GENERAL INFORMATIONi
Gene namei EGFR
Synonyms ERBB, ERBB1, ERRP
Gene descriptioni Epidermal growth factor receptor
Protein classi Cancer-related genes
Disease related genes
Enzymes
FDA approved drug targets
Human disease related genes
Metabolic proteins
Plasma proteins
RAS pathway related proteins
Transporters
Predicted locationi Secreted, Membrane
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi
Chromosome 7
Cytoband p11.2
Chromosome location (bp) 55019017 - 55211628
Number of transcriptsi 7
Ensembl ENSG00000146648 (version 109)
Entrez gene 1956
HGNC HGNC:3236
UniProt P00533 (UniProt - Evidence at protein level)
neXtProt NX_P00533
GeneCards EGFR
Antibodypedia EGFR antibodies


PROTEIN FUNCTION
Protein function (UniProt)i Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses 1, 2, 3, 4. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF 5, 6, 7, 8, 9, 10, 11, 12, 13. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules 14. May also activate the NF-kappa-B signaling cascade 15. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling 16. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin 17. Positively regulates cell migration via interaction with CCDC88A/GIV which retains EGFR at the cell membrane following ligand stimulation, promoting EGFR signaling which triggers cell migration 18. Plays a role in enhancing learning and memory performance (By similarity). Plays a role in mammalian pain signaling (long-lasting hypersensitivity) (By similarity). show less
Molecular function (UniProt)i Developmental protein, Host cell receptor for virus entry, Kinase, Receptor, Transferase, Tyrosine-protein kinase
Biological process (UniProt)i Host-virus interaction
Ligand (UniProt)i ATP-binding, Nucleotide-binding
Gene summary (Entrez)i The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor, thus inducing receptor dimerization and tyrosine autophosphorylation leading to cell proliferation. Mutations in this gene are associated with lung cancer. EGFR is a component of the cytokine storm which contributes to a severe form of Coronavirus Disease 2019 (COVID-19) resulting from infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). [provided by RefSeq, Jul 2020] show less
PROTEIN INFORMATIONi
Splice variant SwissProt TrEMBL Protein class Gene ontology Length & mass Signal peptide
(predicted)		 Transmembrane regions
(predicted)
EGFR-201
ENSP00000275493
ENST00000275493
P00533
[Direct mapping] Epidermal growth factor receptor
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Metabolic proteins
Transporters
   Accessory Factors Involved in Transport
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Amplifications
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
Disease related genes
FDA approved drug targets
   Biotech drugs
   Small molecule drugs
Human disease related genes
   Cancers
   Head and neck cancers
   Cancers of the digestive system
   Cancers of the lung and pleura
   Cancers of the breast and female genital organs
   Cancers of the urinary system
   Cancers of eye, brain, and central nervous system
   Immune system diseases
   Other immune system diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
   DeepTMHMM predicted membrane proteins
Show all
GO:0000139 [Golgi membrane]
GO:0000165 [MAPK cascade]
GO:0000166 [nucleotide binding]
GO:0000902 [cell morphogenesis]
GO:0001503 [ossification]
GO:0001618 [virus receptor activity]
GO:0001892 [embryonic placenta development]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0001942 [hair follicle development]
GO:0003682 [chromatin binding]
GO:0003690 [double-stranded DNA binding]
GO:0004672 [protein kinase activity]
GO:0004709 [MAP kinase kinase kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004714 [transmembrane receptor protein tyrosine kinase activity]
GO:0004888 [transmembrane signaling receptor activity]
GO:0005006 [epidermal growth factor receptor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006468 [protein phosphorylation]
GO:0007165 [signal transduction]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007202 [activation of phospholipase C activity]
GO:0007435 [salivary gland morphogenesis]
GO:0007611 [learning or memory]
GO:0008283 [cell population proliferation]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008544 [epidermis development]
GO:0009925 [basal plasma membrane]
GO:0009986 [cell surface]
GO:0010008 [endosome membrane]
GO:0010750 [positive regulation of nitric oxide mediated signal transduction]
GO:0014066 [regulation of phosphatidylinositol 3-kinase signaling]
GO:0016004 [phospholipase activator activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016323 [basolateral plasma membrane]
GO:0016740 [transferase activity]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019899 [enzyme binding]
GO:0019900 [kinase binding]
GO:0019903 [protein phosphatase binding]
GO:0021795 [cerebral cortex cell migration]
GO:0022008 [neurogenesis]
GO:0030054 [cell junction]
GO:0030139 [endocytic vesicle]
GO:0030235 [nitric-oxide synthase regulator activity]
GO:0030296 [protein tyrosine kinase activator activity]
GO:0030297 [transmembrane receptor protein tyrosine kinase activator activity]
GO:0030307 [positive regulation of cell growth]
GO:0030335 [positive regulation of cell migration]
GO:0030669 [clathrin-coated endocytic vesicle membrane]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031901 [early endosome membrane]
GO:0031965 [nuclear membrane]
GO:0032587 [ruffle membrane]
GO:0032991 [protein-containing complex]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0033674 [positive regulation of kinase activity]
GO:0034614 [cellular response to reactive oxygen species]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0038127 [ERBB signaling pathway]
GO:0038134 [ERBB2-EGFR signaling pathway]
GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway]
GO:0042127 [regulation of cell population proliferation]
GO:0042177 [negative regulation of protein catabolic process]
GO:0042327 [positive regulation of phosphorylation]
GO:0042802 [identical protein binding]
GO:0043066 [negative regulation of apoptotic process]
GO:0043235 [receptor complex]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0045121 [membrane raft]
GO:0045296 [cadherin binding]
GO:0045737 [positive regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0045739 [positive regulation of DNA repair]
GO:0045740 [positive regulation of DNA replication]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046328 [regulation of JNK cascade]
GO:0046718 [viral entry into host cell]
GO:0046777 [protein autophosphorylation]
GO:0048146 [positive regulation of fibroblast proliferation]
GO:0048408 [epidermal growth factor binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048546 [digestive tract morphogenesis]
GO:0050673 [epithelial cell proliferation]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0050730 [regulation of peptidyl-tyrosine phosphorylation]
GO:0050999 [regulation of nitric-oxide synthase activity]
GO:0051015 [actin filament binding]
GO:0051117 [ATPase binding]
GO:0051205 [protein insertion into membrane]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0060571 [morphogenesis of an epithelial fold]
GO:0061029 [eyelid development in camera-type eye]
GO:0070141 [response to UV-A]
GO:0070372 [regulation of ERK1 and ERK2 cascade]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0070435 [Shc-EGFR complex]
GO:0071230 [cellular response to amino acid stimulus]
GO:0071276 [cellular response to cadmium ion]
GO:0071363 [cellular response to growth factor stimulus]
GO:0071364 [cellular response to epidermal growth factor stimulus]
GO:0071392 [cellular response to estradiol stimulus]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
GO:0097489 [multivesicular body, internal vesicle lumen]
GO:0097708 [intracellular vesicle]
GO:0098590 [plasma membrane region]
GO:0098609 [cell-cell adhesion]
GO:0140677 [molecular function activator activity]
GO:1900020 [positive regulation of protein kinase C activity]
GO:1900087 [positive regulation of G1/S transition of mitotic cell cycle]
GO:1901224 [positive regulation of NIK/NF-kappaB signaling]
GO:1902895 [positive regulation of miRNA transcription]
GO:1903078 [positive regulation of protein localization to plasma membrane]
GO:1905208 [negative regulation of cardiocyte differentiation]
Show all
 1210 aa
134.3 kDa 		Yes 1
EGFR-202
ENSP00000342376
ENST00000342916
P00533
[Direct mapping] Epidermal growth factor receptor
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Metabolic proteins
Transporters
   Accessory Factors Involved in Transport
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
   DeepTMHMM predicted secreted proteins
   DeepSig predicted secreted proteins
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Amplifications
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
Disease related genes
FDA approved drug targets
   Biotech drugs
   Small molecule drugs
Human disease related genes
   Cancers
   Head and neck cancers
   Cancers of the digestive system
   Cancers of the lung and pleura
   Cancers of the breast and female genital organs
   Cancers of the urinary system
   Cancers of eye, brain, and central nervous system
   Immune system diseases
   Other immune system diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0000165 [MAPK cascade]
GO:0000166 [nucleotide binding]
GO:0001503 [ossification]
GO:0001618 [virus receptor activity]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0003682 [chromatin binding]
GO:0003690 [double-stranded DNA binding]
GO:0004672 [protein kinase activity]
GO:0004709 [MAP kinase kinase kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004714 [transmembrane receptor protein tyrosine kinase activity]
GO:0004888 [transmembrane signaling receptor activity]
GO:0005006 [epidermal growth factor receptor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006468 [protein phosphorylation]
GO:0007165 [signal transduction]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007202 [activation of phospholipase C activity]
GO:0007611 [learning or memory]
GO:0008284 [positive regulation of cell population proliferation]
GO:0009925 [basal plasma membrane]
GO:0009986 [cell surface]
GO:0010008 [endosome membrane]
GO:0010750 [positive regulation of nitric oxide mediated signal transduction]
GO:0014066 [regulation of phosphatidylinositol 3-kinase signaling]
GO:0016020 [membrane]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016323 [basolateral plasma membrane]
GO:0016740 [transferase activity]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019899 [enzyme binding]
GO:0019900 [kinase binding]
GO:0019903 [protein phosphatase binding]
GO:0022008 [neurogenesis]
GO:0030054 [cell junction]
GO:0030235 [nitric-oxide synthase regulator activity]
GO:0030296 [protein tyrosine kinase activator activity]
GO:0030307 [positive regulation of cell growth]
GO:0030335 [positive regulation of cell migration]
GO:0030669 [clathrin-coated endocytic vesicle membrane]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031901 [early endosome membrane]
GO:0031965 [nuclear membrane]
GO:0032587 [ruffle membrane]
GO:0032991 [protein-containing complex]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0033674 [positive regulation of kinase activity]
GO:0034614 [cellular response to reactive oxygen species]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0038127 [ERBB signaling pathway]
GO:0038134 [ERBB2-EGFR signaling pathway]
GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway]
GO:0042127 [regulation of cell population proliferation]
GO:0042177 [negative regulation of protein catabolic process]
GO:0042327 [positive regulation of phosphorylation]
GO:0042802 [identical protein binding]
GO:0043066 [negative regulation of apoptotic process]
GO:0043235 [receptor complex]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0045121 [membrane raft]
GO:0045296 [cadherin binding]
GO:0045737 [positive regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0045739 [positive regulation of DNA repair]
GO:0045740 [positive regulation of DNA replication]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046328 [regulation of JNK cascade]
GO:0046718 [viral entry into host cell]
GO:0046777 [protein autophosphorylation]
GO:0048408 [epidermal growth factor binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0050730 [regulation of peptidyl-tyrosine phosphorylation]
GO:0050999 [regulation of nitric-oxide synthase activity]
GO:0051015 [actin filament binding]
GO:0051117 [ATPase binding]
GO:0051205 [protein insertion into membrane]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0070141 [response to UV-A]
GO:0070372 [regulation of ERK1 and ERK2 cascade]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0070435 [Shc-EGFR complex]
GO:0071276 [cellular response to cadmium ion]
GO:0071364 [cellular response to epidermal growth factor stimulus]
GO:0071392 [cellular response to estradiol stimulus]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
GO:0097489 [multivesicular body, internal vesicle lumen]
GO:0097708 [intracellular vesicle]
GO:0098590 [plasma membrane region]
GO:0098609 [cell-cell adhesion]
GO:1900020 [positive regulation of protein kinase C activity]
GO:1900087 [positive regulation of G1/S transition of mitotic cell cycle]
GO:1901224 [positive regulation of NIK/NF-kappaB signaling]
GO:1902895 [positive regulation of miRNA transcription]
GO:1903078 [positive regulation of protein localization to plasma membrane]
GO:1905208 [negative regulation of cardiocyte differentiation]
Show all
 628 aa
69.2 kDa 		Yes 0
EGFR-203
ENSP00000345973
ENST00000344576
P00533
[Direct mapping] Epidermal growth factor receptor
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Metabolic proteins
Transporters
   Accessory Factors Involved in Transport
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
   DeepTMHMM predicted secreted proteins
   DeepSig predicted secreted proteins
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Amplifications
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
Disease related genes
FDA approved drug targets
   Biotech drugs
   Small molecule drugs
Human disease related genes
   Cancers
   Head and neck cancers
   Cancers of the digestive system
   Cancers of the lung and pleura
   Cancers of the breast and female genital organs
   Cancers of the urinary system
   Cancers of eye, brain, and central nervous system
   Immune system diseases
   Other immune system diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0000165 [MAPK cascade]
GO:0000166 [nucleotide binding]
GO:0001503 [ossification]
GO:0001618 [virus receptor activity]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0003682 [chromatin binding]
GO:0003690 [double-stranded DNA binding]
GO:0004672 [protein kinase activity]
GO:0004709 [MAP kinase kinase kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004714 [transmembrane receptor protein tyrosine kinase activity]
GO:0004888 [transmembrane signaling receptor activity]
GO:0005006 [epidermal growth factor receptor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006468 [protein phosphorylation]
GO:0007165 [signal transduction]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007202 [activation of phospholipase C activity]
GO:0007611 [learning or memory]
GO:0008284 [positive regulation of cell population proliferation]
GO:0009925 [basal plasma membrane]
GO:0009986 [cell surface]
GO:0010008 [endosome membrane]
GO:0010750 [positive regulation of nitric oxide mediated signal transduction]
GO:0014066 [regulation of phosphatidylinositol 3-kinase signaling]
GO:0016020 [membrane]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016323 [basolateral plasma membrane]
GO:0016740 [transferase activity]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019899 [enzyme binding]
GO:0019900 [kinase binding]
GO:0019903 [protein phosphatase binding]
GO:0022008 [neurogenesis]
GO:0030054 [cell junction]
GO:0030235 [nitric-oxide synthase regulator activity]
GO:0030296 [protein tyrosine kinase activator activity]
GO:0030307 [positive regulation of cell growth]
GO:0030335 [positive regulation of cell migration]
GO:0030669 [clathrin-coated endocytic vesicle membrane]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031901 [early endosome membrane]
GO:0031965 [nuclear membrane]
GO:0032587 [ruffle membrane]
GO:0032991 [protein-containing complex]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0033674 [positive regulation of kinase activity]
GO:0034614 [cellular response to reactive oxygen species]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0038127 [ERBB signaling pathway]
GO:0038134 [ERBB2-EGFR signaling pathway]
GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway]
GO:0042127 [regulation of cell population proliferation]
GO:0042177 [negative regulation of protein catabolic process]
GO:0042327 [positive regulation of phosphorylation]
GO:0042802 [identical protein binding]
GO:0043066 [negative regulation of apoptotic process]
GO:0043235 [receptor complex]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0045121 [membrane raft]
GO:0045296 [cadherin binding]
GO:0045737 [positive regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0045739 [positive regulation of DNA repair]
GO:0045740 [positive regulation of DNA replication]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046328 [regulation of JNK cascade]
GO:0046718 [viral entry into host cell]
GO:0046777 [protein autophosphorylation]
GO:0048408 [epidermal growth factor binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0050730 [regulation of peptidyl-tyrosine phosphorylation]
GO:0050999 [regulation of nitric-oxide synthase activity]
GO:0051015 [actin filament binding]
GO:0051117 [ATPase binding]
GO:0051205 [protein insertion into membrane]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0070141 [response to UV-A]
GO:0070372 [regulation of ERK1 and ERK2 cascade]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0070435 [Shc-EGFR complex]
GO:0071276 [cellular response to cadmium ion]
GO:0071364 [cellular response to epidermal growth factor stimulus]
GO:0071392 [cellular response to estradiol stimulus]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
GO:0097489 [multivesicular body, internal vesicle lumen]
GO:0097708 [intracellular vesicle]
GO:0098590 [plasma membrane region]
GO:0098609 [cell-cell adhesion]
GO:1900020 [positive regulation of protein kinase C activity]
GO:1900087 [positive regulation of G1/S transition of mitotic cell cycle]
GO:1901224 [positive regulation of NIK/NF-kappaB signaling]
GO:1902895 [positive regulation of miRNA transcription]
GO:1903078 [positive regulation of protein localization to plasma membrane]
GO:1905208 [negative regulation of cardiocyte differentiation]
Show all
 705 aa
77.3 kDa 		Yes 0
EGFR-204
ENSP00000413843
ENST00000420316
P00533
[Direct mapping] Epidermal growth factor receptor
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Metabolic proteins
Transporters
   Accessory Factors Involved in Transport
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
   DeepTMHMM predicted secreted proteins
   DeepSig predicted secreted proteins
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Amplifications
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
Disease related genes
FDA approved drug targets
   Biotech drugs
   Small molecule drugs
Human disease related genes
   Cancers
   Head and neck cancers
   Cancers of the digestive system
   Cancers of the lung and pleura
   Cancers of the breast and female genital organs
   Cancers of the urinary system
   Cancers of eye, brain, and central nervous system
   Immune system diseases
   Other immune system diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0000165 [MAPK cascade]
GO:0000166 [nucleotide binding]
GO:0001503 [ossification]
GO:0001618 [virus receptor activity]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0003682 [chromatin binding]
GO:0003690 [double-stranded DNA binding]
GO:0004672 [protein kinase activity]
GO:0004709 [MAP kinase kinase kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004714 [transmembrane receptor protein tyrosine kinase activity]
GO:0004888 [transmembrane signaling receptor activity]
GO:0005006 [epidermal growth factor receptor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006468 [protein phosphorylation]
GO:0007165 [signal transduction]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007202 [activation of phospholipase C activity]
GO:0007611 [learning or memory]
GO:0008284 [positive regulation of cell population proliferation]
GO:0009925 [basal plasma membrane]
GO:0009986 [cell surface]
GO:0010008 [endosome membrane]
GO:0010750 [positive regulation of nitric oxide mediated signal transduction]
GO:0014066 [regulation of phosphatidylinositol 3-kinase signaling]
GO:0016020 [membrane]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016323 [basolateral plasma membrane]
GO:0016740 [transferase activity]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019899 [enzyme binding]
GO:0019900 [kinase binding]
GO:0019903 [protein phosphatase binding]
GO:0022008 [neurogenesis]
GO:0030054 [cell junction]
GO:0030235 [nitric-oxide synthase regulator activity]
GO:0030296 [protein tyrosine kinase activator activity]
GO:0030307 [positive regulation of cell growth]
GO:0030335 [positive regulation of cell migration]
GO:0030669 [clathrin-coated endocytic vesicle membrane]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031901 [early endosome membrane]
GO:0031965 [nuclear membrane]
GO:0032587 [ruffle membrane]
GO:0032991 [protein-containing complex]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0033674 [positive regulation of kinase activity]
GO:0034614 [cellular response to reactive oxygen species]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0038127 [ERBB signaling pathway]
GO:0038134 [ERBB2-EGFR signaling pathway]
GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway]
GO:0042127 [regulation of cell population proliferation]
GO:0042177 [negative regulation of protein catabolic process]
GO:0042327 [positive regulation of phosphorylation]
GO:0042802 [identical protein binding]
GO:0043066 [negative regulation of apoptotic process]
GO:0043235 [receptor complex]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0045121 [membrane raft]
GO:0045296 [cadherin binding]
GO:0045737 [positive regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0045739 [positive regulation of DNA repair]
GO:0045740 [positive regulation of DNA replication]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046328 [regulation of JNK cascade]
GO:0046718 [viral entry into host cell]
GO:0046777 [protein autophosphorylation]
GO:0048408 [epidermal growth factor binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0050730 [regulation of peptidyl-tyrosine phosphorylation]
GO:0050999 [regulation of nitric-oxide synthase activity]
GO:0051015 [actin filament binding]
GO:0051117 [ATPase binding]
GO:0051205 [protein insertion into membrane]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0070141 [response to UV-A]
GO:0070372 [regulation of ERK1 and ERK2 cascade]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0070435 [Shc-EGFR complex]
GO:0071276 [cellular response to cadmium ion]
GO:0071364 [cellular response to epidermal growth factor stimulus]
GO:0071392 [cellular response to estradiol stimulus]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
GO:0097489 [multivesicular body, internal vesicle lumen]
GO:0097708 [intracellular vesicle]
GO:0098590 [plasma membrane region]
GO:0098609 [cell-cell adhesion]
GO:1900020 [positive regulation of protein kinase C activity]
GO:1900087 [positive regulation of G1/S transition of mitotic cell cycle]
GO:1901224 [positive regulation of NIK/NF-kappaB signaling]
GO:1902895 [positive regulation of miRNA transcription]
GO:1903078 [positive regulation of protein localization to plasma membrane]
GO:1905208 [negative regulation of cardiocyte differentiation]
Show all
 405 aa
44.7 kDa 		Yes 0
EGFR-205
ENSP00000413354
ENST00000450046
C9JYS6
[Direct mapping] Epidermal growth factor receptor
Show all
Metabolic proteins
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
RAS pathway related proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Amplifications
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
Human disease related genes
   Cancers
   Head and neck cancers
   Cancers of the digestive system
   Cancers of the lung and pleura
   Cancers of the breast and female genital organs
   Cancers of the urinary system
   Cancers of eye, brain, and central nervous system
   Immune system diseases
   Other immune system diseases
Protein evidence (Ezkurdia et al 2014)
   DeepTMHMM predicted membrane proteins
Show all
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0016021 [integral component of membrane]
Show all
 1157 aa
128.7 kDa 		No 1
EGFR-206
ENSP00000415559
ENST00000455089
Q504U8
[Direct mapping] Receptor protein-tyrosine kinase
Show all
Metabolic proteins
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
RAS pathway related proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Amplifications
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
Human disease related genes
   Cancers
   Head and neck cancers
   Cancers of the digestive system
   Cancers of the lung and pleura
   Cancers of the breast and female genital organs
   Cancers of the urinary system
   Cancers of eye, brain, and central nervous system
   Immune system diseases
   Other immune system diseases
Protein evidence (Ezkurdia et al 2014)
   DeepTMHMM predicted membrane proteins
Show all
GO:0000166 [nucleotide binding]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004714 [transmembrane receptor protein tyrosine kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
GO:0006898 [receptor-mediated endocytosis]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0038127 [ERBB signaling pathway]
GO:0042127 [regulation of cell population proliferation]
GO:0043235 [receptor complex]
GO:0046777 [protein autophosphorylation]
GO:0098590 [plasma membrane region]
Show all
 1091 aa
120.7 kDa 		Yes 1
EGFR-211
ENSP00000514824
ENST00000700145
Metabolic proteins
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
RAS pathway related proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Amplifications
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
Human disease related genes
   Cancers
   Head and neck cancers
   Cancers of the digestive system
   Cancers of the lung and pleura
   Cancers of the breast and female genital organs
   Cancers of the urinary system
   Cancers of eye, brain, and central nervous system
   Immune system diseases
   Other immune system diseases
Protein evidence (Ezkurdia et al 2014)
   DeepTMHMM predicted membrane proteins
Show all
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
 344 aa
37.9 kDa 		No 1

Contact

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The Human Protein Atlas

The Human Protein Atlas project is funded
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