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On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units.
Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set.
If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.
h
m
l
n
Glial cells:
Not detected
Neuronal cells:
Medium
Neuronal projections:
High
Synapses:
High
RNA expressioni
A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas (HPA), Genotype-Tissue Expression (GTEx) portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets.
The mRNA expression levels in pig are based on RNA-seq data generated by the Human Protein Atlas (HPA), and for mouse, HPA data and in situ hybridization generated by the Allen brain atlas are reported.
Scroll down to view mRNA expression data in more detail.
Consensus:
74.7
nTPM
HPA Brain:
284.2
nTPM
GTEx:
74.7
nTPM
Pig:
49.4
nTPM
Mouse:
89.4
nTPM
Allen mouse:
8.4
Expression energy
HYPOTHALAMUS - Extended tissue profilei
For selected proteins extended tissue profiling is performed in addition to standard tissue microarrays. The section below contains results from the extended profiling.
, antibody HPA002064
Glial cells
Not detected
Neuronal cells
Medium
Neuronal projections
High
Synapses
High
HYPOTHALAMUS - Extended tissue profilei
For selected proteins extended tissue profiling is performed in addition to standard tissue microarrays. The section below contains results from the extended profiling.
, antibody HPA076209
Glial cells
Not detected
Neuronal cells
Medium
Neuronal projections
Low
Synapses
High
HYPOTHALAMUS - HPA Brain RNA-seq
Max subtype nTPMi
Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.
284.2
Sample id
Sample description
nTPM
Arcuate nucleus nTPM: 284.2
2226
Male, age 75, left hemisphere
338.5
1961
Female, age 42, unknown
230.0
Dorsomedial nucleus nTPM: 71.1
2041
Female, age 72, unknown
110.1
2017
Female, age 42, unknown
94.2
1989
Male, age 62, unknown
9.0
Lateral hypothalamic area nTPM: 42.8
2228
Male, age 66, unknown
73.6
1791
Male, age 80, right hemisphere
46.5
2412
Male, age 62, unknown
44.5
2271
Male, age 75, both hemispheres
6.7
Mammillary body nTPM: 1.3
2413
Male, age 66, unknown
1.8
1945
Male, age 80, right hemisphere
1.4
1948
Female, age 72, unknown
1.3
1834
Female, age 42, unknown
1.0
1923
Female, age 72, unknown
0.8
Paraventricular nucleus nTPM: 75.7
2700
Male, age 62, unknown
75.7
Preoptic area nTPM: 100.6
1907
Male, age 80, right hemisphere
157.6
1861
Female, age 42, unknown
91.6
2414
Female, age 72, unknown
52.6
Supraoptic nucleus nTPM: 32.1
1894
Female, age 72, unknown
50.5
2043
Male, age 62, unknown
25.2
2835
Female, age 72, unknown
20.7
Ventromedial nucleus nTPM: 107.0
1822
Female, age 42, unknown
159.0
1982
Female, age 72, unknown
55.0
HYPOTHALAMUS - GTEx RNA-seqi
RNA-Seq data generated by the Genotype-Tissue Expression (GTEx) project from human tissues is reported as mean nTPM. More information can be found on the GTEx portal.
Distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Max subtype nTPMi
Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.
74.7
GTEx sample id
Sample description
nTPM
Brain - Hypothalamus Average nTPM: 74.7
Samples: 202
Max nTPM: 328.4
Min nTPM: 0.3
Std nTPM: 67.5
Median nTPM: 53.5
Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Max subtype nTPMi
Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.
Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Max subtype nTPMi
Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.
89.4
Mouse sample
Sample description
nTPM
Hypothalamus nTPM: 89.4
Samples: 4
Max nTPM: 101.0
Min nTPM: 75.5
Sample A
Male
101.0
Sample B
Male
100.9
Sample C
Female
80.2
Sample D
Female
75.5
HYPOTHALAMUS - Allen Mouse ISHi
In situ hybridization (ISH) data generated by the Allen brain atlas from mouse brain is reported as expression energy. For more details about a particular experiment, click on the corresponding Allen experiment ID.
Max subtype Expression energyi
Max subtype Expression energy is the value for the subtype with the largest average Expression energy across the subtype samples.
The Human Protein Atlas project is funded
