We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Human disease related genes
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
9
Cytoband
p21.3
Chromosome location (bp)
22002903 - 22009305
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Interacts strongly with CDK4 and CDK6. Potent inhibitor. Potential effector of TGF-beta induced cell cycle arrest....show less
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Cell cycle
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Cancers Cancers of the lung and pleura Skin cancers Cancers of soft tissues and bone Cancers of eye, brain, and central nervous system Cancers of haematopoietic and lymphoid tissues Endocrine and metabolic diseases Diabetes Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0000079[regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0001889[liver development] GO:0004861[cyclin-dependent protein serine/threonine kinase inhibitor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0007049[cell cycle] GO:0007568[aging] GO:0008285[negative regulation of cell population proliferation] GO:0014070[response to organic cyclic compound] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0019901[protein kinase binding] GO:0030219[megakaryocyte differentiation] GO:0030511[positive regulation of transforming growth factor beta receptor signaling pathway] GO:0030858[positive regulation of epithelial cell differentiation] GO:0031668[cellular response to extracellular stimulus] GO:0031670[cellular response to nutrient] GO:0034097[response to cytokine] GO:0042326[negative regulation of phosphorylation] GO:0045736[negative regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0048536[spleen development] GO:0050680[negative regulation of epithelial cell proliferation] GO:0060253[negative regulation of glial cell proliferation] GO:0070316[regulation of G0 to G1 transition] GO:0071560[cellular response to transforming growth factor beta stimulus] GO:0090398[cellular senescence] GO:1902807[negative regulation of cell cycle G1/S phase transition] GO:2000045[regulation of G1/S transition of mitotic cell cycle] GO:2000134[negative regulation of G1/S transition of mitotic cell cycle]
P42772 [Direct mapping] Cyclin-dependent kinase 4 inhibitor B
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Cancers Cancers of the lung and pleura Skin cancers Cancers of soft tissues and bone Cancers of eye, brain, and central nervous system Cancers of haematopoietic and lymphoid tissues Endocrine and metabolic diseases Diabetes Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0000079[regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0004861[cyclin-dependent protein serine/threonine kinase inhibitor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0007049[cell cycle] GO:0008285[negative regulation of cell population proliferation] GO:0019901[protein kinase binding] GO:0030219[megakaryocyte differentiation] GO:0030511[positive regulation of transforming growth factor beta receptor signaling pathway] GO:0031668[cellular response to extracellular stimulus] GO:0031670[cellular response to nutrient] GO:0042326[negative regulation of phosphorylation] GO:0045736[negative regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0050680[negative regulation of epithelial cell proliferation] GO:0070316[regulation of G0 to G1 transition] GO:0090398[cellular senescence] GO:2000045[regulation of G1/S transition of mitotic cell cycle]
The Human Protein Atlas project is funded
