative regulation of Ras protein signal transduction] GO:0048013[ephrin receptor signaling pathway] GO:0048514[blood vessel morphogenesis] GO:0050896[response to stimulus] GO:0051020[GTPase binding] GO:0051252[regulation of RNA metabolic process]
The Human Protein Atlas project is funded
