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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Disease related genes Human disease related genes Metabolic proteins Plasma proteins Potential drug targets Transporters
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
18
Cytoband
q21.1
Chromosome location (bp)
46080248 - 46104334
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. Subunit alpha does not bear the catalytic high-affinity ATP-binding sites (By similarity). Binds the bacterial siderophore enterobactin and can promote mitochondrial accumulation of enterobactin-derived iron ions 1....show less
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
ATP synthesis, Hydrogen ion transport, Ion transport, Transport
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
ATP-binding, Nucleotide-binding
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, using an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). This gene encodes the alpha subunit of the catalytic core. Alternatively spliced transcript variants encoding the different isoforms have been identified. Pseudogenes of this gene are located on chromosomes 9, 2, and 16. [provided by RefSeq, Mar 2012]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
P25705 [Direct mapping] ATP synthase subunit alpha, mitochondrial
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V9HW26 [Target identity:100%; Query identity:100%] ATP synthase subunit alpha
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Metabolic proteins Transporters Primary Active Transporters Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Disease related genes Potential drug targets Human disease related genes Congenital disorders of metabolism Mitochondrial diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000166[nucleotide binding] GO:0001937[negative regulation of endothelial cell proliferation] GO:0003723[RNA binding] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005739[mitochondrion] GO:0005743[mitochondrial inner membrane] GO:0005753[mitochondrial proton-transporting ATP synthase complex] GO:0005754[mitochondrial proton-transporting ATP synthase, catalytic core] GO:0005759[mitochondrial matrix] GO:0005886[plasma membrane] GO:0006629[lipid metabolic process] GO:0006754[ATP biosynthetic process] GO:0006811[ion transport] GO:0008180[COP9 signalosome] GO:0015986[proton motive force-driven ATP synthesis] GO:0016020[membrane] GO:0016469[proton-transporting two-sector ATPase complex] GO:0031090[organelle membrane] GO:0032559[adenyl ribonucleotide binding] GO:0042288[MHC class I protein binding] GO:0042776[proton motive force-driven mitochondrial ATP synthesis] GO:0043531[ADP binding] GO:0043532[angiostatin binding] GO:0043536[positive regulation of blood vessel endothelial cell migration] GO:0045259[proton-transporting ATP synthase complex] GO:0045261[proton-transporting ATP synthase complex, catalytic core F(1)] GO:0046034[ATP metabolic process] GO:0046933[proton-transporting ATP synthase activity, rotational mechanism] GO:0070062[extracellular exosome] GO:1902600[proton transmembrane transport]
P25705 [Direct mapping] ATP synthase subunit alpha, mitochondrial
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V9HW26 [Target identity:100%; Query identity:100%] ATP synthase subunit alpha
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Metabolic proteins Transporters Primary Active Transporters Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Disease related genes Potential drug targets Human disease related genes Congenital disorders of metabolism Mitochondrial diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000166[nucleotide binding] GO:0000275[mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1)] GO:0001937[negative regulation of endothelial cell proliferation] GO:0002020[protease binding] GO:0003723[RNA binding] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005739[mitochondrion] GO:0005743[mitochondrial inner membrane] GO:0005753[mitochondrial proton-transporting ATP synthase complex] GO:0005754[mitochondrial proton-transporting ATP synthase, catalytic core] GO:0005759[mitochondrial matrix] GO:0005886[plasma membrane] GO:0006629[lipid metabolic process] GO:0006754[ATP biosynthetic process] GO:0006811[ion transport] GO:0006915[apoptotic process] GO:0007568[aging] GO:0008180[COP9 signalosome] GO:0009986[cell surface] GO:0014850[response to muscle activity] GO:0015986[proton motive force-driven ATP synthesis] GO:0016020[membrane] GO:0016469[proton-transporting two-sector ATPase complex] GO:0016887[ATP hydrolysis activity] GO:0031090[organelle membrane] GO:0032559[adenyl ribonucleotide binding] GO:0042288[MHC class I protein binding] GO:0042776[proton motive force-driven mitochondrial ATP synthesis] GO:0043531[ADP binding] GO:0043532[angiostatin binding] GO:0043536[positive regulation of blood vessel endothelial cell migration] GO:0045121[membrane raft] GO:0045259[proton-transporting ATP synthase complex] GO:0045261[proton-transporting ATP synthase complex, catalytic core F(1)] GO:0045471[response to ethanol] GO:0046034[ATP metabolic process] GO:0046933[proton-transporting ATP synthase activity, rotational mechanism] GO:0070062[extracellular exosome] GO:0071549[cellular response to dexamethasone stimulus] GO:0071732[cellular response to nitric oxide] GO:1902600[proton transmembrane transport]
K7ENJ4 [Direct mapping] ATP synthase subunit alpha, mitochondrial
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Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital disorders of metabolism Mitochondrial diseases Protein evidence (Ezkurdia et al 2014)
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GO:0005524[ATP binding] GO:0015986[proton motive force-driven ATP synthesis] GO:0045261[proton-transporting ATP synthase complex, catalytic core F(1)] GO:0046933[proton-transporting ATP synthase activity, rotational mechanism]
K7EK77 [Direct mapping] ATP synthase subunit alpha, mitochondrial
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Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital disorders of metabolism Mitochondrial diseases Protein evidence (Ezkurdia et al 2014)
K7EJP1 [Direct mapping] ATP synthase subunit alpha, mitochondrial
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Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital disorders of metabolism Mitochondrial diseases Protein evidence (Ezkurdia et al 2014)
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GO:0000166[nucleotide binding] GO:0005524[ATP binding] GO:0006811[ion transport] GO:0015986[proton motive force-driven ATP synthesis] GO:0045261[proton-transporting ATP synthase complex, catalytic core F(1)] GO:0046034[ATP metabolic process] GO:0046933[proton-transporting ATP synthase activity, rotational mechanism] GO:1902600[proton transmembrane transport]
K7ERX7 [Direct mapping] ATP synthase subunit alpha, mitochondrial
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Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital disorders of metabolism Mitochondrial diseases Protein evidence (Ezkurdia et al 2014)
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GO:0000166[nucleotide binding] GO:0005524[ATP binding] GO:0006811[ion transport] GO:0015986[proton motive force-driven ATP synthesis] GO:0045261[proton-transporting ATP synthase complex, catalytic core F(1)] GO:0046034[ATP metabolic process] GO:0046933[proton-transporting ATP synthase activity, rotational mechanism] GO:1902600[proton transmembrane transport]
P25705 [Direct mapping] ATP synthase subunit alpha, mitochondrial
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Metabolic proteins Transporters Primary Active Transporters Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Disease related genes Potential drug targets Human disease related genes Congenital disorders of metabolism Mitochondrial diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000166[nucleotide binding] GO:0001937[negative regulation of endothelial cell proliferation] GO:0003723[RNA binding] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005739[mitochondrion] GO:0005743[mitochondrial inner membrane] GO:0005753[mitochondrial proton-transporting ATP synthase complex] GO:0005754[mitochondrial proton-transporting ATP synthase, catalytic core] GO:0005759[mitochondrial matrix] GO:0005886[plasma membrane] GO:0006629[lipid metabolic process] GO:0006754[ATP biosynthetic process] GO:0006811[ion transport] GO:0008180[COP9 signalosome] GO:0015986[proton motive force-driven ATP synthesis] GO:0016020[membrane] GO:0016469[proton-transporting two-sector ATPase complex] GO:0031090[organelle membrane] GO:0032559[adenyl ribonucleotide binding] GO:0042288[MHC class I protein binding] GO:0042776[proton motive force-driven mitochondrial ATP synthesis] GO:0043531[ADP binding] GO:0043532[angiostatin binding] GO:0043536[positive regulation of blood vessel endothelial cell migration] GO:0045259[proton-transporting ATP synthase complex] GO:0045261[proton-transporting ATP synthase complex, catalytic core F(1)] GO:0046034[ATP metabolic process] GO:0046933[proton-transporting ATP synthase activity, rotational mechanism] GO:0070062[extracellular exosome] GO:1902600[proton transmembrane transport]
K7EQH4 [Direct mapping] ATP synthase subunit alpha, mitochondrial
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Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital disorders of metabolism Mitochondrial diseases Protein evidence (Ezkurdia et al 2014)
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GO:0000166[nucleotide binding] GO:0005524[ATP binding] GO:0006811[ion transport] GO:0015986[proton motive force-driven ATP synthesis] GO:0045261[proton-transporting ATP synthase complex, catalytic core F(1)] GO:0046034[ATP metabolic process] GO:0046933[proton-transporting ATP synthase activity, rotational mechanism] GO:1902600[proton transmembrane transport]
P25705 [Direct mapping] ATP synthase subunit alpha, mitochondrial
Show all
Metabolic proteins Transporters Primary Active Transporters Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Disease related genes Potential drug targets Human disease related genes Congenital disorders of metabolism Mitochondrial diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166[nucleotide binding] GO:0001937[negative regulation of endothelial cell proliferation] GO:0003723[RNA binding] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005739[mitochondrion] GO:0005743[mitochondrial inner membrane] GO:0005753[mitochondrial proton-transporting ATP synthase complex] GO:0005754[mitochondrial proton-transporting ATP synthase, catalytic core] GO:0005759[mitochondrial matrix] GO:0005886[plasma membrane] GO:0006629[lipid metabolic process] GO:0006754[ATP biosynthetic process] GO:0006811[ion transport] GO:0008180[COP9 signalosome] GO:0015986[proton motive force-driven ATP synthesis] GO:0016020[membrane] GO:0016469[proton-transporting two-sector ATPase complex] GO:0031090[organelle membrane] GO:0032559[adenyl ribonucleotide binding] GO:0042288[MHC class I protein binding] GO:0042776[proton motive force-driven mitochondrial ATP synthesis] GO:0043531[ADP binding] GO:0043532[angiostatin binding] GO:0043536[positive regulation of blood vessel endothelial cell migration] GO:0045259[proton-transporting ATP synthase complex] GO:0045261[proton-transporting ATP synthase complex, catalytic core F(1)] GO:0046034[ATP metabolic process] GO:0046933[proton-transporting ATP synthase activity, rotational mechanism] GO:0070062[extracellular exosome] GO:1902600[proton transmembrane transport]
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