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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Disease related genes Human disease related genes Plasma proteins Transcription factors
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
12
Cytoband
q14.3
Chromosome location (bp)
65824460 - 65966291
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Functions as a transcriptional regulator. Functions in cell cycle regulation through CCNA2. Plays an important role in chromosome condensation during the meiotic G2/M transition of spermatocytes. Plays a role in postnatal myogenesis, is involved in satellite cell activation (By similarity). Positively regulates IGF2 expression through PLAG1 and in a PLAG1-independent manner 1....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
DNA-binding
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
This gene encodes a protein that belongs to the non-histone chromosomal high mobility group (HMG) protein family. HMG proteins function as architectural factors and are essential components of the enhancesome. This protein contains structural DNA-binding domains and may act as a transcriptional regulating factor. Identification of the deletion, amplification, and rearrangement of this gene that are associated with myxoid liposarcoma suggests a role in adipogenesis and mesenchymal differentiation. A gene knock out study of the mouse counterpart demonstrated that this gene is involved in diet-induced obesity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
P52926 [Direct mapping] High mobility group protein HMGI-C
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors beta-Sheet binding to DNA Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Human disease related genes Congenital malformations Other congenital malformations Reproductive system diseases Reproductive system diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000228[nuclear chromosome] GO:0000785[chromatin] GO:0000976[transcription cis-regulatory region binding] GO:0001837[epithelial to mesenchymal transition] GO:0002062[chondrocyte differentiation] GO:0003131[mesodermal-endodermal cell signaling] GO:0003676[nucleic acid binding] GO:0003677[DNA binding] GO:0003680[minor groove of adenine-thymine-rich DNA binding] GO:0003712[transcription coregulator activity] GO:0003714[transcription corepressor activity] GO:0003906[DNA-(apurinic or apyrimidinic site) endonuclease activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0006284[base-excision repair] GO:0006325[chromatin organization] GO:0006351[DNA-templated transcription] GO:0006355[regulation of DNA-templated transcription] GO:0007049[cell cycle] GO:0008301[DNA binding, bending] GO:0009615[response to virus] GO:0010564[regulation of cell cycle process] GO:0010628[positive regulation of gene expression] GO:0030261[chromosome condensation] GO:0031492[nucleosomal DNA binding] GO:0031507[heterochromatin formation] GO:0032993[protein-DNA complex] GO:0035497[cAMP response element binding] GO:0035500[MH2 domain binding] GO:0035501[MH1 domain binding] GO:0035556[intracellular signal transduction] GO:0035985[senescence-associated heterochromatin focus] GO:0035987[endodermal cell differentiation] GO:0035988[chondrocyte proliferation] GO:0043066[negative regulation of apoptotic process] GO:0043392[negative regulation of DNA binding] GO:0043922[negative regulation by host of viral transcription] GO:0045444[fat cell differentiation] GO:0045766[positive regulation of angiogenesis] GO:0045869[negative regulation of single stranded viral RNA replication via double stranded DNA intermediate] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046332[SMAD binding] GO:0048333[mesodermal cell differentiation] GO:0048762[mesenchymal cell differentiation] GO:0048863[stem cell differentiation] GO:0051301[cell division] GO:0051575[5'-deoxyribose-5-phosphate lyase activity] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0070742[C2H2 zinc finger domain binding] GO:0071141[SMAD protein complex] GO:0071864[positive regulation of cell proliferation in bone marrow] GO:0071902[positive regulation of protein serine/threonine kinase activity] GO:0090402[oncogene-induced cell senescence] GO:2000036[regulation of stem cell population maintenance] GO:2000648[positive regulation of stem cell proliferation] GO:2000773[negative regulation of cellular senescence] GO:2001033[negative regulation of double-strand break repair via nonhomologous end joining]
F5H2A4 [Direct mapping] High mobility group protein HMGI-C
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Human disease related genes Congenital malformations Other congenital malformations Reproductive system diseases Reproductive system diseases Protein evidence (Ezkurdia et al 2014)
P52926 [Direct mapping] High mobility group protein HMGI-C
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors beta-Sheet binding to DNA Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Human disease related genes Congenital malformations Other congenital malformations Reproductive system diseases Reproductive system diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000228[nuclear chromosome] GO:0000785[chromatin] GO:0000976[transcription cis-regulatory region binding] GO:0001837[epithelial to mesenchymal transition] GO:0002062[chondrocyte differentiation] GO:0003131[mesodermal-endodermal cell signaling] GO:0003676[nucleic acid binding] GO:0003677[DNA binding] GO:0003680[minor groove of adenine-thymine-rich DNA binding] GO:0003712[transcription coregulator activity] GO:0003714[transcription corepressor activity] GO:0003906[DNA-(apurinic or apyrimidinic site) endonuclease activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0006284[base-excision repair] GO:0006325[chromatin organization] GO:0006351[DNA-templated transcription] GO:0006355[regulation of DNA-templated transcription] GO:0007049[cell cycle] GO:0008301[DNA binding, bending] GO:0009615[response to virus] GO:0010564[regulation of cell cycle process] GO:0010628[positive regulation of gene expression] GO:0030261[chromosome condensation] GO:0031492[nucleosomal DNA binding] GO:0031507[heterochromatin formation] GO:0032993[protein-DNA complex] GO:0035497[cAMP response element binding] GO:0035500[MH2 domain binding] GO:0035501[MH1 domain binding] GO:0035556[intracellular signal transduction] GO:0035985[senescence-associated heterochromatin focus] GO:0035987[endodermal cell differentiation] GO:0035988[chondrocyte proliferation] GO:0043066[negative regulation of apoptotic process] GO:0043392[negative regulation of DNA binding] GO:0043922[negative regulation by host of viral transcription] GO:0045444[fat cell differentiation] GO:0045766[positive regulation of angiogenesis] GO:0045869[negative regulation of single stranded viral RNA replication via double stranded DNA intermediate] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046332[SMAD binding] GO:0048333[mesodermal cell differentiation] GO:0048762[mesenchymal cell differentiation] GO:0048863[stem cell differentiation] GO:0051301[cell division] GO:0051575[5'-deoxyribose-5-phosphate lyase activity] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0070742[C2H2 zinc finger domain binding] GO:0071141[SMAD protein complex] GO:0071864[positive regulation of cell proliferation in bone marrow] GO:0071902[positive regulation of protein serine/threonine kinase activity] GO:0090402[oncogene-induced cell senescence] GO:2000036[regulation of stem cell population maintenance] GO:2000648[positive regulation of stem cell proliferation] GO:2000773[negative regulation of cellular senescence] GO:2001033[negative regulation of double-strand break repair via nonhomologous end joining]
P52926 [Direct mapping] High mobility group protein HMGI-C
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors beta-Sheet binding to DNA Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Human disease related genes Congenital malformations Other congenital malformations Reproductive system diseases Reproductive system diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000228[nuclear chromosome] GO:0000785[chromatin] GO:0000976[transcription cis-regulatory region binding] GO:0001837[epithelial to mesenchymal transition] GO:0002062[chondrocyte differentiation] GO:0003131[mesodermal-endodermal cell signaling] GO:0003676[nucleic acid binding] GO:0003677[DNA binding] GO:0003680[minor groove of adenine-thymine-rich DNA binding] GO:0003712[transcription coregulator activity] GO:0003714[transcription corepressor activity] GO:0003906[DNA-(apurinic or apyrimidinic site) endonuclease activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0006284[base-excision repair] GO:0006325[chromatin organization] GO:0006351[DNA-templated transcription] GO:0006355[regulation of DNA-templated transcription] GO:0007049[cell cycle] GO:0008301[DNA binding, bending] GO:0009615[response to virus] GO:0010564[regulation of cell cycle process] GO:0010628[positive regulation of gene expression] GO:0030261[chromosome condensation] GO:0031492[nucleosomal DNA binding] GO:0031507[heterochromatin formation] GO:0032993[protein-DNA complex] GO:0035497[cAMP response element binding] GO:0035500[MH2 domain binding] GO:0035501[MH1 domain binding] GO:0035556[intracellular signal transduction] GO:0035985[senescence-associated heterochromatin focus] GO:0035987[endodermal cell differentiation] GO:0035988[chondrocyte proliferation] GO:0043066[negative regulation of apoptotic process] GO:0043392[negative regulation of DNA binding] GO:0043922[negative regulation by host of viral transcription] GO:0045444[fat cell differentiation] GO:0045766[positive regulation of angiogenesis] GO:0045869[negative regulation of single stranded viral RNA replication via double stranded DNA intermediate] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046332[SMAD binding] GO:0048333[mesodermal cell differentiation] GO:0048762[mesenchymal cell differentiation] GO:0048863[stem cell differentiation] GO:0051301[cell division] GO:0051575[5'-deoxyribose-5-phosphate lyase activity] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0070742[C2H2 zinc finger domain binding] GO:0071141[SMAD protein complex] GO:0071864[positive regulation of cell proliferation in bone marrow] GO:0071902[positive regulation of protein serine/threonine kinase activity] GO:0090402[oncogene-induced cell senescence] GO:2000036[regulation of stem cell population maintenance] GO:2000648[positive regulation of stem cell proliferation] GO:2000773[negative regulation of cellular senescence] GO:2001033[negative regulation of double-strand break repair via nonhomologous end joining]
P52926 [Direct mapping] High mobility group protein HMGI-C
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors beta-Sheet binding to DNA Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Human disease related genes Congenital malformations Other congenital malformations Reproductive system diseases Reproductive system diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000228[nuclear chromosome] GO:0000785[chromatin] GO:0000976[transcription cis-regulatory region binding] GO:0001837[epithelial to mesenchymal transition] GO:0002062[chondrocyte differentiation] GO:0003131[mesodermal-endodermal cell signaling] GO:0003676[nucleic acid binding] GO:0003677[DNA binding] GO:0003680[minor groove of adenine-thymine-rich DNA binding] GO:0003712[transcription coregulator activity] GO:0003714[transcription corepressor activity] GO:0003906[DNA-(apurinic or apyrimidinic site) endonuclease activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0006284[base-excision repair] GO:0006325[chromatin organization] GO:0006351[DNA-templated transcription] GO:0006355[regulation of DNA-templated transcription] GO:0007049[cell cycle] GO:0008301[DNA binding, bending] GO:0009615[response to virus] GO:0010564[regulation of cell cycle process] GO:0010628[positive regulation of gene expression] GO:0030261[chromosome condensation] GO:0031492[nucleosomal DNA binding] GO:0031507[heterochromatin formation] GO:0032993[protein-DNA complex] GO:0035497[cAMP response element binding] GO:0035500[MH2 domain binding] GO:0035501[MH1 domain binding] GO:0035556[intracellular signal transduction] GO:0035985[senescence-associated heterochromatin focus] GO:0035987[endodermal cell differentiation] GO:0035988[chondrocyte proliferation] GO:0043066[negative regulation of apoptotic process] GO:0043392[negative regulation of DNA binding] GO:0043922[negative regulation by host of viral transcription] GO:0045444[fat cell differentiation] GO:0045766[positive regulation of angiogenesis] GO:0045869[negative regulation of single stranded viral RNA replication via double stranded DNA intermediate] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046332[SMAD binding] GO:0048333[mesodermal cell differentiation] GO:0048762[mesenchymal cell differentiation] GO:0048863[stem cell differentiation] GO:0051301[cell division] GO:0051575[5'-deoxyribose-5-phosphate lyase activity] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0070742[C2H2 zinc finger domain binding] GO:0071141[SMAD protein complex] GO:0071864[positive regulation of cell proliferation in bone marrow] GO:0071902[positive regulation of protein serine/threonine kinase activity] GO:0090402[oncogene-induced cell senescence] GO:2000036[regulation of stem cell population maintenance] GO:2000648[positive regulation of stem cell proliferation] GO:2000773[negative regulation of cellular senescence] GO:2001033[negative regulation of double-strand break repair via nonhomologous end joining]
F5H6H0 [Direct mapping] High mobility group protein HMGI-C
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Human disease related genes Congenital malformations Other congenital malformations Reproductive system diseases Reproductive system diseases Protein evidence (Ezkurdia et al 2014)
F5H2U8 [Direct mapping] High mobility group protein HMGI-C
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Human disease related genes Congenital malformations Other congenital malformations Reproductive system diseases Reproductive system diseases Protein evidence (Ezkurdia et al 2014)
The Human Protein Atlas project is funded
