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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
5
Cytoband
q14.1
Chromosome location (bp)
79372636 - 79514134
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoform 1 regulates the trafficking and surface expression of GRM5. Isoform 3 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1 to regulate synaptic metabotropic glutamate function. Isoform 3, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development. Forms a high-order complex with SHANK1, which in turn is necessary for the structural and functional integrity of dendritic spines (By similarity). Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA 1....show less
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a member of the homer family of dendritic proteins. Members of this family regulate group 1 metabotrophic glutamate receptor function. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0007206[phospholipase C-activating G protein-coupled glutamate receptor signaling pathway] GO:0007216[G protein-coupled glutamate receptor signaling pathway] GO:0007268[chemical synaptic transmission] GO:0009967[positive regulation of signal transduction] GO:0014069[postsynaptic density] GO:0030425[dendrite] GO:0035256[G protein-coupled glutamate receptor binding] GO:0035591[signaling adaptor activity] GO:0042995[cell projection] GO:0043197[dendritic spine] GO:0044309[neuron spine] GO:0044325[transmembrane transporter binding] GO:0045202[synapse] GO:0051262[protein tetramerization] GO:0051592[response to calcium ion] GO:0051966[regulation of synaptic transmission, glutamatergic] GO:0099173[postsynapse organization] GO:1902950[regulation of dendritic spine maintenance] GO:2001256[regulation of store-operated calcium entry] GO:2001257[regulation of cation channel activity]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0007206[phospholipase C-activating G protein-coupled glutamate receptor signaling pathway] GO:0007216[G protein-coupled glutamate receptor signaling pathway] GO:0007268[chemical synaptic transmission] GO:0009967[positive regulation of signal transduction] GO:0014069[postsynaptic density] GO:0030425[dendrite] GO:0035256[G protein-coupled glutamate receptor binding] GO:0035591[signaling adaptor activity] GO:0042995[cell projection] GO:0043197[dendritic spine] GO:0044309[neuron spine] GO:0044325[transmembrane transporter binding] GO:0045202[synapse] GO:0051262[protein tetramerization] GO:0051592[response to calcium ion] GO:0051966[regulation of synaptic transmission, glutamatergic] GO:0099173[postsynapse organization] GO:1902950[regulation of dendritic spine maintenance] GO:2001256[regulation of store-operated calcium entry] GO:2001257[regulation of cation channel activity]
The Human Protein Atlas project is funded
