GENERAL INFORMATIONi
Gene namei GSN
Synonyms DKFZp313L0718
Gene descriptioni Gelsolin
Protein classi Cancer-related genes
Disease related genes
Human disease related genes
Plasma proteins
Predicted locationi Secreted, Intracellular
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi
Chromosome 9
Cytoband q33.2
Chromosome location (bp) 121207794 - 121332843
Number of transcriptsi 9
Ensembl ENSG00000148180 (version 109)
Entrez gene 2934
HGNC HGNC:4620
UniProt P06396 (UniProt - Evidence at protein level)
neXtProt NX_P06396
GeneCards GSN
Antibodypedia GSN antibodies


PROTEIN FUNCTION
Protein function (UniProt)i Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed 1. Plays a role in ciliogenesis 2. show less
Molecular function (UniProt)i Actin capping, Actin-binding
Biological process (UniProt)i Cilium biogenesis/degradation
Ligand (UniProt)i Calcium, Metal-binding
Gene summary (Entrez)i The protein encoded by this gene binds to the ""plus"" ends of actin monomers and filaments to prevent monomer exchange. The encoded calcium-regulated protein functions in both assembly and disassembly of actin filaments. Defects in this gene are a cause of familial amyloidosis Finnish type (FAF). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] show less
PROTEIN INFORMATIONi
Splice variant SwissProt TrEMBL Protein class Gene ontology Length & mass Signal peptide
(predicted)		 Transmembrane regions
(predicted)
GSN-203
ENSP00000362914
ENST00000373808
P06396
[Direct mapping] Gelsolin
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Human disease related genes
   Nervous system diseases
   Neurodegenerative diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002102 [podosome]
GO:0003779 [actin binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006911 [phagocytosis, engulfment]
GO:0007417 [central nervous system development]
GO:0008154 [actin polymerization or depolymerization]
GO:0010628 [positive regulation of gene expression]
GO:0014891 [striated muscle atrophy]
GO:0015629 [actin cytoskeleton]
GO:0016528 [sarcoplasm]
GO:0030030 [cell projection organization]
GO:0030031 [cell projection assembly]
GO:0030041 [actin filament polymerization]
GO:0030042 [actin filament depolymerization]
GO:0030478 [actin cap]
GO:0030864 [cortical actin cytoskeleton]
GO:0031648 [protein destabilization]
GO:0034774 [secretory granule lumen]
GO:0035994 [response to muscle stretch]
GO:0036313 [phosphatidylinositol 3-kinase catalytic subunit binding]
GO:0042989 [sequestering of actin monomers]
GO:0045010 [actin nucleation]
GO:0045159 [myosin II binding]
GO:0046597 [negative regulation of viral entry into host cell]
GO:0046872 [metal ion binding]
GO:0051014 [actin filament severing]
GO:0051015 [actin filament binding]
GO:0051016 [barbed-end actin filament capping]
GO:0051127 [positive regulation of actin nucleation]
GO:0051693 [actin filament capping]
GO:0055119 [relaxation of cardiac muscle]
GO:0060271 [cilium assembly]
GO:0070062 [extracellular exosome]
GO:0071801 [regulation of podosome assembly]
GO:0072562 [blood microparticle]
GO:0086003 [cardiac muscle cell contraction]
GO:0090527 [actin filament reorganization]
GO:0097017 [renal protein absorption]
GO:0097284 [hepatocyte apoptotic process]
GO:1902174 [positive regulation of keratinocyte apoptotic process]
GO:1903903 [regulation of establishment of T cell polarity]
GO:1903906 [regulation of plasma membrane raft polarization]
GO:1903909 [regulation of receptor clustering]
GO:1903923 [positive regulation of protein processing in phagocytic vesicle]
GO:1904813 [ficolin-1-rich granule lumen]
GO:1990000 [amyloid fibril formation]
GO:2001269 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
Show all
 742 aa
81.9 kDa 		No 0
GSN-204
ENSP00000362924
ENST00000373818
P06396
[Direct mapping] Gelsolin
Show all
A0A384MEF1
[Target identity:100%; Query identity:100%] Gelsolin
Show all
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
   DeepTMHMM predicted secreted proteins
   DeepSig predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Human disease related genes
   Nervous system diseases
   Neurodegenerative diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
   DeepTMHMM predicted membrane proteins
Show all
GO:0002102 [podosome]
GO:0003779 [actin binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006911 [phagocytosis, engulfment]
GO:0007417 [central nervous system development]
GO:0008154 [actin polymerization or depolymerization]
GO:0010628 [positive regulation of gene expression]
GO:0014891 [striated muscle atrophy]
GO:0015629 [actin cytoskeleton]
GO:0016528 [sarcoplasm]
GO:0030030 [cell projection organization]
GO:0030031 [cell projection assembly]
GO:0030041 [actin filament polymerization]
GO:0030042 [actin filament depolymerization]
GO:0030478 [actin cap]
GO:0030864 [cortical actin cytoskeleton]
GO:0031648 [protein destabilization]
GO:0034774 [secretory granule lumen]
GO:0035994 [response to muscle stretch]
GO:0036313 [phosphatidylinositol 3-kinase catalytic subunit binding]
GO:0042989 [sequestering of actin monomers]
GO:0045010 [actin nucleation]
GO:0045159 [myosin II binding]
GO:0046597 [negative regulation of viral entry into host cell]
GO:0046872 [metal ion binding]
GO:0051014 [actin filament severing]
GO:0051015 [actin filament binding]
GO:0051016 [barbed-end actin filament capping]
GO:0051127 [positive regulation of actin nucleation]
GO:0051693 [actin filament capping]
GO:0055119 [relaxation of cardiac muscle]
GO:0060271 [cilium assembly]
GO:0070062 [extracellular exosome]
GO:0071801 [regulation of podosome assembly]
GO:0072562 [blood microparticle]
GO:0086003 [cardiac muscle cell contraction]
GO:0090527 [actin filament reorganization]
GO:0097017 [renal protein absorption]
GO:0097284 [hepatocyte apoptotic process]
GO:1902174 [positive regulation of keratinocyte apoptotic process]
GO:1903903 [regulation of establishment of T cell polarity]
GO:1903906 [regulation of plasma membrane raft polarization]
GO:1903909 [regulation of receptor clustering]
GO:1903923 [positive regulation of protein processing in phagocytic vesicle]
GO:1904813 [ficolin-1-rich granule lumen]
GO:1990000 [amyloid fibril formation]
GO:2001269 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
Show all
 782 aa
85.7 kDa 		Yes 0
GSN-205
ENSP00000362929
ENST00000373823
P06396
[Direct mapping] Gelsolin
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Human disease related genes
   Nervous system diseases
   Neurodegenerative diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002102 [podosome]
GO:0003779 [actin binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006911 [phagocytosis, engulfment]
GO:0007417 [central nervous system development]
GO:0008154 [actin polymerization or depolymerization]
GO:0010628 [positive regulation of gene expression]
GO:0014891 [striated muscle atrophy]
GO:0015629 [actin cytoskeleton]
GO:0016528 [sarcoplasm]
GO:0030030 [cell projection organization]
GO:0030031 [cell projection assembly]
GO:0030041 [actin filament polymerization]
GO:0030042 [actin filament depolymerization]
GO:0030478 [actin cap]
GO:0030864 [cortical actin cytoskeleton]
GO:0031648 [protein destabilization]
GO:0034774 [secretory granule lumen]
GO:0035994 [response to muscle stretch]
GO:0036313 [phosphatidylinositol 3-kinase catalytic subunit binding]
GO:0042989 [sequestering of actin monomers]
GO:0045010 [actin nucleation]
GO:0045159 [myosin II binding]
GO:0046597 [negative regulation of viral entry into host cell]
GO:0046872 [metal ion binding]
GO:0051014 [actin filament severing]
GO:0051015 [actin filament binding]
GO:0051016 [barbed-end actin filament capping]
GO:0051127 [positive regulation of actin nucleation]
GO:0051693 [actin filament capping]
GO:0055119 [relaxation of cardiac muscle]
GO:0060271 [cilium assembly]
GO:0070062 [extracellular exosome]
GO:0071801 [regulation of podosome assembly]
GO:0072562 [blood microparticle]
GO:0086003 [cardiac muscle cell contraction]
GO:0090527 [actin filament reorganization]
GO:0097017 [renal protein absorption]
GO:0097284 [hepatocyte apoptotic process]
GO:1902174 [positive regulation of keratinocyte apoptotic process]
GO:1903903 [regulation of establishment of T cell polarity]
GO:1903906 [regulation of plasma membrane raft polarization]
GO:1903909 [regulation of receptor clustering]
GO:1903923 [positive regulation of protein processing in phagocytic vesicle]
GO:1904813 [ficolin-1-rich granule lumen]
GO:1990000 [amyloid fibril formation]
GO:2001269 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
Show all
 731 aa
80.6 kDa 		No 0
GSN-206
ENSP00000377882
ENST00000394353
A0A0A0MS51
[Direct mapping] Gelsolin
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Nervous system diseases
   Neurodegenerative diseases
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005509 [calcium ion binding]
GO:0030030 [cell projection organization]
GO:0045010 [actin nucleation]
GO:0051014 [actin filament severing]
GO:0051015 [actin filament binding]
GO:0051016 [barbed-end actin filament capping]
Show all
 748 aa
82.5 kDa 		No 0
GSN-207
ENSP00000404226
ENST00000432226
P06396
[Direct mapping] Gelsolin
Show all
Q5T0I0
[Direct mapping] Macrophage-capping protein
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Human disease related genes
   Nervous system diseases
   Neurodegenerative diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001726 [ruffle]
GO:0002102 [podosome]
GO:0003779 [actin binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006911 [phagocytosis, engulfment]
GO:0007417 [central nervous system development]
GO:0008154 [actin polymerization or depolymerization]
GO:0010628 [positive regulation of gene expression]
GO:0014891 [striated muscle atrophy]
GO:0015629 [actin cytoskeleton]
GO:0016192 [vesicle-mediated transport]
GO:0016528 [sarcoplasm]
GO:0030027 [lamellipodium]
GO:0030030 [cell projection organization]
GO:0030031 [cell projection assembly]
GO:0030036 [actin cytoskeleton organization]
GO:0030041 [actin filament polymerization]
GO:0030042 [actin filament depolymerization]
GO:0030478 [actin cap]
GO:0030864 [cortical actin cytoskeleton]
GO:0031648 [protein destabilization]
GO:0034774 [secretory granule lumen]
GO:0035994 [response to muscle stretch]
GO:0036313 [phosphatidylinositol 3-kinase catalytic subunit binding]
GO:0042470 [melanosome]
GO:0042989 [sequestering of actin monomers]
GO:0042995 [cell projection]
GO:0045010 [actin nucleation]
GO:0045159 [myosin II binding]
GO:0045335 [phagocytic vesicle]
GO:0046597 [negative regulation of viral entry into host cell]
GO:0046872 [metal ion binding]
GO:0051014 [actin filament severing]
GO:0051015 [actin filament binding]
GO:0051016 [barbed-end actin filament capping]
GO:0051127 [positive regulation of actin nucleation]
GO:0051693 [actin filament capping]
GO:0055119 [relaxation of cardiac muscle]
GO:0060271 [cilium assembly]
GO:0070062 [extracellular exosome]
GO:0071346 [cellular response to interferon-gamma]
GO:0071801 [regulation of podosome assembly]
GO:0072562 [blood microparticle]
GO:0086003 [cardiac muscle cell contraction]
GO:0090527 [actin filament reorganization]
GO:0097017 [renal protein absorption]
GO:0097284 [hepatocyte apoptotic process]
GO:1902174 [positive regulation of keratinocyte apoptotic process]
GO:1903903 [regulation of establishment of T cell polarity]
GO:1903906 [regulation of plasma membrane raft polarization]
GO:1903909 [regulation of receptor clustering]
GO:1903923 [positive regulation of protein processing in phagocytic vesicle]
GO:1904813 [ficolin-1-rich granule lumen]
GO:1990000 [amyloid fibril formation]
GO:2001269 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
Show all
 731 aa
80.6 kDa 		No 0
GSN-209
ENSP00000409358
ENST00000449733
A0A0A0MT01
[Direct mapping] Gelsolin
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Nervous system diseases
   Neurodegenerative diseases
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005509 [calcium ion binding]
GO:0030030 [cell projection organization]
GO:0045010 [actin nucleation]
GO:0051014 [actin filament severing]
GO:0051015 [actin filament binding]
GO:0051016 [barbed-end actin filament capping]
Show all
 767 aa
84.7 kDa 		No 0
GSN-210
ENSP00000489067
ENST00000477104
A0A0U1RQL8
[Direct mapping] Macrophage-capping protein
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Nervous system diseases
   Neurodegenerative diseases
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001726 [ruffle]
GO:0003779 [actin binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0008154 [actin polymerization or depolymerization]
GO:0030027 [lamellipodium]
GO:0042470 [melanosome]
GO:0042995 [cell projection]
GO:0051014 [actin filament severing]
GO:0051015 [actin filament binding]
GO:0051016 [barbed-end actin filament capping]
GO:0051693 [actin filament capping]
Show all
 232 aa
26.3 kDa 		No 0
GSN-215
ENSP00000445823
ENST00000545652
P06396
[Direct mapping] Gelsolin
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Human disease related genes
   Nervous system diseases
   Neurodegenerative diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002102 [podosome]
GO:0003779 [actin binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006911 [phagocytosis, engulfment]
GO:0007417 [central nervous system development]
GO:0008154 [actin polymerization or depolymerization]
GO:0010628 [positive regulation of gene expression]
GO:0014891 [striated muscle atrophy]
GO:0015629 [actin cytoskeleton]
GO:0016528 [sarcoplasm]
GO:0030030 [cell projection organization]
GO:0030031 [cell projection assembly]
GO:0030041 [actin filament polymerization]
GO:0030042 [actin filament depolymerization]
GO:0030478 [actin cap]
GO:0030864 [cortical actin cytoskeleton]
GO:0031648 [protein destabilization]
GO:0034774 [secretory granule lumen]
GO:0035994 [response to muscle stretch]
GO:0036313 [phosphatidylinositol 3-kinase catalytic subunit binding]
GO:0042989 [sequestering of actin monomers]
GO:0045010 [actin nucleation]
GO:0045159 [myosin II binding]
GO:0046597 [negative regulation of viral entry into host cell]
GO:0046872 [metal ion binding]
GO:0051014 [actin filament severing]
GO:0051015 [actin filament binding]
GO:0051016 [barbed-end actin filament capping]
GO:0051127 [positive regulation of actin nucleation]
GO:0051693 [actin filament capping]
GO:0055119 [relaxation of cardiac muscle]
GO:0060271 [cilium assembly]
GO:0070062 [extracellular exosome]
GO:0071801 [regulation of podosome assembly]
GO:0072562 [blood microparticle]
GO:0086003 [cardiac muscle cell contraction]
GO:0090527 [actin filament reorganization]
GO:0097017 [renal protein absorption]
GO:0097284 [hepatocyte apoptotic process]
GO:1902174 [positive regulation of keratinocyte apoptotic process]
GO:1903903 [regulation of establishment of T cell polarity]
GO:1903906 [regulation of plasma membrane raft polarization]
GO:1903909 [regulation of receptor clustering]
GO:1903923 [positive regulation of protein processing in phagocytic vesicle]
GO:1904813 [ficolin-1-rich granule lumen]
GO:1990000 [amyloid fibril formation]
GO:2001269 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
Show all
 739 aa
81.5 kDa 		No 0
GSN-216
ENSP00000514432
ENST00000699558
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Nervous system diseases
   Neurodegenerative diseases
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0045010 [actin nucleation]
GO:0051014 [actin filament severing]
GO:0051015 [actin filament binding]
GO:0051016 [barbed-end actin filament capping]
Show all
 755 aa
83.3 kDa 		No 0

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