GENERAL INFORMATIONi
Gene namei ITGB1
Synonyms CD29, FNRB, GPIIA, MDF2, MSK12
Gene descriptioni Integrin subunit beta 1
Protein classi Cancer-related genes
CD markers
FDA approved drug targets
Plasma proteins
Transporters
Predicted locationi Membrane, Intracellular
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi
Chromosome 10
Cytoband p11.22
Chromosome location (bp) 32887273 - 33005792
Number of transcriptsi 26
Ensembl ENSG00000150093 (version 109)
Entrez gene 3688
HGNC HGNC:6153
UniProt P05556 (UniProt - Evidence at protein level)
neXtProt NX_P05556
GeneCards ITGB1
Antibodypedia ITGB1 antibodies


PROTEIN FUNCTION
Protein function (UniProt)i Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion (By similarity). Integrin alpha-4/beta-1 is a receptor for VCAM1. It recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Integrin alpha-V/beta-1 is a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. When associated with alpha-7 integrin, regulates cell adhesion and laminin matrix deposition. Involved in promoting endothelial cell motility and angiogenesis. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process and the formation of mineralized bone nodules. May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and RACK1, serves as a platform for SRC activation or inactivation. Plays a mechanistic adhesive role during telophase, required for the successful completion of cytokinesis. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. ITGA4:ITGB1 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling 1, 2. ITGA4:ITGB1 and ITGA5:ITGB1 bind to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 3, 4. ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 5, 6. ITGA5:ITGB1 acts as a receptor for fibronectin FN1 and mediates R-G-D-dependent cell adhesion to FN1 7. ITGA5:ITGB1 is a receptor for IL1B and binding is essential for IL1B signaling 8. ITGA5:ITGB3 is a receptor for soluble CD40LG and is required for CD40/CD40LG signaling 9. Plays an important role in myoblast differentiation and fusion during skeletal myogenesis (By similarity). ITGA9:ITGB1 may play a crucial role in SVEP1/polydom-mediated myoblast cell adhesion (By similarity). Integrins ITGA9:ITGB1 and ITGA4:ITGB1 repress PRKCA-mediated L-type voltage-gated channel Ca(2+) influx and ROCK-mediated calcium sensitivity in vascular smooth muscle cells via their interaction with SVEP1, thereby inhibit vasocontraction 10. show less
Molecular function (UniProt)i Host cell receptor for virus entry, Integrin, Receptor
Biological process (UniProt)i Cell adhesion, Host-virus interaction, Myogenesis
Ligand (UniProt)i Calcium, Magnesium, Metal-binding
Gene summary (Entrez)i Integrins are heterodimeric proteins made up of alpha and beta subunits. At least 18 alpha and 8 beta subunits have been described in mammals. Integrin family members are membrane receptors involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metastatic diffusion of tumor cells. This gene encodes a beta subunit. Multiple alternatively spliced transcript variants which encode different protein isoforms have been found for this gene. [provided by RefSeq, Jul 2008] show less
PROTEIN INFORMATIONi
Splice variant SwissProt TrEMBL Protein class Gene ontology Length & mass Signal peptide
(predicted)		 Transmembrane regions
(predicted)
ITGB1-201
ENSP00000303351
ENST00000302278
P05556
[Direct mapping] Integrin beta-1
Show all
CD markers
Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
FDA approved drug targets
   Biotech drugs
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
   DeepTMHMM predicted membrane proteins
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000132 [establishment of mitotic spindle orientation]
GO:0001618 [virus receptor activity]
GO:0001701 [in utero embryonic development]
GO:0001726 [ruffle]
GO:0001968 [fibronectin binding]
GO:0002020 [protease binding]
GO:0002042 [cell migration involved in sprouting angiogenesis]
GO:0002052 [positive regulation of neuroblast proliferation]
GO:0003779 [actin binding]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006909 [phagocytosis]
GO:0006968 [cellular defense response]
GO:0007155 [cell adhesion]
GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules]
GO:0007159 [leukocyte cell-cell adhesion]
GO:0007160 [cell-matrix adhesion]
GO:0007161 [calcium-independent cell-matrix adhesion]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007405 [neuroblast proliferation]
GO:0007517 [muscle organ development]
GO:0007520 [myoblast fusion]
GO:0008283 [cell population proliferation]
GO:0008305 [integrin complex]
GO:0008354 [germ cell migration]
GO:0008542 [visual learning]
GO:0009897 [external side of plasma membrane]
GO:0009986 [cell surface]
GO:0010008 [endosome membrane]
GO:0010710 [regulation of collagen catabolic process]
GO:0010763 [positive regulation of fibroblast migration]
GO:0014704 [intercalated disc]
GO:0015026 [coreceptor activity]
GO:0016020 [membrane]
GO:0016477 [cell migration]
GO:0019960 [C-X3-C chemokine binding]
GO:0021943 [formation of radial glial scaffolds]
GO:0023035 [CD40 signaling pathway]
GO:0030027 [lamellipodium]
GO:0030030 [cell projection organization]
GO:0030032 [lamellipodium assembly]
GO:0030175 [filopodium]
GO:0030182 [neuron differentiation]
GO:0030183 [B cell differentiation]
GO:0030335 [positive regulation of cell migration]
GO:0031175 [neuron projection development]
GO:0031410 [cytoplasmic vesicle]
GO:0031589 [cell-substrate adhesion]
GO:0031594 [neuromuscular junction]
GO:0031623 [receptor internalization]
GO:0032154 [cleavage furrow]
GO:0032587 [ruffle membrane]
GO:0033627 [cell adhesion mediated by integrin]
GO:0033631 [cell-cell adhesion mediated by integrin]
GO:0034113 [heterotypic cell-cell adhesion]
GO:0034665 [integrin alpha1-beta1 complex]
GO:0034666 [integrin alpha2-beta1 complex]
GO:0034667 [integrin alpha3-beta1 complex]
GO:0034668 [integrin alpha4-beta1 complex]
GO:0034674 [integrin alpha5-beta1 complex]
GO:0034677 [integrin alpha7-beta1 complex]
GO:0034678 [integrin alpha8-beta1 complex]
GO:0034680 [integrin alpha10-beta1 complex]
GO:0034681 [integrin alpha11-beta1 complex]
GO:0035024 [negative regulation of Rho protein signal transduction]
GO:0035313 [wound healing, spreading of epidermal cells]
GO:0035633 [maintenance of blood-brain barrier]
GO:0035748 [myelin sheath abaxonal region]
GO:0038023 [signaling receptor activity]
GO:0042383 [sarcolemma]
GO:0042470 [melanosome]
GO:0042995 [cell projection]
GO:0043065 [positive regulation of apoptotic process]
GO:0043197 [dendritic spine]
GO:0043235 [receptor complex]
GO:0043236 [laminin binding]
GO:0043547 [positive regulation of GTPase activity]
GO:0044877 [protein-containing complex binding]
GO:0045121 [membrane raft]
GO:0045202 [synapse]
GO:0045214 [sarcomere organization]
GO:0045296 [cadherin binding]
GO:0045445 [myoblast differentiation]
GO:0045665 [negative regulation of neuron differentiation]
GO:0045766 [positive regulation of angiogenesis]
GO:0046718 [viral entry into host cell]
GO:0046872 [metal ion binding]
GO:0046982 [protein heterodimerization activity]
GO:0048333 [mesodermal cell differentiation]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048626 [myoblast fate specification]
GO:0048675 [axon extension]
GO:0048813 [dendrite morphogenesis]
GO:0050804 [modulation of chemical synaptic transmission]
GO:0050839 [cell adhesion molecule binding]
GO:0050901 [leukocyte tethering or rolling]
GO:0051726 [regulation of cell cycle]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0051951 [positive regulation of glutamate uptake involved in transmission of nerve impulse]
GO:0055007 [cardiac muscle cell differentiation]
GO:0055037 [recycling endosome]
GO:0060379 [cardiac muscle cell myoblast differentiation]
GO:0060912 [cardiac cell fate specification]
GO:0070062 [extracellular exosome]
GO:0070161 [anchoring junction]
GO:0071404 [cellular response to low-density lipoprotein particle stimulus]
GO:0071711 [basement membrane organization]
GO:0090303 [positive regulation of wound healing]
GO:0097060 [synaptic membrane]
GO:0097386 [glial cell projection]
GO:0098639 [collagen binding involved in cell-matrix adhesion]
GO:0098685 [Schaffer collateral - CA1 synapse]
GO:0098978 [glutamatergic synapse]
GO:0150003 [regulation of spontaneous synaptic transmission]
GO:0150053 [cerebellar climbing fiber to Purkinje cell synapse]
GO:0150103 [reactive gliosis]
GO:1901979 [regulation of inward rectifier potassium channel activity]
GO:1903078 [positive regulation of protein localization to plasma membrane]
GO:1905806 [regulation of synapse pruning]
GO:1990782 [protein tyrosine kinase binding]
GO:2000273 [positive regulation of signaling receptor activity]
GO:2000811 [negative regulation of anoikis]
Show all
 798 aa
88.4 kDa 		Yes 1
ITGB1-202
ENSP00000379350
ENST00000396033
P05556
[Direct mapping] Integrin beta-1
Show all
CD markers
Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
FDA approved drug targets
   Biotech drugs
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
   DeepTMHMM predicted membrane proteins
Show all
GO:0000132 [establishment of mitotic spindle orientation]
GO:0001618 [virus receptor activity]
GO:0001726 [ruffle]
GO:0001968 [fibronectin binding]
GO:0002020 [protease binding]
GO:0003779 [actin binding]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006909 [phagocytosis]
GO:0006968 [cellular defense response]
GO:0007155 [cell adhesion]
GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules]
GO:0007159 [leukocyte cell-cell adhesion]
GO:0007160 [cell-matrix adhesion]
GO:0007161 [calcium-independent cell-matrix adhesion]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007517 [muscle organ development]
GO:0007520 [myoblast fusion]
GO:0008305 [integrin complex]
GO:0009986 [cell surface]
GO:0010008 [endosome membrane]
GO:0010710 [regulation of collagen catabolic process]
GO:0010763 [positive regulation of fibroblast migration]
GO:0015026 [coreceptor activity]
GO:0016020 [membrane]
GO:0016477 [cell migration]
GO:0019960 [C-X3-C chemokine binding]
GO:0023035 [CD40 signaling pathway]
GO:0030027 [lamellipodium]
GO:0030030 [cell projection organization]
GO:0030032 [lamellipodium assembly]
GO:0030175 [filopodium]
GO:0030183 [B cell differentiation]
GO:0030335 [positive regulation of cell migration]
GO:0031589 [cell-substrate adhesion]
GO:0031594 [neuromuscular junction]
GO:0031623 [receptor internalization]
GO:0032154 [cleavage furrow]
GO:0032587 [ruffle membrane]
GO:0033627 [cell adhesion mediated by integrin]
GO:0033631 [cell-cell adhesion mediated by integrin]
GO:0034113 [heterotypic cell-cell adhesion]
GO:0034665 [integrin alpha1-beta1 complex]
GO:0034666 [integrin alpha2-beta1 complex]
GO:0034667 [integrin alpha3-beta1 complex]
GO:0034668 [integrin alpha4-beta1 complex]
GO:0034674 [integrin alpha5-beta1 complex]
GO:0034678 [integrin alpha8-beta1 complex]
GO:0034680 [integrin alpha10-beta1 complex]
GO:0034681 [integrin alpha11-beta1 complex]
GO:0035313 [wound healing, spreading of epidermal cells]
GO:0035633 [maintenance of blood-brain barrier]
GO:0038023 [signaling receptor activity]
GO:0042383 [sarcolemma]
GO:0042470 [melanosome]
GO:0042995 [cell projection]
GO:0043065 [positive regulation of apoptotic process]
GO:0043235 [receptor complex]
GO:0043236 [laminin binding]
GO:0043547 [positive regulation of GTPase activity]
GO:0044877 [protein-containing complex binding]
GO:0045121 [membrane raft]
GO:0045296 [cadherin binding]
GO:0045445 [myoblast differentiation]
GO:0045766 [positive regulation of angiogenesis]
GO:0046718 [viral entry into host cell]
GO:0046872 [metal ion binding]
GO:0046982 [protein heterodimerization activity]
GO:0048333 [mesodermal cell differentiation]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050839 [cell adhesion molecule binding]
GO:0050901 [leukocyte tethering or rolling]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0051951 [positive regulation of glutamate uptake involved in transmission of nerve impulse]
GO:0055037 [recycling endosome]
GO:0070062 [extracellular exosome]
GO:0070161 [anchoring junction]
GO:0071404 [cellular response to low-density lipoprotein particle stimulus]
GO:0090303 [positive regulation of wound healing]
GO:0097386 [glial cell projection]
GO:0098639 [collagen binding involved in cell-matrix adhesion]
GO:0150003 [regulation of spontaneous synaptic transmission]
GO:0150103 [reactive gliosis]
GO:1901979 [regulation of inward rectifier potassium channel activity]
GO:1903078 [positive regulation of protein localization to plasma membrane]
GO:1990782 [protein tyrosine kinase binding]
GO:2000273 [positive regulation of signaling receptor activity]
GO:2000811 [negative regulation of anoikis]
Show all
 798 aa
88.4 kDa 		Yes 1
ITGB1-203
ENSP00000400544
ENST00000414670
Q5T3E4
[Direct mapping] Integrin beta-1
Show all
   MEMSAT3 predicted membrane proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
   DeepTMHMM predicted secreted proteins
   DeepSig predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0007155 [cell adhesion]
GO:0007160 [cell-matrix adhesion]
GO:0007229 [integrin-mediated signaling pathway]
GO:0008305 [integrin complex]
GO:0038023 [signaling receptor activity]
Show all
 49 aa
5.3 kDa 		Yes 0
ITGB1-204
ENSP00000404546
ENST00000417122
P05556
[Direct mapping] Integrin beta-1
Show all
Q5T3E5
[Direct mapping] Integrin beta-1
Show all
CD markers
Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
FDA approved drug targets
   Biotech drugs
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
   DeepTMHMM predicted membrane proteins
Show all
GO:0000132 [establishment of mitotic spindle orientation]
GO:0001618 [virus receptor activity]
GO:0001726 [ruffle]
GO:0001968 [fibronectin binding]
GO:0002020 [protease binding]
GO:0003779 [actin binding]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006909 [phagocytosis]
GO:0006968 [cellular defense response]
GO:0007155 [cell adhesion]
GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules]
GO:0007159 [leukocyte cell-cell adhesion]
GO:0007160 [cell-matrix adhesion]
GO:0007161 [calcium-independent cell-matrix adhesion]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007517 [muscle organ development]
GO:0007520 [myoblast fusion]
GO:0008305 [integrin complex]
GO:0009986 [cell surface]
GO:0010008 [endosome membrane]
GO:0010710 [regulation of collagen catabolic process]
GO:0010763 [positive regulation of fibroblast migration]
GO:0015026 [coreceptor activity]
GO:0016020 [membrane]
GO:0016477 [cell migration]
GO:0019960 [C-X3-C chemokine binding]
GO:0023035 [CD40 signaling pathway]
GO:0030027 [lamellipodium]
GO:0030030 [cell projection organization]
GO:0030032 [lamellipodium assembly]
GO:0030175 [filopodium]
GO:0030183 [B cell differentiation]
GO:0030335 [positive regulation of cell migration]
GO:0031589 [cell-substrate adhesion]
GO:0031594 [neuromuscular junction]
GO:0031623 [receptor internalization]
GO:0032154 [cleavage furrow]
GO:0032587 [ruffle membrane]
GO:0033627 [cell adhesion mediated by integrin]
GO:0033631 [cell-cell adhesion mediated by integrin]
GO:0034113 [heterotypic cell-cell adhesion]
GO:0034665 [integrin alpha1-beta1 complex]
GO:0034666 [integrin alpha2-beta1 complex]
GO:0034667 [integrin alpha3-beta1 complex]
GO:0034668 [integrin alpha4-beta1 complex]
GO:0034674 [integrin alpha5-beta1 complex]
GO:0034678 [integrin alpha8-beta1 complex]
GO:0034680 [integrin alpha10-beta1 complex]
GO:0034681 [integrin alpha11-beta1 complex]
GO:0035313 [wound healing, spreading of epidermal cells]
GO:0035633 [maintenance of blood-brain barrier]
GO:0038023 [signaling receptor activity]
GO:0042383 [sarcolemma]
GO:0042470 [melanosome]
GO:0042995 [cell projection]
GO:0043065 [positive regulation of apoptotic process]
GO:0043235 [receptor complex]
GO:0043236 [laminin binding]
GO:0043547 [positive regulation of GTPase activity]
GO:0044877 [protein-containing complex binding]
GO:0045121 [membrane raft]
GO:0045296 [cadherin binding]
GO:0045445 [myoblast differentiation]
GO:0045766 [positive regulation of angiogenesis]
GO:0046718 [viral entry into host cell]
GO:0046872 [metal ion binding]
GO:0046982 [protein heterodimerization activity]
GO:0048333 [mesodermal cell differentiation]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050839 [cell adhesion molecule binding]
GO:0050901 [leukocyte tethering or rolling]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0051951 [positive regulation of glutamate uptake involved in transmission of nerve impulse]
GO:0055037 [recycling endosome]
GO:0070062 [extracellular exosome]
GO:0070161 [anchoring junction]
GO:0071404 [cellular response to low-density lipoprotein particle stimulus]
GO:0090303 [positive regulation of wound healing]
GO:0097386 [glial cell projection]
GO:0098639 [collagen binding involved in cell-matrix adhesion]
GO:0150003 [regulation of spontaneous synaptic transmission]
GO:0150103 [reactive gliosis]
GO:1901979 [regulation of inward rectifier potassium channel activity]
GO:1903078 [positive regulation of protein localization to plasma membrane]
GO:1990782 [protein tyrosine kinase binding]
GO:2000273 [positive regulation of signaling receptor activity]
GO:2000811 [negative regulation of anoikis]
Show all
 798 aa
88.4 kDa 		Yes 1
ITGB1-205
ENSP00000388694
ENST00000423113
P05556
[Direct mapping] Integrin beta-1
Show all
CD markers
Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
FDA approved drug targets
   Biotech drugs
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
   DeepTMHMM predicted membrane proteins
Show all
GO:0000132 [establishment of mitotic spindle orientation]
GO:0001618 [virus receptor activity]
GO:0001726 [ruffle]
GO:0001968 [fibronectin binding]
GO:0002020 [protease binding]
GO:0003779 [actin binding]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006909 [phagocytosis]
GO:0006968 [cellular defense response]
GO:0007155 [cell adhesion]
GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules]
GO:0007159 [leukocyte cell-cell adhesion]
GO:0007160 [cell-matrix adhesion]
GO:0007161 [calcium-independent cell-matrix adhesion]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007517 [muscle organ development]
GO:0007520 [myoblast fusion]
GO:0008305 [integrin complex]
GO:0009986 [cell surface]
GO:0010008 [endosome membrane]
GO:0010710 [regulation of collagen catabolic process]
GO:0010763 [positive regulation of fibroblast migration]
GO:0015026 [coreceptor activity]
GO:0016020 [membrane]
GO:0016477 [cell migration]
GO:0019960 [C-X3-C chemokine binding]
GO:0023035 [CD40 signaling pathway]
GO:0030027 [lamellipodium]
GO:0030030 [cell projection organization]
GO:0030032 [lamellipodium assembly]
GO:0030175 [filopodium]
GO:0030183 [B cell differentiation]
GO:0030335 [positive regulation of cell migration]
GO:0031589 [cell-substrate adhesion]
GO:0031594 [neuromuscular junction]
GO:0031623 [receptor internalization]
GO:0032154 [cleavage furrow]
GO:0032587 [ruffle membrane]
GO:0033627 [cell adhesion mediated by integrin]
GO:0033631 [cell-cell adhesion mediated by integrin]
GO:0034113 [heterotypic cell-cell adhesion]
GO:0034665 [integrin alpha1-beta1 complex]
GO:0034666 [integrin alpha2-beta1 complex]
GO:0034667 [integrin alpha3-beta1 complex]
GO:0034668 [integrin alpha4-beta1 complex]
GO:0034674 [integrin alpha5-beta1 complex]
GO:0034678 [integrin alpha8-beta1 complex]
GO:0034680 [integrin alpha10-beta1 complex]
GO:0034681 [integrin alpha11-beta1 complex]
GO:0035313 [wound healing, spreading of epidermal cells]
GO:0035633 [maintenance of blood-brain barrier]
GO:0038023 [signaling receptor activity]
GO:0042383 [sarcolemma]
GO:0042470 [melanosome]
GO:0042995 [cell projection]
GO:0043065 [positive regulation of apoptotic process]
GO:0043235 [receptor complex]
GO:0043236 [laminin binding]
GO:0043547 [positive regulation of GTPase activity]
GO:0044877 [protein-containing complex binding]
GO:0045121 [membrane raft]
GO:0045296 [cadherin binding]
GO:0045445 [myoblast differentiation]
GO:0045766 [positive regulation of angiogenesis]
GO:0046718 [viral entry into host cell]
GO:0046872 [metal ion binding]
GO:0046982 [protein heterodimerization activity]
GO:0048333 [mesodermal cell differentiation]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050839 [cell adhesion molecule binding]
GO:0050901 [leukocyte tethering or rolling]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0051951 [positive regulation of glutamate uptake involved in transmission of nerve impulse]
GO:0055037 [recycling endosome]
GO:0070062 [extracellular exosome]
GO:0070161 [anchoring junction]
GO:0071404 [cellular response to low-density lipoprotein particle stimulus]
GO:0090303 [positive regulation of wound healing]
GO:0097386 [glial cell projection]
GO:0098639 [collagen binding involved in cell-matrix adhesion]
GO:0150003 [regulation of spontaneous synaptic transmission]
GO:0150103 [reactive gliosis]
GO:1901979 [regulation of inward rectifier potassium channel activity]
GO:1903078 [positive regulation of protein localization to plasma membrane]
GO:1990782 [protein tyrosine kinase binding]
GO:2000273 [positive regulation of signaling receptor activity]
GO:2000811 [negative regulation of anoikis]
Show all
 801 aa
88.9 kDa 		Yes 1
ITGB1-206
ENSP00000398029
ENST00000437302
P05556
[Direct mapping] Integrin beta-1
Show all
Q5T3E6
[Direct mapping] Integrin beta-1
Show all
CD markers
Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
FDA approved drug targets
   Biotech drugs
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
   DeepTMHMM predicted membrane proteins
Show all
GO:0000132 [establishment of mitotic spindle orientation]
GO:0001618 [virus receptor activity]
GO:0001726 [ruffle]
GO:0001968 [fibronectin binding]
GO:0002020 [protease binding]
GO:0003779 [actin binding]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006909 [phagocytosis]
GO:0006968 [cellular defense response]
GO:0007155 [cell adhesion]
GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules]
GO:0007159 [leukocyte cell-cell adhesion]
GO:0007160 [cell-matrix adhesion]
GO:0007161 [calcium-independent cell-matrix adhesion]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007517 [muscle organ development]
GO:0007520 [myoblast fusion]
GO:0008305 [integrin complex]
GO:0009986 [cell surface]
GO:0010008 [endosome membrane]
GO:0010710 [regulation of collagen catabolic process]
GO:0010763 [positive regulation of fibroblast migration]
GO:0015026 [coreceptor activity]
GO:0016020 [membrane]
GO:0016477 [cell migration]
GO:0019960 [C-X3-C chemokine binding]
GO:0023035 [CD40 signaling pathway]
GO:0030027 [lamellipodium]
GO:0030030 [cell projection organization]
GO:0030032 [lamellipodium assembly]
GO:0030175 [filopodium]
GO:0030183 [B cell differentiation]
GO:0030335 [positive regulation of cell migration]
GO:0031589 [cell-substrate adhesion]
GO:0031594 [neuromuscular junction]
GO:0031623 [receptor internalization]
GO:0032154 [cleavage furrow]
GO:0032587 [ruffle membrane]
GO:0033627 [cell adhesion mediated by integrin]
GO:0033631 [cell-cell adhesion mediated by integrin]
GO:0034113 [heterotypic cell-cell adhesion]
GO:0034665 [integrin alpha1-beta1 complex]
GO:0034666 [integrin alpha2-beta1 complex]
GO:0034667 [integrin alpha3-beta1 complex]
GO:0034668 [integrin alpha4-beta1 complex]
GO:0034674 [integrin alpha5-beta1 complex]
GO:0034678 [integrin alpha8-beta1 complex]
GO:0034680 [integrin alpha10-beta1 complex]
GO:0034681 [integrin alpha11-beta1 complex]
GO:0035313 [wound healing, spreading of epidermal cells]
GO:0035633 [maintenance of blood-brain barrier]
GO:0038023 [signaling receptor activity]
GO:0042383 [sarcolemma]
GO:0042470 [melanosome]
GO:0042995 [cell projection]
GO:0043065 [positive regulation of apoptotic process]
GO:0043235 [receptor complex]
GO:0043236 [laminin binding]
GO:0043547 [positive regulation of GTPase activity]
GO:0044877 [protein-containing complex binding]
GO:0045121 [membrane raft]
GO:0045296 [cadherin binding]
GO:0045445 [myoblast differentiation]
GO:0045766 [positive regulation of angiogenesis]
GO:0046718 [viral entry into host cell]
GO:0046872 [metal ion binding]
GO:0046982 [protein heterodimerization activity]
GO:0048333 [mesodermal cell differentiation]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050839 [cell adhesion molecule binding]
GO:0050901 [leukocyte tethering or rolling]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0051951 [positive regulation of glutamate uptake involved in transmission of nerve impulse]
GO:0055037 [recycling endosome]
GO:0070062 [extracellular exosome]
GO:0070161 [anchoring junction]
GO:0071404 [cellular response to low-density lipoprotein particle stimulus]
GO:0090303 [positive regulation of wound healing]
GO:0097386 [glial cell projection]
GO:0098639 [collagen binding involved in cell-matrix adhesion]
GO:0150003 [regulation of spontaneous synaptic transmission]
GO:0150103 [reactive gliosis]
GO:1901979 [regulation of inward rectifier potassium channel activity]
GO:1903078 [positive regulation of protein localization to plasma membrane]
GO:1990782 [protein tyrosine kinase binding]
GO:2000273 [positive regulation of signaling receptor activity]
GO:2000811 [negative regulation of anoikis]
Show all
 798 aa
88.4 kDa 		Yes 1
ITGB1-209
ENSP00000420416
ENST00000472147
C9JNE0
[Direct mapping] Integrin beta-1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
 14 aa
1.5 kDa 		No 0
ITGB1-210
ENSP00000420282
ENST00000474568
C9JPK5
[Direct mapping] Integrin beta
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
   DeepTMHMM predicted membrane proteins
Show all
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0007155 [cell adhesion]
GO:0007160 [cell-matrix adhesion]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007517 [muscle organ development]
GO:0008305 [integrin complex]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0030027 [lamellipodium]
GO:0032587 [ruffle membrane]
GO:0038023 [signaling receptor activity]
GO:0042470 [melanosome]
GO:0042995 [cell projection]
GO:0055037 [recycling endosome]
GO:0070161 [anchoring junction]
Show all
 809 aa
90.1 kDa 		Yes 1
ITGB1-212
ENSP00000417537
ENST00000480226
E7EQW5
[Direct mapping] Integrin beta
Show all
   MEMSAT3 predicted membrane proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
   DeepTMHMM predicted secreted proteins
   DeepSig predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005925 [focal adhesion]
GO:0007155 [cell adhesion]
GO:0007160 [cell-matrix adhesion]
GO:0007229 [integrin-mediated signaling pathway]
GO:0008305 [integrin complex]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0038023 [signaling receptor activity]
GO:0055037 [recycling endosome]
Show all
 163 aa
18.4 kDa 		Yes 0
ITGB1-214
ENSP00000417508
ENST00000488427
H7C4K3
[Direct mapping] Integrin beta
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
   DeepTMHMM predicted membrane proteins
Show all
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0007155 [cell adhesion]
GO:0007160 [cell-matrix adhesion]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007517 [muscle organ development]
GO:0008305 [integrin complex]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0030027 [lamellipodium]
GO:0032587 [ruffle membrane]
GO:0038023 [signaling receptor activity]
GO:0042470 [melanosome]
GO:0042995 [cell projection]
GO:0055037 [recycling endosome]
GO:0070161 [anchoring junction]
Show all
 741 aa
82.2 kDa 		No 1
ITGB1-215
ENSP00000418725
ENST00000488494
E7EUI6
[Direct mapping] Integrin beta
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
   DeepTMHMM predicted membrane proteins
Show all
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0007155 [cell adhesion]
GO:0007160 [cell-matrix adhesion]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007517 [muscle organ development]
GO:0008305 [integrin complex]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0030027 [lamellipodium]
GO:0032587 [ruffle membrane]
GO:0038023 [signaling receptor activity]
GO:0042470 [melanosome]
GO:0042995 [cell projection]
GO:0055037 [recycling endosome]
GO:0070161 [anchoring junction]
Show all
 801 aa
88.7 kDa 		Yes 1
ITGB1-217
ENSP00000436214
ENST00000528877
E9PQJ2
[Direct mapping] Integrin beta-1
Show all
   MEMSAT3 predicted membrane proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
   DeepTMHMM predicted secreted proteins
   DeepSig predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0007155 [cell adhesion]
GO:0007160 [cell-matrix adhesion]
GO:0007229 [integrin-mediated signaling pathway]
GO:0008305 [integrin complex]
GO:0038023 [signaling receptor activity]
Show all
 104 aa
11.3 kDa 		Yes 0
ITGB1-218
ENSP00000431326
ENST00000534049
E9PLR6
[Direct mapping] Integrin beta-1
Show all
   MEMSAT3 predicted membrane proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
   DeepTMHMM predicted secreted proteins
   DeepSig predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0007155 [cell adhesion]
GO:0007160 [cell-matrix adhesion]
GO:0007229 [integrin-mediated signaling pathway]
GO:0008305 [integrin complex]
GO:0038023 [signaling receptor activity]
Show all
 143 aa
16 kDa 		Yes 0
ITGB1-219
ENSP00000503306
ENST00000609742
A0A7I2V348
[Direct mapping] Integrin beta
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
   DeepTMHMM predicted membrane proteins
Show all
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0007155 [cell adhesion]
GO:0007160 [cell-matrix adhesion]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007517 [muscle organ development]
GO:0008305 [integrin complex]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0030027 [lamellipodium]
GO:0032587 [ruffle membrane]
GO:0038023 [signaling receptor activity]
GO:0042470 [melanosome]
GO:0042995 [cell projection]
GO:0055037 [recycling endosome]
GO:0070161 [anchoring junction]
Show all
 793 aa
88 kDa 		Yes 1
ITGB1-220
ENSP00000504641
ENST00000676460
P05556
[Direct mapping] Integrin beta-1
Show all
CD markers
Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
FDA approved drug targets
   Biotech drugs
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
   DeepTMHMM predicted membrane proteins
Show all
GO:0000132 [establishment of mitotic spindle orientation]
GO:0001618 [virus receptor activity]
GO:0001726 [ruffle]
GO:0001968 [fibronectin binding]
GO:0002020 [protease binding]
GO:0003779 [actin binding]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006909 [phagocytosis]
GO:0006968 [cellular defense response]
GO:0007155 [cell adhesion]
GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules]
GO:0007159 [leukocyte cell-cell adhesion]
GO:0007160 [cell-matrix adhesion]
GO:0007161 [calcium-independent cell-matrix adhesion]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007517 [muscle organ development]
GO:0007520 [myoblast fusion]
GO:0008305 [integrin complex]
GO:0009986 [cell surface]
GO:0010008 [endosome membrane]
GO:0010710 [regulation of collagen catabolic process]
GO:0010763 [positive regulation of fibroblast migration]
GO:0015026 [coreceptor activity]
GO:0016020 [membrane]
GO:0016477 [cell migration]
GO:0019960 [C-X3-C chemokine binding]
GO:0023035 [CD40 signaling pathway]
GO:0030027 [lamellipodium]
GO:0030030 [cell projection organization]
GO:0030032 [lamellipodium assembly]
GO:0030175 [filopodium]
GO:0030183 [B cell differentiation]
GO:0030335 [positive regulation of cell migration]
GO:0031589 [cell-substrate adhesion]
GO:0031594 [neuromuscular junction]
GO:0031623 [receptor internalization]
GO:0032154 [cleavage furrow]
GO:0032587 [ruffle membrane]
GO:0033627 [cell adhesion mediated by integrin]
GO:0033631 [cell-cell adhesion mediated by integrin]
GO:0034113 [heterotypic cell-cell adhesion]
GO:0034665 [integrin alpha1-beta1 complex]
GO:0034666 [integrin alpha2-beta1 complex]
GO:0034667 [integrin alpha3-beta1 complex]
GO:0034668 [integrin alpha4-beta1 complex]
GO:0034674 [integrin alpha5-beta1 complex]
GO:0034678 [integrin alpha8-beta1 complex]
GO:0034680 [integrin alpha10-beta1 complex]
GO:0034681 [integrin alpha11-beta1 complex]
GO:0035313 [wound healing, spreading of epidermal cells]
GO:0035633 [maintenance of blood-brain barrier]
GO:0038023 [signaling receptor activity]
GO:0042383 [sarcolemma]
GO:0042470 [melanosome]
GO:0042995 [cell projection]
GO:0043065 [positive regulation of apoptotic process]
GO:0043235 [receptor complex]
GO:0043236 [laminin binding]
GO:0043547 [positive regulation of GTPase activity]
GO:0044877 [protein-containing complex binding]
GO:0045121 [membrane raft]
GO:0045296 [cadherin binding]
GO:0045445 [myoblast differentiation]
GO:0045766 [positive regulation of angiogenesis]
GO:0046718 [viral entry into host cell]
GO:0046872 [metal ion binding]
GO:0046982 [protein heterodimerization activity]
GO:0048333 [mesodermal cell differentiation]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050839 [cell adhesion molecule binding]
GO:0050901 [leukocyte tethering or rolling]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0051951 [positive regulation of glutamate uptake involved in transmission of nerve impulse]
GO:0055037 [recycling endosome]
GO:0070062 [extracellular exosome]
GO:0070161 [anchoring junction]
GO:0071404 [cellular response to low-density lipoprotein particle stimulus]
GO:0090303 [positive regulation of wound healing]
GO:0097386 [glial cell projection]
GO:0098639 [collagen binding involved in cell-matrix adhesion]
GO:0150003 [regulation of spontaneous synaptic transmission]
GO:0150103 [reactive gliosis]
GO:1901979 [regulation of inward rectifier potassium channel activity]
GO:1903078 [positive regulation of protein localization to plasma membrane]
GO:1990782 [protein tyrosine kinase binding]
GO:2000273 [positive regulation of signaling receptor activity]
GO:2000811 [negative regulation of anoikis]
Show all
 789 aa
87.4 kDa 		Yes 1
ITGB1-222
ENSP00000502979
ENST00000676659
P05556
[Direct mapping] Integrin beta-1
Show all
CD markers
Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
FDA approved drug targets
   Biotech drugs
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
   DeepTMHMM predicted membrane proteins
Show all
GO:0000132 [establishment of mitotic spindle orientation]
GO:0001618 [virus receptor activity]
GO:0001726 [ruffle]
GO:0001968 [fibronectin binding]
GO:0002020 [protease binding]
GO:0003779 [actin binding]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006909 [phagocytosis]
GO:0006968 [cellular defense response]
GO:0007155 [cell adhesion]
GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules]
GO:0007159 [leukocyte cell-cell adhesion]
GO:0007160 [cell-matrix adhesion]
GO:0007161 [calcium-independent cell-matrix adhesion]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007517 [muscle organ development]
GO:0007520 [myoblast fusion]
GO:0008305 [integrin complex]
GO:0009986 [cell surface]
GO:0010008 [endosome membrane]
GO:0010710 [regulation of collagen catabolic process]
GO:0010763 [positive regulation of fibroblast migration]
GO:0015026 [coreceptor activity]
GO:0016020 [membrane]
GO:0016477 [cell migration]
GO:0019960 [C-X3-C chemokine binding]
GO:0023035 [CD40 signaling pathway]
GO:0030027 [lamellipodium]
GO:0030030 [cell projection organization]
GO:0030032 [lamellipodium assembly]
GO:0030175 [filopodium]
GO:0030183 [B cell differentiation]
GO:0030335 [positive regulation of cell migration]
GO:0031589 [cell-substrate adhesion]
GO:0031594 [neuromuscular junction]
GO:0031623 [receptor internalization]
GO:0032154 [cleavage furrow]
GO:0032587 [ruffle membrane]
GO:0033627 [cell adhesion mediated by integrin]
GO:0033631 [cell-cell adhesion mediated by integrin]
GO:0034113 [heterotypic cell-cell adhesion]
GO:0034665 [integrin alpha1-beta1 complex]
GO:0034666 [integrin alpha2-beta1 complex]
GO:0034667 [integrin alpha3-beta1 complex]
GO:0034668 [integrin alpha4-beta1 complex]
GO:0034674 [integrin alpha5-beta1 complex]
GO:0034678 [integrin alpha8-beta1 complex]
GO:0034680 [integrin alpha10-beta1 complex]
GO:0034681 [integrin alpha11-beta1 complex]
GO:0035313 [wound healing, spreading of epidermal cells]
GO:0035633 [maintenance of blood-brain barrier]
GO:0038023 [signaling receptor activity]
GO:0042383 [sarcolemma]
GO:0042470 [melanosome]
GO:0042995 [cell projection]
GO:0043065 [positive regulation of apoptotic process]
GO:0043235 [receptor complex]
GO:0043236 [laminin binding]
GO:0043547 [positive regulation of GTPase activity]
GO:0044877 [protein-containing complex binding]
GO:0045121 [membrane raft]
GO:0045296 [cadherin binding]
GO:0045445 [myoblast differentiation]
GO:0045766 [positive regulation of angiogenesis]
GO:0046718 [viral entry into host cell]
GO:0046872 [metal ion binding]
GO:0046982 [protein heterodimerization activity]
GO:0048333 [mesodermal cell differentiation]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050839 [cell adhesion molecule binding]
GO:0050901 [leukocyte tethering or rolling]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0051951 [positive regulation of glutamate uptake involved in transmission of nerve impulse]
GO:0055037 [recycling endosome]
GO:0070062 [extracellular exosome]
GO:0070161 [anchoring junction]
GO:0071404 [cellular response to low-density lipoprotein particle stimulus]
GO:0090303 [positive regulation of wound healing]
GO:0097386 [glial cell projection]
GO:0098639 [collagen binding involved in cell-matrix adhesion]
GO:0150003 [regulation of spontaneous synaptic transmission]
GO:0150103 [reactive gliosis]
GO:1901979 [regulation of inward rectifier potassium channel activity]
GO:1903078 [positive regulation of protein localization to plasma membrane]
GO:1990782 [protein tyrosine kinase binding]
GO:2000273 [positive regulation of signaling receptor activity]
GO:2000811 [negative regulation of anoikis]
Show all
 819 aa
91 kDa 		Yes 1
ITGB1-224
ENSP00000504267
ENST00000676964
H7C4K3
[Direct mapping] Integrin beta
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
   DeepTMHMM predicted membrane proteins
Show all
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0007155 [cell adhesion]
GO:0007160 [cell-matrix adhesion]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007517 [muscle organ development]
GO:0008305 [integrin complex]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0030027 [lamellipodium]
GO:0032587 [ruffle membrane]
GO:0038023 [signaling receptor activity]
GO:0042470 [melanosome]
GO:0042995 [cell projection]
GO:0055037 [recycling endosome]
GO:0070161 [anchoring junction]
Show all
 741 aa
82.2 kDa 		No 1
ITGB1-225
ENSP00000504508
ENST00000677310
P05556
[Direct mapping] Integrin beta-1
Show all
CD markers
Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
FDA approved drug targets
   Biotech drugs
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
   DeepTMHMM predicted membrane proteins
Show all
GO:0000132 [establishment of mitotic spindle orientation]
GO:0001618 [virus receptor activity]
GO:0001726 [ruffle]
GO:0001968 [fibronectin binding]
GO:0002020 [protease binding]
GO:0003779 [actin binding]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006909 [phagocytosis]
GO:0006968 [cellular defense response]
GO:0007155 [cell adhesion]
GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules]
GO:0007159 [leukocyte cell-cell adhesion]
GO:0007160 [cell-matrix adhesion]
GO:0007161 [calcium-independent cell-matrix adhesion]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007517 [muscle organ development]
GO:0007520 [myoblast fusion]
GO:0008305 [integrin complex]
GO:0009986 [cell surface]
GO:0010008 [endosome membrane]
GO:0010710 [regulation of collagen catabolic process]
GO:0010763 [positive regulation of fibroblast migration]
GO:0015026 [coreceptor activity]
GO:0016020 [membrane]
GO:0016477 [cell migration]
GO:0019960 [C-X3-C chemokine binding]
GO:0023035 [CD40 signaling pathway]
GO:0030027 [lamellipodium]
GO:0030030 [cell projection organization]
GO:0030032 [lamellipodium assembly]
GO:0030175 [filopodium]
GO:0030183 [B cell differentiation]
GO:0030335 [positive regulation of cell migration]
GO:0031589 [cell-substrate adhesion]
GO:0031594 [neuromuscular junction]
GO:0031623 [receptor internalization]
GO:0032154 [cleavage furrow]
GO:0032587 [ruffle membrane]
GO:0033627 [cell adhesion mediated by integrin]
GO:0033631 [cell-cell adhesion mediated by integrin]
GO:0034113 [heterotypic cell-cell adhesion]
GO:0034665 [integrin alpha1-beta1 complex]
GO:0034666 [integrin alpha2-beta1 complex]
GO:0034667 [integrin alpha3-beta1 complex]
GO:0034668 [integrin alpha4-beta1 complex]
GO:0034674 [integrin alpha5-beta1 complex]
GO:0034678 [integrin alpha8-beta1 complex]
GO:0034680 [integrin alpha10-beta1 complex]
GO:0034681 [integrin alpha11-beta1 complex]
GO:0035313 [wound healing, spreading of epidermal cells]
GO:0035633 [maintenance of blood-brain barrier]
GO:0038023 [signaling receptor activity]
GO:0042383 [sarcolemma]
GO:0042470 [melanosome]
GO:0042995 [cell projection]
GO:0043065 [positive regulation of apoptotic process]
GO:0043235 [receptor complex]
GO:0043236 [laminin binding]
GO:0043547 [positive regulation of GTPase activity]
GO:0044877 [protein-containing complex binding]
GO:0045121 [membrane raft]
GO:0045296 [cadherin binding]
GO:0045445 [myoblast differentiation]
GO:0045766 [positive regulation of angiogenesis]
GO:0046718 [viral entry into host cell]
GO:0046872 [metal ion binding]
GO:0046982 [protein heterodimerization activity]
GO:0048333 [mesodermal cell differentiation]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050839 [cell adhesion molecule binding]
GO:0050901 [leukocyte tethering or rolling]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0051951 [positive regulation of glutamate uptake involved in transmission of nerve impulse]
GO:0055037 [recycling endosome]
GO:0070062 [extracellular exosome]
GO:0070161 [anchoring junction]
GO:0071404 [cellular response to low-density lipoprotein particle stimulus]
GO:0090303 [positive regulation of wound healing]
GO:0097386 [glial cell projection]
GO:0098639 [collagen binding involved in cell-matrix adhesion]
GO:0150003 [regulation of spontaneous synaptic transmission]
GO:0150103 [reactive gliosis]
GO:1901979 [regulation of inward rectifier potassium channel activity]
GO:1903078 [positive regulation of protein localization to plasma membrane]
GO:1990782 [protein tyrosine kinase binding]
GO:2000273 [positive regulation of signaling receptor activity]
GO:2000811 [negative regulation of anoikis]
Show all
 825 aa
91.6 kDa 		Yes 1
ITGB1-226
ENSP00000504791
ENST00000677363
C9JPK5
[Direct mapping] Integrin beta
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
   DeepTMHMM predicted membrane proteins
Show all
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0007155 [cell adhesion]
GO:0007160 [cell-matrix adhesion]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007517 [muscle organ development]
GO:0008305 [integrin complex]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0030027 [lamellipodium]
GO:0032587 [ruffle membrane]
GO:0038023 [signaling receptor activity]
GO:0042470 [melanosome]
GO:0042995 [cell projection]
GO:0055037 [recycling endosome]
GO:0070161 [anchoring junction]
Show all
 809 aa
90.1 kDa 		Yes 1
ITGB1-227
ENSP00000503546
ENST00000677999
P05556
[Direct mapping] Integrin beta-1
Show all
CD markers
Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
FDA approved drug targets
   Biotech drugs
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
   DeepTMHMM predicted membrane proteins
Show all
GO:0000132 [establishment of mitotic spindle orientation]
GO:0001618 [virus receptor activity]
GO:0001726 [ruffle]
GO:0001968 [fibronectin binding]
GO:0002020 [protease binding]
GO:0003779 [actin binding]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006909 [phagocytosis]
GO:0006968 [cellular defense response]
GO:0007155 [cell adhesion]
GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules]
GO:0007159 [leukocyte cell-cell adhesion]
GO:0007160 [cell-matrix adhesion]
GO:0007161 [calcium-independent cell-matrix adhesion]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007517 [muscle organ development]
GO:0007520 [myoblast fusion]
GO:0008305 [integrin complex]
GO:0009986 [cell surface]
GO:0010008 [endosome membrane]
GO:0010710 [regulation of collagen catabolic process]
GO:0010763 [positive regulation of fibroblast migration]
GO:0015026 [coreceptor activity]
GO:0016020 [membrane]
GO:0016477 [cell migration]
GO:0019960 [C-X3-C chemokine binding]
GO:0023035 [CD40 signaling pathway]
GO:0030027 [lamellipodium]
GO:0030030 [cell projection organization]
GO:0030032 [lamellipodium assembly]
GO:0030175 [filopodium]
GO:0030183 [B cell differentiation]
GO:0030335 [positive regulation of cell migration]
GO:0031589 [cell-substrate adhesion]
GO:0031594 [neuromuscular junction]
GO:0031623 [receptor internalization]
GO:0032154 [cleavage furrow]
GO:0032587 [ruffle membrane]
GO:0033627 [cell adhesion mediated by integrin]
GO:0033631 [cell-cell adhesion mediated by integrin]
GO:0034113 [heterotypic cell-cell adhesion]
GO:0034665 [integrin alpha1-beta1 complex]
GO:0034666 [integrin alpha2-beta1 complex]
GO:0034667 [integrin alpha3-beta1 complex]
GO:0034668 [integrin alpha4-beta1 complex]
GO:0034674 [integrin alpha5-beta1 complex]
GO:0034678 [integrin alpha8-beta1 complex]
GO:0034680 [integrin alpha10-beta1 complex]
GO:0034681 [integrin alpha11-beta1 complex]
GO:0035313 [wound healing, spreading of epidermal cells]
GO:0035633 [maintenance of blood-brain barrier]
GO:0038023 [signaling receptor activity]
GO:0042383 [sarcolemma]
GO:0042470 [melanosome]
GO:0042995 [cell projection]
GO:0043065 [positive regulation of apoptotic process]
GO:0043235 [receptor complex]
GO:0043236 [laminin binding]
GO:0043547 [positive regulation of GTPase activity]
GO:0044877 [protein-containing complex binding]
GO:0045121 [membrane raft]
GO:0045296 [cadherin binding]
GO:0045445 [myoblast differentiation]
GO:0045766 [positive regulation of angiogenesis]
GO:0046718 [viral entry into host cell]
GO:0046872 [metal ion binding]
GO:0046982 [protein heterodimerization activity]
GO:0048333 [mesodermal cell differentiation]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050839 [cell adhesion molecule binding]
GO:0050901 [leukocyte tethering or rolling]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0051951 [positive regulation of glutamate uptake involved in transmission of nerve impulse]
GO:0055037 [recycling endosome]
GO:0070062 [extracellular exosome]
GO:0070161 [anchoring junction]
GO:0071404 [cellular response to low-density lipoprotein particle stimulus]
GO:0090303 [positive regulation of wound healing]
GO:0097386 [glial cell projection]
GO:0098639 [collagen binding involved in cell-matrix adhesion]
GO:0150003 [regulation of spontaneous synaptic transmission]
GO:0150103 [reactive gliosis]
GO:1901979 [regulation of inward rectifier potassium channel activity]
GO:1903078 [positive regulation of protein localization to plasma membrane]
GO:1990782 [protein tyrosine kinase binding]
GO:2000273 [positive regulation of signaling receptor activity]
GO:2000811 [negative regulation of anoikis]
Show all
 798 aa
88.4 kDa 		Yes 1
ITGB1-230
ENSP00000502883
ENST00000678591
A0A7I2V2F9
[Direct mapping] Integrin beta
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
   DeepTMHMM predicted membrane proteins
Show all
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0007155 [cell adhesion]
GO:0007160 [cell-matrix adhesion]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007517 [muscle organ development]
GO:0008305 [integrin complex]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0030027 [lamellipodium]
GO:0032587 [ruffle membrane]
GO:0038023 [signaling receptor activity]
GO:0042470 [melanosome]
GO:0042995 [cell projection]
GO:0055037 [recycling endosome]
GO:0070161 [anchoring junction]
Show all
 794 aa
87.9 kDa 		Yes 1
ITGB1-231
ENSP00000504205
ENST00000678701
P05556
[Direct mapping] Integrin beta-1
Show all
CD markers
Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
FDA approved drug targets
   Biotech drugs
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
   DeepTMHMM predicted membrane proteins
Show all
GO:0000132 [establishment of mitotic spindle orientation]
GO:0001618 [virus receptor activity]
GO:0001726 [ruffle]
GO:0001968 [fibronectin binding]
GO:0002020 [protease binding]
GO:0003779 [actin binding]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006909 [phagocytosis]
GO:0006968 [cellular defense response]
GO:0007155 [cell adhesion]
GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules]
GO:0007159 [leukocyte cell-cell adhesion]
GO:0007160 [cell-matrix adhesion]
GO:0007161 [calcium-independent cell-matrix adhesion]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007517 [muscle organ development]
GO:0007520 [myoblast fusion]
GO:0008305 [integrin complex]
GO:0009986 [cell surface]
GO:0010008 [endosome membrane]
GO:0010710 [regulation of collagen catabolic process]
GO:0010763 [positive regulation of fibroblast migration]
GO:0015026 [coreceptor activity]
GO:0016020 [membrane]
GO:0016477 [cell migration]
GO:0019960 [C-X3-C chemokine binding]
GO:0023035 [CD40 signaling pathway]
GO:0030027 [lamellipodium]
GO:0030030 [cell projection organization]
GO:0030032 [lamellipodium assembly]
GO:0030175 [filopodium]
GO:0030183 [B cell differentiation]
GO:0030335 [positive regulation of cell migration]
GO:0031589 [cell-substrate adhesion]
GO:0031594 [neuromuscular junction]
GO:0031623 [receptor internalization]
GO:0032154 [cleavage furrow]
GO:0032587 [ruffle membrane]
GO:0033627 [cell adhesion mediated by integrin]
GO:0033631 [cell-cell adhesion mediated by integrin]
GO:0034113 [heterotypic cell-cell adhesion]
GO:0034665 [integrin alpha1-beta1 complex]
GO:0034666 [integrin alpha2-beta1 complex]
GO:0034667 [integrin alpha3-beta1 complex]
GO:0034668 [integrin alpha4-beta1 complex]
GO:0034674 [integrin alpha5-beta1 complex]
GO:0034678 [integrin alpha8-beta1 complex]
GO:0034680 [integrin alpha10-beta1 complex]
GO:0034681 [integrin alpha11-beta1 complex]
GO:0035313 [wound healing, spreading of epidermal cells]
GO:0035633 [maintenance of blood-brain barrier]
GO:0038023 [signaling receptor activity]
GO:0042383 [sarcolemma]
GO:0042470 [melanosome]
GO:0042995 [cell projection]
GO:0043065 [positive regulation of apoptotic process]
GO:0043235 [receptor complex]
GO:0043236 [laminin binding]
GO:0043547 [positive regulation of GTPase activity]
GO:0044877 [protein-containing complex binding]
GO:0045121 [membrane raft]
GO:0045296 [cadherin binding]
GO:0045445 [myoblast differentiation]
GO:0045766 [positive regulation of angiogenesis]
GO:0046718 [viral entry into host cell]
GO:0046872 [metal ion binding]
GO:0046982 [protein heterodimerization activity]
GO:0048333 [mesodermal cell differentiation]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050839 [cell adhesion molecule binding]
GO:0050901 [leukocyte tethering or rolling]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0051951 [positive regulation of glutamate uptake involved in transmission of nerve impulse]
GO:0055037 [recycling endosome]
GO:0070062 [extracellular exosome]
GO:0070161 [anchoring junction]
GO:0071404 [cellular response to low-density lipoprotein particle stimulus]
GO:0090303 [positive regulation of wound healing]
GO:0097386 [glial cell projection]
GO:0098639 [collagen binding involved in cell-matrix adhesion]
GO:0150003 [regulation of spontaneous synaptic transmission]
GO:0150103 [reactive gliosis]
GO:1901979 [regulation of inward rectifier potassium channel activity]
GO:1903078 [positive regulation of protein localization to plasma membrane]
GO:1990782 [protein tyrosine kinase binding]
GO:2000273 [positive regulation of signaling receptor activity]
GO:2000811 [negative regulation of anoikis]
Show all
 798 aa
88.4 kDa 		Yes 1
ITGB1-232
ENSP00000503538
ENST00000678766
P05556
[Direct mapping] Integrin beta-1
Show all
CD markers
Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
FDA approved drug targets
   Biotech drugs
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
   DeepTMHMM predicted membrane proteins
Show all
GO:0000132 [establishment of mitotic spindle orientation]
GO:0001618 [virus receptor activity]
GO:0001726 [ruffle]
GO:0001968 [fibronectin binding]
GO:0002020 [protease binding]
GO:0003779 [actin binding]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006909 [phagocytosis]
GO:0006968 [cellular defense response]
GO:0007155 [cell adhesion]
GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules]
GO:0007159 [leukocyte cell-cell adhesion]
GO:0007160 [cell-matrix adhesion]
GO:0007161 [calcium-independent cell-matrix adhesion]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007517 [muscle organ development]
GO:0007520 [myoblast fusion]
GO:0008305 [integrin complex]
GO:0009986 [cell surface]
GO:0010008 [endosome membrane]
GO:0010710 [regulation of collagen catabolic process]
GO:0010763 [positive regulation of fibroblast migration]
GO:0015026 [coreceptor activity]
GO:0016020 [membrane]
GO:0016477 [cell migration]
GO:0019960 [C-X3-C chemokine binding]
GO:0023035 [CD40 signaling pathway]
GO:0030027 [lamellipodium]
GO:0030030 [cell projection organization]
GO:0030032 [lamellipodium assembly]
GO:0030175 [filopodium]
GO:0030183 [B cell differentiation]
GO:0030335 [positive regulation of cell migration]
GO:0031589 [cell-substrate adhesion]
GO:0031594 [neuromuscular junction]
GO:0031623 [receptor internalization]
GO:0032154 [cleavage furrow]
GO:0032587 [ruffle membrane]
GO:0033627 [cell adhesion mediated by integrin]
GO:0033631 [cell-cell adhesion mediated by integrin]
GO:0034113 [heterotypic cell-cell adhesion]
GO:0034665 [integrin alpha1-beta1 complex]
GO:0034666 [integrin alpha2-beta1 complex]
GO:0034667 [integrin alpha3-beta1 complex]
GO:0034668 [integrin alpha4-beta1 complex]
GO:0034674 [integrin alpha5-beta1 complex]
GO:0034678 [integrin alpha8-beta1 complex]
GO:0034680 [integrin alpha10-beta1 complex]
GO:0034681 [integrin alpha11-beta1 complex]
GO:0035313 [wound healing, spreading of epidermal cells]
GO:0035633 [maintenance of blood-brain barrier]
GO:0038023 [signaling receptor activity]
GO:0042383 [sarcolemma]
GO:0042470 [melanosome]
GO:0042995 [cell projection]
GO:0043065 [positive regulation of apoptotic process]
GO:0043235 [receptor complex]
GO:0043236 [laminin binding]
GO:0043547 [positive regulation of GTPase activity]
GO:0044877 [protein-containing complex binding]
GO:0045121 [membrane raft]
GO:0045296 [cadherin binding]
GO:0045445 [myoblast differentiation]
GO:0045766 [positive regulation of angiogenesis]
GO:0046718 [viral entry into host cell]
GO:0046872 [metal ion binding]
GO:0046982 [protein heterodimerization activity]
GO:0048333 [mesodermal cell differentiation]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050839 [cell adhesion molecule binding]
GO:0050901 [leukocyte tethering or rolling]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0051951 [positive regulation of glutamate uptake involved in transmission of nerve impulse]
GO:0055037 [recycling endosome]
GO:0070062 [extracellular exosome]
GO:0070161 [anchoring junction]
GO:0071404 [cellular response to low-density lipoprotein particle stimulus]
GO:0090303 [positive regulation of wound healing]
GO:0097386 [glial cell projection]
GO:0098639 [collagen binding involved in cell-matrix adhesion]
GO:0150003 [regulation of spontaneous synaptic transmission]
GO:0150103 [reactive gliosis]
GO:1901979 [regulation of inward rectifier potassium channel activity]
GO:1903078 [positive regulation of protein localization to plasma membrane]
GO:1990782 [protein tyrosine kinase binding]
GO:2000273 [positive regulation of signaling receptor activity]
GO:2000811 [negative regulation of anoikis]
Show all
 825 aa
91.6 kDa 		Yes 1
ITGB1-233
ENSP00000503916
ENST00000678943
P05556
[Direct mapping] Integrin beta-1
Show all
CD markers
Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
FDA approved drug targets
   Biotech drugs
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
   DeepTMHMM predicted membrane proteins
Show all
GO:0000132 [establishment of mitotic spindle orientation]
GO:0001618 [virus receptor activity]
GO:0001726 [ruffle]
GO:0001968 [fibronectin binding]
GO:0002020 [protease binding]
GO:0003779 [actin binding]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006909 [phagocytosis]
GO:0006968 [cellular defense response]
GO:0007155 [cell adhesion]
GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules]
GO:0007159 [leukocyte cell-cell adhesion]
GO:0007160 [cell-matrix adhesion]
GO:0007161 [calcium-independent cell-matrix adhesion]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007517 [muscle organ development]
GO:0007520 [myoblast fusion]
GO:0008305 [integrin complex]
GO:0009986 [cell surface]
GO:0010008 [endosome membrane]
GO:0010710 [regulation of collagen catabolic process]
GO:0010763 [positive regulation of fibroblast migration]
GO:0015026 [coreceptor activity]
GO:0016020 [membrane]
GO:0016477 [cell migration]
GO:0019960 [C-X3-C chemokine binding]
GO:0023035 [CD40 signaling pathway]
GO:0030027 [lamellipodium]
GO:0030030 [cell projection organization]
GO:0030032 [lamellipodium assembly]
GO:0030175 [filopodium]
GO:0030183 [B cell differentiation]
GO:0030335 [positive regulation of cell migration]
GO:0031589 [cell-substrate adhesion]
GO:0031594 [neuromuscular junction]
GO:0031623 [receptor internalization]
GO:0032154 [cleavage furrow]
GO:0032587 [ruffle membrane]
GO:0033627 [cell adhesion mediated by integrin]
GO:0033631 [cell-cell adhesion mediated by integrin]
GO:0034113 [heterotypic cell-cell adhesion]
GO:0034665 [integrin alpha1-beta1 complex]
GO:0034666 [integrin alpha2-beta1 complex]
GO:0034667 [integrin alpha3-beta1 complex]
GO:0034668 [integrin alpha4-beta1 complex]
GO:0034674 [integrin alpha5-beta1 complex]
GO:0034678 [integrin alpha8-beta1 complex]
GO:0034680 [integrin alpha10-beta1 complex]
GO:0034681 [integrin alpha11-beta1 complex]
GO:0035313 [wound healing, spreading of epidermal cells]
GO:0035633 [maintenance of blood-brain barrier]
GO:0038023 [signaling receptor activity]
GO:0042383 [sarcolemma]
GO:0042470 [melanosome]
GO:0042995 [cell projection]
GO:0043065 [positive regulation of apoptotic process]
GO:0043235 [receptor complex]
GO:0043236 [laminin binding]
GO:0043547 [positive regulation of GTPase activity]
GO:0044877 [protein-containing complex binding]
GO:0045121 [membrane raft]
GO:0045296 [cadherin binding]
GO:0045445 [myoblast differentiation]
GO:0045766 [positive regulation of angiogenesis]
GO:0046718 [viral entry into host cell]
GO:0046872 [metal ion binding]
GO:0046982 [protein heterodimerization activity]
GO:0048333 [mesodermal cell differentiation]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050839 [cell adhesion molecule binding]
GO:0050901 [leukocyte tethering or rolling]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0051951 [positive regulation of glutamate uptake involved in transmission of nerve impulse]
GO:0055037 [recycling endosome]
GO:0070062 [extracellular exosome]
GO:0070161 [anchoring junction]
GO:0071404 [cellular response to low-density lipoprotein particle stimulus]
GO:0090303 [positive regulation of wound healing]
GO:0097386 [glial cell projection]
GO:0098639 [collagen binding involved in cell-matrix adhesion]
GO:0150003 [regulation of spontaneous synaptic transmission]
GO:0150103 [reactive gliosis]
GO:1901979 [regulation of inward rectifier potassium channel activity]
GO:1903078 [positive regulation of protein localization to plasma membrane]
GO:1990782 [protein tyrosine kinase binding]
GO:2000273 [positive regulation of signaling receptor activity]
GO:2000811 [negative regulation of anoikis]
Show all
 798 aa
88.4 kDa 		Yes 1
ITGB1-234
ENSP00000504444
ENST00000678952
P05556
[Direct mapping] Integrin beta-1
Show all
CD markers
Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
FDA approved drug targets
   Biotech drugs
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
   DeepTMHMM predicted membrane proteins
Show all
GO:0000132 [establishment of mitotic spindle orientation]
GO:0001618 [virus receptor activity]
GO:0001726 [ruffle]
GO:0001968 [fibronectin binding]
GO:0002020 [protease binding]
GO:0003779 [actin binding]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006909 [phagocytosis]
GO:0006968 [cellular defense response]
GO:0007155 [cell adhesion]
GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules]
GO:0007159 [leukocyte cell-cell adhesion]
GO:0007160 [cell-matrix adhesion]
GO:0007161 [calcium-independent cell-matrix adhesion]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007517 [muscle organ development]
GO:0007520 [myoblast fusion]
GO:0008305 [integrin complex]
GO:0009986 [cell surface]
GO:0010008 [endosome membrane]
GO:0010710 [regulation of collagen catabolic process]
GO:0010763 [positive regulation of fibroblast migration]
GO:0015026 [coreceptor activity]
GO:0016020 [membrane]
GO:0016477 [cell migration]
GO:0019960 [C-X3-C chemokine binding]
GO:0023035 [CD40 signaling pathway]
GO:0030027 [lamellipodium]
GO:0030030 [cell projection organization]
GO:0030032 [lamellipodium assembly]
GO:0030175 [filopodium]
GO:0030183 [B cell differentiation]
GO:0030335 [positive regulation of cell migration]
GO:0031589 [cell-substrate adhesion]
GO:0031594 [neuromuscular junction]
GO:0031623 [receptor internalization]
GO:0032154 [cleavage furrow]
GO:0032587 [ruffle membrane]
GO:0033627 [cell adhesion mediated by integrin]
GO:0033631 [cell-cell adhesion mediated by integrin]
GO:0034113 [heterotypic cell-cell adhesion]
GO:0034665 [integrin alpha1-beta1 complex]
GO:0034666 [integrin alpha2-beta1 complex]
GO:0034667 [integrin alpha3-beta1 complex]
GO:0034668 [integrin alpha4-beta1 complex]
GO:0034674 [integrin alpha5-beta1 complex]
GO:0034678 [integrin alpha8-beta1 complex]
GO:0034680 [integrin alpha10-beta1 complex]
GO:0034681 [integrin alpha11-beta1 complex]
GO:0035313 [wound healing, spreading of epidermal cells]
GO:0035633 [maintenance of blood-brain barrier]
GO:0038023 [signaling receptor activity]
GO:0042383 [sarcolemma]
GO:0042470 [melanosome]
GO:0042995 [cell projection]
GO:0043065 [positive regulation of apoptotic process]
GO:0043235 [receptor complex]
GO:0043236 [laminin binding]
GO:0043547 [positive regulation of GTPase activity]
GO:0044877 [protein-containing complex binding]
GO:0045121 [membrane raft]
GO:0045296 [cadherin binding]
GO:0045445 [myoblast differentiation]
GO:0045766 [positive regulation of angiogenesis]
GO:0046718 [viral entry into host cell]
GO:0046872 [metal ion binding]
GO:0046982 [protein heterodimerization activity]
GO:0048333 [mesodermal cell differentiation]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050839 [cell adhesion molecule binding]
GO:0050901 [leukocyte tethering or rolling]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0051951 [positive regulation of glutamate uptake involved in transmission of nerve impulse]
GO:0055037 [recycling endosome]
GO:0070062 [extracellular exosome]
GO:0070161 [anchoring junction]
GO:0071404 [cellular response to low-density lipoprotein particle stimulus]
GO:0090303 [positive regulation of wound healing]
GO:0097386 [glial cell projection]
GO:0098639 [collagen binding involved in cell-matrix adhesion]
GO:0150003 [regulation of spontaneous synaptic transmission]
GO:0150103 [reactive gliosis]
GO:1901979 [regulation of inward rectifier potassium channel activity]
GO:1903078 [positive regulation of protein localization to plasma membrane]
GO:1990782 [protein tyrosine kinase binding]
GO:2000273 [positive regulation of signaling receptor activity]
GO:2000811 [negative regulation of anoikis]
Show all
 798 aa
88.4 kDa 		Yes 1
ITGB1-236
ENSP00000504012
ENST00000679187
H7C4K3
[Direct mapping] Integrin beta
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
   DeepTMHMM predicted membrane proteins
Show all
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0007155 [cell adhesion]
GO:0007160 [cell-matrix adhesion]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007517 [muscle organ development]
GO:0008305 [integrin complex]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0030027 [lamellipodium]
GO:0032587 [ruffle membrane]
GO:0038023 [signaling receptor activity]
GO:0042470 [melanosome]
GO:0042995 [cell projection]
GO:0055037 [recycling endosome]
GO:0070161 [anchoring junction]
Show all
 741 aa
82.2 kDa 		No 1

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The Human Protein Atlas

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