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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Transporters
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
2
Cytoband
q13
Chromosome location (bp)
111119378 - 111168445
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Induces apoptosis and anoikis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-alpha1, isoform Bim-alpha2 and isoform Bim-alpha3 induce apoptosis, although less potent than isoform BimEL, isoform BimL and isoform BimS. Isoform Bim-gamma induces apoptosis. Isoform Bim-alpha3 induces apoptosis possibly through a caspase-mediated pathway. Isoform BimAC and isoform BimABC lack the ability to induce apoptosis....show less
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Apoptosis
Gene summary (Entrez)i
Useful information about the gene from Entrez
The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified. [provided by RefSeq, Jun 2013]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Transporters Accessory Factors Involved in Transport Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0005515[protein binding] GO:0005739[mitochondrion] GO:0005741[mitochondrial outer membrane] GO:0005829[cytosol] GO:0006915[apoptotic process] GO:0007127[meiosis I] GO:0008630[intrinsic apoptotic signaling pathway in response to DNA damage] GO:0012505[endomembrane system] GO:0016020[membrane] GO:0031334[positive regulation of protein-containing complex assembly] GO:0034976[response to endoplasmic reticulum stress] GO:0042981[regulation of apoptotic process] GO:0043065[positive regulation of apoptotic process] GO:0071385[cellular response to glucocorticoid stimulus] GO:0090200[positive regulation of release of cytochrome c from mitochondria] GO:0097136[Bcl-2 family protein complex] GO:1902237[positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway] GO:1903896[positive regulation of IRE1-mediated unfolded protein response] GO:2000271[positive regulation of fibroblast apoptotic process]
Transporters Accessory Factors Involved in Transport THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0005515[protein binding] GO:0005739[mitochondrion] GO:0005741[mitochondrial outer membrane] GO:0005829[cytosol] GO:0006915[apoptotic process] GO:0007127[meiosis I] GO:0008630[intrinsic apoptotic signaling pathway in response to DNA damage] GO:0012505[endomembrane system] GO:0016020[membrane] GO:0031334[positive regulation of protein-containing complex assembly] GO:0034976[response to endoplasmic reticulum stress] GO:0042981[regulation of apoptotic process] GO:0043065[positive regulation of apoptotic process] GO:0071385[cellular response to glucocorticoid stimulus] GO:0090200[positive regulation of release of cytochrome c from mitochondria] GO:0097136[Bcl-2 family protein complex] GO:1902237[positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway] GO:1903896[positive regulation of IRE1-mediated unfolded protein response] GO:2000271[positive regulation of fibroblast apoptotic process]
Transporters Accessory Factors Involved in Transport Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001701[in utero embryonic development] GO:0001776[leukocyte homeostasis] GO:0001782[B cell homeostasis] GO:0001822[kidney development] GO:0002260[lymphocyte homeostasis] GO:0002262[myeloid cell homeostasis] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005741[mitochondrial outer membrane] GO:0005829[cytosol] GO:0005874[microtubule] GO:0006915[apoptotic process] GO:0006919[activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0007127[meiosis I] GO:0007160[cell-matrix adhesion] GO:0007283[spermatogenesis] GO:0007420[brain development] GO:0008017[microtubule binding] GO:0008584[male gonad development] GO:0008630[intrinsic apoptotic signaling pathway in response to DNA damage] GO:0009791[post-embryonic development] GO:0010942[positive regulation of cell death] GO:0012505[endomembrane system] GO:0016020[membrane] GO:0019051[induction by virus of host apoptotic process] GO:0019901[protein kinase binding] GO:0030879[mammary gland development] GO:0031334[positive regulation of protein-containing complex assembly] GO:0034263[positive regulation of autophagy in response to ER overload] GO:0034976[response to endoplasmic reticulum stress] GO:0035148[tube formation] GO:0042475[odontogenesis of dentin-containing tooth] GO:0042981[regulation of apoptotic process] GO:0043029[T cell homeostasis] GO:0043065[positive regulation of apoptotic process] GO:0043231[intracellular membrane-bounded organelle] GO:0043280[positive regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043525[positive regulation of neuron apoptotic process] GO:0043583[ear development] GO:0045787[positive regulation of cell cycle] GO:0046620[regulation of organ growth] GO:0048066[developmental pigmentation] GO:0048070[regulation of developmental pigmentation] GO:0048536[spleen development] GO:0048538[thymus development] GO:0048563[post-embryonic animal organ morphogenesis] GO:0060090[molecular adaptor activity] GO:0070227[lymphocyte apoptotic process] GO:0070230[positive regulation of lymphocyte apoptotic process] GO:0070231[T cell apoptotic process] GO:0070234[positive regulation of T cell apoptotic process] GO:0070242[thymocyte apoptotic process] GO:0071385[cellular response to glucocorticoid stimulus] GO:0071392[cellular response to estradiol stimulus] GO:0090200[positive regulation of release of cytochrome c from mitochondria] GO:0097136[Bcl-2 family protein complex] GO:0097140[BIM-BCL-xl complex] GO:0097141[BIM-BCL-2 complex] GO:0097192[extrinsic apoptotic signaling pathway in absence of ligand] GO:1902110[positive regulation of mitochondrial membrane permeability involved in apoptotic process] GO:1902237[positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway] GO:1902263[apoptotic process involved in embryonic digit morphogenesis] GO:1903896[positive regulation of IRE1-mediated unfolded protein response] GO:1904646[cellular response to amyloid-beta] GO:2000271[positive regulation of fibroblast apoptotic process] GO:2001244[positive regulation of intrinsic apoptotic signaling pathway]
Transporters Accessory Factors Involved in Transport THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0005515[protein binding] GO:0005739[mitochondrion] GO:0005741[mitochondrial outer membrane] GO:0005829[cytosol] GO:0006915[apoptotic process] GO:0007127[meiosis I] GO:0008630[intrinsic apoptotic signaling pathway in response to DNA damage] GO:0012505[endomembrane system] GO:0016020[membrane] GO:0031334[positive regulation of protein-containing complex assembly] GO:0034976[response to endoplasmic reticulum stress] GO:0042981[regulation of apoptotic process] GO:0043065[positive regulation of apoptotic process] GO:0071385[cellular response to glucocorticoid stimulus] GO:0090200[positive regulation of release of cytochrome c from mitochondria] GO:0097136[Bcl-2 family protein complex] GO:1902237[positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway] GO:1903896[positive regulation of IRE1-mediated unfolded protein response] GO:2000271[positive regulation of fibroblast apoptotic process]
Transporters Accessory Factors Involved in Transport Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515[protein binding] GO:0005739[mitochondrion] GO:0005741[mitochondrial outer membrane] GO:0005829[cytosol] GO:0006915[apoptotic process] GO:0007127[meiosis I] GO:0008630[intrinsic apoptotic signaling pathway in response to DNA damage] GO:0012505[endomembrane system] GO:0016020[membrane] GO:0031334[positive regulation of protein-containing complex assembly] GO:0034976[response to endoplasmic reticulum stress] GO:0042981[regulation of apoptotic process] GO:0043065[positive regulation of apoptotic process] GO:0071385[cellular response to glucocorticoid stimulus] GO:0090200[positive regulation of release of cytochrome c from mitochondria] GO:0097136[Bcl-2 family protein complex] GO:1902237[positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway] GO:1903896[positive regulation of IRE1-mediated unfolded protein response] GO:2000271[positive regulation of fibroblast apoptotic process]
Transporters Accessory Factors Involved in Transport Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0005515[protein binding] GO:0005739[mitochondrion] GO:0005741[mitochondrial outer membrane] GO:0005829[cytosol] GO:0006915[apoptotic process] GO:0007127[meiosis I] GO:0008630[intrinsic apoptotic signaling pathway in response to DNA damage] GO:0012505[endomembrane system] GO:0016020[membrane] GO:0031334[positive regulation of protein-containing complex assembly] GO:0034976[response to endoplasmic reticulum stress] GO:0042981[regulation of apoptotic process] GO:0043065[positive regulation of apoptotic process] GO:0071385[cellular response to glucocorticoid stimulus] GO:0090200[positive regulation of release of cytochrome c from mitochondria] GO:0097136[Bcl-2 family protein complex] GO:1902237[positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway] GO:1903896[positive regulation of IRE1-mediated unfolded protein response] GO:2000271[positive regulation of fibroblast apoptotic process]
Transporters Accessory Factors Involved in Transport Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515[protein binding] GO:0005739[mitochondrion] GO:0005741[mitochondrial outer membrane] GO:0005829[cytosol] GO:0006915[apoptotic process] GO:0007127[meiosis I] GO:0008630[intrinsic apoptotic signaling pathway in response to DNA damage] GO:0012505[endomembrane system] GO:0016020[membrane] GO:0031334[positive regulation of protein-containing complex assembly] GO:0034976[response to endoplasmic reticulum stress] GO:0042981[regulation of apoptotic process] GO:0043065[positive regulation of apoptotic process] GO:0071385[cellular response to glucocorticoid stimulus] GO:0090200[positive regulation of release of cytochrome c from mitochondria] GO:0097136[Bcl-2 family protein complex] GO:1902237[positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway] GO:1903896[positive regulation of IRE1-mediated unfolded protein response] GO:2000271[positive regulation of fibroblast apoptotic process]
Transporters Accessory Factors Involved in Transport Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515[protein binding] GO:0005739[mitochondrion] GO:0005741[mitochondrial outer membrane] GO:0005829[cytosol] GO:0006915[apoptotic process] GO:0007127[meiosis I] GO:0008630[intrinsic apoptotic signaling pathway in response to DNA damage] GO:0012505[endomembrane system] GO:0016020[membrane] GO:0031334[positive regulation of protein-containing complex assembly] GO:0034976[response to endoplasmic reticulum stress] GO:0042981[regulation of apoptotic process] GO:0043065[positive regulation of apoptotic process] GO:0071385[cellular response to glucocorticoid stimulus] GO:0090200[positive regulation of release of cytochrome c from mitochondria] GO:0097136[Bcl-2 family protein complex] GO:1902237[positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway] GO:1903896[positive regulation of IRE1-mediated unfolded protein response] GO:2000271[positive regulation of fibroblast apoptotic process]
Transporters Accessory Factors Involved in Transport Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515[protein binding] GO:0005739[mitochondrion] GO:0005741[mitochondrial outer membrane] GO:0005829[cytosol] GO:0006915[apoptotic process] GO:0007127[meiosis I] GO:0008630[intrinsic apoptotic signaling pathway in response to DNA damage] GO:0012505[endomembrane system] GO:0016020[membrane] GO:0031334[positive regulation of protein-containing complex assembly] GO:0034976[response to endoplasmic reticulum stress] GO:0042981[regulation of apoptotic process] GO:0043065[positive regulation of apoptotic process] GO:0071385[cellular response to glucocorticoid stimulus] GO:0090200[positive regulation of release of cytochrome c from mitochondria] GO:0097136[Bcl-2 family protein complex] GO:1902237[positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway] GO:1903896[positive regulation of IRE1-mediated unfolded protein response] GO:2000271[positive regulation of fibroblast apoptotic process]
Transporters Accessory Factors Involved in Transport Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515[protein binding] GO:0005739[mitochondrion] GO:0005741[mitochondrial outer membrane] GO:0005829[cytosol] GO:0006915[apoptotic process] GO:0007127[meiosis I] GO:0008630[intrinsic apoptotic signaling pathway in response to DNA damage] GO:0012505[endomembrane system] GO:0016020[membrane] GO:0031334[positive regulation of protein-containing complex assembly] GO:0034976[response to endoplasmic reticulum stress] GO:0042981[regulation of apoptotic process] GO:0043065[positive regulation of apoptotic process] GO:0071385[cellular response to glucocorticoid stimulus] GO:0090200[positive regulation of release of cytochrome c from mitochondria] GO:0097136[Bcl-2 family protein complex] GO:1902237[positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway] GO:1903896[positive regulation of IRE1-mediated unfolded protein response] GO:2000271[positive regulation of fibroblast apoptotic process]
Transporters Accessory Factors Involved in Transport Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515[protein binding] GO:0005739[mitochondrion] GO:0005741[mitochondrial outer membrane] GO:0005829[cytosol] GO:0006915[apoptotic process] GO:0007127[meiosis I] GO:0008630[intrinsic apoptotic signaling pathway in response to DNA damage] GO:0012505[endomembrane system] GO:0016020[membrane] GO:0031334[positive regulation of protein-containing complex assembly] GO:0034976[response to endoplasmic reticulum stress] GO:0042981[regulation of apoptotic process] GO:0043065[positive regulation of apoptotic process] GO:0071385[cellular response to glucocorticoid stimulus] GO:0090200[positive regulation of release of cytochrome c from mitochondria] GO:0097136[Bcl-2 family protein complex] GO:1902237[positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway] GO:1903896[positive regulation of IRE1-mediated unfolded protein response] GO:2000271[positive regulation of fibroblast apoptotic process]
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