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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Enzymes Metabolic proteins Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
5
Cytoband
q21.1
Chromosome location (bp)
102753981 - 103029730
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Bifunctional enzyme that catalyzes the post-translational modification of inactive peptidylglycine precursors to the corresponding bioactive alpha-amidated peptides, a terminal modification in biosynthesis of many neural and endocrine peptides 1. Alpha-amidation involves two sequential reactions, both of which are catalyzed by separate catalytic domains of the enzyme. The first step, catalyzed by peptidyl alpha-hydroxylating monooxygenase (PHM) domain, is the copper-, ascorbate-, and O2-dependent stereospecific hydroxylation (with S stereochemistry) at the alpha-carbon (C-alpha) of the C-terminal glycine of the peptidylglycine substrate 2. The second step, catalyzed by the peptidylglycine amidoglycolate lyase (PAL) domain, is the zinc-dependent cleavage of the N-C-alpha bond, producing the alpha-amidated peptide and glyoxylate 3. Similarly, catalyzes the two-step conversion of an N-fatty acylglycine to a primary fatty acid amide and glyoxylate (By similarity)....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Lipid metabolism
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Calcium, Copper, Metal-binding, Vitamin C, Zinc
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a multifunctional protein. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme includes two domains with distinct catalytic activities, a peptidylglycine alpha-hydroxylating monooxygenase (PHM) domain and a peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) domain. These catalytic domains work sequentially to catalyze the conversion of neuroendocrine peptides to active alpha-amidated products. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
GO:0003824[catalytic activity] GO:0004497[monooxygenase activity] GO:0005507[copper ion binding] GO:0005515[protein binding] GO:0006518[peptide metabolic process] GO:0008152[metabolic process] GO:0016020[membrane] GO:0016715[oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen] GO:0016829[lyase activity] GO:0030658[transport vesicle membrane] GO:0031418[L-ascorbic acid binding] GO:0046872[metal ion binding]
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
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GO:0003824[catalytic activity] GO:0004598[peptidylamidoglycolate lyase activity] GO:0005515[protein binding] GO:0006518[peptide metabolic process] GO:0016020[membrane] GO:0016715[oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen] GO:0016829[lyase activity] GO:0046872[metal ion binding]
Metabolic proteins MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins DeepTMHMM predicted secreted proteins DeepSig predicted secreted proteins Protein evidence (Ezkurdia et al 2014)
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GO:0003824[catalytic activity] GO:0004497[monooxygenase activity] GO:0005507[copper ion binding] GO:0005515[protein binding] GO:0006518[peptide metabolic process] GO:0008152[metabolic process] GO:0016020[membrane] GO:0016715[oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen] GO:0016829[lyase activity] GO:0030658[transport vesicle membrane] GO:0031418[L-ascorbic acid binding] GO:0046872[metal ion binding]
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824[catalytic activity] GO:0004497[monooxygenase activity] GO:0005507[copper ion binding] GO:0005515[protein binding] GO:0006518[peptide metabolic process] GO:0008152[metabolic process] GO:0016020[membrane] GO:0016715[oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen] GO:0016829[lyase activity] GO:0030658[transport vesicle membrane] GO:0031418[L-ascorbic acid binding] GO:0046872[metal ion binding]
GO:0003824[catalytic activity] GO:0004497[monooxygenase activity] GO:0005507[copper ion binding] GO:0005515[protein binding] GO:0006518[peptide metabolic process] GO:0008152[metabolic process] GO:0016020[membrane] GO:0016715[oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen] GO:0016829[lyase activity] GO:0030658[transport vesicle membrane] GO:0031418[L-ascorbic acid binding] GO:0046872[metal ion binding]
GO:0003824[catalytic activity] GO:0004497[monooxygenase activity] GO:0005507[copper ion binding] GO:0005515[protein binding] GO:0006518[peptide metabolic process] GO:0008152[metabolic process] GO:0016020[membrane] GO:0016715[oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen] GO:0016829[lyase activity] GO:0030658[transport vesicle membrane] GO:0031418[L-ascorbic acid binding] GO:0046872[metal ion binding]
The Human Protein Atlas project is funded
