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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Human disease related genes
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
7
Cytoband
Chromosome location (bp)
2728105 - 2844308
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems 1,2,3,4,5,6,7,8,9. Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF12/LARG) 10,11,12. GNA12-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1) (By similarity). GNA12-dependent Rho signaling also regulates protein phosphatese 2A activation causing dephosphorylation of its target proteins 13,14. Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway and up-regulating pro-inflammatory cytokine production 15,16,17,18. Inhibits CDH1-mediated cell adhesion in process independent from Rho activation 19,20. Together with NAPA promotes CDH5 localization to plasma membrane 21. May play a role in the control of cell migration through the TOR signaling cascade 22....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Transducer
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Predicted to enable D5 dopamine receptor binding activity; G-protein beta/gamma-subunit complex binding activity; and GTPase activity. Involved in regulation of TOR signaling and regulation of proteasomal ubiquitin-dependent protein catabolic process. Located in focal adhesion. [provided by Alliance of Genome Resources, Apr 2022]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Q03113 [Direct mapping] Guanine nucleotide-binding protein subunit alpha-12
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Cancers Cancers of haematopoietic and lymphoid tissues Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000166[nucleotide binding] GO:0001664[G protein-coupled receptor binding] GO:0001701[in utero embryonic development] GO:0003924[GTPase activity] GO:0005515[protein binding] GO:0005525[GTP binding] GO:0005737[cytoplasm] GO:0005834[heterotrimeric G-protein complex] GO:0005886[plasma membrane] GO:0005925[focal adhesion] GO:0007165[signal transduction] GO:0007186[G protein-coupled receptor signaling pathway] GO:0007188[adenylate cyclase-modulating G protein-coupled receptor signaling pathway] GO:0007266[Rho protein signal transduction] GO:0007596[blood coagulation] GO:0008217[regulation of blood pressure] GO:0008360[regulation of cell shape] GO:0009410[response to xenobiotic stimulus] GO:0010259[multicellular organism aging] GO:0010762[regulation of fibroblast migration] GO:0016020[membrane] GO:0016328[lateral plasma membrane] GO:0019001[guanyl nucleotide binding] GO:0019888[protein phosphatase regulator activity] GO:0030154[cell differentiation] GO:0031526[brush border membrane] GO:0031683[G-protein beta/gamma-subunit complex binding] GO:0031752[D5 dopamine receptor binding] GO:0032006[regulation of TOR signaling] GO:0032434[regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0032516[positive regulation of phosphoprotein phosphatase activity] GO:0035556[intracellular signal transduction] GO:0042733[embryonic digit morphogenesis] GO:0043005[neuron projection] GO:0043025[neuronal cell body] GO:0046872[metal ion binding] GO:0051721[protein phosphatase 2A binding] GO:1904706[negative regulation of vascular associated smooth muscle cell proliferation] GO:1904753[negative regulation of vascular associated smooth muscle cell migration]
E9PC54 [Direct mapping] Guanine nucleotide-binding protein subunit alpha-12
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Phobius predicted membrane proteins THUMBUP predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Cancers Cancers of haematopoietic and lymphoid tissues Protein evidence (Ezkurdia et al 2014)
Q03113 [Direct mapping] Guanine nucleotide-binding protein subunit alpha-12
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Cancers Cancers of haematopoietic and lymphoid tissues Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000166[nucleotide binding] GO:0001664[G protein-coupled receptor binding] GO:0003924[GTPase activity] GO:0005515[protein binding] GO:0005525[GTP binding] GO:0005737[cytoplasm] GO:0005834[heterotrimeric G-protein complex] GO:0005886[plasma membrane] GO:0005925[focal adhesion] GO:0007165[signal transduction] GO:0007186[G protein-coupled receptor signaling pathway] GO:0007188[adenylate cyclase-modulating G protein-coupled receptor signaling pathway] GO:0007266[Rho protein signal transduction] GO:0007596[blood coagulation] GO:0010762[regulation of fibroblast migration] GO:0016020[membrane] GO:0016328[lateral plasma membrane] GO:0019001[guanyl nucleotide binding] GO:0019888[protein phosphatase regulator activity] GO:0031526[brush border membrane] GO:0031683[G-protein beta/gamma-subunit complex binding] GO:0031752[D5 dopamine receptor binding] GO:0032006[regulation of TOR signaling] GO:0032434[regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0032516[positive regulation of phosphoprotein phosphatase activity] GO:0043005[neuron projection] GO:0043025[neuronal cell body] GO:0046872[metal ion binding] GO:0051721[protein phosphatase 2A binding]
C9J2Y7 [Direct mapping] Guanine nucleotide-binding protein subunit alpha-12
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Cancers Cancers of haematopoietic and lymphoid tissues Protein evidence (Ezkurdia et al 2014)
The Human Protein Atlas project is funded
