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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Disease related genes Human disease related genes Nuclear receptors Transcription factors
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
2
Cytoband
q24.1
Chromosome location (bp)
156324437 - 156342348
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development 1,2. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons (By similarity)....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
DNA-binding, Receptor
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Transcription, Transcription regulation
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Metal-binding, Zinc
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcription factor. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson disease, schizophernia, and manic depression. Misregulation of this gene may be associated with rheumatoid arthritis. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
P43354 [Direct mapping] Nuclear receptor subfamily 4 group A member 2
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F1D8N6 [Target identity:100%; Query identity:100%] Nuclear receptor subfamily 4 group A member 2
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Nuclear receptors Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes Mutational cancer driver genes Disease related genes Human disease related genes Nervous system diseases Neurodegenerative diseases Mapped to neXtProt neXtProt - Evidence at protein level
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000977[RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0001666[response to hypoxia] GO:0001764[neuron migration] GO:0001975[response to amphetamine] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0004879[nuclear receptor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005667[transcription regulator complex] GO:0005737[cytoplasm] GO:0006351[DNA-templated transcription] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006366[transcription by RNA polymerase II] GO:0007165[signal transduction] GO:0007399[nervous system development] GO:0008013[beta-catenin binding] GO:0008270[zinc ion binding] GO:0008344[adult locomotory behavior] GO:0009791[post-embryonic development] GO:0010467[gene expression] GO:0010468[regulation of gene expression] GO:0016607[nuclear speck] GO:0021952[central nervous system projection neuron axonogenesis] GO:0021953[central nervous system neuron differentiation] GO:0021986[habenula development] GO:0030182[neuron differentiation] GO:0030522[intracellular receptor signaling pathway] GO:0031668[cellular response to extracellular stimulus] GO:0032991[protein-containing complex] GO:0034599[cellular response to oxidative stress] GO:0035259[nuclear glucocorticoid receptor binding] GO:0042053[regulation of dopamine metabolic process] GO:0042416[dopamine biosynthetic process] GO:0042417[dopamine metabolic process] GO:0042551[neuron maturation] GO:0043085[positive regulation of catalytic activity] GO:0043524[negative regulation of neuron apoptotic process] GO:0043565[sequence-specific DNA binding] GO:0043576[regulation of respiratory gaseous exchange] GO:0045444[fat cell differentiation] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding] GO:0046965[nuclear retinoid X receptor binding] GO:0046982[protein heterodimerization activity] GO:0050896[response to stimulus] GO:0051402[neuron apoptotic process] GO:0051866[general adaptation syndrome] GO:0060070[canonical Wnt signaling pathway] GO:0071376[cellular response to corticotropin-releasing hormone stimulus] GO:0071542[dopaminergic neuron differentiation] GO:1904948[midbrain dopaminergic neuron differentiation] GO:1990837[sequence-specific double-stranded DNA binding] GO:2001234[negative regulation of apoptotic signaling pathway]
F8W6I3 [Direct mapping] Nuclear receptor subfamily 4 group A member 2
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutational cancer driver genes Human disease related genes Nervous system diseases Neurodegenerative diseases
P43354 [Direct mapping] Nuclear receptor subfamily 4 group A member 2
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F1D8N6 [Target identity:100%; Query identity:100%] Nuclear receptor subfamily 4 group A member 2
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Nuclear receptors Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes Mutational cancer driver genes Disease related genes Human disease related genes Nervous system diseases Neurodegenerative diseases Mapped to neXtProt neXtProt - Evidence at protein level
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0001764[neuron migration] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0004879[nuclear receptor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005667[transcription regulator complex] GO:0005737[cytoplasm] GO:0006351[DNA-templated transcription] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0007165[signal transduction] GO:0008013[beta-catenin binding] GO:0008270[zinc ion binding] GO:0016607[nuclear speck] GO:0021953[central nervous system neuron differentiation] GO:0030522[intracellular receptor signaling pathway] GO:0031668[cellular response to extracellular stimulus] GO:0032991[protein-containing complex] GO:0035259[nuclear glucocorticoid receptor binding] GO:0043565[sequence-specific DNA binding] GO:0045444[fat cell differentiation] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding] GO:0046965[nuclear retinoid X receptor binding] GO:0046982[protein heterodimerization activity] GO:0050896[response to stimulus] GO:0060070[canonical Wnt signaling pathway] GO:0071376[cellular response to corticotropin-releasing hormone stimulus] GO:0071542[dopaminergic neuron differentiation] GO:1904948[midbrain dopaminergic neuron differentiation] GO:1990837[sequence-specific double-stranded DNA binding] GO:2001234[negative regulation of apoptotic signaling pathway]
C9JWQ1 [Direct mapping] Nuclear receptor subfamily 4 group A member 2
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutational cancer driver genes Human disease related genes Nervous system diseases Neurodegenerative diseases
C9IYM5 [Direct mapping] Nuclear receptor subfamily 4 group A member 2
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutational cancer driver genes Human disease related genes Nervous system diseases Neurodegenerative diseases
P43354 [Direct mapping] Nuclear receptor subfamily 4 group A member 2
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Nuclear receptors Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes Mutational cancer driver genes Disease related genes Human disease related genes Nervous system diseases Neurodegenerative diseases Mapped to neXtProt neXtProt - Evidence at protein level
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0001764[neuron migration] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0004879[nuclear receptor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005667[transcription regulator complex] GO:0005737[cytoplasm] GO:0006351[DNA-templated transcription] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0007165[signal transduction] GO:0008013[beta-catenin binding] GO:0008270[zinc ion binding] GO:0016607[nuclear speck] GO:0021953[central nervous system neuron differentiation] GO:0030522[intracellular receptor signaling pathway] GO:0031668[cellular response to extracellular stimulus] GO:0032991[protein-containing complex] GO:0035259[nuclear glucocorticoid receptor binding] GO:0043565[sequence-specific DNA binding] GO:0045444[fat cell differentiation] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding] GO:0046965[nuclear retinoid X receptor binding] GO:0046982[protein heterodimerization activity] GO:0050896[response to stimulus] GO:0060070[canonical Wnt signaling pathway] GO:0071376[cellular response to corticotropin-releasing hormone stimulus] GO:0071542[dopaminergic neuron differentiation] GO:1904948[midbrain dopaminergic neuron differentiation] GO:1990837[sequence-specific double-stranded DNA binding] GO:2001234[negative regulation of apoptotic signaling pathway]
C9J8W4 [Direct mapping] Nuclear receptor subfamily 4 group A member 2
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutational cancer driver genes Human disease related genes Nervous system diseases Neurodegenerative diseases
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GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0004879[nuclear receptor activity] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0006351[DNA-templated transcription] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0008270[zinc ion binding] GO:0030522[intracellular receptor signaling pathway] GO:0043565[sequence-specific DNA binding] GO:0046872[metal ion binding] GO:0050896[response to stimulus]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutational cancer driver genes Human disease related genes Nervous system diseases Neurodegenerative diseases
MEMSAT3 predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutational cancer driver genes Human disease related genes Nervous system diseases Neurodegenerative diseases
F1DAL2 [Target identity:100%; Query identity:100%] Nuclear receptor subfamily 4 group A member 2
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutational cancer driver genes Human disease related genes Nervous system diseases Neurodegenerative diseases
Show all
GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0004879[nuclear receptor activity] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0006351[DNA-templated transcription] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0008270[zinc ion binding] GO:0030522[intracellular receptor signaling pathway] GO:0043565[sequence-specific DNA binding] GO:0046872[metal ion binding] GO:0050896[response to stimulus]
The Human Protein Atlas project is funded
