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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
10
Cytoband
q24.33
Chromosome location (bp)
103367966 - 103389065
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription 1. TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) 2. The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 3,4,5,6. The TFIID complex structure can be divided into 3 modules TFIID-A, TFIID-B, and TFIID-C 7. TAF5 is involved in two modules of TFIID, in TFIID-A together with TAF3 and TBP, and in TFIID-B with TAF8 8. Involved in contacts between TFIID and TFIIF in the PIC 9....show less
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes an integral subunit of TFIID associated with all transcriptionally competent forms of that complex. This subunit interacts strongly with two TFIID subunits that show similarity to histones H3 and H4, and it may participate in forming a nucleosome-like core in the TFIID complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000785[chromatin] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005669[transcription factor TFIID complex] GO:0006282[regulation of DNA repair] GO:0006352[DNA-templated transcription initiation] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006367[transcription initiation at RNA polymerase II promoter] GO:0006468[protein phosphorylation] GO:0015629[actin cytoskeleton] GO:0016251[RNA polymerase II general transcription initiation factor activity] GO:0033276[transcription factor TFTC complex] GO:0035521[monoubiquitinated histone deubiquitination] GO:0035522[monoubiquitinated histone H2A deubiquitination] GO:0042789[mRNA transcription by RNA polymerase II] GO:0042802[identical protein binding] GO:0043966[histone H3 acetylation] GO:0045893[positive regulation of DNA-templated transcription] GO:0051123[RNA polymerase II preinitiation complex assembly] GO:0060261[positive regulation of transcription initiation by RNA polymerase II]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785[chromatin] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005669[transcription factor TFIID complex] GO:0006282[regulation of DNA repair] GO:0006352[DNA-templated transcription initiation] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006367[transcription initiation at RNA polymerase II promoter] GO:0006468[protein phosphorylation] GO:0015629[actin cytoskeleton] GO:0016251[RNA polymerase II general transcription initiation factor activity] GO:0033276[transcription factor TFTC complex] GO:0035521[monoubiquitinated histone deubiquitination] GO:0035522[monoubiquitinated histone H2A deubiquitination] GO:0042789[mRNA transcription by RNA polymerase II] GO:0042802[identical protein binding] GO:0043966[histone H3 acetylation] GO:0045893[positive regulation of DNA-templated transcription] GO:0051123[RNA polymerase II preinitiation complex assembly] GO:0060261[positive regulation of transcription initiation by RNA polymerase II]
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