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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
X
Cytoband
p11.22
Chromosome location (bp)
50202713 - 50351914
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Cyclins are positive regulatory subunits of the cyclin-dependent kinases (CDKs), and thereby play an essential role in the control of the cell cycle, notably via their destruction during cell division. Its tissue specificity suggest that it may be required during early meiotic prophase I....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Cyclin
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Cell cycle, Cell division, Meiosis
Gene summary (Entrez)i
Useful information about the gene from Entrez
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as positive regulators of cyclin-dependent kinases (CDKs), and thereby play an essential role in the control of the cell cycle. Different cyclins exhibit distinct expression and degradation patterns, which contribute to the temporal coordination of each mitotic event. Studies of similar genes in chicken and drosophila suggest that this cyclin may associate with CDC2 and CDK2 kinases, and may be required for proper spindle reorganization and restoration of the interphase nucleus. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level
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GO:0000079[regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0000307[cyclin-dependent protein kinase holoenzyme complex] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005813[centrosome] GO:0007049[cell cycle] GO:0010389[regulation of G2/M transition of mitotic cell cycle] GO:0016538[cyclin-dependent protein serine/threonine kinase regulator activity] GO:0016607[nuclear speck] GO:0019901[protein kinase binding] GO:0044772[mitotic cell cycle phase transition] GO:0051301[cell division] GO:0051321[meiotic cell cycle]
SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0000079[regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0000307[cyclin-dependent protein kinase holoenzyme complex] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005813[centrosome] GO:0007049[cell cycle] GO:0010389[regulation of G2/M transition of mitotic cell cycle] GO:0016538[cyclin-dependent protein serine/threonine kinase regulator activity] GO:0016607[nuclear speck] GO:0019901[protein kinase binding] GO:0044772[mitotic cell cycle phase transition] GO:0051301[cell division] GO:0051321[meiotic cell cycle]
SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0000079[regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0000307[cyclin-dependent protein kinase holoenzyme complex] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005813[centrosome] GO:0007049[cell cycle] GO:0010389[regulation of G2/M transition of mitotic cell cycle] GO:0016538[cyclin-dependent protein serine/threonine kinase regulator activity] GO:0016607[nuclear speck] GO:0019901[protein kinase binding] GO:0044772[mitotic cell cycle phase transition] GO:0051301[cell division] GO:0051321[meiotic cell cycle]
SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014)
Show all
GO:0000079[regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0000307[cyclin-dependent protein kinase holoenzyme complex] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005813[centrosome] GO:0007049[cell cycle] GO:0010389[regulation of G2/M transition of mitotic cell cycle] GO:0016538[cyclin-dependent protein serine/threonine kinase regulator activity] GO:0016607[nuclear speck] GO:0019901[protein kinase binding] GO:0044772[mitotic cell cycle phase transition] GO:0051301[cell division] GO:0051321[meiotic cell cycle]
The Human Protein Atlas project is funded
