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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Disease related genes Human disease related genes Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
10
Cytoband
q26.11
Chromosome location (bp)
119651380 - 119677819
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSPA8/HSC70 1,2. Has anti-apoptotic activity 3. Plays a role in the HSF1 nucleocytoplasmic transport 4....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Chaperone
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Apoptosis
Gene summary (Entrez)i
Useful information about the gene from Entrez
BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The protein encoded by this gene contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
O95817 [Direct mapping] BAG family molecular chaperone regulator 3
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Disease related genes Human disease related genes Cardiovascular diseases Cardiac diseases Musculoskeletal diseases Muscular diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000045[autophagosome assembly] GO:0000774[adenyl-nucleotide exchange factor activity] GO:0001725[stress fiber] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006457[protein folding] GO:0006915[apoptotic process] GO:0007420[brain development] GO:0008625[extrinsic apoptotic signaling pathway via death domain receptors] GO:0010658[striated muscle cell apoptotic process] GO:0010664[negative regulation of striated muscle cell apoptotic process] GO:0016020[membrane] GO:0016235[aggresome] GO:0021510[spinal cord development] GO:0030018[Z disc] GO:0034605[cellular response to heat] GO:0034620[cellular response to unfolded protein] GO:0042307[positive regulation of protein import into nucleus] GO:0043005[neuron projection] GO:0043066[negative regulation of apoptotic process] GO:0044877[protein-containing complex binding] GO:0045296[cadherin binding] GO:0045505[dynein intermediate chain binding] GO:0046716[muscle cell cellular homeostasis] GO:0046827[positive regulation of protein export from nucleus] GO:0050821[protein stabilization] GO:0051087[chaperone binding] GO:0061684[chaperone-mediated autophagy] GO:0070842[aggresome assembly] GO:0071260[cellular response to mechanical stimulus] GO:0097192[extrinsic apoptotic signaling pathway in absence of ligand] GO:0097201[negative regulation of transcription from RNA polymerase II promoter in response to stress] GO:0098840[protein transport along microtubule] GO:0101031[chaperone complex] GO:0140597[protein carrier chaperone] GO:1903215[negative regulation of protein targeting to mitochondrion] GO:1905337[positive regulation of aggrephagy]
C9JFK9 [Direct mapping] BAG family molecular chaperone regulator 3
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Cardiovascular diseases Cardiac diseases Musculoskeletal diseases Muscular diseases Protein evidence (Ezkurdia et al 2014)
The Human Protein Atlas project is funded
