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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Disease related genes Enzymes FDA approved drug targets Human disease related genes Plasma proteins RAS pathway related proteins Transporters
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
9
Cytoband
q21.33
Chromosome location (bp)
84668375 - 85095751
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity (By similarity). Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4. Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2 1,2. Upon ligand-binding, undergoes homodimerization, autophosphorylation and activation 3. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades. Through SHC1, FRS2, SH2B1, SH2B2 activates the GRB2-Ras-MAPK cascade that regulates for instance neuronal differentiation including neurite outgrowth. Through the same effectors controls the Ras-PI3 kinase-AKT1 signaling cascade that mainly regulates growth and survival. Through PLCG1 and the downstream protein kinase C-regulated pathways controls synaptic plasticity. Thereby, plays a role in learning and memory by regulating both short term synaptic function and long-term potentiation. PLCG1 also leads to NF-Kappa-B activation and the transcription of genes involved in cell survival. Hence, it is able to suppress anoikis, the apoptosis resulting from loss of cell-matrix interactions. May also play a role in neutrophin-dependent calcium signaling in glial cells and mediate communication between neurons and glia....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Differentiation, Neurogenesis
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
ATP-binding, Nucleotide-binding
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Transporters Accessory Factors Involved in Transport Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Cancers Cancers of eye, brain, and central nervous system Nervous system diseases Epilepsy Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) DeepTMHMM predicted membrane proteins
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GO:0000166[nucleotide binding] GO:0001570[vasculogenesis] GO:0001764[neuron migration] GO:0001934[positive regulation of protein phosphorylation] GO:0002020[protease binding] GO:0004672[protein kinase activity] GO:0004713[protein tyrosine kinase activity] GO:0004714[transmembrane receptor protein tyrosine kinase activity] GO:0005030[neurotrophin receptor activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005737[cytoplasm] GO:0005768[endosome] GO:0005769[early endosome] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0005887[integral component of plasma membrane] GO:0006468[protein phosphorylation] GO:0007169[transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007399[nervous system development] GO:0007612[learning] GO:0007623[circadian rhythm] GO:0007631[feeding behavior] GO:0008284[positive regulation of cell population proliferation] GO:0010008[endosome membrane] GO:0010628[positive regulation of gene expression] GO:0010976[positive regulation of neuron projection development] GO:0014047[glutamate secretion] GO:0014068[positive regulation of phosphatidylinositol 3-kinase signaling] GO:0014069[postsynaptic density] GO:0016020[membrane] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016740[transferase activity] GO:0018105[peptidyl-serine phosphorylation] GO:0018108[peptidyl-tyrosine phosphorylation] GO:0019222[regulation of metabolic process] GO:0019227[neuronal action potential propagation] GO:0021954[central nervous system neuron development] GO:0021987[cerebral cortex development] GO:0022011[myelination in peripheral nervous system] GO:0030154[cell differentiation] GO:0030182[neuron differentiation] GO:0030424[axon] GO:0030425[dendrite] GO:0031547[brain-derived neurotrophic factor receptor signaling pathway] GO:0031901[early endosome membrane] GO:0033138[positive regulation of peptidyl-serine phosphorylation] GO:0033674[positive regulation of kinase activity] GO:0038179[neurotrophin signaling pathway] GO:0042490[mechanoreceptor differentiation] GO:0042803[protein homodimerization activity] GO:0042995[cell projection] GO:0043087[regulation of GTPase activity] GO:0043121[neurotrophin binding] GO:0043195[terminal bouton] GO:0043197[dendritic spine] GO:0043235[receptor complex] GO:0043410[positive regulation of MAPK cascade] GO:0043524[negative regulation of neuron apoptotic process] GO:0043679[axon terminus] GO:0045202[synapse] GO:0046548[retinal rod cell development] GO:0046777[protein autophosphorylation] GO:0048403[brain-derived neurotrophic factor binding] GO:0048471[perinuclear region of cytoplasm] GO:0048709[oligodendrocyte differentiation] GO:0048935[peripheral nervous system neuron development] GO:0050772[positive regulation of axonogenesis] GO:0051716[cellular response to stimulus] GO:0051896[regulation of protein kinase B signaling] GO:0051965[positive regulation of synapse assembly] GO:0060041[retina development in camera-type eye] GO:0060175[brain-derived neurotrophic factor receptor activity] GO:0060291[long-term synaptic potentiation] GO:0071230[cellular response to amino acid stimulus] GO:0099183[trans-synaptic signaling by BDNF, modulating synaptic transmission] GO:0099551[trans-synaptic signaling by neuropeptide, modulating synaptic transmission] GO:1902430[negative regulation of amyloid-beta formation] GO:1990090[cellular response to nerve growth factor stimulus] GO:1990416[cellular response to brain-derived neurotrophic factor stimulus] GO:2000811[negative regulation of anoikis]
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Transporters Accessory Factors Involved in Transport Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Cancers Cancers of eye, brain, and central nervous system Nervous system diseases Epilepsy Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014) DeepTMHMM predicted membrane proteins
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GO:0000166[nucleotide binding] GO:0001764[neuron migration] GO:0001934[positive regulation of protein phosphorylation] GO:0002020[protease binding] GO:0004672[protein kinase activity] GO:0004713[protein tyrosine kinase activity] GO:0004714[transmembrane receptor protein tyrosine kinase activity] GO:0005030[neurotrophin receptor activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005737[cytoplasm] GO:0005768[endosome] GO:0005769[early endosome] GO:0005886[plasma membrane] GO:0005887[integral component of plasma membrane] GO:0006468[protein phosphorylation] GO:0007169[transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007399[nervous system development] GO:0007612[learning] GO:0008284[positive regulation of cell population proliferation] GO:0010008[endosome membrane] GO:0010628[positive regulation of gene expression] GO:0010976[positive regulation of neuron projection development] GO:0014068[positive regulation of phosphatidylinositol 3-kinase signaling] GO:0014069[postsynaptic density] GO:0016020[membrane] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016740[transferase activity] GO:0018108[peptidyl-tyrosine phosphorylation] GO:0021954[central nervous system neuron development] GO:0021987[cerebral cortex development] GO:0030154[cell differentiation] GO:0030182[neuron differentiation] GO:0030424[axon] GO:0030425[dendrite] GO:0031547[brain-derived neurotrophic factor receptor signaling pathway] GO:0031901[early endosome membrane] GO:0033674[positive regulation of kinase activity] GO:0038179[neurotrophin signaling pathway] GO:0042803[protein homodimerization activity] GO:0042995[cell projection] GO:0043087[regulation of GTPase activity] GO:0043121[neurotrophin binding] GO:0043197[dendritic spine] GO:0043235[receptor complex] GO:0043410[positive regulation of MAPK cascade] GO:0043524[negative regulation of neuron apoptotic process] GO:0043679[axon terminus] GO:0045202[synapse] GO:0046777[protein autophosphorylation] GO:0048403[brain-derived neurotrophic factor binding] GO:0048471[perinuclear region of cytoplasm] GO:0050772[positive regulation of axonogenesis] GO:0051716[cellular response to stimulus] GO:0051896[regulation of protein kinase B signaling] GO:0060175[brain-derived neurotrophic factor receptor activity] GO:0099551[trans-synaptic signaling by neuropeptide, modulating synaptic transmission] GO:1902430[negative regulation of amyloid-beta formation] GO:1990090[cellular response to nerve growth factor stimulus] GO:1990416[cellular response to brain-derived neurotrophic factor stimulus]
Q5VWE5 [Target identity:100%; Query identity:100%] Neurotrophic tyrosine kinase, receptor, type 2, isoform CRA_a; cDNA FLJ76753, highly similar to Homo sapiens neurotrophic tyrosine kinase, receptor, type 2 (NTRK2), transcript variant b, mRNA
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Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Transporters Accessory Factors Involved in Transport Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Cancers Cancers of eye, brain, and central nervous system Nervous system diseases Epilepsy Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014) DeepTMHMM predicted membrane proteins
Show all
GO:0000166[nucleotide binding] GO:0001764[neuron migration] GO:0001934[positive regulation of protein phosphorylation] GO:0002020[protease binding] GO:0004672[protein kinase activity] GO:0004713[protein tyrosine kinase activity] GO:0004714[transmembrane receptor protein tyrosine kinase activity] GO:0005030[neurotrophin receptor activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005737[cytoplasm] GO:0005768[endosome] GO:0005769[early endosome] GO:0005886[plasma membrane] GO:0005887[integral component of plasma membrane] GO:0006468[protein phosphorylation] GO:0007169[transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007399[nervous system development] GO:0007612[learning] GO:0008284[positive regulation of cell population proliferation] GO:0010008[endosome membrane] GO:0010628[positive regulation of gene expression] GO:0010976[positive regulation of neuron projection development] GO:0014068[positive regulation of phosphatidylinositol 3-kinase signaling] GO:0014069[postsynaptic density] GO:0016020[membrane] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016740[transferase activity] GO:0018108[peptidyl-tyrosine phosphorylation] GO:0021954[central nervous system neuron development] GO:0021987[cerebral cortex development] GO:0030154[cell differentiation] GO:0030182[neuron differentiation] GO:0030424[axon] GO:0030425[dendrite] GO:0031547[brain-derived neurotrophic factor receptor signaling pathway] GO:0031901[early endosome membrane] GO:0033674[positive regulation of kinase activity] GO:0038179[neurotrophin signaling pathway] GO:0042803[protein homodimerization activity] GO:0042995[cell projection] GO:0043087[regulation of GTPase activity] GO:0043121[neurotrophin binding] GO:0043197[dendritic spine] GO:0043235[receptor complex] GO:0043410[positive regulation of MAPK cascade] GO:0043524[negative regulation of neuron apoptotic process] GO:0043679[axon terminus] GO:0045202[synapse] GO:0046777[protein autophosphorylation] GO:0048403[brain-derived neurotrophic factor binding] GO:0048471[perinuclear region of cytoplasm] GO:0050772[positive regulation of axonogenesis] GO:0051716[cellular response to stimulus] GO:0051896[regulation of protein kinase B signaling] GO:0060175[brain-derived neurotrophic factor receptor activity] GO:0099551[trans-synaptic signaling by neuropeptide, modulating synaptic transmission] GO:1902430[negative regulation of amyloid-beta formation] GO:1990090[cellular response to nerve growth factor stimulus] GO:1990416[cellular response to brain-derived neurotrophic factor stimulus]
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Transporters Accessory Factors Involved in Transport Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Cancers Cancers of eye, brain, and central nervous system Nervous system diseases Epilepsy Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) DeepTMHMM predicted membrane proteins
Show all
GO:0000166[nucleotide binding] GO:0001764[neuron migration] GO:0001934[positive regulation of protein phosphorylation] GO:0002020[protease binding] GO:0004672[protein kinase activity] GO:0004713[protein tyrosine kinase activity] GO:0004714[transmembrane receptor protein tyrosine kinase activity] GO:0005030[neurotrophin receptor activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005737[cytoplasm] GO:0005768[endosome] GO:0005769[early endosome] GO:0005886[plasma membrane] GO:0005887[integral component of plasma membrane] GO:0006468[protein phosphorylation] GO:0007169[transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007399[nervous system development] GO:0007612[learning] GO:0008284[positive regulation of cell population proliferation] GO:0010008[endosome membrane] GO:0010628[positive regulation of gene expression] GO:0010976[positive regulation of neuron projection development] GO:0014068[positive regulation of phosphatidylinositol 3-kinase signaling] GO:0014069[postsynaptic density] GO:0016020[membrane] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016740[transferase activity] GO:0018108[peptidyl-tyrosine phosphorylation] GO:0021954[central nervous system neuron development] GO:0021987[cerebral cortex development] GO:0030154[cell differentiation] GO:0030182[neuron differentiation] GO:0030424[axon] GO:0030425[dendrite] GO:0031547[brain-derived neurotrophic factor receptor signaling pathway] GO:0031901[early endosome membrane] GO:0033674[positive regulation of kinase activity] GO:0038179[neurotrophin signaling pathway] GO:0042803[protein homodimerization activity] GO:0042995[cell projection] GO:0043087[regulation of GTPase activity] GO:0043121[neurotrophin binding] GO:0043197[dendritic spine] GO:0043235[receptor complex] GO:0043410[positive regulation of MAPK cascade] GO:0043524[negative regulation of neuron apoptotic process] GO:0043679[axon terminus] GO:0045202[synapse] GO:0046777[protein autophosphorylation] GO:0048403[brain-derived neurotrophic factor binding] GO:0048471[perinuclear region of cytoplasm] GO:0050772[positive regulation of axonogenesis] GO:0051716[cellular response to stimulus] GO:0051896[regulation of protein kinase B signaling] GO:0060175[brain-derived neurotrophic factor receptor activity] GO:0099551[trans-synaptic signaling by neuropeptide, modulating synaptic transmission] GO:1902430[negative regulation of amyloid-beta formation] GO:1990090[cellular response to nerve growth factor stimulus] GO:1990416[cellular response to brain-derived neurotrophic factor stimulus]
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Transporters Accessory Factors Involved in Transport Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Cancers Cancers of eye, brain, and central nervous system Nervous system diseases Epilepsy Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) DeepTMHMM predicted membrane proteins
Show all
GO:0000166[nucleotide binding] GO:0001764[neuron migration] GO:0001934[positive regulation of protein phosphorylation] GO:0002020[protease binding] GO:0004672[protein kinase activity] GO:0004713[protein tyrosine kinase activity] GO:0004714[transmembrane receptor protein tyrosine kinase activity] GO:0005030[neurotrophin receptor activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005737[cytoplasm] GO:0005768[endosome] GO:0005769[early endosome] GO:0005886[plasma membrane] GO:0005887[integral component of plasma membrane] GO:0006468[protein phosphorylation] GO:0007169[transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007399[nervous system development] GO:0007612[learning] GO:0008284[positive regulation of cell population proliferation] GO:0010008[endosome membrane] GO:0010628[positive regulation of gene expression] GO:0010976[positive regulation of neuron projection development] GO:0014068[positive regulation of phosphatidylinositol 3-kinase signaling] GO:0014069[postsynaptic density] GO:0016020[membrane] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016740[transferase activity] GO:0018108[peptidyl-tyrosine phosphorylation] GO:0021954[central nervous system neuron development] GO:0021987[cerebral cortex development] GO:0030154[cell differentiation] GO:0030182[neuron differentiation] GO:0030424[axon] GO:0030425[dendrite] GO:0031547[brain-derived neurotrophic factor receptor signaling pathway] GO:0031901[early endosome membrane] GO:0033674[positive regulation of kinase activity] GO:0038179[neurotrophin signaling pathway] GO:0042803[protein homodimerization activity] GO:0042995[cell projection] GO:0043087[regulation of GTPase activity] GO:0043121[neurotrophin binding] GO:0043197[dendritic spine] GO:0043235[receptor complex] GO:0043410[positive regulation of MAPK cascade] GO:0043524[negative regulation of neuron apoptotic process] GO:0043679[axon terminus] GO:0045202[synapse] GO:0046777[protein autophosphorylation] GO:0048403[brain-derived neurotrophic factor binding] GO:0048471[perinuclear region of cytoplasm] GO:0050772[positive regulation of axonogenesis] GO:0051716[cellular response to stimulus] GO:0051896[regulation of protein kinase B signaling] GO:0060175[brain-derived neurotrophic factor receptor activity] GO:0099551[trans-synaptic signaling by neuropeptide, modulating synaptic transmission] GO:1902430[negative regulation of amyloid-beta formation] GO:1990090[cellular response to nerve growth factor stimulus] GO:1990416[cellular response to brain-derived neurotrophic factor stimulus]
Q5VWE5 [Target identity:100%; Query identity:100%] Neurotrophic tyrosine kinase, receptor, type 2, isoform CRA_a; cDNA FLJ76753, highly similar to Homo sapiens neurotrophic tyrosine kinase, receptor, type 2 (NTRK2), transcript variant b, mRNA
Show all
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Transporters Accessory Factors Involved in Transport Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Cancers Cancers of eye, brain, and central nervous system Nervous system diseases Epilepsy Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014) DeepTMHMM predicted membrane proteins
Show all
GO:0000166[nucleotide binding] GO:0001764[neuron migration] GO:0001934[positive regulation of protein phosphorylation] GO:0002020[protease binding] GO:0004672[protein kinase activity] GO:0004713[protein tyrosine kinase activity] GO:0004714[transmembrane receptor protein tyrosine kinase activity] GO:0005030[neurotrophin receptor activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005737[cytoplasm] GO:0005768[endosome] GO:0005769[early endosome] GO:0005886[plasma membrane] GO:0005887[integral component of plasma membrane] GO:0006468[protein phosphorylation] GO:0007169[transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007399[nervous system development] GO:0007612[learning] GO:0008284[positive regulation of cell population proliferation] GO:0010008[endosome membrane] GO:0010628[positive regulation of gene expression] GO:0010976[positive regulation of neuron projection development] GO:0014068[positive regulation of phosphatidylinositol 3-kinase signaling] GO:0014069[postsynaptic density] GO:0016020[membrane] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016740[transferase activity] GO:0018108[peptidyl-tyrosine phosphorylation] GO:0021954[central nervous system neuron development] GO:0021987[cerebral cortex development] GO:0030154[cell differentiation] GO:0030182[neuron differentiation] GO:0030424[axon] GO:0030425[dendrite] GO:0031547[brain-derived neurotrophic factor receptor signaling pathway] GO:0031901[early endosome membrane] GO:0033674[positive regulation of kinase activity] GO:0038179[neurotrophin signaling pathway] GO:0042803[protein homodimerization activity] GO:0042995[cell projection] GO:0043087[regulation of GTPase activity] GO:0043121[neurotrophin binding] GO:0043197[dendritic spine] GO:0043235[receptor complex] GO:0043410[positive regulation of MAPK cascade] GO:0043524[negative regulation of neuron apoptotic process] GO:0043679[axon terminus] GO:0045202[synapse] GO:0046777[protein autophosphorylation] GO:0048403[brain-derived neurotrophic factor binding] GO:0048471[perinuclear region of cytoplasm] GO:0050772[positive regulation of axonogenesis] GO:0051716[cellular response to stimulus] GO:0051896[regulation of protein kinase B signaling] GO:0060175[brain-derived neurotrophic factor receptor activity] GO:0099551[trans-synaptic signaling by neuropeptide, modulating synaptic transmission] GO:1902430[negative regulation of amyloid-beta formation] GO:1990090[cellular response to nerve growth factor stimulus] GO:1990416[cellular response to brain-derived neurotrophic factor stimulus]
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Transporters Accessory Factors Involved in Transport Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Cancers Cancers of eye, brain, and central nervous system Nervous system diseases Epilepsy Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014) DeepTMHMM predicted membrane proteins
Show all
GO:0000166[nucleotide binding] GO:0001764[neuron migration] GO:0001934[positive regulation of protein phosphorylation] GO:0002020[protease binding] GO:0004672[protein kinase activity] GO:0004713[protein tyrosine kinase activity] GO:0004714[transmembrane receptor protein tyrosine kinase activity] GO:0005030[neurotrophin receptor activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005737[cytoplasm] GO:0005768[endosome] GO:0005769[early endosome] GO:0005886[plasma membrane] GO:0005887[integral component of plasma membrane] GO:0006468[protein phosphorylation] GO:0007169[transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007399[nervous system development] GO:0007612[learning] GO:0008284[positive regulation of cell population proliferation] GO:0010008[endosome membrane] GO:0010628[positive regulation of gene expression] GO:0010976[positive regulation of neuron projection development] GO:0014068[positive regulation of phosphatidylinositol 3-kinase signaling] GO:0014069[postsynaptic density] GO:0016020[membrane] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016740[transferase activity] GO:0018108[peptidyl-tyrosine phosphorylation] GO:0021954[central nervous system neuron development] GO:0021987[cerebral cortex development] GO:0030154[cell differentiation] GO:0030182[neuron differentiation] GO:0030424[axon] GO:0030425[dendrite] GO:0031547[brain-derived neurotrophic factor receptor signaling pathway] GO:0031901[early endosome membrane] GO:0033674[positive regulation of kinase activity] GO:0038179[neurotrophin signaling pathway] GO:0042803[protein homodimerization activity] GO:0042995[cell projection] GO:0043087[regulation of GTPase activity] GO:0043121[neurotrophin binding] GO:0043197[dendritic spine] GO:0043235[receptor complex] GO:0043410[positive regulation of MAPK cascade] GO:0043524[negative regulation of neuron apoptotic process] GO:0043679[axon terminus] GO:0045202[synapse] GO:0046777[protein autophosphorylation] GO:0048403[brain-derived neurotrophic factor binding] GO:0048471[perinuclear region of cytoplasm] GO:0050772[positive regulation of axonogenesis] GO:0051716[cellular response to stimulus] GO:0051896[regulation of protein kinase B signaling] GO:0060175[brain-derived neurotrophic factor receptor activity] GO:0099551[trans-synaptic signaling by neuropeptide, modulating synaptic transmission] GO:1902430[negative regulation of amyloid-beta formation] GO:1990090[cellular response to nerve growth factor stimulus] GO:1990416[cellular response to brain-derived neurotrophic factor stimulus]
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Transporters Accessory Factors Involved in Transport Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Cancers Cancers of eye, brain, and central nervous system Nervous system diseases Epilepsy Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014) DeepTMHMM predicted membrane proteins
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GO:0000166[nucleotide binding] GO:0001764[neuron migration] GO:0001934[positive regulation of protein phosphorylation] GO:0002020[protease binding] GO:0004672[protein kinase activity] GO:0004713[protein tyrosine kinase activity] GO:0004714[transmembrane receptor protein tyrosine kinase activity] GO:0005030[neurotrophin receptor activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005737[cytoplasm] GO:0005768[endosome] GO:0005769[early endosome] GO:0005886[plasma membrane] GO:0005887[integral component of plasma membrane] GO:0006468[protein phosphorylation] GO:0007169[transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007399[nervous system development] GO:0007612[learning] GO:0008284[positive regulation of cell population proliferation] GO:0010008[endosome membrane] GO:0010628[positive regulation of gene expression] GO:0010976[positive regulation of neuron projection development] GO:0014068[positive regulation of phosphatidylinositol 3-kinase signaling] GO:0014069[postsynaptic density] GO:0016020[membrane] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016740[transferase activity] GO:0018108[peptidyl-tyrosine phosphorylation] GO:0021954[central nervous system neuron development] GO:0021987[cerebral cortex development] GO:0030154[cell differentiation] GO:0030182[neuron differentiation] GO:0030424[axon] GO:0030425[dendrite] GO:0031547[brain-derived neurotrophic factor receptor signaling pathway] GO:0031901[early endosome membrane] GO:0033674[positive regulation of kinase activity] GO:0038179[neurotrophin signaling pathway] GO:0042803[protein homodimerization activity] GO:0042995[cell projection] GO:0043087[regulation of GTPase activity] GO:0043121[neurotrophin binding] GO:0043197[dendritic spine] GO:0043235[receptor complex] GO:0043410[positive regulation of MAPK cascade] GO:0043524[negative regulation of neuron apoptotic process] GO:0043679[axon terminus] GO:0045202[synapse] GO:0046777[protein autophosphorylation] GO:0048403[brain-derived neurotrophic factor binding] GO:0048471[perinuclear region of cytoplasm] GO:0050772[positive regulation of axonogenesis] GO:0051716[cellular response to stimulus] GO:0051896[regulation of protein kinase B signaling] GO:0060175[brain-derived neurotrophic factor receptor activity] GO:0099551[trans-synaptic signaling by neuropeptide, modulating synaptic transmission] GO:1902430[negative regulation of amyloid-beta formation] GO:1990090[cellular response to nerve growth factor stimulus] GO:1990416[cellular response to brain-derived neurotrophic factor stimulus]
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Transporters Accessory Factors Involved in Transport Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Cancers Cancers of eye, brain, and central nervous system Nervous system diseases Epilepsy Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014) DeepTMHMM predicted membrane proteins
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GO:0000166[nucleotide binding] GO:0001764[neuron migration] GO:0001934[positive regulation of protein phosphorylation] GO:0002020[protease binding] GO:0004672[protein kinase activity] GO:0004713[protein tyrosine kinase activity] GO:0004714[transmembrane receptor protein tyrosine kinase activity] GO:0005030[neurotrophin receptor activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005737[cytoplasm] GO:0005768[endosome] GO:0005769[early endosome] GO:0005886[plasma membrane] GO:0005887[integral component of plasma membrane] GO:0006468[protein phosphorylation] GO:0007169[transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007399[nervous system development] GO:0007612[learning] GO:0008284[positive regulation of cell population proliferation] GO:0010008[endosome membrane] GO:0010628[positive regulation of gene expression] GO:0010976[positive regulation of neuron projection development] GO:0014068[positive regulation of phosphatidylinositol 3-kinase signaling] GO:0014069[postsynaptic density] GO:0016020[membrane] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016740[transferase activity] GO:0018108[peptidyl-tyrosine phosphorylation] GO:0021954[central nervous system neuron development] GO:0021987[cerebral cortex development] GO:0030154[cell differentiation] GO:0030182[neuron differentiation] GO:0030424[axon] GO:0030425[dendrite] GO:0031547[brain-derived neurotrophic factor receptor signaling pathway] GO:0031901[early endosome membrane] GO:0033674[positive regulation of kinase activity] GO:0038179[neurotrophin signaling pathway] GO:0042803[protein homodimerization activity] GO:0042995[cell projection] GO:0043087[regulation of GTPase activity] GO:0043121[neurotrophin binding] GO:0043197[dendritic spine] GO:0043235[receptor complex] GO:0043410[positive regulation of MAPK cascade] GO:0043524[negative regulation of neuron apoptotic process] GO:0043679[axon terminus] GO:0045202[synapse] GO:0046777[protein autophosphorylation] GO:0048403[brain-derived neurotrophic factor binding] GO:0048471[perinuclear region of cytoplasm] GO:0050772[positive regulation of axonogenesis] GO:0051716[cellular response to stimulus] GO:0051896[regulation of protein kinase B signaling] GO:0060175[brain-derived neurotrophic factor receptor activity] GO:0099551[trans-synaptic signaling by neuropeptide, modulating synaptic transmission] GO:1902430[negative regulation of amyloid-beta formation] GO:1990090[cellular response to nerve growth factor stimulus] GO:1990416[cellular response to brain-derived neurotrophic factor stimulus]
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Transporters Accessory Factors Involved in Transport Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Cancers Cancers of eye, brain, and central nervous system Nervous system diseases Epilepsy Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014) DeepTMHMM predicted membrane proteins
Show all
GO:0000166[nucleotide binding] GO:0001764[neuron migration] GO:0001934[positive regulation of protein phosphorylation] GO:0002020[protease binding] GO:0004672[protein kinase activity] GO:0004713[protein tyrosine kinase activity] GO:0004714[transmembrane receptor protein tyrosine kinase activity] GO:0005030[neurotrophin receptor activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005737[cytoplasm] GO:0005768[endosome] GO:0005769[early endosome] GO:0005886[plasma membrane] GO:0005887[integral component of plasma membrane] GO:0006468[protein phosphorylation] GO:0007169[transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007399[nervous system development] GO:0007612[learning] GO:0008284[positive regulation of cell population proliferation] GO:0010008[endosome membrane] GO:0010628[positive regulation of gene expression] GO:0010976[positive regulation of neuron projection development] GO:0014068[positive regulation of phosphatidylinositol 3-kinase signaling] GO:0014069[postsynaptic density] GO:0016020[membrane] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016740[transferase activity] GO:0018108[peptidyl-tyrosine phosphorylation] GO:0021954[central nervous system neuron development] GO:0021987[cerebral cortex development] GO:0030154[cell differentiation] GO:0030182[neuron differentiation] GO:0030424[axon] GO:0030425[dendrite] GO:0031547[brain-derived neurotrophic factor receptor signaling pathway] GO:0031901[early endosome membrane] GO:0033674[positive regulation of kinase activity] GO:0038179[neurotrophin signaling pathway] GO:0042803[protein homodimerization activity] GO:0042995[cell projection] GO:0043087[regulation of GTPase activity] GO:0043121[neurotrophin binding] GO:0043197[dendritic spine] GO:0043235[receptor complex] GO:0043410[positive regulation of MAPK cascade] GO:0043524[negative regulation of neuron apoptotic process] GO:0043679[axon terminus] GO:0045202[synapse] GO:0046777[protein autophosphorylation] GO:0048403[brain-derived neurotrophic factor binding] GO:0048471[perinuclear region of cytoplasm] GO:0050772[positive regulation of axonogenesis] GO:0051716[cellular response to stimulus] GO:0051896[regulation of protein kinase B signaling] GO:0060175[brain-derived neurotrophic factor receptor activity] GO:0099551[trans-synaptic signaling by neuropeptide, modulating synaptic transmission] GO:1902430[negative regulation of amyloid-beta formation] GO:1990090[cellular response to nerve growth factor stimulus] GO:1990416[cellular response to brain-derived neurotrophic factor stimulus]
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Transporters Accessory Factors Involved in Transport Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Cancers Cancers of eye, brain, and central nervous system Nervous system diseases Epilepsy Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014) DeepTMHMM predicted membrane proteins
Show all
GO:0000166[nucleotide binding] GO:0001764[neuron migration] GO:0001934[positive regulation of protein phosphorylation] GO:0002020[protease binding] GO:0004672[protein kinase activity] GO:0004713[protein tyrosine kinase activity] GO:0004714[transmembrane receptor protein tyrosine kinase activity] GO:0005030[neurotrophin receptor activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005737[cytoplasm] GO:0005768[endosome] GO:0005769[early endosome] GO:0005886[plasma membrane] GO:0005887[integral component of plasma membrane] GO:0006468[protein phosphorylation] GO:0007169[transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007399[nervous system development] GO:0007612[learning] GO:0008284[positive regulation of cell population proliferation] GO:0010008[endosome membrane] GO:0010628[positive regulation of gene expression] GO:0010976[positive regulation of neuron projection development] GO:0014068[positive regulation of phosphatidylinositol 3-kinase signaling] GO:0014069[postsynaptic density] GO:0016020[membrane] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016740[transferase activity] GO:0018108[peptidyl-tyrosine phosphorylation] GO:0021954[central nervous system neuron development] GO:0021987[cerebral cortex development] GO:0030154[cell differentiation] GO:0030182[neuron differentiation] GO:0030424[axon] GO:0030425[dendrite] GO:0031547[brain-derived neurotrophic factor receptor signaling pathway] GO:0031901[early endosome membrane] GO:0033674[positive regulation of kinase activity] GO:0038179[neurotrophin signaling pathway] GO:0042803[protein homodimerization activity] GO:0042995[cell projection] GO:0043087[regulation of GTPase activity] GO:0043121[neurotrophin binding] GO:0043197[dendritic spine] GO:0043235[receptor complex] GO:0043410[positive regulation of MAPK cascade] GO:0043524[negative regulation of neuron apoptotic process] GO:0043679[axon terminus] GO:0045202[synapse] GO:0046777[protein autophosphorylation] GO:0048403[brain-derived neurotrophic factor binding] GO:0048471[perinuclear region of cytoplasm] GO:0050772[positive regulation of axonogenesis] GO:0051716[cellular response to stimulus] GO:0051896[regulation of protein kinase B signaling] GO:0060175[brain-derived neurotrophic factor receptor activity] GO:0099551[trans-synaptic signaling by neuropeptide, modulating synaptic transmission] GO:1902430[negative regulation of amyloid-beta formation] GO:1990090[cellular response to nerve growth factor stimulus] GO:1990416[cellular response to brain-derived neurotrophic factor stimulus]
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Transporters Accessory Factors Involved in Transport Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Cancers Cancers of eye, brain, and central nervous system Nervous system diseases Epilepsy Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014) DeepTMHMM predicted membrane proteins
Show all
GO:0000166[nucleotide binding] GO:0001764[neuron migration] GO:0001934[positive regulation of protein phosphorylation] GO:0002020[protease binding] GO:0004672[protein kinase activity] GO:0004713[protein tyrosine kinase activity] GO:0004714[transmembrane receptor protein tyrosine kinase activity] GO:0005030[neurotrophin receptor activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005737[cytoplasm] GO:0005768[endosome] GO:0005769[early endosome] GO:0005886[plasma membrane] GO:0005887[integral component of plasma membrane] GO:0006468[protein phosphorylation] GO:0007169[transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007399[nervous system development] GO:0007612[learning] GO:0008284[positive regulation of cell population proliferation] GO:0010008[endosome membrane] GO:0010628[positive regulation of gene expression] GO:0010976[positive regulation of neuron projection development] GO:0014068[positive regulation of phosphatidylinositol 3-kinase signaling] GO:0014069[postsynaptic density] GO:0016020[membrane] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016740[transferase activity] GO:0018108[peptidyl-tyrosine phosphorylation] GO:0021954[central nervous system neuron development] GO:0021987[cerebral cortex development] GO:0030154[cell differentiation] GO:0030182[neuron differentiation] GO:0030424[axon] GO:0030425[dendrite] GO:0031547[brain-derived neurotrophic factor receptor signaling pathway] GO:0031901[early endosome membrane] GO:0033674[positive regulation of kinase activity] GO:0038179[neurotrophin signaling pathway] GO:0042803[protein homodimerization activity] GO:0042995[cell projection] GO:0043087[regulation of GTPase activity] GO:0043121[neurotrophin binding] GO:0043197[dendritic spine] GO:0043235[receptor complex] GO:0043410[positive regulation of MAPK cascade] GO:0043524[negative regulation of neuron apoptotic process] GO:0043679[axon terminus] GO:0045202[synapse] GO:0046777[protein autophosphorylation] GO:0048403[brain-derived neurotrophic factor binding] GO:0048471[perinuclear region of cytoplasm] GO:0050772[positive regulation of axonogenesis] GO:0051716[cellular response to stimulus] GO:0051896[regulation of protein kinase B signaling] GO:0060175[brain-derived neurotrophic factor receptor activity] GO:0099551[trans-synaptic signaling by neuropeptide, modulating synaptic transmission] GO:1902430[negative regulation of amyloid-beta formation] GO:1990090[cellular response to nerve growth factor stimulus] GO:1990416[cellular response to brain-derived neurotrophic factor stimulus]
Q5VWE5 [Target identity:100%; Query identity:100%] Neurotrophic tyrosine kinase, receptor, type 2, isoform CRA_a; cDNA FLJ76753, highly similar to Homo sapiens neurotrophic tyrosine kinase, receptor, type 2 (NTRK2), transcript variant b, mRNA
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Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Transporters Accessory Factors Involved in Transport Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Cancers Cancers of eye, brain, and central nervous system Nervous system diseases Epilepsy Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014) DeepTMHMM predicted membrane proteins
Show all
GO:0000166[nucleotide binding] GO:0001764[neuron migration] GO:0001934[positive regulation of protein phosphorylation] GO:0002020[protease binding] GO:0004672[protein kinase activity] GO:0004713[protein tyrosine kinase activity] GO:0004714[transmembrane receptor protein tyrosine kinase activity] GO:0005030[neurotrophin receptor activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005737[cytoplasm] GO:0005768[endosome] GO:0005769[early endosome] GO:0005886[plasma membrane] GO:0005887[integral component of plasma membrane] GO:0006468[protein phosphorylation] GO:0007169[transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007399[nervous system development] GO:0007612[learning] GO:0008284[positive regulation of cell population proliferation] GO:0010008[endosome membrane] GO:0010628[positive regulation of gene expression] GO:0010976[positive regulation of neuron projection development] GO:0014068[positive regulation of phosphatidylinositol 3-kinase signaling] GO:0014069[postsynaptic density] GO:0016020[membrane] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016740[transferase activity] GO:0018108[peptidyl-tyrosine phosphorylation] GO:0021954[central nervous system neuron development] GO:0021987[cerebral cortex development] GO:0030154[cell differentiation] GO:0030182[neuron differentiation] GO:0030424[axon] GO:0030425[dendrite] GO:0031547[brain-derived neurotrophic factor receptor signaling pathway] GO:0031901[early endosome membrane] GO:0033674[positive regulation of kinase activity] GO:0038179[neurotrophin signaling pathway] GO:0042803[protein homodimerization activity] GO:0042995[cell projection] GO:0043087[regulation of GTPase activity] GO:0043121[neurotrophin binding] GO:0043197[dendritic spine] GO:0043235[receptor complex] GO:0043410[positive regulation of MAPK cascade] GO:0043524[negative regulation of neuron apoptotic process] GO:0043679[axon terminus] GO:0045202[synapse] GO:0046777[protein autophosphorylation] GO:0048403[brain-derived neurotrophic factor binding] GO:0048471[perinuclear region of cytoplasm] GO:0050772[positive regulation of axonogenesis] GO:0051716[cellular response to stimulus] GO:0051896[regulation of protein kinase B signaling] GO:0060175[brain-derived neurotrophic factor receptor activity] GO:0099551[trans-synaptic signaling by neuropeptide, modulating synaptic transmission] GO:1902430[negative regulation of amyloid-beta formation] GO:1990090[cellular response to nerve growth factor stimulus] GO:1990416[cellular response to brain-derived neurotrophic factor stimulus]
Q5VWE5 [Target identity:100%; Query identity:100%] Neurotrophic tyrosine kinase, receptor, type 2, isoform CRA_a; cDNA FLJ76753, highly similar to Homo sapiens neurotrophic tyrosine kinase, receptor, type 2 (NTRK2), transcript variant b, mRNA
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Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Transporters Accessory Factors Involved in Transport Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Cancers Cancers of eye, brain, and central nervous system Nervous system diseases Epilepsy Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014) DeepTMHMM predicted membrane proteins
Show all
GO:0000166[nucleotide binding] GO:0001764[neuron migration] GO:0001934[positive regulation of protein phosphorylation] GO:0002020[protease binding] GO:0004672[protein kinase activity] GO:0004713[protein tyrosine kinase activity] GO:0004714[transmembrane receptor protein tyrosine kinase activity] GO:0005030[neurotrophin receptor activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005737[cytoplasm] GO:0005768[endosome] GO:0005769[early endosome] GO:0005886[plasma membrane] GO:0005887[integral component of plasma membrane] GO:0006468[protein phosphorylation] GO:0007169[transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007399[nervous system development] GO:0007612[learning] GO:0008284[positive regulation of cell population proliferation] GO:0010008[endosome membrane] GO:0010628[positive regulation of gene expression] GO:0010976[positive regulation of neuron projection development] GO:0014068[positive regulation of phosphatidylinositol 3-kinase signaling] GO:0014069[postsynaptic density] GO:0016020[membrane] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016740[transferase activity] GO:0018108[peptidyl-tyrosine phosphorylation] GO:0021954[central nervous system neuron development] GO:0021987[cerebral cortex development] GO:0030154[cell differentiation] GO:0030182[neuron differentiation] GO:0030424[axon] GO:0030425[dendrite] GO:0031547[brain-derived neurotrophic factor receptor signaling pathway] GO:0031901[early endosome membrane] GO:0033674[positive regulation of kinase activity] GO:0038179[neurotrophin signaling pathway] GO:0042803[protein homodimerization activity] GO:0042995[cell projection] GO:0043087[regulation of GTPase activity] GO:0043121[neurotrophin binding] GO:0043197[dendritic spine] GO:0043235[receptor complex] GO:0043410[positive regulation of MAPK cascade] GO:0043524[negative regulation of neuron apoptotic process] GO:0043679[axon terminus] GO:0045202[synapse] GO:0046777[protein autophosphorylation] GO:0048403[brain-derived neurotrophic factor binding] GO:0048471[perinuclear region of cytoplasm] GO:0050772[positive regulation of axonogenesis] GO:0051716[cellular response to stimulus] GO:0051896[regulation of protein kinase B signaling] GO:0060175[brain-derived neurotrophic factor receptor activity] GO:0099551[trans-synaptic signaling by neuropeptide, modulating synaptic transmission] GO:1902430[negative regulation of amyloid-beta formation] GO:1990090[cellular response to nerve growth factor stimulus] GO:1990416[cellular response to brain-derived neurotrophic factor stimulus]
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Transporters Accessory Factors Involved in Transport Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Cancers Cancers of eye, brain, and central nervous system Nervous system diseases Epilepsy Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014) DeepTMHMM predicted membrane proteins
Show all
GO:0000166[nucleotide binding] GO:0001764[neuron migration] GO:0001934[positive regulation of protein phosphorylation] GO:0002020[protease binding] GO:0004672[protein kinase activity] GO:0004713[protein tyrosine kinase activity] GO:0004714[transmembrane receptor protein tyrosine kinase activity] GO:0005030[neurotrophin receptor activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005737[cytoplasm] GO:0005768[endosome] GO:0005769[early endosome] GO:0005886[plasma membrane] GO:0005887[integral component of plasma membrane] GO:0006468[protein phosphorylation] GO:0007169[transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007399[nervous system development] GO:0007612[learning] GO:0008284[positive regulation of cell population proliferation] GO:0010008[endosome membrane] GO:0010628[positive regulation of gene expression] GO:0010976[positive regulation of neuron projection development] GO:0014068[positive regulation of phosphatidylinositol 3-kinase signaling] GO:0014069[postsynaptic density] GO:0016020[membrane] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016740[transferase activity] GO:0018108[peptidyl-tyrosine phosphorylation] GO:0021954[central nervous system neuron development] GO:0021987[cerebral cortex development] GO:0030154[cell differentiation] GO:0030182[neuron differentiation] GO:0030424[axon] GO:0030425[dendrite] GO:0031547[brain-derived neurotrophic factor receptor signaling pathway] GO:0031901[early endosome membrane] GO:0033674[positive regulation of kinase activity] GO:0038179[neurotrophin signaling pathway] GO:0042803[protein homodimerization activity] GO:0042995[cell projection] GO:0043087[regulation of GTPase activity] GO:0043121[neurotrophin binding] GO:0043197[dendritic spine] GO:0043235[receptor complex] GO:0043410[positive regulation of MAPK cascade] GO:0043524[negative regulation of neuron apoptotic process] GO:0043679[axon terminus] GO:0045202[synapse] GO:0046777[protein autophosphorylation] GO:0048403[brain-derived neurotrophic factor binding] GO:0048471[perinuclear region of cytoplasm] GO:0050772[positive regulation of axonogenesis] GO:0051716[cellular response to stimulus] GO:0051896[regulation of protein kinase B signaling] GO:0060175[brain-derived neurotrophic factor receptor activity] GO:0099551[trans-synaptic signaling by neuropeptide, modulating synaptic transmission] GO:1902430[negative regulation of amyloid-beta formation] GO:1990090[cellular response to nerve growth factor stimulus] GO:1990416[cellular response to brain-derived neurotrophic factor stimulus]
Q5VWE5 [Target identity:100%; Query identity:100%] Neurotrophic tyrosine kinase, receptor, type 2, isoform CRA_a; cDNA FLJ76753, highly similar to Homo sapiens neurotrophic tyrosine kinase, receptor, type 2 (NTRK2), transcript variant b, mRNA
Show all
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Transporters Accessory Factors Involved in Transport Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Cancers Cancers of eye, brain, and central nervous system Nervous system diseases Epilepsy Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014) DeepTMHMM predicted membrane proteins
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GO:0000166[nucleotide binding] GO:0001764[neuron migration] GO:0001934[positive regulation of protein phosphorylation] GO:0002020[protease binding] GO:0004672[protein kinase activity] GO:0004713[protein tyrosine kinase activity] GO:0004714[transmembrane receptor protein tyrosine kinase activity] GO:0005030[neurotrophin receptor activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005737[cytoplasm] GO:0005768[endosome] GO:0005769[early endosome] GO:0005886[plasma membrane] GO:0005887[integral component of plasma membrane] GO:0006468[protein phosphorylation] GO:0007169[transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007399[nervous system development] GO:0007612[learning] GO:0008284[positive regulation of cell population proliferation] GO:0010008[endosome membrane] GO:0010628[positive regulation of gene expression] GO:0010976[positive regulation of neuron projection development] GO:0014068[positive regulation of phosphatidylinositol 3-kinase signaling] GO:0014069[postsynaptic density] GO:0016020[membrane] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016740[transferase activity] GO:0018108[peptidyl-tyrosine phosphorylation] GO:0021954[central nervous system neuron development] GO:0021987[cerebral cortex development] GO:0030154[cell differentiation] GO:0030182[neuron differentiation] GO:0030424[axon] GO:0030425[dendrite] GO:0031547[brain-derived neurotrophic factor receptor signaling pathway] GO:0031901[early endosome membrane] GO:0033674[positive regulation of kinase activity] GO:0038179[neurotrophin signaling pathway] GO:0042803[protein homodimerization activity] GO:0042995[cell projection] GO:0043087[regulation of GTPase activity] GO:0043121[neurotrophin binding] GO:0043197[dendritic spine] GO:0043235[receptor complex] GO:0043410[positive regulation of MAPK cascade] GO:0043524[negative regulation of neuron apoptotic process] GO:0043679[axon terminus] GO:0045202[synapse] GO:0046777[protein autophosphorylation] GO:0048403[brain-derived neurotrophic factor binding] GO:0048471[perinuclear region of cytoplasm] GO:0050772[positive regulation of axonogenesis] GO:0051716[cellular response to stimulus] GO:0051896[regulation of protein kinase B signaling] GO:0060175[brain-derived neurotrophic factor receptor activity] GO:0099551[trans-synaptic signaling by neuropeptide, modulating synaptic transmission] GO:1902430[negative regulation of amyloid-beta formation] GO:1990090[cellular response to nerve growth factor stimulus] GO:1990416[cellular response to brain-derived neurotrophic factor stimulus]
Q5VWE5 [Target identity:100%; Query identity:100%] Neurotrophic tyrosine kinase, receptor, type 2, isoform CRA_a; cDNA FLJ76753, highly similar to Homo sapiens neurotrophic tyrosine kinase, receptor, type 2 (NTRK2), transcript variant b, mRNA
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Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Transporters Accessory Factors Involved in Transport Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Cancers Cancers of eye, brain, and central nervous system Nervous system diseases Epilepsy Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014) DeepTMHMM predicted membrane proteins
Show all
GO:0000166[nucleotide binding] GO:0001764[neuron migration] GO:0001934[positive regulation of protein phosphorylation] GO:0002020[protease binding] GO:0004672[protein kinase activity] GO:0004713[protein tyrosine kinase activity] GO:0004714[transmembrane receptor protein tyrosine kinase activity] GO:0005030[neurotrophin receptor activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005737[cytoplasm] GO:0005768[endosome] GO:0005769[early endosome] GO:0005886[plasma membrane] GO:0005887[integral component of plasma membrane] GO:0006468[protein phosphorylation] GO:0007169[transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007399[nervous system development] GO:0007612[learning] GO:0008284[positive regulation of cell population proliferation] GO:0010008[endosome membrane] GO:0010628[positive regulation of gene expression] GO:0010976[positive regulation of neuron projection development] GO:0014068[positive regulation of phosphatidylinositol 3-kinase signaling] GO:0014069[postsynaptic density] GO:0016020[membrane] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016740[transferase activity] GO:0018108[peptidyl-tyrosine phosphorylation] GO:0021954[central nervous system neuron development] GO:0021987[cerebral cortex development] GO:0030154[cell differentiation] GO:0030182[neuron differentiation] GO:0030424[axon] GO:0030425[dendrite] GO:0031547[brain-derived neurotrophic factor receptor signaling pathway] GO:0031901[early endosome membrane] GO:0033674[positive regulation of kinase activity] GO:0038179[neurotrophin signaling pathway] GO:0042803[protein homodimerization activity] GO:0042995[cell projection] GO:0043087[regulation of GTPase activity] GO:0043121[neurotrophin binding] GO:0043197[dendritic spine] GO:0043235[receptor complex] GO:0043410[positive regulation of MAPK cascade] GO:0043524[negative regulation of neuron apoptotic process] GO:0043679[axon terminus] GO:0045202[synapse] GO:0046777[protein autophosphorylation] GO:0048403[brain-derived neurotrophic factor binding] GO:0048471[perinuclear region of cytoplasm] GO:0050772[positive regulation of axonogenesis] GO:0051716[cellular response to stimulus] GO:0051896[regulation of protein kinase B signaling] GO:0060175[brain-derived neurotrophic factor receptor activity] GO:0099551[trans-synaptic signaling by neuropeptide, modulating synaptic transmission] GO:1902430[negative regulation of amyloid-beta formation] GO:1990090[cellular response to nerve growth factor stimulus] GO:1990416[cellular response to brain-derived neurotrophic factor stimulus]
Q5VWE5 [Target identity:100%; Query identity:100%] Neurotrophic tyrosine kinase, receptor, type 2, isoform CRA_a; cDNA FLJ76753, highly similar to Homo sapiens neurotrophic tyrosine kinase, receptor, type 2 (NTRK2), transcript variant b, mRNA
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Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Transporters Accessory Factors Involved in Transport Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Cancers Cancers of eye, brain, and central nervous system Nervous system diseases Epilepsy Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014) DeepTMHMM predicted membrane proteins
Show all
GO:0000166[nucleotide binding] GO:0001764[neuron migration] GO:0001934[positive regulation of protein phosphorylation] GO:0002020[protease binding] GO:0004672[protein kinase activity] GO:0004713[protein tyrosine kinase activity] GO:0004714[transmembrane receptor protein tyrosine kinase activity] GO:0005030[neurotrophin receptor activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005737[cytoplasm] GO:0005768[endosome] GO:0005769[early endosome] GO:0005886[plasma membrane] GO:0005887[integral component of plasma membrane] GO:0006468[protein phosphorylation] GO:0007169[transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007399[nervous system development] GO:0007612[learning] GO:0008284[positive regulation of cell population proliferation] GO:0010008[endosome membrane] GO:0010628[positive regulation of gene expression] GO:0010976[positive regulation of neuron projection development] GO:0014068[positive regulation of phosphatidylinositol 3-kinase signaling] GO:0014069[postsynaptic density] GO:0016020[membrane] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016740[transferase activity] GO:0018108[peptidyl-tyrosine phosphorylation] GO:0021954[central nervous system neuron development] GO:0021987[cerebral cortex development] GO:0030154[cell differentiation] GO:0030182[neuron differentiation] GO:0030424[axon] GO:0030425[dendrite] GO:0031547[brain-derived neurotrophic factor receptor signaling pathway] GO:0031901[early endosome membrane] GO:0033674[positive regulation of kinase activity] GO:0038179[neurotrophin signaling pathway] GO:0042803[protein homodimerization activity] GO:0042995[cell projection] GO:0043087[regulation of GTPase activity] GO:0043121[neurotrophin binding] GO:0043197[dendritic spine] GO:0043235[receptor complex] GO:0043410[positive regulation of MAPK cascade] GO:0043524[negative regulation of neuron apoptotic process] GO:0043679[axon terminus] GO:0045202[synapse] GO:0046777[protein autophosphorylation] GO:0048403[brain-derived neurotrophic factor binding] GO:0048471[perinuclear region of cytoplasm] GO:0050772[positive regulation of axonogenesis] GO:0051716[cellular response to stimulus] GO:0051896[regulation of protein kinase B signaling] GO:0060175[brain-derived neurotrophic factor receptor activity] GO:0099551[trans-synaptic signaling by neuropeptide, modulating synaptic transmission] GO:1902430[negative regulation of amyloid-beta formation] GO:1990090[cellular response to nerve growth factor stimulus] GO:1990416[cellular response to brain-derived neurotrophic factor stimulus]
Q5VWE5 [Target identity:100%; Query identity:100%] Neurotrophic tyrosine kinase, receptor, type 2, isoform CRA_a; cDNA FLJ76753, highly similar to Homo sapiens neurotrophic tyrosine kinase, receptor, type 2 (NTRK2), transcript variant b, mRNA
Show all
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Transporters Accessory Factors Involved in Transport Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Cancers Cancers of eye, brain, and central nervous system Nervous system diseases Epilepsy Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014) DeepTMHMM predicted membrane proteins
Show all
GO:0000166[nucleotide binding] GO:0001764[neuron migration] GO:0001934[positive regulation of protein phosphorylation] GO:0002020[protease binding] GO:0004672[protein kinase activity] GO:0004713[protein tyrosine kinase activity] GO:0004714[transmembrane receptor protein tyrosine kinase activity] GO:0005030[neurotrophin receptor activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005737[cytoplasm] GO:0005768[endosome] GO:0005769[early endosome] GO:0005886[plasma membrane] GO:0005887[integral component of plasma membrane] GO:0006468[protein phosphorylation] GO:0007169[transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007399[nervous system development] GO:0007612[learning] GO:0008284[positive regulation of cell population proliferation] GO:0010008[endosome membrane] GO:0010628[positive regulation of gene expression] GO:0010976[positive regulation of neuron projection development] GO:0014068[positive regulation of phosphatidylinositol 3-kinase signaling] GO:0014069[postsynaptic density] GO:0016020[membrane] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016740[transferase activity] GO:0018108[peptidyl-tyrosine phosphorylation] GO:0021954[central nervous system neuron development] GO:0021987[cerebral cortex development] GO:0030154[cell differentiation] GO:0030182[neuron differentiation] GO:0030424[axon] GO:0030425[dendrite] GO:0031547[brain-derived neurotrophic factor receptor signaling pathway] GO:0031901[early endosome membrane] GO:0033674[positive regulation of kinase activity] GO:0038179[neurotrophin signaling pathway] GO:0042803[protein homodimerization activity] GO:0042995[cell projection] GO:0043087[regulation of GTPase activity] GO:0043121[neurotrophin binding] GO:0043197[dendritic spine] GO:0043235[receptor complex] GO:0043410[positive regulation of MAPK cascade] GO:0043524[negative regulation of neuron apoptotic process] GO:0043679[axon terminus] GO:0045202[synapse] GO:0046777[protein autophosphorylation] GO:0048403[brain-derived neurotrophic factor binding] GO:0048471[perinuclear region of cytoplasm] GO:0050772[positive regulation of axonogenesis] GO:0051716[cellular response to stimulus] GO:0051896[regulation of protein kinase B signaling] GO:0060175[brain-derived neurotrophic factor receptor activity] GO:0099551[trans-synaptic signaling by neuropeptide, modulating synaptic transmission] GO:1902430[negative regulation of amyloid-beta formation] GO:1990090[cellular response to nerve growth factor stimulus] GO:1990416[cellular response to brain-derived neurotrophic factor stimulus]
Q5VWE5 [Target identity:100%; Query identity:100%] Neurotrophic tyrosine kinase, receptor, type 2, isoform CRA_a; cDNA FLJ76753, highly similar to Homo sapiens neurotrophic tyrosine kinase, receptor, type 2 (NTRK2), transcript variant b, mRNA
Show all
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Transporters Accessory Factors Involved in Transport Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Cancers Cancers of eye, brain, and central nervous system Nervous system diseases Epilepsy Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014) DeepTMHMM predicted membrane proteins
Show all
GO:0000166[nucleotide binding] GO:0001764[neuron migration] GO:0001934[positive regulation of protein phosphorylation] GO:0002020[protease binding] GO:0004672[protein kinase activity] GO:0004713[protein tyrosine kinase activity] GO:0004714[transmembrane receptor protein tyrosine kinase activity] GO:0005030[neurotrophin receptor activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005737[cytoplasm] GO:0005768[endosome] GO:0005769[early endosome] GO:0005886[plasma membrane] GO:0005887[integral component of plasma membrane] GO:0006468[protein phosphorylation] GO:0007169[transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007399[nervous system development] GO:0007612[learning] GO:0008284[positive regulation of cell population proliferation] GO:0010008[endosome membrane] GO:0010628[positive regulation of gene expression] GO:0010976[positive regulation of neuron projection development] GO:0014068[positive regulation of phosphatidylinositol 3-kinase signaling] GO:0014069[postsynaptic density] GO:0016020[membrane] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016740[transferase activity] GO:0018108[peptidyl-tyrosine phosphorylation] GO:0021954[central nervous system neuron development] GO:0021987[cerebral cortex development] GO:0030154[cell differentiation] GO:0030182[neuron differentiation] GO:0030424[axon] GO:0030425[dendrite] GO:0031547[brain-derived neurotrophic factor receptor signaling pathway] GO:0031901[early endosome membrane] GO:0033674[positive regulation of kinase activity] GO:0038179[neurotrophin signaling pathway] GO:0042803[protein homodimerization activity] GO:0042995[cell projection] GO:0043087[regulation of GTPase activity] GO:0043121[neurotrophin binding] GO:0043197[dendritic spine] GO:0043235[receptor complex] GO:0043410[positive regulation of MAPK cascade] GO:0043524[negative regulation of neuron apoptotic process] GO:0043679[axon terminus] GO:0045202[synapse] GO:0046777[protein autophosphorylation] GO:0048403[brain-derived neurotrophic factor binding] GO:0048471[perinuclear region of cytoplasm] GO:0050772[positive regulation of axonogenesis] GO:0051716[cellular response to stimulus] GO:0051896[regulation of protein kinase B signaling] GO:0060175[brain-derived neurotrophic factor receptor activity] GO:0099551[trans-synaptic signaling by neuropeptide, modulating synaptic transmission] GO:1902430[negative regulation of amyloid-beta formation] GO:1990090[cellular response to nerve growth factor stimulus] GO:1990416[cellular response to brain-derived neurotrophic factor stimulus]
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Transporters Accessory Factors Involved in Transport Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Cancers Cancers of eye, brain, and central nervous system Nervous system diseases Epilepsy Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014) DeepTMHMM predicted membrane proteins
Show all
GO:0000166[nucleotide binding] GO:0001764[neuron migration] GO:0001934[positive regulation of protein phosphorylation] GO:0002020[protease binding] GO:0004672[protein kinase activity] GO:0004713[protein tyrosine kinase activity] GO:0004714[transmembrane receptor protein tyrosine kinase activity] GO:0005030[neurotrophin receptor activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005737[cytoplasm] GO:0005768[endosome] GO:0005769[early endosome] GO:0005886[plasma membrane] GO:0005887[integral component of plasma membrane] GO:0006468[protein phosphorylation] GO:0007169[transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007399[nervous system development] GO:0007612[learning] GO:0008284[positive regulation of cell population proliferation] GO:0010008[endosome membrane] GO:0010628[positive regulation of gene expression] GO:0010976[positive regulation of neuron projection development] GO:0014068[positive regulation of phosphatidylinositol 3-kinase signaling] GO:0014069[postsynaptic density] GO:0016020[membrane] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016740[transferase activity] GO:0018108[peptidyl-tyrosine phosphorylation] GO:0021954[central nervous system neuron development] GO:0021987[cerebral cortex development] GO:0030154[cell differentiation] GO:0030182[neuron differentiation] GO:0030424[axon] GO:0030425[dendrite] GO:0031547[brain-derived neurotrophic factor receptor signaling pathway] GO:0031901[early endosome membrane] GO:0033674[positive regulation of kinase activity] GO:0038179[neurotrophin signaling pathway] GO:0042803[protein homodimerization activity] GO:0042995[cell projection] GO:0043087[regulation of GTPase activity] GO:0043121[neurotrophin binding] GO:0043197[dendritic spine] GO:0043235[receptor complex] GO:0043410[positive regulation of MAPK cascade] GO:0043524[negative regulation of neuron apoptotic process] GO:0043679[axon terminus] GO:0045202[synapse] GO:0046777[protein autophosphorylation] GO:0048403[brain-derived neurotrophic factor binding] GO:0048471[perinuclear region of cytoplasm] GO:0050772[positive regulation of axonogenesis] GO:0051716[cellular response to stimulus] GO:0051896[regulation of protein kinase B signaling] GO:0060175[brain-derived neurotrophic factor receptor activity] GO:0099551[trans-synaptic signaling by neuropeptide, modulating synaptic transmission] GO:1902430[negative regulation of amyloid-beta formation] GO:1990090[cellular response to nerve growth factor stimulus] GO:1990416[cellular response to brain-derived neurotrophic factor stimulus]
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Transporters Accessory Factors Involved in Transport Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Cancers Cancers of eye, brain, and central nervous system Nervous system diseases Epilepsy Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014) DeepTMHMM predicted membrane proteins
Show all
GO:0000166[nucleotide binding] GO:0001764[neuron migration] GO:0001934[positive regulation of protein phosphorylation] GO:0002020[protease binding] GO:0004672[protein kinase activity] GO:0004713[protein tyrosine kinase activity] GO:0004714[transmembrane receptor protein tyrosine kinase activity] GO:0005030[neurotrophin receptor activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005737[cytoplasm] GO:0005768[endosome] GO:0005769[early endosome] GO:0005886[plasma membrane] GO:0005887[integral component of plasma membrane] GO:0006468[protein phosphorylation] GO:0007169[transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007399[nervous system development] GO:0007612[learning] GO:0008284[positive regulation of cell population proliferation] GO:0010008[endosome membrane] GO:0010628[positive regulation of gene expression] GO:0010976[positive regulation of neuron projection development] GO:0014068[positive regulation of phosphatidylinositol 3-kinase signaling] GO:0014069[postsynaptic density] GO:0016020[membrane] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016740[transferase activity] GO:0018108[peptidyl-tyrosine phosphorylation] GO:0021954[central nervous system neuron development] GO:0021987[cerebral cortex development] GO:0030154[cell differentiation] GO:0030182[neuron differentiation] GO:0030424[axon] GO:0030425[dendrite] GO:0031547[brain-derived neurotrophic factor receptor signaling pathway] GO:0031901[early endosome membrane] GO:0033674[positive regulation of kinase activity] GO:0038179[neurotrophin signaling pathway] GO:0042803[protein homodimerization activity] GO:0042995[cell projection] GO:0043087[regulation of GTPase activity] GO:0043121[neurotrophin binding] GO:0043197[dendritic spine] GO:0043235[receptor complex] GO:0043410[positive regulation of MAPK cascade] GO:0043524[negative regulation of neuron apoptotic process] GO:0043679[axon terminus] GO:0045202[synapse] GO:0046777[protein autophosphorylation] GO:0048403[brain-derived neurotrophic factor binding] GO:0048471[perinuclear region of cytoplasm] GO:0050772[positive regulation of axonogenesis] GO:0051716[cellular response to stimulus] GO:0051896[regulation of protein kinase B signaling] GO:0060175[brain-derived neurotrophic factor receptor activity] GO:0099551[trans-synaptic signaling by neuropeptide, modulating synaptic transmission] GO:1902430[negative regulation of amyloid-beta formation] GO:1990090[cellular response to nerve growth factor stimulus] GO:1990416[cellular response to brain-derived neurotrophic factor stimulus]
Q5VWE5 [Target identity:100%; Query identity:100%] Neurotrophic tyrosine kinase, receptor, type 2, isoform CRA_a; cDNA FLJ76753, highly similar to Homo sapiens neurotrophic tyrosine kinase, receptor, type 2 (NTRK2), transcript variant b, mRNA
Show all
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Transporters Accessory Factors Involved in Transport Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Cancers Cancers of eye, brain, and central nervous system Nervous system diseases Epilepsy Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014) DeepTMHMM predicted membrane proteins
Show all
GO:0000166[nucleotide binding] GO:0001764[neuron migration] GO:0001934[positive regulation of protein phosphorylation] GO:0002020[protease binding] GO:0004672[protein kinase activity] GO:0004713[protein tyrosine kinase activity] GO:0004714[transmembrane receptor protein tyrosine kinase activity] GO:0005030[neurotrophin receptor activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005737[cytoplasm] GO:0005768[endosome] GO:0005769[early endosome] GO:0005886[plasma membrane] GO:0005887[integral component of plasma membrane] GO:0006468[protein phosphorylation] GO:0007169[transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007399[nervous system development] GO:0007612[learning] GO:0008284[positive regulation of cell population proliferation] GO:0010008[endosome membrane] GO:0010628[positive regulation of gene expression] GO:0010976[positive regulation of neuron projection development] GO:0014068[positive regulation of phosphatidylinositol 3-kinase signaling] GO:0014069[postsynaptic density] GO:0016020[membrane] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016740[transferase activity] GO:0018108[peptidyl-tyrosine phosphorylation] GO:0021954[central nervous system neuron development] GO:0021987[cerebral cortex development] GO:0030154[cell differentiation] GO:0030182[neuron differentiation] GO:0030424[axon] GO:0030425[dendrite] GO:0031547[brain-derived neurotrophic factor receptor signaling pathway] GO:0031901[early endosome membrane] GO:0033674[positive regulation of kinase activity] GO:0038179[neurotrophin signaling pathway] GO:0042803[protein homodimerization activity] GO:0042995[cell projection] GO:0043087[regulation of GTPase activity] GO:0043121[neurotrophin binding] GO:0043197[dendritic spine] GO:0043235[receptor complex] GO:0043410[positive regulation of MAPK cascade] GO:0043524[negative regulation of neuron apoptotic process] GO:0043679[axon terminus] GO:0045202[synapse] GO:0046777[protein autophosphorylation] GO:0048403[brain-derived neurotrophic factor binding] GO:0048471[perinuclear region of cytoplasm] GO:0050772[positive regulation of axonogenesis] GO:0051716[cellular response to stimulus] GO:0051896[regulation of protein kinase B signaling] GO:0060175[brain-derived neurotrophic factor receptor activity] GO:0099551[trans-synaptic signaling by neuropeptide, modulating synaptic transmission] GO:1902430[negative regulation of amyloid-beta formation] GO:1990090[cellular response to nerve growth factor stimulus] GO:1990416[cellular response to brain-derived neurotrophic factor stimulus]
Q5VWE5 [Target identity:100%; Query identity:100%] Neurotrophic tyrosine kinase, receptor, type 2, isoform CRA_a; cDNA FLJ76753, highly similar to Homo sapiens neurotrophic tyrosine kinase, receptor, type 2 (NTRK2), transcript variant b, mRNA
Show all
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Transporters Accessory Factors Involved in Transport Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Cancers Cancers of eye, brain, and central nervous system Nervous system diseases Epilepsy Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) DeepTMHMM predicted membrane proteins
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GO:0000166[nucleotide binding] GO:0001764[neuron migration] GO:0001934[positive regulation of protein phosphorylation] GO:0002020[protease binding] GO:0004672[protein kinase activity] GO:0004713[protein tyrosine kinase activity] GO:0004714[transmembrane receptor protein tyrosine kinase activity] GO:0005030[neurotrophin receptor activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005737[cytoplasm] GO:0005768[endosome] GO:0005769[early endosome] GO:0005886[plasma membrane] GO:0005887[integral component of plasma membrane] GO:0006468[protein phosphorylation] GO:0007169[transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007399[nervous system development] GO:0007612[learning] GO:0008284[positive regulation of cell population proliferation] GO:0010008[endosome membrane] GO:0010628[positive regulation of gene expression] GO:0010976[positive regulation of neuron projection development] GO:0014068[positive regulation of phosphatidylinositol 3-kinase signaling] GO:0014069[postsynaptic density] GO:0016020[membrane] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016740[transferase activity] GO:0018108[peptidyl-tyrosine phosphorylation] GO:0021954[central nervous system neuron development] GO:0021987[cerebral cortex development] GO:0030154[cell differentiation] GO:0030182[neuron differentiation] GO:0030424[axon] GO:0030425[dendrite] GO:0031547[brain-derived neurotrophic factor receptor signaling pathway] GO:0031901[early endosome membrane] GO:0033674[positive regulation of kinase activity] GO:0038179[neurotrophin signaling pathway] GO:0042803[protein homodimerization activity] GO:0042995[cell projection] GO:0043087[regulation of GTPase activity] GO:0043121[neurotrophin binding] GO:0043197[dendritic spine] GO:0043235[receptor complex] GO:0043410[positive regulation of MAPK cascade] GO:0043524[negative regulation of neuron apoptotic process] GO:0043679[axon terminus] GO:0045202[synapse] GO:0046777[protein autophosphorylation] GO:0048403[brain-derived neurotrophic factor binding] GO:0048471[perinuclear region of cytoplasm] GO:0050772[positive regulation of axonogenesis] GO:0051716[cellular response to stimulus] GO:0051896[regulation of protein kinase B signaling] GO:0060175[brain-derived neurotrophic factor receptor activity] GO:0099551[trans-synaptic signaling by neuropeptide, modulating synaptic transmission] GO:1902430[negative regulation of amyloid-beta formation] GO:1990090[cellular response to nerve growth factor stimulus] GO:1990416[cellular response to brain-derived neurotrophic factor stimulus]
Q5VWE5 [Target identity:100%; Query identity:100%] Neurotrophic tyrosine kinase, receptor, type 2, isoform CRA_a; cDNA FLJ76753, highly similar to Homo sapiens neurotrophic tyrosine kinase, receptor, type 2 (NTRK2), transcript variant b, mRNA
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Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Transporters Accessory Factors Involved in Transport Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Cancers Cancers of eye, brain, and central nervous system Nervous system diseases Epilepsy Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014) DeepTMHMM predicted membrane proteins
Show all
GO:0000166[nucleotide binding] GO:0001764[neuron migration] GO:0001934[positive regulation of protein phosphorylation] GO:0002020[protease binding] GO:0004672[protein kinase activity] GO:0004713[protein tyrosine kinase activity] GO:0004714[transmembrane receptor protein tyrosine kinase activity] GO:0005030[neurotrophin receptor activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005737[cytoplasm] GO:0005768[endosome] GO:0005769[early endosome] GO:0005886[plasma membrane] GO:0005887[integral component of plasma membrane] GO:0006468[protein phosphorylation] GO:0007169[transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007399[nervous system development] GO:0007612[learning] GO:0008284[positive regulation of cell population proliferation] GO:0010008[endosome membrane] GO:0010628[positive regulation of gene expression] GO:0010976[positive regulation of neuron projection development] GO:0014068[positive regulation of phosphatidylinositol 3-kinase signaling] GO:0014069[postsynaptic density] GO:0016020[membrane] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016740[transferase activity] GO:0018108[peptidyl-tyrosine phosphorylation] GO:0021954[central nervous system neuron development] GO:0021987[cerebral cortex development] GO:0030154[cell differentiation] GO:0030182[neuron differentiation] GO:0030424[axon] GO:0030425[dendrite] GO:0031547[brain-derived neurotrophic factor receptor signaling pathway] GO:0031901[early endosome membrane] GO:0033674[positive regulation of kinase activity] GO:0038179[neurotrophin signaling pathway] GO:0042803[protein homodimerization activity] GO:0042995[cell projection] GO:0043087[regulation of GTPase activity] GO:0043121[neurotrophin binding] GO:0043197[dendritic spine] GO:0043235[receptor complex] GO:0043410[positive regulation of MAPK cascade] GO:0043524[negative regulation of neuron apoptotic process] GO:0043679[axon terminus] GO:0045202[synapse] GO:0046777[protein autophosphorylation] GO:0048403[brain-derived neurotrophic factor binding] GO:0048471[perinuclear region of cytoplasm] GO:0050772[positive regulation of axonogenesis] GO:0051716[cellular response to stimulus] GO:0051896[regulation of protein kinase B signaling] GO:0060175[brain-derived neurotrophic factor receptor activity] GO:0099551[trans-synaptic signaling by neuropeptide, modulating synaptic transmission] GO:1902430[negative regulation of amyloid-beta formation] GO:1990090[cellular response to nerve growth factor stimulus] GO:1990416[cellular response to brain-derived neurotrophic factor stimulus]
MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins DeepTMHMM predicted secreted proteins Predicted intracellular proteins RAS pathway related proteins Human disease related genes Cancers Cancers of eye, brain, and central nervous system Nervous system diseases Epilepsy Protein evidence (Ezkurdia et al 2014)
Q5VWE5 [Target identity:100%; Query identity:100%] Neurotrophic tyrosine kinase, receptor, type 2, isoform CRA_a; cDNA FLJ76753, highly similar to Homo sapiens neurotrophic tyrosine kinase, receptor, type 2 (NTRK2), transcript variant b, mRNA
Show all
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Transporters Accessory Factors Involved in Transport Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Cancers Cancers of eye, brain, and central nervous system Nervous system diseases Epilepsy Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014) DeepTMHMM predicted membrane proteins
Show all
GO:0000166[nucleotide binding] GO:0001764[neuron migration] GO:0001934[positive regulation of protein phosphorylation] GO:0002020[protease binding] GO:0004672[protein kinase activity] GO:0004713[protein tyrosine kinase activity] GO:0004714[transmembrane receptor protein tyrosine kinase activity] GO:0005030[neurotrophin receptor activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005737[cytoplasm] GO:0005768[endosome] GO:0005769[early endosome] GO:0005886[plasma membrane] GO:0005887[integral component of plasma membrane] GO:0006468[protein phosphorylation] GO:0007169[transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007399[nervous system development] GO:0007612[learning] GO:0008284[positive regulation of cell population proliferation] GO:0010008[endosome membrane] GO:0010628[positive regulation of gene expression] GO:0010976[positive regulation of neuron projection development] GO:0014068[positive regulation of phosphatidylinositol 3-kinase signaling] GO:0014069[postsynaptic density] GO:0016020[membrane] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016740[transferase activity] GO:0018108[peptidyl-tyrosine phosphorylation] GO:0021954[central nervous system neuron development] GO:0021987[cerebral cortex development] GO:0030154[cell differentiation] GO:0030182[neuron differentiation] GO:0030424[axon] GO:0030425[dendrite] GO:0031547[brain-derived neurotrophic factor receptor signaling pathway] GO:0031901[early endosome membrane] GO:0033674[positive regulation of kinase activity] GO:0038179[neurotrophin signaling pathway] GO:0042803[protein homodimerization activity] GO:0042995[cell projection] GO:0043087[regulation of GTPase activity] GO:0043121[neurotrophin binding] GO:0043197[dendritic spine] GO:0043235[receptor complex] GO:0043410[positive regulation of MAPK cascade] GO:0043524[negative regulation of neuron apoptotic process] GO:0043679[axon terminus] GO:0045202[synapse] GO:0046777[protein autophosphorylation] GO:0048403[brain-derived neurotrophic factor binding] GO:0048471[perinuclear region of cytoplasm] GO:0050772[positive regulation of axonogenesis] GO:0051716[cellular response to stimulus] GO:0051896[regulation of protein kinase B signaling] GO:0060175[brain-derived neurotrophic factor receptor activity] GO:0099551[trans-synaptic signaling by neuropeptide, modulating synaptic transmission] GO:1902430[negative regulation of amyloid-beta formation] GO:1990090[cellular response to nerve growth factor stimulus] GO:1990416[cellular response to brain-derived neurotrophic factor stimulus]
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Transporters Accessory Factors Involved in Transport Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Cancers Cancers of eye, brain, and central nervous system Nervous system diseases Epilepsy Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) DeepTMHMM predicted membrane proteins
Show all
GO:0000166[nucleotide binding] GO:0001764[neuron migration] GO:0001934[positive regulation of protein phosphorylation] GO:0002020[protease binding] GO:0004672[protein kinase activity] GO:0004713[protein tyrosine kinase activity] GO:0004714[transmembrane receptor protein tyrosine kinase activity] GO:0005030[neurotrophin receptor activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005737[cytoplasm] GO:0005768[endosome] GO:0005769[early endosome] GO:0005886[plasma membrane] GO:0005887[integral component of plasma membrane] GO:0006468[protein phosphorylation] GO:0007169[transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007399[nervous system development] GO:0007612[learning] GO:0008284[positive regulation of cell population proliferation] GO:0010008[endosome membrane] GO:0010628[positive regulation of gene expression] GO:0010976[positive regulation of neuron projection development] GO:0014068[positive regulation of phosphatidylinositol 3-kinase signaling] GO:0014069[postsynaptic density] GO:0016020[membrane] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016740[transferase activity] GO:0018108[peptidyl-tyrosine phosphorylation] GO:0021954[central nervous system neuron development] GO:0021987[cerebral cortex development] GO:0030154[cell differentiation] GO:0030182[neuron differentiation] GO:0030424[axon] GO:0030425[dendrite] GO:0031547[brain-derived neurotrophic factor receptor signaling pathway] GO:0031901[early endosome membrane] GO:0033674[positive regulation of kinase activity] GO:0038179[neurotrophin signaling pathway] GO:0042803[protein homodimerization activity] GO:0042995[cell projection] GO:0043087[regulation of GTPase activity] GO:0043121[neurotrophin binding] GO:0043197[dendritic spine] GO:0043235[receptor complex] GO:0043410[positive regulation of MAPK cascade] GO:0043524[negative regulation of neuron apoptotic process] GO:0043679[axon terminus] GO:0045202[synapse] GO:0046777[protein autophosphorylation] GO:0048403[brain-derived neurotrophic factor binding] GO:0048471[perinuclear region of cytoplasm] GO:0050772[positive regulation of axonogenesis] GO:0051716[cellular response to stimulus] GO:0051896[regulation of protein kinase B signaling] GO:0060175[brain-derived neurotrophic factor receptor activity] GO:0099551[trans-synaptic signaling by neuropeptide, modulating synaptic transmission] GO:1902430[negative regulation of amyloid-beta formation] GO:1990090[cellular response to nerve growth factor stimulus] GO:1990416[cellular response to brain-derived neurotrophic factor stimulus]
The Human Protein Atlas project is funded
